Abstract
Nucleoli are the sites of ribosomal gene (rDNA) transcription, and also the assembly and processing of eukaryotic ribosomal subunits Hadjiolov (1985). Specific proteins associated with rDNA transcription machinery and pre-ribosomal subunits are sorted and assembled in these nuclear territories. In addition proteins that are thought to provide structural support for the spatial arrangement of the rDNA and to play a role in the ordered translocation of pre-ribosomal subunits from their primary sites of assembly to their sites of translocation.
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References
Bell, S.P. et al. (1988) Functional Cooperativity Between Transcription Factors UBF1 and SL1 Mediates Human Ribosomal RNA Synthesis. Science, 241, 1192–1197.
Chan, E.K.L. et al. (1991) Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor. J. Exp. Med., 174, 1239–1244.
Derenzini, M. and Ploton, D. (1991) Interphase nucleolar organizer regions in cancer cells. Int. Rev. Exp. Pathol., 32, 149–191.
Dilworth, S.M. (1991) A perichromosomal region contains proteins phosphorylated during mitosis in Xenopus-laevis cells. J. Cell Sci., 98, 309–315.
Dilworth, S.M. and Dingwall, C. (1988) Chromatin assembly in vitro and in vivo. BioEssays, 9, 44–49.
Earnshaw, W.C. and Bernat, R.L. (1991) Chromosomal passengers: toward an integrated view of mitosis. Chromosoma, 100, 139–146.
Earnshaw, W.C. et al. (1985) Topoisomerase II is a structural componant of mitotic chromosome scaffolds. J. Cell Biol., 100, 1706–1715.
Earnshaw, W.C. and Heck, M.M.S. (1985) Localization of topoisomerase II in mitotic chromosomes. J. Cell Biol., 100, 1716–1725.
Fischer, D., Weisenberger, D. and Scheer, U. (1991) Assigning functions to nucleolar structures. Chromosoma, 101, 133–140.
Gas, N., Escande, M.-L. and Stevens, B.J. (1985) Immunolocalization of the 100 kDa nucleolar protein during the mitotic cycle in CHO cells. Biol. Cell, 53, 209–218.
Gautier, T. et al. (1992a) Identification and characterization of a new set of nucleolar ribonucleoproteins which line the chromosomes during mitosis. Exp. Cell Res., 200, 5–15.
Gautier, T. et al. (1992b) The ultrastructure of the chromosome periphery in human cells. An in situ study using cryomethods in electron microscopy. Chromosoma, 101, 502–510.
Gautier, T. et al. (1992c) Relocation of nucleolar proteins around chromosomes at mitosis- A study by confocal laser scanning microscopy. J. Cell Sci., 102, 729–737.
Goodpasture, C. and Bloom, S.E. (1975) Visualization of nucleolar organizer regions in mammalian chromosomes using silver staining. Chromosoma, 53, 37–50.
Guldner, H.-H. et al. (1986) Scl 70 autoantibodies from scleroderma patients recognize a 95 kDa protein identified as DNA topoisomerase I. Chromosoma, 94, 132–138.
Hadjiolov, A.A. (1985) The nucleolus and the ribosome biogenesis. Springer-Verlag, Wien, New-York.
Hernandez-Verdun, D. (1986) Structural organization of the nucleolus in mammalian cells., in Methods and Achievements in experimental pathology (eds G. Jasmin and R. Simard), Karger, S., Basel, pp. 26–62.
Hernandez-Verdun, D. (1991) The nucleolus today. J. Cell Sei., 99, 465–471.
Hernandez-Verdun, D. et al. (1980) Ultrastructural localization of Ag-NOR stained proteins in the nucleolus during the cell cycle and in other nucleolar structures. Chromosoma, 79, 349–362.
Howell, W.M. and Black, D.A. (1980) Controlled silver-staining of nucleolus organizer regions with a protective colloidal developer: a 1-step method. Experientia, 36, 1014–1015.
Hozak, P., Roussel, P. and Hernandez-Verdun, D. (1992) Procedures for specific detection of silver stained nucleolar proteins on Western blots. J. Histochem. Cytochem., 40: 1089–1096.
Hügle, B. et al. (1985a) Localization of ribosomal protein S1 in the granular component of the interphase nucleolus and its distribution during mitosis. J. Cell Biol., 100, 873–886.
Hügle, B., Scheer, U. and Franke, W.W. (1985b) Ribocharin: a nuclear M 40,000 protein specific to precursor particles of the large ribosomal subunit. Cell, 41, 615–627.
Jordan, E.G. (1991) Interpreting nucleolar structure; where are the transcribing genes. J. Cell Sei., 98, 437–449.
McKeon, F.D. et al. (1984) The redistribution of a conserved nuclear envelope protein during the cell cycle suggests a pathway for chromosome condensation. Cell, 36, 83–92.
Ochs, R. et al. (1983) Localization of nucleolar phosphoproteins B23 and C23 during mitosis. Exp. Cell Res., 146, 139–149.
Ochs, R.L. et al. (1985) Fibrillarin: a new protein of the nucleolus identified by autoimmune sera. Biol. Cell, 54, 123–134.
Peter, M. et al. (1990) Identification of major nucleolar proteins as candidate mitotic substrates of Cdc2 kinase. Cell, 60, 791–801.
Pfeifle, J., Boller, K. and Anderer, F.A. (1986) Phosphoprotein pp135 is an essential component of the nucleolus organizer region (NOR). Exp. Cell Res., 162, 11–22.
Ploton, D. et al. (1987) Behaviour of nucleolus during mitosis. A comparative ultrastructural study of various cancerous cell lines using the Ag-NOR staining procedure. Chromosoma, 95, 95–107.
Puvion-Dutilleul, F. et al. (1991) Localization of U3 RNA molecules in nucleoli of HeLa and mouse 3T3 cells by high resolution in situ hybridization. Eur. J. Cell Biol., 56, 178–186.
Rattner, J.B. (1992) Integrating chromosome structure with function. Chromosome, 101, 259–264.
Reeder, R.H. (1990) rRNA synthesis in the nucleolus. Trends Genet., 6, 390–395.
Scheer, U. and Rose, K.M. (1984) Localization of RNA polymerase I in interphase cells and mitotic chromosomes by light and electron microscopic immunocytochemistry. Proc. Natl. Acad. Sci., 81, 1431–1435.
Shi, L. et al. (1987) Involvement of a nucleolar component, perichromonucleolin, in the condensation and decondensation of chromosomes. Proc. Natl. Acad. Sci. USA, 84, 7953–7956.
Sollner-Webb, B. and Mougey, E.B. (1991) News from the nucleolus: rRNA gene expression. TIBS, 16, 58–62.
Sommerville, J. (1986) Nucleolar structure and ribosome biogenesis. Trends Biochem. Sci., 11, 438–442.
Spector, D.L. and Smith, H.C. (1986) Redistribution of U- snRNPs during mitosis. Exp. Cell Res., 163, 87–94.
Verheijen, R. et al. (1989) Ki-67 detects a nuclear matrix-associated proliferation-related antigen II. Localization in mitotic cells and association with chromosomes. J. Cell Sci., 92, 531–540.
Yasuda, Y. and Maul, G.G. (1990) A nucleolar auto-antigen is part of a major chromosomal surface component. Chromosoma, 99, 152–160.
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Hernandez-Verdun, D., Roussel, P., Gautier, T. (1993). Nucleolar proteins during mitosis. In: Chromosomes Today. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1510-0_6
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DOI: https://doi.org/10.1007/978-94-011-1510-0_6
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