Skip to main content

Managing the effluent from bio-industrial processes

  • Chapter
Biosafety in Industrial Biotechnology

Abstract

In the bioindustries, the disposal of waste materials is of at least as great importance as in other fields of industry. While biological materials are in many ways ‘natural’ and subject to ready biodegradation by natural processes, nevertheless the environmental impact of large quantities of biodegradable materials released over a short period of time and/or at high concentrations must be considered. Moreover, those bioprocesses which handle potentially pathogenic or otherwise hazardous material must be subject to further constraints. Because of the immediate short-term hazards presented by the uncontrolled release of such organisms, from the health of the industrial workers, to the local population both human and animal, a system of management is necessary to ensure the safe disposal of bioindustrial wastes. Nor must the potential hazard to plant life be ignored; plant pathogens are also used in industrial processes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Grady, C.P.L. and Lim, H.C. (1980). Biological Waste Treatment: Theory and Applications. New York: Marcel Dekker.

    Google Scholar 

  2. Control of Substances Hazardous to Health Regulations (1988). Health and Safety Executive. HMSO. ISBN 0 11 087657.

    Google Scholar 

  3. HSE Advisory Committee on Dangerous Pathogens (1990). Categorization of Pathogens According to Hazard and Categories of Containment. London: HMSO.

    Google Scholar 

  4. ACGM/HSE Note 6 (1987). Guidelines for the Large Scale use of Genetically Manipulated Organisms. ACGM Secretariat, Baynards House, 1, Chepstow Place, London W2 4TF.

    Google Scholar 

  5. ACGM/HSE Note 8 (1988). Laboratory Containment Facilities for Genetic Manipulation. ACGM Secretariat, Baynards House, 1, Chepstow Place, London W2 4TF.

    Google Scholar 

  6. Keir, D. (1991). Role of probabilistic safety assessment in biotechnology risk assessment. In Proceedings of the SCI Symposium, Risk Assessment in Biotechnology, London, 20/06/ 91.

    Google Scholar 

  7. Jefferis, R.P. and Schlager, S.T. (1986). Using fault analysis methods to improve bioreactor safety, Ann. N.Y. Acad. Sci., 469, 53–62.

    Article  Google Scholar 

  8. Van Deelen, CL. and Logtenburg, M.T. (1989). The Assessment of Risk in Scaled Up Biotechnological Processing (Progress Report of Activity 1): TNO Division of Technology for Society, Report 88-371/R.27/1VS, Luan Van Westenak 502, Apeldoorn, Netherlands.

    Google Scholar 

  9. Georgio, R.J. and Wu, J.J. (1986). Design of Large Scale Containment Facilities for Recombinant DNA Fermentations, TIBTECH, March, pp. 60–65.

    Google Scholar 

  10. Walker, P.D., Narendranathan, T.J., Brown, D.C., Woolhouse, F. and Vranch, S.P. (1987). Containment of micro-organisms during fermentation and downstream processing. In Separations for Biotechnology, Werrall, M.S. and Hudson, M.J. (Eds), Ellis-Horwood/SCI, pp. 469–482.

    Google Scholar 

  11. Leaver, G., Salusbury, T.T., Stewart, I.W. (1988). Containment Monitoring Methods -Micro-organisms and their Products. DTI: Industrial Biosafety Project: Confidential State-of-the-Art Report No. CR 3009 (BS).

    Google Scholar 

  12. Acheson, E.D., Barnes, H.R., Gardner, M.J., Osmond, C, Pannett, B. and Taylor, CP. (1984). Formaldehyde in the British chemical industry. Lancet, 17 March.

    Google Scholar 

  13. Trujillo, R. and David, T.J. (1972). Appl. Microbiol., 23, 618–622.

    CAS  Google Scholar 

  14. Russell, A.D. (1982). The Destruction of Microbial Spores. London: Academic Press.

    Google Scholar 

  15. Gardner, J.F. and Peel, M.M. (1986). Introduction to Sterilization and Dins infection. London: Churchill Livingstone.

    Google Scholar 

  16. Russell, A.D., Hugo, W.B. and Ayliffe, G.A J. (Eds) (1982). Principles and Practice of Disinfection, Preservation and Sterilization. London: Blackwell Scientific.

    Google Scholar 

  17. Block, S.S. (Ed.) (1991). Disinfection, Sterilization and Preservation (4th edn) Philadelphia: Lea and Febiger.

    Google Scholar 

  18. Smelt, J.P.P.M. and Mossell, D.A.A. (1982). Applications of thermal processes in the food industry. In Russell, A.D., Hugo, W.B. and Ayliffe, G.A.J. (Eds) Principles and Practice of Disinfection, Preservation and Sterilization. London: Blackwell Scientific.

    Google Scholar 

  19. Working Party on Pressure Steam Sterilizers (1959). Sterilization by Steam under increased Pressure. A Report to the MRC, Lancet (i), 425-35.

    Google Scholar 

  20. McBride, RJ. (1985). The F0 Concept: The Parenteral Society.

    Google Scholar 

  21. Peto, S. and Maidment, B.J. (1969). Tables of the upper limit to the estimate of the density of contaminating particles in a medium. J. Hyg. Camb., 67, 533–583.

    Article  CAS  Google Scholar 

  22. Safety Precautions: Notes for Guidance. Public Health Laboratory Service staff handbook, 1988 edn.

    Google Scholar 

  23. Safety of Pressure Systems: Pressure Systems and Transferable Gas Container Regulations, 1989. Approved Code of Practice HSC: 1990. London: HMSO.

    Google Scholar 

  24. Grossell, S.S. (1990). An overview of equipment for containment and disposal of emergency relief system effluent. J. Loss Prev. Process Ind., 3, 112–124.

    Article  Google Scholar 

  25. Kieffer, R.G., quoting Theodore Byers (1986). Why validation. In Validation of Aseptic Pharmaceutical Processes, Carleton, F.J. and Agalloco, J.P. (Eds). New York: Marcel Dekker.

    Google Scholar 

  26. Kemper, C.A. (1986). Design, installation and calibration of thermocouple measuring systems. In Validation of Aseptic Pharmaceutical Processes, Carleton, F.J. and Agalloco, J.P. (Eds) New York: Marcel Dekker.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Court, J.R. (1994). Managing the effluent from bio-industrial processes. In: Hambleton, P., Melling, J., Salusbury, T.T. (eds) Biosafety in Industrial Biotechnology. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1352-6_12

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-1352-6_12

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4590-2

  • Online ISBN: 978-94-011-1352-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics