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Abstract

This chapter is concerned with the physiology of the developing mammal from the time the major organs have developed to birth. Fetal physiology is of interest not only because during fetal life the foundations for future growth and performance are established, but also because the physiology of one animal growing within another is of interest for its own sake. As the fetus grows in size and the various body systems develop, so the ‘physiology’ of the fetus changes. Much of what we know has been based on studies in the last third of gestation when the fetus is relatively large. Special interest has also been directed to the fetus immediately before birth for, by understanding the behaviour of the fetus before birth, it is hoped to limit the damage caused by the delivery and to optimize the care of the newborn afterwards. Less is known about the physiology of the fetus in mid-gestation, although the development of several clinical techniques (ultrasonography, amniocentesis and fetal blood sampling) over the last decade has increased our knowledge of the biology of the human mid-trimester fetus (Pesonen et al, 1983; Nicolaides et al, 1985; Forestier, 1987; Forestier et al, 1987; Peters and Nicolaides, 1990; Fisk and Rodeck, 1992; Stephenson, 1993).

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References

  • Abramovich, D.R. (1970) Fetal factors influencing amniotic fluid volume and composition of liquor amnii. Journal of Obstetrics and Gynaecology of the British Commonwealth, 77, 865–877.

    CAS  PubMed  Google Scholar 

  • Abrams, R.M. (1978) Thermal physiology of the fetus, in Temperature Regulation and Energy Metabolism in the Newborn, (ed. J.C. Sinclair), Grune & Stratton, New York.

    Google Scholar 

  • Ackerman, G.A. (1967) The lymphocyte: its morphology and embryological origin, in The Lymphocyte in Immunology and Haemopoiesis, (ed. J.M. Yoffey), Edward Arnold, London, pp. 11–30.

    Google Scholar 

  • Adamson, T., Brodecky, V., Lambert, T., Maloney, J., Ritchie, B. and Walker, A. (1973) The production and composition of lung liquid in the in-utero fetal lamb, in Fetal and Neonatal Physiology (eds K. Comline, K. Cross, G.S. Dawes and P.W. Nathanielsz), Bycroft Centenary Symposium, Cambridge University Press, Cambridge, UK.

    Google Scholar 

  • Alberts, J.R. (1978) Huddling by rat pups: Group behavioural mechanisms of temperature regulation and energy conservation. Journal of Comparative and Physiological Psychology, 92, 231–245.

    CAS  PubMed  Google Scholar 

  • Alcorn, D., Adamson, T., Lambert, T., Maloney, J., Ritchie, B. and Robinson, P. (1977) Morphological effects of chronic tracheal liga-tion and drainage in the fetal lamb lung. Journal of Anatomy, 123, 649–660.

    CAS  PubMed  Google Scholar 

  • Al-Dahhan, J., Haycock, G.B., Chantier, C. and Stimmler, L. (1983a) Sodium homeostasis in terms and preterm neonates. 1. Renal aspects. Archives of Disease in Childhood, 58, 335–342.

    CAS  PubMed  Google Scholar 

  • Al-Dahhan, J., Haycock, G.B., Chantier, C. and Stimmler, J. (1983b) Sodium homeostasis in term and preterm neonates. II. Gastrointestinal aspects. Archives of Disease in Childhood, 58, 343–345.

    CAS  PubMed  Google Scholar 

  • Alexander, D.P. and Nixon, D. A. (1961) The foetal kidney. British Medical Bulletin, 17, 112–117.

    CAS  PubMed  Google Scholar 

  • Alexander, D.P. and Nixon, D.A. (1962) Plasma clearance of p-aminohippuric acid by the kidneys of foetal, neonatal and adult sheep. Nature, 194, 483–484.

    CAS  PubMed  Google Scholar 

  • Alexander, D.P. and Nixon, D.A. (1963) Reabsorption of glucose, fructose and mesoi-nositol by the foetal and postnatal sheep kidney. Journal of Physiology, 167, 480–486.

    CAS  PubMed  Google Scholar 

  • Alexander, D.P., Nixon, D.A., Widdas, W.F. and Wohlzogen, F.X. (1958) Gestational variations in the composition of foetal fluids and foetal urine in the sheep. Journal of Physiology, 140, 1–13.

    CAS  PubMed  Google Scholar 

  • Alexander, G. (1975) Body temperature control on mammalian young. British Medical Bulletin, 31, 62–68.

    CAS  PubMed  Google Scholar 

  • Alpan, G. and Glyman, R. I. (1990). The effect of methylprednisolone on hypoxic pulmonary vasoconstriction in the newborn late-gestation lamb. Pediatric Research, 27(2), 133–136.

    CAS  PubMed  Google Scholar 

  • Alt, J.M., Colenbrander, R., Forsling, M.L. and Macdonald, A.A. (1984) Perinatal development of tubular function in the pig. Quarterly Journal of Experimental Physiology, 609, 693–702.

    Google Scholar 

  • Andersen, H., Bierring, F., Matthiessen, M., Egeberg, J. and Bro-Rasmussen, F. (1964) On the nature of meconium corpuscles in human foetal intestinal epithelium. Acta Pathologica et Microbiologica Scandinavica, 61, 377–393.

    CAS  PubMed  Google Scholar 

  • Anderson, R., Benolken, R., Dudley, P., Landis, D. and Wheeler, T. (1974). Polyunsaturated fatty acids of photoreceptor membranes. Experimental Eye Research, 18, 205–213.

    CAS  PubMed  Google Scholar 

  • Andrews, N.P., Broughton-Pipkin, F. and Heptinstall, S. (1985) Blood platelet behaviour in mothers and neonates. Thrombosis and Haemostasis, 53, 428–432.

    CAS  PubMed  Google Scholar 

  • Anonymous (1987) Erythropoietin. Lancet, i, 781–782.

    Google Scholar 

  • Anonymous (1990) Prone, hot and dead. Lancet, ii, 1104.

    Google Scholar 

  • Anthony, M., Goodall, S., Pappuli, M. and Levene, M. (1992) Measurement of plasma volume in neonates. Archives of Disease in Childhood, 67, 36–40.

    CAS  PubMed  Google Scholar 

  • Aoki, A. (1966) Development of the human renal glomerulus. 1. Differentiation of the filtering membrane. Anatomical Record, 155, 339–352.

    CAS  PubMed  Google Scholar 

  • Aperia, A. and Elinder, G. (1981) Distal tubular sodium reabsorption in the developing rat kidney. American Journal of Physiology, 240, F487–F491.

    CAS  PubMed  Google Scholar 

  • Aperia, A. and Zetterstrom, R. (1982) Renal control of fluid homeostasis in the newborn infant. Clinics in Perinatology, 9, 523–533.

    CAS  PubMed  Google Scholar 

  • Aperia, A., Larsson, L. and Zetterstrom, R. (1981) Hormonal induction of Na-K-ATPase in developing proximal tubular cells. American Journal of Physiology, 241, 356–360.

    Google Scholar 

  • Aperia, A., Herin, P., Lundin, S., Melin, P. and Zetterstrom, R. (1984) Regulation of renal water excretion in newborn full-term infants. Acta Paediatrica Scandinavica, 73, 717–721.

    CAS  PubMed  Google Scholar 

  • Apgar, V. (1953) A proposal for a new method of evaluation of the newborn infant. Current Research in Anesthetics and Analgesia, 32, 260–267.

    CAS  Google Scholar 

  • Arey, L.B. (1974) Developmental anatomy, W.B. Saunders, Philadelphia.

    Google Scholar 

  • Atkinson, S. (1992) Feeding the normal term infant, in Effective Care of the Newborn Infant, (eds J. Sinclair and M. Bracken), Oxford University Press, Oxford, pp. 73–93.

    Google Scholar 

  • Attal, J. (1969) Levels of testosterone, androstene-dione, estrone and estradiol 17β in the testes of fetal sheep. Endocrinology, 85, 280–289.

    CAS  PubMed  Google Scholar 

  • Avery, M.E. and Mead, J. (1959) Surface properties in relation to atelectasis and hyaline membrane disease. American Journal of Diseases in Children, 97, 517–523.

    CAS  Google Scholar 

  • Bailey, D.J., Bradbury, M.W.B. and France, V. (1979) Cation transport across the guinea-pig placenta perfused in situ. Journal of Physiology, 207, 45–56.

    Google Scholar 

  • Bailey, E. and Lockwood, E. (1973) Some aspects of fatty acid oxidation and ketone body formation and utilization during development of the rat. Enzyme, 15, 239–253.

    CAS  PubMed  Google Scholar 

  • Bailie, M.D., Derkx, F.H.M. and Schalekamp, A.D.H. (1980) Release of active and inactive renin by the pig kidney during development. Developmental Pharmacology and Therapeutics, 1, 47–57.

    CAS  PubMed  Google Scholar 

  • Banks-Schlegel, S.P. (1982) Keratin alterations during embryonic epidermal differentiation: a presage of adult epidermal maturation. Journal of Cell Biology, 93, 551–559.

    CAS  PubMed  Google Scholar 

  • Barcroft, J. (1946) Researches on Prenatal Life, Oxford Blackwell Scientific Publications.

    Google Scholar 

  • Bard, H., Fouron, J.-C, Robillard, J.E., Cornet, A. and Soukini, M.A. (1978) Red cell oxygen affinity in fetal sheep: role of 2, 3-DPG and adult haemoglobin. Journal of Applied Physiology, 45, 7–10.

    CAS  PubMed  Google Scholar 

  • Barker, D.J.P., Bull, A.R., Osmond, C. and Simmond, S.J. (1990). Fetal and placental size and risk of hypertension in adult life. British Medical Journal, 301, 259–262.

    CAS  PubMed  Google Scholar 

  • Barnes, N. (1992) Endocrine disorders, in Textbook of Neonatology, 2nd edn (ed. N. Roberton), Churchill Livingstone, Edinburgh, pp. 799–837.

    Google Scholar 

  • Barnes, R.J., Comline, R.S., Dobson, A., Silver, M., Burton, G.J. and Steven, D.H. (1979) On the presence of a ductus venosus in the fetal pig in late gestation. Journal of Developmental Physiology, 1, 105–110.

    CAS  PubMed  Google Scholar 

  • Bassett, J. and Madill, D. (1974) Influence of prolonged glucose infusions on plasma insulin and growth hormone concentrations of foetal lambs. Journal of Endocrinology, 62, 299–309.

    CAS  PubMed  Google Scholar 

  • Battaglia, F.C., Artini, P. G., D’Ambrogio, G., Galli, P. A., Segre, A. and Genazzani, A. R. (1992). Maternal hyperoxygenation in the treatment of intrauterine growth retardation. American Journal of Obstetrics and Gynecology, 167, 430–435.

    CAS  PubMed  Google Scholar 

  • Battaglia, F.C. and Hay, W. (1984). Energy and Substrate requirements for fetal and placental growth and metabolism, in Fetal Physiology and Medicine, (eds R. Beard and P. Nathanielsz), Marcel Dekker, New York, pp. 601–628.

    Google Scholar 

  • Battaglia, F.C. and Meschia, G. (1988) Principal substrates of fetal metabolism. Physiological Reviews, 58, 499–527.

    Google Scholar 

  • Battaglia, F.C. and Meschia, G. (1986) An Introduction to Fetal Physiology, Academic Press, New York.

    Google Scholar 

  • Battaglia, F. C. and Meschia, G. (1988) Fetal Nutrition. Annual Reviews of Nutrition, 8, 43–61.

    CAS  Google Scholar 

  • Battaglia, F.C, McGaughey, H., Makowski, E.L. and Meschia, G. (1970) Postnatal changes in oxygen affinity of sheep red cells: a dual role of diphosphoglyceric acid. American Journal of Physiology, 219, 217–221.

    CAS  PubMed  Google Scholar 

  • Baum, J.D. and Harris, D. (1972) Colloid osmotic pressure in erythroblastosis fetalis. British Medical Journal, i, 601–603.

    Google Scholar 

  • Baum, J.D., Eisenberg, C., Franklin, F.A., Meschia, G. and Battaglia, F.C. (1971) Studies on colloid osmotic pressure in the fetus and newborn infant. Biology of the Neonate, 18, 311–320.

    CAS  PubMed  Google Scholar 

  • Beitins, I.Z., Bayard, F., Levitsky, L., Ances, L.G., Kowarski, A. and Migeon, C.J. (1972) Plasma aldosterone concentration at delivery and during the newborn period. Journal of Clinical Investigation, 51, 386–394.

    CAS  PubMed  Google Scholar 

  • Benavides, C., Perez, R., Espinoza, M., Cabello, G., Riguelme, R., Parer, J. and Llano, A. (1989). Cardiorespiratory functions in the fetal llama. Respiration Physiology, 75, 327–334.

    CAS  PubMed  Google Scholar 

  • Benito, M. (1985). Contribution of brown fat to neonatal thermogenesis. Biology of the Neonate, 48(4), 245–249.

    CAS  PubMed  Google Scholar 

  • Birch, T. (1956-7) The History of the Royal Society of London, 1, 180.

    Google Scholar 

  • Biscoe, T., Purves, M. and Sampson, S. (1969) Types of nervous activity which may be recorded from the carotid sinus nerve in the sheep fetus. Journal of Physiology, 202, 1–23.

    CAS  PubMed  Google Scholar 

  • Black, V.H. and Christensen, A.K. (1969) Differentiation of interstitial cells and Sertoli cells in fetal guinea pig testes. American Journal of Anatomy, 124, 211–238.

    CAS  PubMed  Google Scholar 

  • Bland, R.D. (1986) Lung Fluid Balance Before and After Birth in Respiratory Control and Lung Development in the Fetus and Newborn, (eds B.M. Johnson and P.D. Gluckman), Perinatal Press, New York.

    Google Scholar 

  • Blott, M., Greenough, A., Nicolaides, K., Moscoso, G., Gibb, D. and Campbell, S. (1987) Fetal breathing movements as a predictor of favourable pregnancy outcome after oligohyd-ramnios due to membrane rupture in the second trimester. Lancet, ii, 129–131.

    Google Scholar 

  • Boyd, R.D.H., Haworth, C., Stacey, T.E. and Ward, R.H.T. (1976) Permeability of the sheep placenta to unmetabolised polar non-electrolytes. Journal of Physiology, 256, 617–634.

    CAS  PubMed  Google Scholar 

  • Boyden, E. (1977) Development and growth of the airways, in Development of the Lung, (ed. W. Hodson), Marcel Dekker, New York, pp. 3–35.

    Google Scholar 

  • Boyland, J.W., Colbourn, E.P. and McCance, R.A. (1958) Renal function in the foetal and newborn guinea pig. Journal of Physiology, 141, 323–331.

    Google Scholar 

  • Bradley, R.M. and Mistretta, C.M. (1973) The gustatory sense in foetal sheep during the last third of gestation. Journal of Physiology, 231, 271–282.

