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Cell biology of the satellite cell

  • Chapter
Molecular and Cell Biology of Muscular Dystrophy

Part of the book series: Molecular and Cell Biology of Human Diseases Series ((Mol. Cell Biol. Hu. Dis.))

Abstract

Over the past several years the satellite cell in skeletal muscle has been the subject of renewed interest because of its potential importance in therapy for human muscle diseases due to genetic defects such as Duchenne muscular dystrophy (Griggs and Karpati, 1990; Partridge, 1991). The importance of this cell lies in the fact that it can be isolated with relative ease, can be grown in culture and will survive when returned to the in vivo environment by implantation. The implanted cells are capable of not only surviving in the host muscle, but also of gaining access to myofibres by passing through their basement membranes and eventually fusing with them. The nucleus of the fused cell integrates into the fibre syncytium and carries with it that portion of the normal genome that may be altered or missing in the host muscle. This chapter provides some general background information concerning the functions and behaviour of satellite cells in normal and pathological muscles in order to illustrate some of the characteristics of the cells which might influence the behaviour of myogenic cells following implant therapy.

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Authors
  1. Edward Schultz
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  2. Kathleen M. McCormick
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Editors and Affiliations

  1. Charing Cross & Westminster Medical School, University of London, UK

    Terence Partridge

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Schultz, E., McCormick, K.M. (1993). Cell biology of the satellite cell. In: Partridge, T. (eds) Molecular and Cell Biology of Muscular Dystrophy. Molecular and Cell Biology of Human Diseases Series. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1528-5_8

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  • DOI: https://doi.org/10.1007/978-94-011-1528-5_8

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