Abstract
Chromosomes move in mitosis as a result of interactions between the centromere region and microtubules of the mitotic spindle. It is currently believed that a specialized chromosomal substructure located at the surface of the centromere is responsible for these movements. This structure, the kinetochore, is typically described as a three-layered disk composed of two dense plates with a space between them (Rieder, 1982). The inner dense plate is congruent with the surface of the centromeric heterochromatin, and under some circumstances is not clearly resolved from the surrounding chromatin. In human the three layers are all about 35 nm thick and 430 nm in diameter (diameter estimated from Rieder (1982) assuming 20 microtubules per chromosome).
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© 1993 Springer Science+Business Media Dordrecht
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Earnshaw, W.C. et al. (1993). Molecular cloning and characterization of human centromeric autoantigen CENP-C: a component of the inner kinetochore plate. In: Chromosomes Today. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1510-0_2
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DOI: https://doi.org/10.1007/978-94-011-1510-0_2
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-4660-2
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