    CAS  PubMed  Google Scholar 

  • Brandes, R., Arad, R. and Barash, V. (1987) Cytosolic fatty acid binding proteins in rat placenta. Placenta, 8, 347–350.

    CAS  PubMed  Google Scholar 

  • Bremer, J.L. (1916) The inter-relations of the meso-nephros, kidney and placenta in different classes of animals. American Journal of Anatomy, 19, 179–210.

    Google Scholar 

  • Brenner, R. (1984) Effect of unsaturated acids on membrane structure and enzyme kinetics. Progress in Lipid Research, 23, 69–96.

    CAS  PubMed  Google Scholar 

  • Bressler, M. and Munger, B.L. (1983) Embryonic maturation of sensory terminals of primate facial hairs. Journal of Investigative Dermatology, 80, 245–260.

    CAS  PubMed  Google Scholar 

  • Brod, J. (1973) The Kidney, Butterworths, London.

    Google Scholar 

  • Brody, B., Kinney, H., Kloman, A. and Gilles, F. (1987). Sequence of central nervous system my-elination in human infancy. Journal of Neuropathology and Experimental Neurology, 46, 283–301.

    CAS  PubMed  Google Scholar 

  • Broughton-Pipkin, F. (1973) Vasoactive hormones in immature mammals. D Phil Thesis, University of Oxford.

    Google Scholar 

  • Broughton-Pipkin, F. and Symonds, E.M. (1984) Renin-angiotensin system in early life, in Fetal Medicine and Physiology, (eds R.W. Beard and P. Nathanielsz), Marcel Dekker, New York, pp. 459–480.

    Google Scholar 

  • Broughton-Pipkin, F., Ousey, J., Wallace, C.P. and Rossdale, P.D. (1984) The effect of salt and water loss on the renin-angiotensin aldosterone system in the newborn foal. Equine Veterinary Journal, 16, 292–297.

    CAS  PubMed  Google Scholar 

  • Brunette, M.G. (1989) Effects of parathyroid hormone on PO4 transport through the human placenta microvilli. Pediatric Research, 25, 19–26.

    Google Scholar 

  • Cain, H. and Krause, B. (1971) Der Juxtaglomerulare Apparat der Rattenniere im Verlauf von Wachstum, Reifung und Alterung. Virchows Archiv, 9, 164–179.

    CAS  Google Scholar 

  • Calcagno, P.L. and Rubin, M.I. (1963) Renal extraction of p-aminohippurate in infants and children. Journal of Clinical Investigation, 42, 1632–1639.

    CAS  PubMed  Google Scholar 

  • Canning, J. and Boyd, R. (1984) Mineral and water exchange between mother and fetus, in Fetal Physiology and Medicine, (eds R. Beard and P. Nathanielsz), Marcel Dekker, New York, pp. 481–509.

    Google Scholar 

  • Cannon, B. (1985) The biochemistry of an inefficient tissue: brown adipose tissue. Essays in Biochemistry, 20, 110–164.

    CAS  PubMed  Google Scholar 

  • Care, A.D. and Ross, R. (1984) Fetal calcium homeostasis. Journal of Developmental Physiology, 6, 59–66.

    CAS  PubMed  Google Scholar 

  • Carlson, S., Rhodes, P. and Ferguson, M. (1986) Docosohexanoic acid status of preterm infants at birth and following feeding with human milk or formulas. American Journal of Clinical Nutrition, 44, 798–804.

    CAS  PubMed  Google Scholar 

  • Cartlidge, P.H.T. and Rutter, N. (1986) Serum albumin concentrations and oedema in the newborn. Archives of Disease in Childhood, 61, 657–660.

    CAS  PubMed  Google Scholar 

  • Cartlidge, P.H.T. and Rutter, N. (1987) Percutaneous respiration in the newborn infant. Biology of the Neonate, 54, 68–72.

    Google Scholar 

  • Catt, K.J., Dufau, M.L., Neaves, W.B., Walsh, P.C. and Wilson, J.D. (1975) LH-hCG receptors and testosterone content during differentiation of the testis in the rabbit embryo. Endocrinology, 67, 1157–1165.

    Google Scholar 

  • Chamberlain, G.V.P. and Wilkinson, A.E. (1979) Placental Transfer, Pitman Medical, UK.

    Google Scholar 

  • Charlton, V.E., Reis, B.L. and Lofgren, D.J. (1979a) Consumption of carbohydrates, amino acids and oxygen across the intestinal circulation in the fetal sheep. Journal of Developmental Physiology, 1, 329–336.

    CAS  PubMed  Google Scholar 

  • Charlton Char, V. and Rudolph, A.M. (1979b) Digestion and absorption of carbohydrates by the fetal lamb in utero. Pediatric Research, 13, 1018–1023.

    Google Scholar 

  • Cheung, C.Y. and Brace, R.A. (1988) Fetal hypoxia elevates plasma atrial natriuretic factor concentration. American Journal of Obstetrics and Gynecology, 159, 1263–1268.

    CAS  PubMed  Google Scholar 

  • Cheung, C.Y. and Brace, R.A. (1989). Haemorrhage induced reduction of plasma atrial natriuretic factor in the ovine fetus. International Union of Physiological Societies, Satellite Symposium, Stockholm, (Abstract A3), 89.

    Google Scholar 

  • Chevalier, R.L. (1982) Glomerular number and perfusion during normal and compensatory renal growth in the guinea pig. Pediatric Research, 16, 436–440.

    CAS  PubMed  Google Scholar 

  • Chez, R.A., Smith, F.G. and Hutchinson, D.L. (1964) Renal function in the intrauterine primate fetus. American Journal of Obstetrics and Gynecology, 90, 128–131.

    CAS  PubMed  Google Scholar 

  • Chez, R.A., Mintz, D.H. and Hutchinson, D.L. (1974) Gastric glucose tolerance in the third trimester monkey conceptus. American Journal of Obstetrics and Gynecology, 120, 553–554.

    CAS  PubMed  Google Scholar 

  • Clements, J.A. (1977) Functions of the alveolar lining layer. American Review of Respiratory Disease, 115, 67–71.

    CAS  PubMed  Google Scholar 

  • Clements, J.A., Reyes, F.I., Winter, J.S.D. and Faiman, C. (1976) Studies on human sexual development. III. Fetal pituitary and serum am-niotic fluid concentrations of LH, CH and FSH. Journal of Clinical Endocrinology and Metabolism, 42, 9–19.

    CAS  PubMed  Google Scholar 

  • Clements, M.R. (1988) Vitamin D supply to the rat fetus and neonate. Journal of Clinical Investigation, 81, 7768–7773.

    Google Scholar 

  • Cohen, M. and Carson, B. (1985) Respiratory morbidity benefit of awaiting onset of labour after elective Caesarean section. Obstetrics and Gynecology, 65, 818–824.

    CAS  PubMed  Google Scholar 

  • Cole, B.R., Brocklebank, J.T., Capps, R.G., Murray, B.N. and Robson, A.M. (1972) Maturation of p-aminohippuric acid transport in the developing rabbit kidney: interrelationships of the individual components. Pediatric Research, 12, 992–997.

    Google Scholar 

  • Cole, R.J. and Paul, J. (1966) The effects of erythro-poietin on haem synthesis in mouse yolk sac and cultured foetal liver cells. Journal of Embryology and Experimental Morphology, 15, 245–260.

    CAS  PubMed  Google Scholar 

  • Collins, M., Moessinger, A., Kleinerman, J., James, L. and Blanc, W. (1986) Morphometry of hypoplastic fetal guinea pig lungs following am-niotic fluid leak. Pediatric Research, 20, 955–960.

    CAS  PubMed  Google Scholar 

  • Comline, R. S. and Silver, M. (1975). Placental transfer of blood gases. British Medical Bulletin, 31, 25–31.

    CAS  PubMed  Google Scholar 

  • Comroe, J. (1977) Retrospectroscope, Von Gehr Press, Menlo Park, California.

    Google Scholar 

  • Coulthard, M. (1985) Maturation of glomerular filtration in preterm and mature babies. Early Human Development, 11, 281–292.

    CAS  PubMed  Google Scholar 

  • Court, D.J., Block, B.S.B. and Llanos, A.J. (1984) Effects of β-adrenergic blockade on blood flow distribution during hypoxaemia in fetal sheep. Journal of Developmental Physiology, 6, 349–358.

    CAS  PubMed  Google Scholar 

  • Cross, K.W. (1979) La chaleur animale and the infant brain. Journal of Physiology, 294, 1–21.

    CAS  PubMed  Google Scholar 

  • Crowley, P., Chalmers, I. and Keirse, M. (1990) The effects of corticosteroid administration before preterm delivery: an overview of the evidence from controlled trials. British Journal of Obstetrics and Gynaecology, 97, 11–25.

    CAS  PubMed  Google Scholar 

  • Dancis, J., Braverman, N. and Lind, J. (1957) Plasma protein synthesis in the human fetus and placenta. Journal of Clinical Investigation, 36, 398–404.

    CAS  PubMed  Google Scholar 

  • Dancis, J., Jansen, V. and Levitz, M. (1980) Placental transfer of steroids: Effect of binding to serum albumin and to placenta. American Journal of Physiology, 238, 208.

    Google Scholar 

  • Davidson, D. and Eldemerdash, A. (1990) Endothelium-derived relaxing factor: presence in pulmonary and systemic arteries of the newborn guinea pig. Pediatric Research, 17, 128–132.

    Google Scholar 

  • Davies, J. (1951) Nephric development in the sheep with reference to the problem of the ruminant pronephros. Journal of Anatomy, 85, 6–11.

    CAS  PubMed  Google Scholar 

  • Davies, J. (1952) Correlated anatomical and histo-chemical studies on the mesonephros and placenta of the sheep. American Journal of Anatomy, 91, 263–300.

    CAS  PubMed  Google Scholar 

  • Dawes, G.S. (1968) Fetal and Neonatal Physiology, Year Book Medical Publishers, Chicago.

    Google Scholar 

  • Dawes, G.S. (1986) The rediscovery of fetal breathing movements and its consequences, in Respiratory Control and Lung Development in the Fetus and Newborn, (eds B.M. Johnston and P.D. Gluckman), Perinatology Press, New York.

    Google Scholar 

  • Dean, R.F.A. and McCance, R.A. (1949) The renal response of infants and adults to the administration of hypertonic solutions of sodium chloride and urea. Journal of Physiology, 109, 81–97.

    CAS  PubMed  Google Scholar 

  • Debnam, E.S., Epstein, O., Srai, S.K.S. (1987) Developmental changes in the autographic localisation of iron uptake by the guinea pig duodenum. Journal of Physiology, 394, 164.

    Google Scholar 

  • Delivoria-Papadopoulos, M., Martens, R.J., Forster, R.E. and Oski, F.A. (1974) Postnatal changes in oxygen-hemoglobin affinity and erythrocyte 2, 3-diphosphoglycerate in piglets. Pediatric Research, 8, 66–84.

    Google Scholar 

  • De Prins, F., Hill, D.J., Milner, R.D.G. and Van Assche A. (1988) Effect of maternal hyperali-mentation on intrauterine growth retardation. Archives of Disease in Childhood, 63, 733–736.

    CAS  PubMed  Google Scholar 

  • Demers, L.M., Gabbe, S.G., Villee, C.A. and Greep, R.O. (1972) The effect of insulin on human placental glycogenesis. Endocrinology, 91, 270.

    CAS  PubMed  Google Scholar 

  • Dennis, J., Johnson, A., Mutch, L., Yudkin, P. and Johnson, P. (1989). Acid-base status at birth and neurodevelopmental outcome at four and one-half years. American Journal of Obstetrics and Gynecology, 161, 213–220.

    CAS  PubMed  Google Scholar 

  • Deren, J.S. (1971) Development of structure and function in the fetal and newborn stomach. American Journal of Clinical Nutrition, 24, 144–159.

    CAS  PubMed  Google Scholar 

  • Dewitt, O., Dibba, B. and Prentice, A. (1990). Breast-milk amylase activity in English and Gambian mothers: effects of prolonged lactation, maternal parity, and individual variations. Pediatric Research, 28, 502–506.

    Google Scholar 

  • Dhiab, A.L., Naimi, A.A.H. and Beam, J.G. (1981) The juxtaglomerular apparatus and glomerular granular cells in fetuses and neonates of the rat. Journal of Anatomy, 133, 607–623.

    Google Scholar 

  • Dobbing, J. and Sands, J. (1979) Comparative aspects of the brain growth spurt. Early Human Development, 3, 79–83.

    CAS  PubMed  Google Scholar 

  • Dobrovik-Jenik, D., Ozegovic, B. and Milkovic, S. (1984) Postnatal development of rat kidney plasma membrane Na+/K+-ATPase. Biology of the Neonate, 46, 115–121.

    Google Scholar 

  • Duee, P.H., Pegorier, J.P., El Manoubi, L., Herbin, C., Kohl, C. and Girard, J. (1985) Hepatic triglyceride hydrolysis and development of ketogenesis in rabbits. American Journal of Physiology, 249, 478–484.

    Google Scholar 

  • East, J.M., Chepenik, K.P. and Waite, B.M. (1975) Phospholipase A activities in rat placentas of 14 days gestation. Biochimie Biophysica Acta, 388, 106–112.

    CAS  Google Scholar 

  • Eckberg, D. and Sleight, P. (1992) The Human Baroreflex in Health and Disease, Oxford Medical Publications, Oxford.

    Google Scholar 

  • Edelstone, D. and Rudolph, A. (1979) Preferential streaming of the ductus venosus blood to the brain and heart in fetal lambs. American Journal of Physiology, 237, H724.

    CAS  PubMed  Google Scholar 

  • Edson, J.L. and Hull, D. (1981) The development of cold induced thermogenesis in hamsters. Journal of Developmental Physiology, 6, 387–396.

    Google Scholar 

  • Edson, J.L., Hudson, D.G. and Hull, D. (1975) Evidence for increased fatty acid transfer across the placenta during a maternal fast in rabbits. Biology of the Neonate, 7, 50–56.

    Google Scholar 

  • Eguchi, Y. and Morikawa, Y. (1968) Changes in pituitary gonadal interrelations during perinatal days in the rat. Anatomical Record, 161, 163–170.

    CAS  PubMed  Google Scholar 

  • Elphick, M.C. and Hull, D. (1984) Transfer of fatty acids across the cat placenta. Journal of Developmental Physiology, 6, 517–525.

    CAS  PubMed  Google Scholar 

  • Elphick, M.C., Edson, J.L., Lawlor, J.P. and Hull, D. (1978a) Source of fetal-stored lipids during maternal starvation in rabbits. Biology of the Neonate, 34, 146–149.

    CAS  PubMed  Google Scholar 

  • Elphick, M.C., Harrison, A.T., Lawlor, J.P. and Hull, D. (1978b) Cord blood hypertriglyceridae-mia as an index of fetal stress: use of a simple screening test and results of further biochemical analysis. British Journal of Obstetrics and Gynaecology, 85, 303–310.

