Abstract
IGFBP-I is a 25.3 kDa protein and is one of 6 structurally related proteins which bind and modulate the bioactivity of IGF-I and IGF-II. It is synthesized primarily in the liver and decidualized uterine endometrium, and is distributed primarily in the intravascular space and lymph. Its physiological role appears to be in glucose counter-regulation and IGF-mediated substrate utilization. Measurement of IGFBP-I in serum may serve as a marker of insulin action and hepatocyte function.
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© 1994 Springer Science+Business Media New York
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Seth, J. (1994). Insulin-Like Growth Factor Binding Protein-1. In: Seth, J. (eds) The Immunoassay Kit Directory. The Immunoassay Kit Directory, vol 1 / 3 / 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1414-1_31
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DOI: https://doi.org/10.1007/978-94-011-1414-1_31
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-7923-8860-9
Online ISBN: 978-94-011-1414-1
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