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Molecular Similarity in Drug Design pp 291–331Cite as

Comparative molecular field analysis (CoMFA)

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Abstract

Comparative molecular field analysis (CoMFA) is a method for three-dimensional (3D) quantitative structure-activity relationships (3D-QSAR) developed at Tripos. Although the concept of the approach has been known as dylomms (dynamic lattice-oriented molecular modeling system) (Wise et al., 1983) for over a decade, it was not until recent years that the method became widely used after it was reborn as CoMFA in 1988 (Cramer et al., 1988b,1993). The methodology has been patented (Cramer and Wold, 1991) and the program is available as a QSAR package in SYBYL.1

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    P. M. Dean

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Kim, K.H. (1995). Comparative molecular field analysis (CoMFA). In: Dean, P.M. (eds) Molecular Similarity in Drug Design. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1350-2_12

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