    CAS  PubMed  Google Scholar 

  • Elphick, M.C., Hull, D. and Broughton-Pipkin, F. (1979) The transfer of fatty acids across the sheep placenta. Journal of Developmental Physiology, 1, 31–45.

    CAS  PubMed  Google Scholar 

  • Elphick, M.C., Flecknell, P., Hull, D. and McFadyen, I.R. (1980) Plasma free fatty acid umbilical venous-arterial concentration differences and placental transfer of [14C] palmitic acid in pigs. Journal of Developmental Physiology, 2, 347–356.

    CAS  PubMed  Google Scholar 

  • Emery, J.L. (1956) The distribution of haemopoi-etic foci in the infantile human liver. Journal of Anatomy, 90, 293–297.

    CAS  PubMed  Google Scholar 

  • Euler, A.R., Byrne, W.J., Cousins, L.M., Ament, M.E., Leake, R.D. and Walsh, J.H. (1977) Increased serum gastrin concentration and gastric acid hyposecretion in the immediate newborn period. Gastroenterology, 72, 1271–1273.

    CAS  PubMed  Google Scholar 

  • Euler, A.R., Byrne, W.J. and Meis, P.J. (1979) Basal and pentagastrin stimulated acid secretion in newborn human infants. Pediatric Research, 13, 36–37.

    CAS  PubMed  Google Scholar 

  • Evans, N.J. and Rutter, N. (1986a) Development of the epidermis in the newborn. Biology of the Neonate, 49, 78–80.

    Google Scholar 

  • Evans, N.J. and Rutter, N. (1986b) Percutaneous respiration in the newborn infant. Journal of Pediatrics, 108, 282–286.

    CAS  PubMed  Google Scholar 

  • Faber, J.J. and Hart, F.M. (1966) The rabbit placenta as an organ of diffusional exchange. Comparison with other species by dimensional analysis. Circulation Research, 19, 816–833.

    CAS  PubMed  Google Scholar 

  • Faber, J.J. and Thornburg, K.L. (1983) Placental Physiology, Raven Press, New York.

    Google Scholar 

  • Farbman, A.I. (1965) Electron microscope study of the developing taste bud in rat fungiform papilla. Developmental Biology, 11, 110–135.

    CAS  PubMed  Google Scholar 

  • Fetterman, G.H., Shuplock, N.A., Philipp, F.J. and Gregg, H.S. (1965) The growth and maturation of human glomeruli and proximal convolutions from term to adulthood: studies by microdissection. Pediatrics, 35, 601–619.

    CAS  PubMed  Google Scholar 

  • Fisk, N.M. and Rodeck, C.H. (1992) Antenatal diagnosis and fetal medicine, in Textbook of neo-natology, 2nd edn (ed. N.R.C Roberton), Churchill Livingstone, Edinburgh, pp. 121–150.

    Google Scholar 

  • Flexner, L.B. and Gellhorn, A. (1942) Comparative physiology of placental transfer. American Journal of Obstetrics and Gynecology, 43, 965–974.

    CAS  Google Scholar 

  • Forestier, F. (1987) Some aspects of fetal biology. Fetal Therapy, 2, 181–187.

    CAS  PubMed  Google Scholar 

  • Forestier, F., Daffos, F., Galacteros, F., Bardakjian, J., Rainaut, M. and Beuzard, Y. (1986) Hematological values of 163 normal fetuses between 18 and 30 weeks gestation. Pediatric Research, 20, 342–346.

    CAS  PubMed  Google Scholar 

  • Forestier, F., Daffos, F., Rainaut, M., Bruneau, M. and Trivin, F. (1987) Blood chemistry of normal human fetuses at midtrimester of pregnancy. Pediatric Research, 21, 579–583.

    CAS  PubMed  Google Scholar 

  • Forte, J.G., Forte, T.M., Machen, T.E., Cook, B. and Nalbandov, A.V. (1975) Histamine-stimulated hydrogen ion secretion by in vitro piglet gastric mucosa. Journal of Physiology, 244, 15–31.

    CAS  PubMed  Google Scholar 

  • Foster, D.L., Cruz, T.A.C and Jackson, G.L. (1972) Regulation of luteinizing hormone in the fetal and neonatal lamb. III. Release of LH by the pituitary in vivo in response to crude ovine hypothalamic extract or purified porcine gon-adotrophin releasing factor. Endocrinology, 90, 673–683.

    CAS  PubMed  Google Scholar 

  • Fowden, A.L. (1980) Effects of adrenalin and amino acids on the release of insulin in the sheep fetus. Journal of Endocrinology, 87, 113–121.

    CAS  PubMed  Google Scholar 

  • Fowden, A. (1989) The role of insulin in prenatal growth. Journal of Developmental Physiology, 12, 173–182.

    CAS  PubMed  Google Scholar 

  • Fowden, A.L., Comline, R.S. and Silver, M. (1984) Insulin secretion and carbohydrate metabolism during pregnancy in the mare. Equine Veterinary Journal, 16, 239–246.

    CAS  PubMed  Google Scholar 

  • Fowden, A.L., Coulson, R.L. and Silver, M. (1990) Endocrine regulation of tissue glucose-6-phosphatase activity in the fetal sheep during late gestation. Endocrinology, 126, 2823–2830.

    CAS  PubMed  Google Scholar 

  • Freemark, M. (1986) Epidermal growth factor stimulates glycogen synthesis in fetal rat hepa-tocytes: comparison with the glycogenic effects of insulin-like growth factor I and insulin. Endocrinology, 119, 522–526.

    CAS  PubMed  Google Scholar 

  • Friis, C. (1979) Postnatal development of renal function in piglets: glomerular filtration rate, clearance of PAH and PAH extraction. Biology of the Neonate, 35, 180–187.

    CAS  PubMed  Google Scholar 

  • Friis, C. (1980) Postnatal development of the pig kidney: ultrastructure of the glomerulus and the proximal tubule. Journal of Anatomy, 130, 513–526.

    CAS  PubMed  Google Scholar 

  • Fumia, F.D., Edelstone, D.I. and Holzman, I.R. (1984) Blood flow and oxygen delivery to fetal organs as functions of fetal hematocrit. American Journal of Obstetrics and Gynecology, 150, 274–282.

    CAS  PubMed  Google Scholar 

  • Gartner, L.M. (1981) Disorders of bilirubin metabolism, in Haematology of infancy and childhood, 2nd edn, (eds D.G. Nathan and F.A. Oski), W.B. Saunders, Philadelphia, pp. 86–118.

    Google Scholar 

  • Garzon, B., Ducroc, R. and Geloso, J.-P. (1981) Ontogenesis of gastric acid secretion in the fetal rat. Pediatric Research, 1, 921–925.

    Google Scholar 

  • Garzon, B., Ducroc, R. and Geloso, J.-P. (1982) Ontogenesis of gastric response to agonists and antagonists of acid secretion in fetal rat. Journal of Developmental Physiology, 4, 195–205.

    CAS  PubMed  Google Scholar 

  • Gennser, G., Liedholm, P. and Thorell, J. (1976) Pituitary hormone levels in plasma of the human fetus after administration of LRH. Journal of Clinical Endocrinology and Metabolism, 43, 470–473.

    CAS  PubMed  Google Scholar 

  • Gespach, C., Dupont, C. and Rosselin, G. (1981) Action of histamine and vasoactive intestinal peptide (VIP) on cyclic AMP in gastric glands isolated from human fetal stomach. Experientia, 37, 866–867.

    CAS  PubMed  Google Scholar 

  • Gilbert, G. (1993) Chickenpox during pregnancy. British Medical Journal, 306, 1079–1080.

    CAS  PubMed  Google Scholar 

  • Gilbert, M. (1977) Origin and metabolic fate of plasma glycerol in rat and rabbit fetus. Pediatric Research, 11, 95–99.

    CAS  PubMed  Google Scholar 

  • Girard, J. (1986) Gluconeogenesis in late fetal and early neonatal life. Biology of the Neonate, 50, 237–258.

    CAS  PubMed  Google Scholar 

  • Girard, J., Pintado, E. and Ferre, P. (1979) Fuel metabolism in the mammalian fetus. Annals de Biologie Animale, Biochimie et Biophysique, 19, 181–197.

    CAS  Google Scholar 

  • Giry, J. and Delost, P. (1974) Evolution de l’aldos-teronemie du foetus et du nouveau-ne de cobaye au cours de 1a periode perinatale. Comptes Rendus de L’Academie des Sciences de Paris, 279, 2087–2090.

    CAS  Google Scholar 

  • Gitlin, D., Kumate, J., Morales, C., Noriega, L. and Arevalo, N. (1972) The turnover of amniotic fluid protein in the human conceptus. American Journal of Obstetrics and Gynecology, 113, 632–645.

    CAS  PubMed  Google Scholar 

  • Glader, B.E. and Buchanan, G.R. (1976) The bleeding neonate. Pediatrics, 58, 548–555.

    CAS  PubMed  Google Scholar 

  • Gleiss, J. and Stuttgen, G. (1970) Morphological and functional development of the skin, in Physiology of the Perinatal Period, Vol. 2, (ed. U. Stave), Appleton Century Crofts, New York.

    Google Scholar 

  • Gluckman, P. and Liggins, G. (1984). Regulation of fetal growth, in Fetal Physiology and Medicine, (eds R. Beard and P. Nathanielsz), Marcel Dekker, New York, pp. 511–557.

    Google Scholar 

  • Goldsmith, D.I., Drukker, A., Blaufox, M.D., Edelmann, C.M. and Spitzer, A. (1979) Hemodynamic and excretory responses of the neonatal canine kidney to acute volume expansion. American Journal of Physiology, 237, F392–F397.

    CAS  PubMed  Google Scholar 

  • Gomez, R.A., Meernik, J.G., Kuehl, W.D. and Robillard, J.E. (1984) Developmental aspects of the renal response to haemorrhage during foetal life. Pediatric Research, 18, 40–46.

    CAS  PubMed  Google Scholar 

  • Goncharevskaya, O.A. and Dlouha, H. (1975) The development of various generations of neph-rons during postnatal ontogenesis in the rat. Anatomical Record, 182, 367–376.

    CAS  PubMed  Google Scholar 

  • Grand, R.J., Watkins, J.B. and Torti, F.M. (1976) Development of the human gastrointestinal tract. Gastroenterologe, 70, 790–810.

    CAS  Google Scholar 

  • Green, M.R. and Couchman, J.R. (1984) Distribution of epidermal growth factor receptors in rat tissues during embryonic skin development, hair formation and the adult hair growth cycle. Journal of Investigative Dermatology, 83, 1118–1123.

    Google Scholar 

  • Greenough, A., Morley, C. and Roberton, N. (1992) Acute respiratory disease in the newborn, in Textbook of Neonatology, 2nd edn, (ed. N. Roberton), Churchill Livingstone, Edinburgh, pp. 385–504.

    Google Scholar 

  • Grinsted, J. and Aagesen, L. (1984) Mesonephric excretory function related to its influence on differentiation of fetal gonads. Anatomical Record, 210, 551–556.

    CAS  PubMed  Google Scholar 

  • Gruenwald, P. (1952) Development of the excretory system. Annals of the New York Academy of Sciences, 55, 142–146.

    CAS  PubMed  Google Scholar 

  • Gruskin, A.B., Edelmann, G.M. and Yuan, S. (1970) Matural changes in renal blood flow in piglets. Pediatric Research, 4, 7–13.

    CAS  PubMed  Google Scholar 

  • Guignard, J.-P. (1982) Renal function in the newborn infant. Pediatric Clinics of North America, 29, 777–790.

    CAS  PubMed  Google Scholar 

  • Gustafsson, J., Andersson, S. and Sjovall, J. (1985) Bile acid metabolism during development: metabolism of taurodeoxycholic acid in human fetal liver. Biology of the Neonate, 47, 26–31.

    CAS  PubMed  Google Scholar 

  • Hallidie-Smith, K. (1984) Prostaglandin E1 in suspected ductus-dependent cardiac malformation. Archives of Disease in Childhood, 59, 1020–1026.

    CAS  PubMed  Google Scholar 

  • Hambley, H. and Mufti, G. (1990) Erythropoietin: an old friend revisited. British Medical Journal, 300, 621–622.

    CAS  PubMed  Google Scholar 

  • Hammerlund, K., Hellsing, K., Sedin, G. and Stromberg, B. (1984) Effects of human albumin infusion on transepidermal water loss in newborn infants. Biology of the Neonate, 45, 112–118.

    Google Scholar 

  • Hanson, M. (1993) Fetus and Neonate (Physiology and Clinical Applications), Cambridge University Press, Cambridge.

    Google Scholar 

  • Hardy, K. (1980) Bile acid metabolism in fetal sheep: Perinatal changes in bile acid pool. Journal of Physiology, 309, 1–7.

    CAS  PubMed  Google Scholar 

  • Hargrave, B., Roman, C., Morville, P. and Heymann, M. (1990) Pulmonary vascular effects of exogenous atrial natriuretic peptide in sheep fetuses. Pediatric Research, 27, 140–143.

    CAS  PubMed  Google Scholar 

  • Harpin, V.A. and Rutter, N. (1982) Development of emotional sweating in the newborn infant. Archives of Disease in Childhood, 57, 691–695.

    CAS  PubMed  Google Scholar 

  • Harpin, V.A. and Rutter, N. (1983) Barrier properties of the newborn infant’s skin. Journal of Pediatrics, 102, 419–425.

    CAS  PubMed  Google Scholar 

  • Harris, G.W. and Levine, S. (1965) Sexual differentiation of the brain and its experimental control. Journal of Physiology (London), 181, 739–740.

    Google Scholar 

  • Harris, P.J., Thomas, D. and Morgan, T. O. (1987) Atrial natriuretic peptide inhibits angiotensin-stimulated proximal tubular sodium and water reabsorption. Nature, 326, 697–698.

    CAS  PubMed  Google Scholar 

  • Harrison, M.R., Jeston, J.A. and Ross, N.A. (1980) Correction of congenital diaphragmatic hernia in utero. I. The model: Intrathoracic balloon produces fetal pulmonary hypoplasia. Surgery, 88, 174–182.

    CAS  PubMed  Google Scholar 

  • Harvey, J.W., Asquith, R.L. and McNulty, P.K. (1984) Haematology of foals up to one year old. Equine Veterinary Journal, 16, 347–353.

    CAS  PubMed  Google Scholar 

  • Harvey, W. (1651) Excercitationes de Generationes Animalium, Cambridge, UK.

    Google Scholar 

  • Haugel, A., Leturque, A., Gilbert, M., Kande, J. and Girard, J. (1988) Glucose utilization by the placental and fetal tissues in fed and fasted pregnant rabbits. Pediatric Research, 23, 480–483.

    CAS  PubMed  Google Scholar 

  • Hay, W. (1979) Fetal glucose metabolism. Seminars in Perinatology, 3, 157–176.

