Abstract
L-[1-11C]tyrosine was used to measure the protein synthesis rate in two tumor models in rats. Dynamic PET-data were acquired using a double headed scintillation camera system operated in a coincidence mode. From blood samples the plasma concentration of L-[1-11C]tyrosine was measured as a function of time. A four compartment model was used to analyze the data. The unique solutions for the two different tumor models showed a significant difference in protein synthesis rate.
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Paans, A.M.J., Elsinga, P.H., Vaalburg, W. (1993). Carbon-11 Labeled Tyrosine as a Probe for Modelling the Protein Synthesis Rate. In: Mazoyer, B.M., Heiss, W.D., Comar, D. (eds) PET Studies on Amino Acid Metabolism and Protein Synthesis. Developments in Nuclear Medicine, vol 23. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1620-6_11
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DOI: https://doi.org/10.1007/978-94-011-1620-6_11
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