Abstract
The observation that tumours are the result of clonal expansions of neoplastic cells carrying karyotypic aberrations (Heim and Mitelman, 1987;Sandberg, 1990) lends convincing support to the somatic mutation theory of carcinogenesis. Such chromosomal changes were in the past often dismissed as epiphenomena of no pathogenetic importance, but latterly the paradigm has changed, and they are now generally accepted as crucial events in multistage tumourigenesis.
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References
Christiansen, H. and Lampert, F. (1988) Tumour karyotype discriminates between good and bad prognostic outcome in neuroblastoma. Br. J. Cancer 57, 121–126.
Heim, S. (1990) Cytogenetics in the investigation of haematological disorders, in Baillière s Clinics in Haematology, vol. 3, number 4 (ed I. Cavill), Baillière Tindall, London, pp. 921–948.
Heim, S. and Mitelman, F. (1987) Cancer Cytogenetics. Alan R. Liss Inc., New York.
Heim, S. and Mitelman, F. (1992) Cytogenetics of solid tumours. Recent Adv. Histopathol. 15, 37–66.
Kaneko, Y. et al. (1987) Different karyotypic patterns in early and advanced stage neuroblastomas. Cancer Res. 47, 311–318.
Lundgren, R. et al. (1992) Chromosome abnormalities are associated with unfavorable outcome in prostatic cancer patients. J. Urol. 147, 784–788.
Mitelman, F. (1991) Catalog of Chromosome Aberrations in Cancer. 4th Ed. Wiley-Liss, New York.
Mitelman, F., Kaneko, Y. and Trent, J. (1990) Report of the committee on chromosome changes in neoplasia. Cytogenet. Cell Genet. 55, 358–386.
Pejovic, T. et al. (1992) Prognostic impact of chromo some aberrations in ovarian cancer. Br. J. Cancer 65, 282–286.
Rydholm, A. et al. (1990) Malignant fibrous histiocytomas with a 19p+ marker chromosome have an increased relapse rate. Genes Chrom. Cancer 2, 296–299.
Sandberg, A.A. (1986) Chromosome changes in bladder cancer: Clincal and other correlations. Cancer Genet. Cytogenet., 19, 163–175.
Sandberg, A.A. (1990) Chromosomes in Human Cancer and Leukemia. Elsevier, New York.
Sandberg, A.A., Turc-Carel, C. and Gemmill, R.M. (1988) Chromosomes in solid tumors and beyond. Cancer Res. 48, 1049–1059.
Trent, J.M. et al. (1990) Relation of cytogenetic abnormalities and clinical outcome in metastatic melanoma. N. Engl. J. Med., 322, 1508–1511.
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© 1993 Springer Science+Business Media Dordrecht
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Heim, S. (1993). Chromosomal abnormalities in solid tumours. In: Chromosomes Today. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1510-0_12
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DOI: https://doi.org/10.1007/978-94-011-1510-0_12
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