    PubMed  Google Scholar 

  • Hayward, A.F. (1967) The ultras tructure of developing gastric parietal cells in the foetal rabbit. Journal of Anatomy, 101, 69–81.

    CAS  PubMed  Google Scholar 

  • Heiander, H.F. (1969) Ultrastructure and function of gastric parietal cells in the rat during development. Gastroenterology, 56, 35–52.

    Google Scholar 

  • Helms, P. (1992). Growth of the lung. Growth Matters, 1, 2–3.

    Google Scholar 

  • Hendrickse, W., Stammers, J. P. and Hull, D. (1985) The transfer of free fatty acids across the human placenta. British Journal of Obstetrics and Gynaecology, 92, 945–952.

    CAS  PubMed  Google Scholar 

  • Hensinger, R.N. and Jones, E.T. (1992) Orthopaedic problems in the newborn, in Textbook of Neonatology, (ed. N.R.C. Roberton), Churchill Livingstone, Edinburgh, pp. 889–914.

    Google Scholar 

  • Herbst, J.J. (1989) Development of suck and swallow, in Human Gastrointestinal Development, (ed. E. Lebenthal), Raven Press, New York, pp. 229–239.

    Google Scholar 

  • Herbst, J.J. and Sunshine, P. (1969) Postnatal development of the small intestine of the rat. Pediatric Research, 33, 251–254.

    Google Scholar 

  • Hershfield, M.S. and Nemeth, A.M. (1968) Placental transport of free palmitic and linoleic acids in the guinea-pig. Journal of Lipid Research, 9, 460–468.

    CAS  PubMed  Google Scholar 

  • Hey, E. N. (1969) Environmental temperature and oxygen consumption in newborn babies. Journal of Physiology, 200, 589–603.

    CAS  PubMed  Google Scholar 

  • Heymann, M., Rudolph, A. and Silverman, N. (1976) Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis. New England Journal of Medicine, 295, 530–533.

    CAS  PubMed  Google Scholar 

  • Hill, K.J. (1956) Gastric development and antibody transference in the lamb with some observations on the rat and guinea pig. Quarterly Journal of Experimental Physiology, 41, 421–432.

    CAS  Google Scholar 

  • Hislop, A. and Reid, L. (1981) The growth and development of the respiratory system, in Scientific Foundation of Paediatrics, (eds J.A. Davis and J. Dobbin), Wm Neinemann, London, pp. 390–432.

    Google Scholar 

  • Hodson, W. (1992) Normal and abnormal structural development of the lung, in Fetal and Neonatal Physiology, (eds R. Polin and W. Fox), W B Saunders, Philadelphia, pp. 771–782.

    Google Scholar 

  • Hofman, M.A. (1983) Evolution of brain size in neonatal and adult placental mammals: a theoretical approach. Journal of Theoretical Biology, 105, 317–332.

    CAS  PubMed  Google Scholar 

  • Holbrook, K.A. and Odland, G.F. (1980) Regional development of the human epidermis in the first trimester embryo and the second trimester fetus (ages related to the timing of amniocentesis and fetal biopsy). Journal of Investigative Dermatology, 80, 161–168.

    Google Scholar 

  • Holliman, R.E. (1992) Toxoplasma gondii, in Congenital, Perinatal and Neonatal Infections, (eds A. Greenough, O. Osborne and S. Sutherland), Churchill Livingstone, Edinburgh, pp. 209–221.

    Google Scholar 

  • Holloway, B.R. (1984) Post-natal development of brown adipose tissue in guinea pig-effect of environmental temperature. International Journal of Obesity, 8, 295–303.

    CAS  PubMed  Google Scholar 

  • Holter, P.H., Sanengen, T., Halvorsen, S. and Refsum, H.E. (1987) Regulation of erythro-poiesis in suckling rabbits with and without postnatal anemia: partial suppression of production/release of erythropoiesis stimulating factor(s) by ion supplements. Pediatric Research, 21, 1–4.

    CAS  PubMed  Google Scholar 

  • Holzgreve, W., Fisk, A.S., Goldsmith, P.C. and Goldbus, M.S. (1985) Histochemical demonstration of ornithine transcarbamylase activity in fetal liver. Biology of the Neonate, 47, 339–342.

    CAS  PubMed  Google Scholar 

  • Hooper, S.B. and Harding, R. (1990) Changes in lung liquid dynamics induced by prolonged fetal hypoxemia. Journal of Applied Physiology, 69, 127–135.

    CAS  PubMed  Google Scholar 

  • Horster, M. and Larsson, L. (1976) Mechanism of fluid adsorption during proximal tubule development. Kidney International, 10, 348–363.

    CAS  PubMed  Google Scholar 

  • Horster, M. and Lewy, J.E. (1970) Filtration fraction and extraction of PAH during the neonatal period in the rat. American Journal of Physiology, 219, 1061–1065.

    CAS  PubMed  Google Scholar 

  • Horster, M. and Valtin, H. (1971) Postnatal development of renal function: micropuncture and clearance studies in the dog. Journal of Clinical Investigation, 50, 779–795.

    CAS  PubMed  Google Scholar 

  • Horvath, A., Butkus, A., Maclsaac, R.J., Pontefract, L. and Wintour, E.M. (1988) Effect of hormone-induced premature parturition on haemoglobin switching in sheep. Pediatric Research, 24, 688–692.

    CAS  PubMed  Google Scholar 

  • Houston, I.B. and Zeis, P.M. (1976) Intrauterine renal function and the amniotic fluid. Journal of Physiology, 257, 20–21.

    Google Scholar 

  • Huhtaniemi, I.T., Korenbrot, C.C., Seron-Ferre, M., Foster, D.B., Parer, J.T. and Jaffe, R.B. (1977) Stimulation of testosterone production in vivo and in vitro in the male rhesus monkey fetus in late gestation. Endocrinology, 100, 839–844.

    CAS  PubMed  Google Scholar 

  • Huhtaniemi, L.T., Nozu, K., Warren, D.W., Dufau, M.L. and Catt, K.J. (1982) Acquisition of regulatory mechanisms for gonadotropin receptors and steroidogenesis in the maturing rat tes-tis. Endocrinology, 111, 1711–1720.

    CAS  PubMed  Google Scholar 

  • Hull, D. (1966) The structure and function of brown adipose tissue. British Medical Bulletin, 22, 92–96.

    CAS  PubMed  Google Scholar 

  • Hull, D. (1970) Brown adipose tissue in the newborn, in Scientific Foundations of Obstetrics and Gynaecology, (eds E.E. Philipp, J. Barnes and M. Newton), Wm Heinemann Books, London.

    Google Scholar 

  • Hull, D. (1976) Nutritional Endowments at Birth in Early Nutrition and Later Development, (ed. A.W. Wilkinson), Pitman Medical Publishing Co., Kent, UK, pp. 49–55.

    Google Scholar 

  • Hull, D. (1982) Behavioural thermoregulation in the newborn, in Topics in Perinatal Medicine, (ed. B. Wharton), Pitman.

    Google Scholar 

  • Hull, J. and Hull, D. (1982) Behavioural thermoregulation in newborn rabbits. Journal of Comparative and Physiological Psychology, 285, 924–926.

    Google Scholar 

  • Hutchinson, D.L., Gray, M.J., Plentl, A.A., Alvarez, H., Caldeyro-Barcia, H., Kaplan, B. and Lind, J. (1959) The role of the fetus in the water exchange of the amniotic fluid of normal and hydramniotic patients. Journal of Clinical Investigation, 38, 971–980.

    CAS  PubMed  Google Scholar 

  • Hyman, A.I., Levin, D.L., Rudolph, A.M. and Heymann, M.A. (1975) Angiotensin is not the mediator of hypoxia induced pulmonary vaso-constriction in foetal lambs. Circulation, 52, 132.

    Google Scholar 

  • Hyman, P.E., Clarke, D.D., Everett, S.L., Sonne, B., Stewart, D., Harrada, T., Walsh, J.H. and Taylor, I.L. (1985) Gastric acid secretory function in pre-term infants. Journal of Pediatrics, 106, 467–471.

    CAS  PubMed  Google Scholar 

  • Hytten, F.E. (1979) Water transfer, in Placental Transfer, (eds G.V.P. Chamberlain and A.W. Wilkinson), Pitman Medical, Kent, UK.

    Google Scholar 

  • Hytten, F.E. and Leitch, I. (1971) The Physiology of Human Pregnancy, Blackwell Scientific Publications, Oxford, UK.

    Google Scholar 

  • Iwamoto, H., Oh, W. and Rudolph, A.M. (1985) Renal metabolism in fetal and newborn sheep Pediatric Research, 19, 641–644.

    CAS  PubMed  Google Scholar 

  • Iwamoto, H. and Rudolph, A. (1981) Role of renin-angiotensin system in response to haemorrhage in fetal sheep. American Journal of Physiology, 240, H848–H854.

    CAS  PubMed  Google Scholar 

  • Jacobson, L.O., Marks, E.K. and Gaston, E.O. (1959) Studies on erythropoiesis. XII. The effect of transfusion-induced polycythemia in the mother on the fetus. Blood, 14, 644–653.

    CAS  PubMed  Google Scholar 

  • Jarvis, L.G., Morgan, G., Smith, M.W. and Wooding, F.B.P. (1977) Cell replacement and changing transport function in the neonatal pig colon. Journal of Physiology, 273, 717–729.

    CAS  PubMed  Google Scholar 

  • Jeffcott, I.B. (1975) The transfer of passive immunity to the foal and its relation to immune status after birth. Journal of Reproduction and Fertility, Suppl., 23, 727–733.

    PubMed  Google Scholar 

  • Jenness, R. (1974) Biosynthesis and composition of milk. Journal of Investigative Dermatology, 63, 109–118.

    CAS  PubMed  Google Scholar 

  • Jobe, A. (1984) Fetal lung maturation and the respiratory distress syndrome, in Petal Physiology and Medicine, (eds R. Beard and P. Nathanielsz), Marcel Dekker, New York, pp. 317–351.

    Google Scholar 

  • Jones, C.R., McCabe, R., Hamilton, C.A. and Reid, J.L. (1985) Maternal and fetal platelet responses and adrenoceptor binding character istics. Thrombosis and Haemostasis, 53, 95–98.

    CAS  PubMed  Google Scholar 

  • Jones, C.T. (1982) The Biochemical Development of the Fetus and Neonate. Elsevier Biomedical Press, Oxford.

    Google Scholar 

  • Jones, C.T. and Ashton, I.K. (1976) Lipid biosynthesis in liver slices of the foetal guinea pig. Biochemical Journal, 154, 149–158.

    CAS  PubMed  Google Scholar 

  • Jones, R. and Roberton, N. (1986) Small-for-dates babies, are they really a problem? Archives of Disease in Childhood, 61, 877–880.

    CAS  PubMed  Google Scholar 

  • Joppich, R., Haberle, D. and Weber, P. (1981) Studies in the immaturity of the ADH dependent cAMP system in conscious newborn piglets-possible impairing effects of renal prostaglan-dins. Pediatric Research, 15, 278–281.

    CAS  PubMed  Google Scholar 

  • Jose, P.A., Logan, A.G., Slotkoff, L.M., Lilienfield, L.S., Calcagno, P.L. and Eisner, G.M. (1971) Intrarenal blood flow distribution in canine puppies. Pediatric Research, 5, 335–344.

    CAS  PubMed  Google Scholar 

  • Jost, A. (1953) Problems of fetal endocrinology: the gonadal and hypophyseal hormones. Recent Progress in Hormone Research, 8, 379–413.

    Google Scholar 

  • Jost, A. (1954) Hormones in the development of the foetus. Cold Spring Harbor Symposia on Quantitative Biology, 19, 167–181.

    CAS  PubMed  Google Scholar 

  • Jost, A. and Policard, A. (1948) Contribution expérimentale a l’étude du développement prenatal du poumon chez 1e lapin. Archives d’ Anatomie Microscopique et de Morphologie Expérimentale (Paris), 37, 323–332.

    Google Scholar 

  • Kadowaki, H., Bibb, P.C. and Knox, W.E. (1983) Capacity of cyclic urea synthesis in neonatal rat liver. Biology of the Neonate, 44, 21–27.

    CAS  PubMed  Google Scholar 

  • Kagen, L.J. (1973) Myoglobin, Columbia University Press, New York.

    Google Scholar 

  • Kalpaktsogrou, P.K. and Emery, J.L. (1965) Human bone marrow during the last three months of intrauterine life. Acta Haematologica, 34, 228–238.

    Google Scholar 

  • Kaplan, A. and Friedman, M. (1942) Studies concerning the site of renin formation in the kidney. III. The apparent site of renin formation in the tubules of the mesonephros and metanephros of the hog foetus. Journal of Experimental Medicine, 76, 307–316.

    CAS  PubMed  Google Scholar 

  • Katz, F.H., Beck, P. and Makowski, E.L. (1974) The renin-aldosterone system in mother and fetus at term. American Journal of Obstetrics and Gynecology, 118, 51–55.

    CAS  PubMed  Google Scholar 

  • Kaufman, S. (1992) Organogenesis and histologic development of the liver, in Fetal and Neonatal Physiology, (eds R. Polin and W. Fox), W.B. Saunders, Philadelphia, pp. 1085–1094.

    Google Scholar 

  • Kazimierczak, J. (1971) Development of the renal corpuscle and the juxtaglomerular apparatus. Acta Pathologica, Microbiologica et Immunologica, Scandinavica, Section A, Suppl. 218.

    Google Scholar 

  • Kelley, R. (1973) An ultrastructural and cytochemi-cal study of developing small intestine in man. Journal of Embryology and Experimental Morphology, 29, 411–430.

    CAS  PubMed  Google Scholar 

  • Kervan, A. and Girard, J.R. (1974) Glucose induced increase of plasma insulin in the rat foetus in utero. Journal of Endocrinology, 62, 545–551.

    Google Scholar 

  • Kinmond, S., Aitchinson, T.C., Holland, B.M., Jones, J.G., Turner, T.L. and Wardrop, C.A. J. (1993) Umbilical cord clamping and preterm infants: a randomised trial. British Medical Journal, 306, 172–175.

    CAS  PubMed  Google Scholar 

  • Kinsella, J.P., Neish, S.R., Shaffer, E. and Abman, S.H. (1992). Low dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn. Lancet, 340, 820–919.

    Google Scholar 

  • Kiser, T.E., Convey, E.M., Lin, Y.C., Oxender, W.D. (1975) Luteinizing hormone and andro-gens in the bovine fetus after gonadotropin-releasing hormone. Proceedings of the Society of Experimental Biology and Medicine, 149, 785–789.

    CAS  Google Scholar 

  • Kitterman, J.A. (1986) Physical factors and fetal lung growth, in Respiratory Control and Lung Development in the Fetus and Newborn, (eds B.M. Johnston and P.D. Gluckman), Perinatology Press, Ithaca, New York, pp. 64r–85.

