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Uptake of [11C]Methionine in Non-Brain Tumors

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PET Studies on Amino Acid Metabolism and Protein Synthesis

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 23))

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Abstract

L-[methyl-11C]Methionine ([11C]methionine) has been successfully used to image brain and lung tumors. In this study, the uptake of [11C]methionine in lymphoma, breast cancer and head and neck cancer was studied by positron emission tomography (PET). [11C]Methionine accumulated avidly in 57/61 (93%) tumors. The accumulation of [11C]methionine appears to associate with the proliferative rate of breast cancer. Four different analysis methods of the uptake of [11C]methionine in cancer were studied. The kinetic analysis of the uptake of [11C]methionine in cancer can be substituted with 5 minutes emission scanning 25–40 minutes after the injection, when the radioactivity concentration in the tumor is adjusted for the injected dose and body surface area.

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References

  1. Derlon J-M, Bourdet C, Bustany P et al. [11C]L-Methionine uptake in gliomas. Neurosurgery 1989; 25: 720–728.

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Authors
  1. S. Leskinen-Kallio
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Editors and Affiliations

  1. Groupe d’Imagerie Neuro-fonctionelle, Service Hospitalier Frédéric Joliot, CEA-DRIPP Orsay, et Hôpital R. Debré, Paris, France

    B. M. Mazoyer

  2. Max-Planck-Institute for Neurological Research, Cologne, Germany

    W. D. Heiss

  3. E.E.C. Concerted Action on PET Investigations of Cellular Regeneration and Degeneration, Service Hospitalier Frédéric Joliot, Hôpital d’Orsay, Orsay, France

    D. Comar

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© 1993 Springer Science+Business Media Dordrecht

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Leskinen-Kallio, S. (1993). Uptake of [11C]Methionine in Non-Brain Tumors. In: Mazoyer, B.M., Heiss, W.D., Comar, D. (eds) PET Studies on Amino Acid Metabolism and Protein Synthesis. Developments in Nuclear Medicine, vol 23. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1620-6_17

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  • DOI: https://doi.org/10.1007/978-94-011-1620-6_17

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4706-7

  • Online ISBN: 978-94-011-1620-6

  • eBook Packages: Springer Book Archive

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