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GABAA/Benzodiazepine Receptors in the Developing Mammalian Brain

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Book cover Receptors in the Developing Nervous System

Abstract

GABA (γ-aminobutyric acid) is the main inhibitory transmitter in the brain. Up to 30-40% of the brain synapses use GABA as a neurotransmitter (Bloom and Iversen, 1971). When GABA binds to the GABAA receptor (GABAR) it opens the associated C1-channel allowing the flow of this anion inside the neuron, therefore hyperpolarizing the neuronal membrane and making the cell less reactive to excitatory neurotransmitters. Benzodiazepines (BZDs) are the most widely prescribed drugs. They are potent anxiolytic, antiepileptic and muscle relaxing agents. The psychotropic effects produced by the BZDs (i.e. librium and valium) result from their binding to brain benzodiazepine receptors (BZDRs) that are present in the membranes of many brain neurons (Bräestrup and Squires, 1977; Möhler and Okada, 1977). The BZDR is part of a protein complex that also includes the GABAR and a chloride channel.

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  1. Angel Luis de Blas
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  1. Department of Neuroscience and Anatomy The Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, Pennsylvania, USA

    Ian S. Zagon  & Patricia J. McLaughlin  & 

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de Blas, A.L. (1993). GABAA/Benzodiazepine Receptors in the Developing Mammalian Brain. In: Zagon, I.S., McLaughlin, P.J. (eds) Receptors in the Developing Nervous System. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1544-5_6

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