    Google Scholar 

  • Kitterman, J.A., Ballard, P.L., Clements, J.A., Mescher, G.J. and Tooley, W.H. (1979) Tracheal fluid in fetal lambs: spontaneous decrease prior to birth. Journal of Applied Physiology, 47, 985–989.

    CAS  PubMed  Google Scholar 

  • Kleinman, L.I. and Lubbe, R.J. (1972) Factors affecting the maturation of glomerular filtration rate and renal plasma flow in the newborn dog. Journal of Physiology, 223, 395–409.

    CAS  PubMed  Google Scholar 

  • Koldovsky, O. (1970) Digestion and absorption during development, in Physiology of the Perinatal Period, (ed. U. Stave), Appleton Century Crofts, New York, pp. 379–415.

    Google Scholar 

  • Koletzko, B., Schmidt, E., Brenner, H., Haug, M. and Garzer, G. (1989) Effects of dietary long-chain polyunsaturated fatty acids on the essential fatty acid status of premature infants. Journal of Pediatrics, 148, 669–675.

    CAS  Google Scholar 

  • Krause, W.J., Cutts, H.J. and Leeson, C.R. (1979) Morphological observations on the meso-nephros in the postnatal oppossum, Didelphis virginiana. Journal of Anatomy, 129, 377–397.

    CAS  PubMed  Google Scholar 

  • Kronquist, K.E., Crandall, B.F. and Tabsh, K.M. (1984) Characterization of fetal urinary proteins at midgestion and term. Biology of the Neonate, 46, 267–275.

    CAS  PubMed  Google Scholar 

  • Kühl, P.G., Cotton, R.B., Schweer, H. and Seyberth, H.W. (1989) Endogenous formation of prostanoids in neonates with PPH. Archives of Disease in Childhood, 64, 949–952.

    PubMed  Google Scholar 

  • Lafeber, H.N. (1981) Experimental intrauterine growth retardation in the guinea pig. PhD Thesis, Erasmus University.

    Google Scholar 

  • Lajeunesse, D. and Brunette, N.G. (1988) Sodium gradient-dependent phosphate transport in placental brush border membrane vesicles. Placenta, 9, 117–129.

    CAS  PubMed  Google Scholar 

  • Leat, W.M.F. (1966) Fatty acid composition of the plasma lipids of newborn and maternal ruminants. Biochemical Journal, 98, 598–603.

    CAS  PubMed  Google Scholar 

  • Lebenthal, E. and Lee, P.C. (1980) Glucoamylase and disaccharidase activities in normal subjects and in patients with mucosal injury of the small intestine. Journal of Pediatrics, 97, 389–393.

    CAS  PubMed  Google Scholar 

  • Lebenthal, E., Lee, P.C. and Heitlinger, L.A. (1983) Impact of development of the gastro-intestinal tract on infant feeding. Journal of Pediatrics, 102, 1–9.

    CAS  PubMed  Google Scholar 

  • Leeson, T.S. and Baxter, J.S. (1957) The correlation of structure and function in the mesonephros and metanephros of the rabbit. Journal of Anatomy, 91, 383–390.

    CAS  PubMed  Google Scholar 

  • Leitch, I., Hyteen, F.C. and Billewicz, W.Z. (1959) The maternal and neonatal weights of some mammalia. Proceedings of Zoological Society (London), 133, 11–28.

    Google Scholar 

  • Lemons, J.A., Adcock, E.W., Jones, D., Naughton, H.A., Meshchia, G. and Battaglia, F.C. (1976) Umbilical uptake of amino acids in the unstressed fetal lamb. Journal of Clinical Investigation, 59, 1428.

    Google Scholar 

  • Lemons, J., Vargas, P. and Delaney, J. (1981) Infant of the diabetic mother: Review of 225 cases. Obstetrics and Gynecology, 57, 187–192.

    CAS  PubMed  Google Scholar 

  • de Lemos, C. (1977) The ultrastructure of endocrine cells in the corpus of the stomach of human fetuses. American Journal of Anatomy, 148, 359–384.

    CAS  PubMed  Google Scholar 

  • Lev, R. and Orlic, D. (1973) Uptake of protein in swallowed amitotic fluid by monkey fetal intestine in utero. Gastroenterology, 65, 60–68.

    CAS  PubMed  Google Scholar 

  • Lev, R., Siegel, H.I. and Bartman, J. (1972) Histochemical studies of developing human fetal small intestine. Histochemie, 29, 103–119.

    CAS  PubMed  Google Scholar 

  • Levene, M.I. (1992) Development of audit measures and guidelines for good practice in the management of neonatal respiratory distress syndrome. Archives of Disease in Childhood, 67, 1221–1227.

    Google Scholar 

  • Lichtenberger, L. and Johnson, L.R. (1974) Gastrin in the ontogenic development of the small intestine. American Journal of Physiology, 227, 390–395.

    CAS  PubMed  Google Scholar 

  • Liggins, G. (1990) Obstetric and paediatric collaboration to reduce morbidity after preterm birth. British Journal of Obstetrics and Gynaecology, 97, 1–3.

    CAS  PubMed  Google Scholar 

  • Lind, T. (1978) The biochemistry of amitotic fluid, in Amitotic fluid-Research and Clinical Application, (eds D.V.I. Fairweather and T.K.A.B. Eskes) Amsterdam, Excerpta Medica.

    Google Scholar 

  • Lind, T. (1981) Amitotic fluid, Geigy Scientific Tables (eds K. Diem and C. Lenter) Macclesfield, UK.

    Google Scholar 

  • Lindblad, B.S. (1976) Protein and amino acid metabolism during fetal development, in Fetal Physiology and Medicine, (eds R.W. Berad and P.W. Nathanielsz), W.B. Saunders, London, pp. 80–104.

    Google Scholar 

  • Linderkamp, O., Ozanne, P., Wu, P.Y.K. and Meiselman, H.J. (1984a) Red blood cell aggregation in preterm and term neonates and adults. Pediatric Research, 18, 1356–1360.

    CAS  PubMed  Google Scholar 

  • Linderkamp, O., Versmold, H.T., Riegel, K.P. and Betke, K. (1984b) Contributions of red cells and plasma to blood viscosity in preterm and full-term infants and adults. Pediatrics, 74, 45–51.

    CAS  PubMed  Google Scholar 

  • Linderkamp, O., Gunter, M., Hilt, W. and Vargas, V.M. (1986) Erythrocyte deformability in the fetus, preterm and term neonate. Pediatric Research, 20, 93–96.

    CAS  PubMed  Google Scholar 

  • Lingwood, B., Hardy, K.J., Coghlan, J.P. and Wintour, E.M. (1978a) Effect of aldosterone on urine composition in the chronically-cannulated ovine fetus. Journal of Endocrinology, 76, 553–554.

    CAS  PubMed  Google Scholar 

  • Lingwood, B., Hardy, K.J., Horacek, T., McPhee, M.L., Scoggins, B.A. and Wintour, E.M. (1978b) The effects of antidiuretic hormone on urine flow and composition in the chronically-cannulated ovine fetus. Quarterly Journal of Experimental Physiology, 63, 315–330.

    CAS  Google Scholar 

  • Long, W. and Henry, G. (1992) Autonomie and central neural regulation of fetal cardiovascular function, in Fetal and Neonatal Physiology, (eds R. Polin and W. Fox), W B Saunders, Philadelphia, pp. 629–645.

    Google Scholar 

  • Lucarelli, G., Howard, D. and Stohlman, F. (1964) Regulation of erythropoiesis. XV. Neonatal erythropoiesis and the effect of nephrectomy. Journal of Clinical Investigation, 43, 2195–2203.

    CAS  PubMed  Google Scholar 

  • Lucas, A. (1991) Programming by early nutrition in man, in The Childhood Environment and Adult Disease, (eds G.R. Bock and J. Whelan), Wiley, Chichester, pp. 38–55.

    Google Scholar 

  • Lucas, A., Bloom, S. and Aynsley-Green, A. (1978) Metabolic and endocrine events at the time of first feed of human milk in preterm and term infants. Archives of Disease in Childhood, 53, 731–736.

    CAS  PubMed  Google Scholar 

  • Lucas, A., Christofides, N., Adrian, T., Bloom, S. and Aynsley-Green, A. (1979) Fetal distress, meconium and motilin. Lancet, i, 718.

    Google Scholar 

  • Lucas, A., Bloom, S.R. and Aynsley-Green, A. (1986) gut hormones and ‘minimal enteral feeding’. Acta Paediatrica Scandinavica, 75, 719–723.

    CAS  PubMed  Google Scholar 

  • Lumbers, E.R. and Stevens, A.D. (1983) Changes in fetal renal function in response to infusion of a hyperosmotic solution of mannitol to the ewe. Journal of Physiology, 343, 439–446.

    CAS  PubMed  Google Scholar 

  • MacDonald, A.A. (1979) Patterns of endocrine change in the pig foetus. Animal Reproduction Science, 2, 289–304.

    Google Scholar 

  • MacDonald, A.A. (1983) Blood pressure control and the developing pig fetus. PhD Thesis, Rijksuniversiteit of Utrecht.

    Google Scholar 

  • MacDonald, A.A., Colenbrander, B. and Van Vorstenbosch, C.J.A.H.V. (1982) Physiology and endocrinology of the foetus in late gestation, in Control of Pig Reproduction, (eds D.J.A. Cole and G.R. Foxcroft), Butterworths, London, pp. 377–404.

    Google Scholar 

  • MacDonald, D., Grant, A., Sheridan-Pereira, M., Boylan, P. and Chalmers, I. (1985) The Dublin randomized controlled trial of intrapartum fetal heart rate monitoring. American Journal of Obstetrics and Gynecology, 152, 524–539.

    CAS  PubMed  Google Scholar 

  • MacDonald, M.S. and Emery, J.L. (1959) The late intrauterine and postnatal development of human renal glomeruli. Journal of Anatomy, 93, 331–340.

    CAS  PubMed  Google Scholar 

  • McCance, R.A. (1972) The role of the developing kidney in the maintenance of internal stability. Journal of the Royal College of Physicians, 6, 235–245.

    CAS  Google Scholar 

  • McCance, R.A. and Stanier, M. (1960) The function of the metanephros of foetal rabbits and pigs. Journal of Physiology, 151, 470–483.

    Google Scholar 

  • McCance, R.A. and Widdowson, E.M. (1957) New thoughts on renal function in the early days of life. British Medical Bulletin, 13, 3–6.

    CAS  PubMed  Google Scholar 

  • McCance, R.A. and Widdowson, E.M. (1960) The acid-base relationships of the foetal fluids of the pig. Journal of Physiology, 151, 484–490.

    CAS  PubMed  Google Scholar 

  • McCance, R.A. and Young, W.F. (1941) The secretion of urine by newborn infants. Journal of Physiology, 99, 265–282.

    CAS  PubMed  Google Scholar 

  • McClean, P. and Weaver, L. (1993) Ontogeny of human pancreatic exocrine function. Archives of Disease in Childhood, 68, 62–65.

    CAS  PubMed  Google Scholar 

  • Mclntosh, D. and Isaacs, D. (1993) Varicella zoster virus infection in pregnancy. Archives of Disease in Childhood, 68, 1–2.

    Google Scholar 

  • McNinch, A.W. and Tripp, J.H. (1991) Haemorrhagic disease of the newborn in the British Isles: two year prospective study. British Medical Journal, 303, 1105–1109.

    CAS  PubMed  Google Scholar 

  • Maiback, H.I. and Boisits, E.K. (1982) Neonatal Skin: Structure and Function, Marcel Dekker, New York.

    Google Scholar 

  • Marino, L.R., Blumer, J.L. and Halpin, T.C. (1983) Prostaglandin E concentration in gastric secretions of critically ill full term and premature infants. Pediatric Research, 17, 669–671.

    CAS  PubMed  Google Scholar 

  • Marlow, N. (1992) Do we need an Apgar score? Archives of Disease in Childhood, 67, 765–767.

    CAS  PubMed  Google Scholar 

  • Marodi, L., Leijh, P.C.F. and Van Furth, R. (1984) Characteristics and functional capacities of human cord blood granulocytes and monocytes. Pediatric Research, 18, 1127–1131.

    CAS  PubMed  Google Scholar 

  • Martin, A.A., Kapoor, R. and Scroop, G.C. (1987) Hormonal factors in control of heart rate in hypoxic fetal and neonatal sheep. Journal of Developmental Physiology, 9, 465–480.

    CAS  PubMed  Google Scholar 

  • de Martino, C. and Zamboni, L. (1966) A morphologic study of the mesonephros of the human embryo. Journal of Ultrastructure and Molecular Structure Research, 16, 399–427.

    CAS  Google Scholar 

  • Mathews, T. and Warshaw, J. (1979) Relevance of the gestational age distribution of meconium passage in utero. Pediatrics, 64, 30–31.

    Google Scholar 

  • Matoth, Y. and Zaizov, R. (1971) Regulation of erythropoiesis in the fetal rat, in Erythropoiesis. Regulatory Mechanisms and Developmental Aspects, (ed. Y. Matoth), Academic Press, New York, pp. 17–21.

    Google Scholar 

  • Matson, J.R., Stokes, J.B. and Robillard, J.E. (1981) Effects of inhibition of prostaglandin synthesis on fetal renal function. Kidney International, 20, 621–627.

    CAS  PubMed  Google Scholar 

  • Mears, G.J. and Van Petten, G.R. (1977) Fetal absorption of drugs from the amitotic fluid. Proceedings of the Western Pharmacological Society, 20, 109–114.

    CAS  Google Scholar 

  • Meberg, A., Haga, P. and Johanesen, M. (1980) Plasma erythropoietin levels in mice during the growth period. British Journal of Haematology, 45, 569–574.

    CAS  PubMed  Google Scholar 

  • Mellor, D.J. (1980) Investigation of fluid spaces of the sheep conceptus, in Animal Models in Fetal Medicine, (ed. P.W. Nathanielsz), Elsevier/North Holland Biochemical Press, Amsterdam, pp. 59–106

    Google Scholar 

  • Mellor, D.J. (1984) Investigation of fetal growth in sheep, in Animal Models in Fetal Medicine (IV), Monographs in Fetal Physiology 5, (ed. P.W. Nathanielsz), Elsevier/North Holland Biochemical Press, Amsterdam, pp. 150–175.

    Google Scholar 

  • Mellor, D.J. and Slater, J.S. (1971) Daily changes in amniotic and allantoic fluid during the last three months of pregnancy in conscious, unstressed ewes with catheters in their foetal fluid sac. Journal of Physiology, 217, 573–604.

    CAS  PubMed  Google Scholar 

  • Menard, D. and Arsenault, P. (1985) Explant culture of human fetal small intestine. Gastroenterology, 88, 691–700.

    CAS  PubMed  Google Scholar 

  • Merlet-Benichou, C. and de Rouffignac, C. (1977) Renal clearance studies in fetal and young guinea pigs: effect of salt loading. American Journal of Physiology, 232, F178–F185.

    CAS  PubMed  Google Scholar 

  • Merlet-Benichou, C., Peggorier, M. and Muffat-Joly, M. (1981) Functional and morphologic patterns of renal maturation in the developing guinea pig. American Journal of Physiology, 241, F618–F624.

    CAS  PubMed  Google Scholar 

  • Meschia, G., Cotter, J.R., Makowski, E.L. and Barron, D.H. (1967) Simultaneous measurements of uterine and umbilical blood flows and oxygen uptakes. Quarterly Journal of Experimental Physiology, 52, 1–18.

    Google Scholar 

  • Metcalfe, J., Moll, W., Bartels, H., Hilpert, P. and Parer, J. (1965) Transfer of carbon monoxide and nitrous oxide in the artificially perfused sheep placenta. Circulation Research, 16, 95–101.

    CAS  PubMed  Google Scholar 

  • Metcalfe, J., Bartles, H. and Moll, W. (1967) Gas exchange in the pregnant uterus. Physiological Reviews, 47, 782–838.

    CAS  PubMed  Google Scholar 

  • Milner, A.D. (1993) How does exogenous surfactant work? Archives of Disease in Childhood, 68, 253–254.

    CAS  PubMed  Google Scholar 

  • Milner, A.D. and Vyas, H. (1982) Lung expansion at birth. Journal of Pediatrics, 101, 879–886.

    CAS  PubMed  Google Scholar 

  • Milner, R.D.G. and Hales, C.N. (1965) Effect of intravenous glucose on maternal and umbilical cord insulin. British Medical Journal, i, 284–286.

    Google Scholar 

  • Mistretta, C.M. and Bradley, R.M. (1975) Taste and swallowing in utero: a discussion of fetal sensory function. British Medical Bulletin, 31, 80–84.

    CAS  PubMed  Google Scholar 

  • Moessinger, A.C., Collins, M., Blanc, W., Rey, H. and James, L. (1986) Oligohydramnios induced lung hypoplasia: the influence of timing and duration of gestation. Pediatric Research, 20, 951–954.

    CAS  PubMed  Google Scholar 

  • Moessinger, A.C., Fox, H., Higgins, A., Rey, H. and Haideri, M.A. (1987) Fetal breathing movements are not a reliable predictor of continued lung development in pregnancies complicated by oligohydramnios. Lancet, 2, 1297–1300.

    CAS  PubMed  Google Scholar 

  • Moll, I., Moll, R. and Franke, W.W. (1986) Formation of epidermal and dermal merkel cells during human fetal skin development. Journal of Investigative Dermatology, 87, 779–787.

    CAS  PubMed  Google Scholar 

  • Molteni, A., Rahul, W.J. and Koo, J.H. (1974) Evidence for a vasopresser substance (renin) in human foetal kidneys. Laboratory Investigation, 30, 115–118.

    CAS  Google Scholar 

  • Morales, W., O’Brien, W., Angel, J., Knuppel, R. and Sawai, S. (1989) Fetal lung maturation. The combined use of corticosteroids and thyrotropin releasing hormone. Obstetrics and Gynecology, 73, 111–116.

    CAS  PubMed  Google Scholar 

  • Mott, J. C. (1985) Humoral control of the fetal circulation, in Physiological Development of the Fetus and Newborn, (eds C.T. Jones and P.W. Nathanielsz), Academic Press, London, pp. 113–121.

    Google Scholar 

  • Mount, L.E. (1979) Adaptation to Thermal Environment, Edward Arnold, London.

    Google Scholar 

  • Moxey, P.C. and Trier, J.S. (1979) Development of villus absorptive cells in the human fetal small intestine: a morphological and morphometric study. Anatomical Record, 195, 463–482.

    CAS  PubMed  Google Scholar 

  • Mull, M. and Hathaway, W.E. (1970) Altered platelet function in neonates. Pediatric Research, 4, 229–239.

    CAS  PubMed  Google Scholar 

  • Mulvihill, S.J., Stone, M.M., Debas, H.T. and Fonkalsrud, E.W. (1985) The role of amniotic fluid in fetal nutrition. Journal of Pediatric Surgery, 20, 668–672.

    CAS  PubMed  Google Scholar 

  • Muraca, M., Blanckaert, N., Rubaltelli, F.F. and Fevery, J. (1986) Unconjugated and conjugated bilirubin pigments during perinatal development. 1. Studies on rat serum and intestine. Biology of the Neonate, 49, 90–95.

    CAS  PubMed  Google Scholar 

  • Murphy, S. and Daniels, V.G. (1979) Postnatal amino acid uptake by the rat small intestine. Changes in membrane transport systems for amino acids associated with maturation of jejunal morphology. Journal of Developmental Physiology, 1, 111–126.

    CAS  PubMed  Google Scholar 

  • Nagel, M.D. and Nagel, J. (1984) Serum erythro-poietic activity in the rat around birth. Biology of the Neonate, 46, 44–47.

    CAS  PubMed  Google Scholar 

  • Nathanielsz, P.W. (ed) (1980) Animal Models in Fetal Medicine 1., Elsevier, North Holland, Amsterdam.

    Google Scholar 

  • Naughton, J. (1981) Supply of polyenoic fatty acids to the mammalian brain. International Journal of Biochemistry, 13, 21–32.

    CAS  PubMed  Google Scholar 

  • Nicholls, D.G. (1984) Thermogenic mechanisms in brown fat. Physiological Reviews, 64, 1–64.

    CAS  PubMed  Google Scholar 

  • Nicolaides, K.H., Rodeck, C.H., Millar, D.S. and Mibashan, R.S. (1985) Fetal haematology in rhesus isoimmunisation. British Medical Journal, 290, 661–663.

    CAS  PubMed  Google Scholar 

  • Nickel, R., Schummer, A., Seiferle, E. and Sack, W. (1973) The alimentary canal of the ruminants, in The Viscera of Domestic Animals, Springer Verlag, New York, pp. 147–175.

    Google Scholar 

  • Nugteren, D.H., Christ-Hazelhof, E., van der Beek, A. and Houtsmuller, U.M.T. (1985) metabolism of linoleic acid and other essential fatty acids in the epidermis of the rat. Biochimica et Biophysica Acta, 834, 429–436.

    CAS  PubMed  Google Scholar 

  • O’Callaghan, C. and Stephenson, T. (1992) Pocket Paediatrics, Churchill Livingstone, Edinburgh.

    Google Scholar 

  • Oh, W., Oh, M.A. and Lind, J. (1966) Renal function and blood volume in newborn infants related to placental transfusion. Acta Paediatrica Scandinavica, 56, 19721210.

    Google Scholar 

  • Oka, Y., Ghishan, F.K. and Greene, H.I. (1983) Effect of mouse epidermal growth factor/ urogastrone on the functional maturation of rat intestine. Endocrinology, 112, 94021944.

    Google Scholar 

  • Olver, R.E. (1983) Fluid balance across the fetal alveolar epithelium. American Review of Respiratory Disease, 127, 533–536.

    Google Scholar 

  • Olver, R.E. and Strang, L.B. (1974) Ion fluxes across the pulmonary epithelium and the secretion of lung liquid in the foetal lamb. Journal of Physiology, 241, 327–357.

    CAS  PubMed  Google Scholar 

  • Orchard, M., Lewis, P., Ongari, M., Waddell, K. and Blair, I. (1983) Free 5,8,11-eicosatrienoic acid in human umbilical artery, in Prostacyclin in Pregnancy, (eds P. Lewis, S. Moncada and J. O’Grady), Raven Press, New York, pp. 59–63.

    Google Scholar 

  • OSIRIS Collaborative Group (1992) Early versus delayed administration of a synthetic surfactant-the judgement of OSIRIS. Lancet, ii, 1363–1369.

    Google Scholar 

  • Palme-Kilander, C., Tunell, R. and Chiwei, Y. (1993) Pulmonary gas exchange immediately after birth in spontaneously breathing infants. Archives of Disease in Childhood, 68, 6–10.

    CAS  PubMed  Google Scholar 

  • Parmley, T.H. and Seeds, A.E. (1970) Fetal skin permeability to isotopic water (THO) in early pregnancy. American Journal of Obstetrics and Gynecology, 108, 128–131.

    CAS  PubMed  Google Scholar 

  • Parry, J.S. and Stanier, M.W. (1962) The rate of flow of urine in fetal pigs. Journal of Physiology, 161, 344–350.

    Google Scholar 

  • Pasqualini, J.R., Sumida, C. and Gelly, C. (1972) Mineralocorticosteroid receptors in the foetal compartment of the guinea pig. Journal of Steroid Biochemistry, 3, 543–554.

    CAS  PubMed  Google Scholar 

  • Pasqualini, J.R., Sumida, C., Gelly, C. and Nguyen, B.L. (1976) Specific [3H]-estradiol binding in the fetal uterus and testis of guinea pig. Quantitative evolution of [3H]-estradiol receptors in the different tissues (kidney, lung, uterus and testis) during fetal development. Journal of Steroid Biochemistry, 7, 1031–1038.

    CAS  PubMed  Google Scholar 

  • Pasqualini, J.R., Sumida, C., Gelly, C. and Nguyen, B.L. (1977) A general view of the quantitative evaluation of cytosol and nuclear steroid hormone receptors in the fetal compartment of the guinea pig. Journal of Steroid Biochemistry, 8, 445–451.

    CAS  PubMed  Google Scholar 

  • Pearson, H.A. (1966) Recent advances in hemato-logy. Journal of Pediatrics, 69, 466–482.

    CAS  PubMed  Google Scholar 

  • Peckham, C. and Logan, S. (1993) Screening for toxoplasmosis during pregnancy. Archives of Disease in Childhood, 68, 3–5.

    CAS  PubMed  Google Scholar 

  • Peeters, L.L.H., Sheldon, R.E. and Jones, M.D. (1979) Blood flow to fetal organs as a function of arterial oxygen content. American Journal of Obstetrics and Gynecology, 135, 637–646.

    CAS  PubMed  Google Scholar 

  • Pesonen, E., Haavisto, H., Ammala, P. and Teramo, K. (1983) Intrauterine hydrops caused by premature closure of the foramen ovale. Archives of Disease in Childhood, 58, 1015–1016.

    CAS  PubMed  Google Scholar 

  • Peters, M.T. and Nicolaides, K.H. (1990) Cordocentesis for the diagnosis and treatment of human parvovirus infection. Obstetrics and Gynecology, 75, 501–504.

    CAS  PubMed  Google Scholar 

  • Phillips, A., Dubin, J. and Raye, J. (1981) Metabolic response of the fetal lamb to endo-genously released insulin. American Journal of Obstetrics and Gynecology, 139, 441–445.

    Google Scholar 

  • Pitkin, R.M. and Reynolds, W.A. (1975) Fetal ingestion and metabolism of amitotic fluid protein. American Journal of Obstetrics and Gynecology, 123, 356–361.

    CAS  PubMed  Google Scholar 

  • Pointis, G. and Latreille, M.T. (1986) Absence of LHRH effect on testosterone production by Leydig cells from fetal mouse testis. Journal of Steroid Biochemistry, 24, 307–310.

    CAS  PubMed  Google Scholar 

  • Ponte, J. and Purves, M. (1973) Types of different nerve activity which may be measured in the vagus nerve of the sheep fetus. Journal of Physiology, 229, 51–76.

    CAS  PubMed  Google Scholar 

  • Ponzilius, K.H., Parvizi, N., Elaesser, F. and Ellendorf, F. (1986) Ontogeny of secretory patterns of LH release and effects of gonadectomy in the chronically-catheterized pig fetus and neonate. Biology of Reproduction, 34, 602–612.

    CAS  PubMed  Google Scholar 

  • Posner, B.I. (1974) Insulin receptors in human and animal placental tissue. Diabetes, 23, 209–217.

    CAS  PubMed  Google Scholar 

  • Potau, N., Riudor, E. and Balla (1981) Insulin receptors in human placenta in relation to foetal weight, growth and gestational age. Pediatric Research, 15, 798–802.

    CAS  PubMed  Google Scholar 

  • Potter, E.L. and Thierstein, S.T. (1943) Glomerular development in the kidneys as an index of fetal maturity. Journal of Pediatrics, 22, 695–706.

    Google Scholar 

  • Precht, H., Christopherson, J., Hensel, H. and Larcher, W. (1973) Temperature and Life, Springer-Verlag, Berlin.

    Google Scholar 

  • Prechtl, H.F.R. (1988) Assessment of fetal neuro-logical function and development, in Fetal and Neonatal Neurology and Neurosurgery, (eds M.I. Levene, M.J. Bennett and J. Punt), Churchill Livingstone, Edinburgh.

    Google Scholar 

  • Prentice, A. (1991) Can maternal dietary supplements help in preventing infant malnutrition. Acta Paediatrica Scandinavica, Suppl. 374, 67–77.

    CAS  PubMed  Google Scholar 

  • Pritchard, J.A. (1965) Deglutition by normal and anencephalic fetuses. Obstetrics and Gynecology, 25, 289–297.

    CAS  PubMed  Google Scholar 

  • Purves, M. (1981) The neural control of respiration before and after birth. Perinatal Medicine, 4, 299–336.

    Google Scholar 

  • Raiha, N.C.R. (1971) The development of some enzymes of amino acid metabolism in the human liver, in Metabolic Processes in the Foetus and Newborn Infant, (eds J.H.P. Jonxis, H.K.A. Visser and J.A. Troelstra) Liecka Stenfert, Kroese, Leden, N.V., pp. 26–34.

    Google Scholar 

  • Raiha, N.C.R. and Suinhkonen, J. (1968a) Development of urea-synthesizing enzymes in human liver. Acta Paediatrica Scandinavica, 57, 121–124.

    CAS  PubMed  Google Scholar 

  • Raiha, N.C.R. and Suinhkonen, J. (1968b) Factors influencing the development of urea-synthesizing enzymes in rat liver. Biochemical Journal, 107, 793–797.

    CAS  PubMed  Google Scholar 

  • Randall, G.C.B. and L’Ecuyer, C. (1976) Tissue glycogen and blood glucose and fructose levels in the pig fetus during the second half of gestation. Biology of the Neonate, 28, 74–82.

    CAS  PubMed  Google Scholar 

  • Raux-Eurin, M.C., Pharm Huu Trung, M.T. and Marrec, D. (1977) Plasma aldosterone concentration during the newborn period. Pediatric Research, 11, 182–185.

    CAS  PubMed  Google Scholar 

  • Read, L.C., Upton, F.M., Francis, G.L., Wallace, J.C., Dahlenberg, G.W. and Ballard, F.J. (1984) Changes in the growth-promoting activity of human milk during lactation. Pediatric Research, 19, 213.

    Google Scholar 

  • Rennie, J. and Cooke, R. (1992) Prolonged low dose indomethacin for the persistent ductus arteriosus of prematurity. Archives of Disease in Childhood, 66, 55–58.

    Google Scholar 

  • Resko, J.A. and Ellingwood, W.E. (1985) Negative feedback regulation of gonadotrophin secretion by androgens in fetal rhesus macaques. Biology of Reproduction, 33, 346–352.

    CAS  PubMed  Google Scholar 

  • Rhoda, J., Valens, M., Edwards, D.A. and Roffi, J. (1987) Effect of progesterone on the testosterone and estradiol levels in the hypothalamus of rats. Biology of the Neonate, 51, 255–259.

    CAS  PubMed  Google Scholar 

  • Ricquier, D. (1984) Factors affecting brown adipose tissue activity in animals and man. Clinics in Endocrinology and Metabolism, 13, 501–520.

    CAS  PubMed  Google Scholar 

  • Rigaudiøre N. and Després, G. (1986) Maternal testosterone and sexual differentiation of the male guinea pig foetus. Reproduction, Nutrition, Development, 26, 791–800.

    Google Scholar 

  • Rivers, P. and Frankel, T. (1981) Essential fatty acid deficiency. British Medical Bulletin, 37, 59–64.

    CAS  PubMed  Google Scholar 

  • Robertson, A.F. and Sprecher, H. (1967) Human placental lipid metabolism. III. Synthesis and hydrolysis of phospholipids. Lipids, 2, 403–40

    CAS  PubMed  Google Scholar 

  • Robertson, A. F. and Sprecher, H. (1968) A review of human placental lipid metabolism. Acta Paediatrica Scandinavica, Suppl. 183, 3–17.

    Google Scholar 

  • Roberton, N.R.C. (1986) Textbook of Neonatology, Churchill Livingstone, Edinburgh.

    Google Scholar 

  • Robillard, J.E. and Weitzman, R.E. (1980) Developmental aspects of the fetal renal response to exogenous arginine vasopressin. American Journal of Physiology, 238, F407–F414.

    CAS  PubMed  Google Scholar 

  • Robillard, J.E., Matson, J.R., Sessions, C. and Smith, F.J. (1979) Developmental aspects of renal tubular reabsorption of water in the lamb fetus. Pediatric Research, 13, 606–610.

    CAS  PubMed  Google Scholar 

  • Robillard, J. and Nakamura, K. (1988) Neurohormonal regulation of renal function during development. American Journal of Physiology, 254, F771–F779.

    CAS  PubMed  Google Scholar 

  • Robillard, J.E., Session, C., Kennedey, R.I., Hamel-Robillard, L. and Smith, F.G. (1977) Interrelationships between GFR and renal transport of sodium and chloride during foetal life. American Journal of Obstetrics and Gynecology, 128, 727–734.

    CAS  PubMed  Google Scholar 

  • Robillard, J.E., Ramberg, E., Sessions, C., Consamus, B., van Orden, D., Weismann, D. and Smith, F.J. (1980) Role of aldosterone on renal sodium and potassium excretion during fetal life and newborn period. Developmental Pharmacology and Therapeutics, 1, 201–216.

    CAS  PubMed  Google Scholar 

  • Robillard, J., Nakamura, K., Matherne, G. and Jose, P. (1988) Renal haemodynamics and functional adjustment to postnatal life. Seminars in Perinatology, 12, 143–150.

    CAS  PubMed  Google Scholar 

  • Robinson, A. and Williamson, D. (1980) Physiological role of ketone bodies as substrates and signals in mammalian tissues. Physiological Reviews, 60, 143–189.

    CAS  PubMed  Google Scholar 

  • Rodewald, R. (1973) Intestinal transport of antibodies in newborn rat. Journal of Cell Biology, 58, 189–211.

    CAS  PubMed  Google Scholar 

  • Rosenthal, P. (1992) Bilirubin metabolism in the fetus and neonate, in Fetal and Neonatal Physiology, (eds R. Polin and W. Fox), W.B. Saunders, Philadelphia, pp. 1154–1159.

    Google Scholar 

  • Ross, M. G. (1988) Fetal ANF and arginic vaso-pressive responses to hyperosmolality and hypervolaemia. Pediatric Research, 24, 318–321.

    CAS  PubMed  Google Scholar 

  • Ross, M.G., Ervine, M.G., Lam, R.W., Castro, L., Leake, R.D. and Fisher, D.A. (1987). Plasma atrial natriuretic peptide response to volume expansion in the ovine fetus. American Journal of Obstetrics and Gynecology, 157, 1292–1297.

    CAS  PubMed  Google Scholar 

  • Roux, J.F. and Myers, R.E. (1974) In vitro metabolism of palmitic acid and glucose in the developing tissue of the rhesus monkey. American Journal of Obstetrics and Gynecology, 118, 385–392.

    CAS  PubMed  Google Scholar 

  • Rudolph, A. (1983) Hepatic and ductus venous blood flows during fetal life. Hepatology, 3, 254–258.

    CAS  PubMed  Google Scholar 

  • Rudolph, A.M. and Heyman, M.A. (1980) Methods for studying the circulation of the fetus in utero, in Animal Models in Fetal Medicine, (ed. P.W. Nathanielsz), Elseveir, North Holland, Amsterdam, pp. 1–57.

    Google Scholar 

  • Rudolph, A. and Rudolph, C. (1992) Fetal and postnatal hepatic vasculature and blood flow, in Fetal and Neonatal Physiology, (eds R. Polin and W. Fox), W.B. Saunders, Philadelphia, pp. 1095–1102.

    Google Scholar 

  • Ruoslahti, E. and Hirai, H. (1976) Alphafeto-protein. Scandinavian Journal of Immunology, Suppl. 8, 3–26.

    Google Scholar 

  • Rurak, D., Richardson, B., Patrick, J., Carmichael, L. and Homan, J. (1990) Oxygen consumption in the fetal lamb during sustained hypoxemia with progressive acidemia. American Journal of Physiology, 258, R1108–R1115.

    CAS  PubMed  Google Scholar 

  • Rutter, N. and Hull, D. (1979a) Response of babies to a warm environment. Archives of Disease in Childhood, 54, 178–183.

    CAS  PubMed  Google Scholar 

  • Rutter, N. and Hull, D. (1979b) Water loss from the skin of term and preterm babies. Archives of Disease in Childhood, 54, 858–868.

    CAS  PubMed  Google Scholar 

  • Sacher, G.E. and Staffeldt, E.F. (1974) Relation of gestation time to birth weight for placental mammals: Implications for the theory of vertebrate growth. American Naturist, 198, 593–615.

    Google Scholar 

  • Sadava, D., Depper, M., Gilbert, M., Bernard, B. and McCabe, E.R.B. (1987) Development of enzymes of glycerol metabolism in human fetal liver. Biology of the Neonate, 52, 26–32.

    CAS  PubMed  Google Scholar 

  • Said, H.M., Ghishan, F.K., Greene, H.L. and Hollander, D. (1985) Developmental maturation of riboflavin intestinal transport in the rat. Pediatric Research, 19, 1175–1178.

    CAS  PubMed  Google Scholar 

  • Saigal, S., O’Neil, A., Surainder, Y., Chau, L.B. and Usher, R. (1972) Placental transfusion in hyperbilirubinemia in the premature. Paediatrics, 49, 406–419.

    CAS  Google Scholar 

  • Saraux, B. and Girad-Globa, A. (1982) Development of pancreatic enzymes in fetal and suckling rats with emphasis on lipase and colipase. Journal of Developmental Physiology, 4, 121–137.

    CAS  PubMed  Google Scholar 

  • Schlondorff, D., Weber, H., Trizna, H. and Fine, L.G. (1978) Vasopressin responsiveness of renal adenylate cyclase in newborn rats and rabbits. American Journal of Physiology, 234, F16–F21.

    CAS  PubMed  Google Scholar 

  • Schmidt, U. and Horster, M. (1977) Na-K-activated ATPase: activity maturation in rabbit nephron segments dissected in vitro. American Journal of Physiology, 233, F55–F60.

    CAS  PubMed  Google Scholar 

  • Sengel, P. (1976) Morphogenesis of Skin, Cambridge University Press, Cambridge, UK.

    Google Scholar 

  • Senterre, J. and Salle, B. (1988) Renal aspects of calcium and phosphorus metabolism in preterm infants. Biology of the Neonate, 53 (4), 220–229.

    CAS  PubMed  Google Scholar 

  • Shaffer, S.G. (1987) Extracellular fluid volume changes in very low birthweight infants during first 2 postnatal months. Journal of Pediatrics, 111, 124.

    CAS  PubMed  Google Scholar 

  • Shelley, H.J. (1961) Glycogen reserves and their changes at birth. British Medical Bulletin, 17, 137–144.

    Google Scholar 

  • Shelley, H.J. (1979) Transfer of carbohydrate, in Placental Transfer, (eds G.V.P. Chamberlain and A.W. Wilkinson), Pitman Medical, Kent, UK, pp. 118–142.

    Google Scholar 

  • Shulkes, A. Chick, P. and Hardy, K.J. (1982) Fetal and maternal production and metabolism of gastrin in sheep. Journal of Endocrinology, 94, 183–189.

    CAS  PubMed  Google Scholar 

  • Shulkes, A. Chick, P., Hardy, K.J., Robinson, P. and Trahair, J. (1985) Ontogeny of gastric acidity in the ovine fetus. Journal of Developmental Physiology, 7, 195–206.

    CAS  PubMed  Google Scholar 

  • Sibley, C.P. and Boyd, R.D.H. (1988) Control of transfer across the mature placenta. Oxford Reviews of Reproductive Biology, 10, 382–435.

    CAS  PubMed  Google Scholar 

  • Sibley, C.P., Ward, B.S. and Grazier, J.D. (1986) Electrical activity and sodium transport across in vitro pig placenta. American Journal of Physiology, 250, R474–R484.

    CAS  PubMed  Google Scholar 

  • Siegel, S.R. (1982) Hormonal and renal interaction in body fluid regulation in the newborn infant, in Clinics in Perinatology, Vol. 9, (ed. P.W.W. Wu), W.B. Saunders, Philadelphia, pp. 535–557.

    Google Scholar 

  • Siegel, S.R. and Fisher, D.A. (1980) Ontogeny of the renin-angiotensin-aldosterone system in the fetal and newborn lamb. Pediatric Research, 14, 99–102.

    CAS  PubMed  Google Scholar 

  • Siiteri, P.K. and Wilson, J.D. (1974) Testosterone formation and metabolism during male sexual differentiation in the human embryo. Journal of Clinical Endocrinology and Metabolism, 38, 113–125.

    CAS  PubMed  Google Scholar 

  • Simmons, M., Battaglia, F. and Meschia, G. (1978) In vivo effect of insulin on fetal glucose utilization and transplacental glucose transport. Pediatric Research, 12, 90–92.

    CAS  PubMed  Google Scholar 

  • Simpson, J. and Stephenson, T. (1993) Regulation of extracellular fluid volume in neonates. Early Human Development, (In press).

    Google Scholar 

  • Smith, C.H. (1972) Blood Diseases of Infancy and Childhood, C.V. Mosby, St. Louis.

    Google Scholar 

  • Smith, R.A. and Glomski, C.A. (1977) Embryonic and fetal hemopoiesis in the Mongolian gerbil (Meriones unguiculatus). Anatomical Record, 189, 499–518.

    CAS  PubMed  Google Scholar 

  • Snell, K. and Walker, D.G. (1973) Gluconeo-genesis in the newborn rat: the substrates and their quantitative significance. Enzyme, 15, 40–81.

    CAS  PubMed  Google Scholar 

  • Soifer, S.J. and Heymann, M.A. (1984) Future research directions in persistent pulmonary hypertension of the newborn. Clinics in Perinatology, 11, 745–755.

    CAS  PubMed  Google Scholar 

  • Soifer, S.J., Loitz, R.D., Roman, C. and Heymann, M. A. (1985a) Leukotriene end organ antagonists increase pulmonary blood flow in fetal lambs. American Journal of Physiology, 249, H570–H576.

    CAS  PubMed  Google Scholar 

  • Soifer, S.J., Schreiber, M.D., Loitz, R.D., Roman, C. and Heymann, M.A. (1985b) The effects of leukotriene inhibition on the perinatal pulmonary circulation in the lamb, in The Physiological Development of the Fetus and Newborn, (eds C.T. Jones and P.W. Nathanielsz), Academic Press, London, pp. 451–456.

    Google Scholar 

  • Solinger, A.M. (1985) Immature T lymphocytes in human neonatal blood. Cellular Immunology, 92, 115–122.

    CAS  PubMed  Google Scholar 

  • Spitzer, A. (1982) The role of the kidney in sodium homeostasis during maturation. Kidney International, 21, 539–546.

    CAS  PubMed  Google Scholar 

  • Spitzer, A. and Brandis, M. (1974) Functional and morphologic maturation of the superficial neph-rons. Journal of Clinical Investigation, 53, 279–287.

    CAS  PubMed  Google Scholar 

  • Spitzer, A. and Edelman, C.M. (1971) Maturational changes in pressure gradients for glomerular filtration. American Journal of Physiology, 221, 1431–1435.

    CAS  PubMed  Google Scholar 

  • Stagno, S. (1990) Cytomegalovirus, in Infectious Diseases of the Fetus and Newborn Infant, (eds J.S. Remington and J.O. Klein), W.B. Saunders, Philadelphia.

    Google Scholar 

  • Stamatoyannopoulos, G. and Neinhuis, A.E. (1981) Hemoglobins in Development and Differentiation, Alan R. Liss, New York.

    Google Scholar 

  • Stammers, J.P., Leadon, D.P. and Hull, D. (1987) Fatty acid composition of the plasma lipids of the maternal and newborn horse. Journal of Reproduction and Fertility, Suppl. 35, 615–622.

    CAS  PubMed  Google Scholar 

  • Stanier, M. (1960) The function of the mammalian mesonephros. Journal of Physiology, 151, 472–478.

    CAS  PubMed  Google Scholar 

  • Stanier, M.W. (1972) Development of intrasolute gradients in foetal and postnatal life. Pflugers Archives, 2336, 263–270.

    Google Scholar 

  • Steer, P., Lucas, A. and Sinclair, J. (1992) Feeding the low birth weight infant, in Effective Care of the Newborn Infant, (eds J. Sinclair and M. Bracken), Oxford University Press, Oxford, pp. 94–138.

    Google Scholar 

  • Stein, S., Cherian, M.G. and Mazur, A. (1971) Biochemistry of rat haemoglobins. Federation Proceedings, 30, 1257.

    Google Scholar 

  • Stephenson, T.J. (1993) Fetus, in Essential paediatrics, (eds D. Hull and D.I. Johnston), 3rd edn, Churchill Livingstone, Edinburgh, pp. 32–43.

    Google Scholar 

  • Stephenson, T.J. and Broughton-Pipkin, F. (1990) Atrial natriuretic factor: the heart as an endocrine organ. Archives of Disease in Childhood, 65, 1293–1294.

    CAS  PubMed  Google Scholar 

  • Stephenson, T. and Rutter, N. (1992a) Fluid requirements, in Intravenous Feeding of the Neonate, (eds V. Yu and A. Macmahon), Edward Arnold, London, pp. 3–12.

    Google Scholar 

  • Stephenson, T. and Rutter, N. (1992b) Thermoregulation and fluid balance in the newborn, in Forfar and Arneil’s Textbook of Paediatrics, (eds N. McIntosh and A. Campbell), Churchill Livingstone, Edinburgh, pp. 158–165.

    Google Scholar 

  • Stephenson, T.J., Stammers, J.P. and Hull, D. (1990a) Effects of altering umbilical flow and umbilical free fatty acid concentration on transfer of free fatty acids across the rabbit placenta. Journal of Developmental Physiology, 15, 221–227.

    Google Scholar 

  • Stephenson, T.J., Stammers, J.P. and Hull, D. (1990b) Maternal to fetal transfer of free fatty acids in the ‘in situ’ perfused rabbit placenta. Journal of Developmental Physiology, 13, 117–123.

    CAS  PubMed  Google Scholar 

  • Stephenson, T.J., Broughton-Pipkin, F. and Elias-Jones, A. (1991) Factors influencing plasma renin and renin substrate in premature infants. Archives of Disease in Childhood, 66, 1150–1154.

    CAS  PubMed  Google Scholar 

  • Stephenson, T.J., Stammers, J.P. and Hull, D. (1993a) Placental transfer of free fatty acids: importance of fetal albumin concentration and acid base status. Biology of the Neonate, 63, 273–280.

    CAS  PubMed  Google Scholar 

  • Stephenson, T.J., Stammers, J.P. and Hull, D. (1993b) Effect of exogenous lipid on placental transfer in the anaesthetized rabbit. Journal of Physiology, 53P, (in press).

    Google Scholar 

  • Stevens, D.H. (1975) Comparative Placentation-essays in structure and function, Academic Press, London.

    Google Scholar 

  • Stone, R.T. (1981) In vitro liver synthesis and serum levels of alpha fetoprotein and albumin in the fetal pig. Biology of Reproduction, 24, 573–580.

    CAS  PubMed  Google Scholar 

  • Strang, L.B. (1977) Neonatal Respiration, Physiological and Clinical Studies, Blackwell Scientific Publications, Oxford.

    Google Scholar 

  • Stulc, J. (1988) Is there control of solute transport at placental level? Placenta, 9, 19–26.

    CAS  PubMed  Google Scholar 

  • Sujov, P., Kellerman, L., Zelter, M. and Hochberg, Z. (1984) Plasma and urine osmola-lity in full-term and pre-term infants. Acta Paediatrica Scandinavica, 73, 722–726.

    CAS  PubMed  Google Scholar 

  • Sulyok, E., Nemeth, M., Tenyi, I., Csaba, I.F., Varga, F., Gyory, E. and Thurzo, V. (1979) Relationship between maturity, electrolyte balance and the function of the renin-angiotensin-aldosterone system in newborn infants. Biology of the Neonate, 35, 60–65.

    CAS  PubMed  Google Scholar 

  • Sumida, C. and Pasqualini, J.R. (1979) Determination of cytosol and nuclear estradiol-binding sites in fetal guinea pig uterus by [3H] estradiol exchange. Endocrinology, 105, 406–413.

    CAS  PubMed  Google Scholar 

  • Tanner, J.M. (1978) Foetus into Man: Physical Growth from Conception to Maturity, Open Books, London.

    Google Scholar 

  • Tarnow-Mordi, W., Shaw, J., Liu, D., Gardner, D. and Flynn, F. (1981) Iatrogenic hyponatraemia of the newborn due to maternal fluid overload: a prospective study. British Medical Journal, 283, 639–642.

    CAS  PubMed  Google Scholar 

  • Tchernia, G., Mielot, F., Coulombel, L. and Mohandas, N. (1981) Characterization of circulating erythroid progenitor cells in human newborn blood. Journal of Laboratory and Clinical Medicine, 97, 322–331.

    CAS  PubMed  Google Scholar 

  • Teitel, D. (1992) Physiologic development of the cardiovascular system in the fetus, in Fetal and Neonatal Physiology, (eds R. Polin and W. Fox), W.B. Saunders, Philadelphia, pp. 609–619.

    Google Scholar 

  • Thorburn, G.D., Waters, M.J., Young, I.R., Dolling, M., Buntine, D. and Hopkins, K.S. (1981) Epidermal growth factor: a critical factor in fetal maturation?, in The Fetus and Independent Life, Ciba Foundation Symposium, 86, Pitman, London.

    Google Scholar 

  • Tiedemann, K. (1976) The mesonephros of cat and sheep. Comparative morphological and histo-chemical studies. Advances in Anatomy, Embryology and Cell Biology, 52, 7–119.

    Google Scholar 

  • Tomoda, S. Brace, R.A. and Longo, L.D. (1985) Amniotic fluid volume and fetal swallowing rate in sheep. American Journal of Physiology, 249, R133–R138.

    CAS  PubMed  Google Scholar 

  • Towstoless, M.K., McDougall, J.G. and Wintour, E.M. (1989) Gestational changes in renal responsiveness to cortisol in the ovine fetus. Pediatric Research, 26, 6–10.

    CAS  PubMed  Google Scholar 

  • Trahair, J.F. and Robinson, P.M. (1986) The development of the ovine small intestine. Anatomical Record, 214, 294–303.

    CAS  PubMed  Google Scholar 

  • Tsai-Morris, C.H., Knox, G., Luna, S. and Dufau, M.L. (1986) Acquisition of estradiol-mediated regulatory mechanism of steroidogenesis in cultured fetal rat Ley dig cells. Journal of Biological Chemistry, 261, 3471–3474.

    CAS  PubMed  Google Scholar 

  • Ts’ao, C., Green, D. and Schultz, K. (1976) Function and ultrastructure of platelets of neo-nates: enhanced ristocetin aggregation of neonatal platelets. British Journal of Haematology, 32, 225–233.

    CAS  Google Scholar 

  • Tsuda, F., Nickerson, P.A. and Molteni, A. (1971) Ultrastructural study of developing juxta-glomerular cells in the rat. Laboratory Investigation, 25, 644–652.

    CAS  PubMed  Google Scholar 

  • Tudehope, D. and Smyth, M. (1979) Is transient tachypnoea of the newborn always a benign condition? Australian Paediatric Journal, 15, 160–165.

    CAS  PubMed  Google Scholar 

  • Tudvad, F. and Vesterdal, J. (1953) The maximal tubular transport of glucose and para-aminohippurate in premature infants. Acta Paediatrica Scandinavica, 42, 337–345.

    CAS  Google Scholar 

  • Tuvemo, T. (1980) Role of prostaglandins, prosta-cyclin and thromboxanes in the control of the umbilical-placental circulation. Seminars in Perinatology, 4, 91–95.

    CAS  PubMed  Google Scholar 

  • Uauy, R., Birch, D., Birch, E., Tyson, J. and Hoffman, D. (1990) Effect of dietary omega-3 fatty acids on retinal function of very-low-birth weight neonates. Pediatric Research, 28, 485–492.

    CAS  PubMed  Google Scholar 

  • Vanapruks, V. and Prapaitrakul, K. (1989) Water intoxication and hyponatraemic convulsions in neonates. Archives of Disease in Childhood, 64, 734–735.

    CAS  PubMed  Google Scholar 

  • Van Assche, F.A. and Hoet, J.J. (1984) Endocrine pancreas of the pregnant mother, fetus and newborn, in Petal Physiology and Medicine, (eds R.W. Beard and P.W. Nathanielsz), 2nd edn, Marcel Dekker, New York, pp. 127–152.

    Google Scholar 

  • Van Assche, F.A. and Robertson, W.B. (eds) (1982) Petal Growth Retardation. Churchill Livingstone, Edinburgh.

    Google Scholar 

  • Van Dijk, J.P. (1988) Regulatory aspects of placenta iron transfer-a comparative study. Placenta, 9, 215–226.

    PubMed  Google Scholar 

  • Varille, V., Nakamura, K., McWeeny, O. and Matherne, G. (1989) Renal hemodynamic response to atrial natriuretic factor in fetal and newborn sheep. Pediatric Research, 25, 291–294.

    CAS  PubMed  Google Scholar 

  • Vernier, R.L. and Birch-Andersen, A. (1962) Studies of the human fetal kidney. 1. Development of the glomerulus. Journal of Pediatrics, 60, 754–768.

    CAS  PubMed  Google Scholar 

  • Vernon, R. and Walker, D.G. (1970) Glycerol metabolism in the neonatal rat. Biochemical Journal, 118, 531–536.

    CAS  PubMed  Google Scholar 

  • Veyssiere, G., Berger, M., Jean-Faucher, C., de Turckheim, M. and Jean, C. (1976) Levels of testosterone in the plasma, gonads and adrenal during fetal development of the rabbit. Endocrinology, 99, 1263–1268.

    CAS  PubMed  Google Scholar 

  • Veyssiere, G., Berger, M., Jean-Faucher, C., de Turckheim, M. and Jean, C. (1977) Effect of luteinising hormone (LH) and LH-releasing hormone (LHRH) on testosterone production in vivo in fetal rabbit testis in late gestation. Biology of the Neonate, 32, 327–330.

    CAS  PubMed  Google Scholar 

  • Vinter, J. and Hull, D. (1982) Onset of thermo-genesis in response to cold in newborn mice. Biology of the Neonate, 42, 145–151.

    CAS  PubMed  Google Scholar 

  • Vyas, H. (1986) The effect of mode of delivery on lung expansion at birth. Doctor of Medicine Thesis, University of Nottingham.

    Google Scholar 

  • Walker, A. (1984) Physiological control of the fetal cardiovascular system, in Fetal Physiology and Medicine, (eds R. Beard and P. Nathanielsz), Marcel Dekker, New York, pp. 287–316.

    Google Scholar 

  • Warshaw, J.B. (1972) Cellular energy metabolism during fetal development. IV. Fatty acid activation, acetyl transfer and fatty acid oxidation during development of the chick and rat. Developmental Biology, 28, 537–544.

    CAS  PubMed  Google Scholar 

  • Warshaw, J.B. (1979) Fatty-acid metabolism during development. Seminars in Perinatology, 3, 131–139.

    CAS  PubMed  Google Scholar 

  • Weatherall, D. (1982) The New Genetics and Clinical Practice, The Nuffield Provincial Hospitals Trust, London.

    Google Scholar 

  • Weaver, L. (1992) Breast and gut: the relationship between lactating mammary function and neonatal gastrointestinal function. Proceedings of the Nutrition Society, 51, 155–163.

    CAS  PubMed  Google Scholar 

  • Weaver, L. and Lucas, A. (1993) Development of bowel habit in preterm infants. Archives of Disease in Childhood, 68, 317–320.

    CAS  PubMed  Google Scholar 

  • Weston, W.L. (ed.) (1985) Practical Pediatric Dermatology. 2nd edn, Little and Brown, Boston.

    Google Scholar 

  • Widdowson, E. (1950) Chemical composition of newly born animals. Nature, 166, 626–628.

    CAS  PubMed  Google Scholar 

  • Widdowson, E.M. (1970) The harmony of growth. Lancet, i, 901–905.

    Google Scholar 

  • Wigglesworth, J.S. and Desai, R. (1979) Effects on lung growth of cervical cord section in the rabbit fetus. journal of Endocrinology, 3, 51–65.

    CAS  Google Scholar 

  • Wilkins, B. (1992) Renal function in sick very low birth weight infants. 1. Glomerular filtration rate. Archives of Disease in Childhood, 67, 1140–1145.

    CAS  PubMed  Google Scholar 

  • Witsett, J.A., Johnson, C.L. and Hawkins, K. (1979) Differences in localisation of insulin receptors and adenylate cyclase in the human placenta. American Journal of Obstetrics and Gynecology, 133, 204–207.

    Google Scholar 

  • Wright, G.H. (1963) Net transfers of water, sodium, chloride and hydrogen ions across the gastric mucosa of the rabbit foetus. Journal of Physiology, 163, 281–292.

    Google Scholar 

  • Yoffey, J.M. and Thomas, D.B. (1964) The development of bone marrow in the human fetus. Journal of Anatomy, 98, 463–464.

    Google Scholar 

  • Young, M. (1979) Transfer of amino acids, (eds G.V.P. Chamberlain and A.W. Wilkinson) Pitman Medical, UK.

    Google Scholar 

  • Young, S., LeSoëuf, P., Geelhoed, G., Stick, S.M., Turner, K.J. and Landau, L. (1991) The influence of a family history of asthma and parental smoking on airway responsiveness in early infancy. New England Journal of Medicine, 324, 1168–1173.

    CAS  PubMed  Google Scholar 

  • Zamboni, L. and Upadhyay, S. (1981) Ephemeral, rudimentary glomerular structures in the meso-nephros of the mouse. Anatomical Record, 201, 641–644.

    CAS  PubMed  Google Scholar 

  • Zanjani, E.D., Peterson, E.N., Gordon, A.S. and Wasserman, L.R. (1974) Erthropoetin production in the fetus: role of the kidney and maternal anemia. Journal of Laboratory and Clinical Medicine, 83, 281–287.

    CAS  PubMed  Google Scholar 

  • Zanjani, E.D., Poster, J., Mann, L.J. and Wasserman, L.R. (1977) Kidney Hormones. Vol. 2 Erythropoietin. (ed. J.W. Fisher), Academic Press, London, pp.463–493.

    Google Scholar 

  • Zanjani, E.D., Ascensao, J.L., McGlave, P., Banisadre, M. and Ash, R.C. (1981) Studies on the liver to kidney switch of erythropoietin production. Journal of Clinical Investigation, 67, 1183–1188.

    CAS  PubMed  Google Scholar 

  • Zimmermann, T., Hummel, L. and Wagner, H. (1986) Quantitative studies on the fetal lipid metabolism in rats: Liver fatty acid esterification and conversion into carbon dioxide, and hepatic output of triglycerides and phospholipids into serum. Biology of the Neonate, 49, 43–50.

    CAS  PubMed  Google Scholar 

  • Zimmermann, T., Winkler, L., Möller, W., Schubert, M. and Goetze, E. (1979) Synthesis of arachidonic acid in human placenta in vitro. Biology of the Neonate, 35, 209–212.

    CAS  PubMed  Google Scholar 

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Broughton-Pipkin, F., Hull, D., Stephenson, T. (1994). Fetal Physiology. In: Lamming, G.E. (eds) Marshall’s Physiology of Reproduction. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1286-4_8

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  • DOI: https://doi.org/10.1007/978-94-011-1286-4_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4561-2

  • Online ISBN: 978-94-011-1286-4

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