Skip to main content

Hormones of the Placenta: hCG and hPL

  • Chapter
Book cover Marshall’s Physiology of Reproduction
  • 508 Accesses

Abstract

The pre-eminent function of the human placenta is transfer of nutrients, gases and waste products between the mother and the fetus. At the same time, it is also extraordinarily active in the synthesis of a wide range of proteins and other molecules. Some of these are the structural proteins, enzymes, etc., which are part of the normal functional equipment of cells throughout the body and thus are in no sense specific to this particular organ. The respiratory enzymes are one example. Another example, though slightly more limited in overall distribution, is the group of enzymes responsible for steroid synthesis and interconversion; these do not differ from their counterparts in other steroid-producing tissues. In addition, the placenta contains low concentrations of ACTH-related peptides and hypothalamic releasing hormones, none of which differs significantly from their hypothalamic-pituitary counterparts (J.N. Lee et al., 1981, 1982).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adejuwon, CA., Koide, S.S., Mitsudo, S.M. and Segal, S.J. (1980) Apparent chorionic gonadotro-pin immunoreactivity in human nonplacental tissues, in Chorionic Gonadotropin, (ed. S.J. Segal), Plenum Press, New York, pp. 411–419.

    Chapter  Google Scholar 

  • Aggarwal, P.B., Farmer, S.W., Papkoff, H. and Stewart, F. (1980) Purification and characterization of donkey chorionic gonadotrophin (abstract). Journal of Endocrinology, 85, 449–455.

    Article  PubMed  CAS  Google Scholar 

  • Ajabor, I.N. and Yen, S.S.C. (1972) Effect of sustained hyperglycemia on the levels of human chorionic somatomammotropin in mid-pregnancy. American Journal of Obstetrics and Gynecology, 112, 908–911.

    PubMed  CAS  Google Scholar 

  • Akar, A.H., Wehmann, R.E., Blithe, D.L., Blacker, C. and Nisula, B.C. (1988) A radio-immunoassay for the core fragment of the human chorionic gonadotropin β-subunit. Journal of Clinical Endocrinology and Metabolism, 66, 538–545.

    Article  PubMed  CAS  Google Scholar 

  • Alexander, I., Anthony, F. and Letchworth, A.T. (1982) Placental protein profile and glucose studies in a normal pregnancy with extremely low levels of human placental lactogen. Case Report. British Journal of Obstetrics and Gynaecology, 89, 241–243.

    Article  PubMed  CAS  Google Scholar 

  • Alfthan, H., Schroder, U., Fraser, R., Koskimies, A., Halila, H. and Stenman, U.H. (1988) Choriogonadotrophin and its β-subunits separated by hydrophobic-interaction chromato-graphy and quantified in serum during pregnancy by time-resolved immunofluoro-metric assay. Clinical Chemistry, 34, 1758–1762.

    PubMed  CAS  Google Scholar 

  • Allen, W.R. (1979) The maternal recognition of pregnancy, in CIBA Foundation Symposium, Excerpta Medica, Amsterdam, pp. 323–352.

    Google Scholar 

  • Aloj, S.M., Edelhoch, H., Handwerger, S. and Sherwood, L.M. (1972) Correlation in the structure and function of human placental lactogen and human growth hormone. II. The effects of disulfide bond modifications on the conformation of human placental lactogen (abstract). Endocrinology, 91, 728–737.

    Article  PubMed  CAS  Google Scholar 

  • Anderson, B., Milstead, A., Kennedy, G. and Nilson, J.H. (1988) Cyclic AMP phorbol esters interact synergistically to regulate expression of chorionic gonadotrophin genes. Journal of Biological Chemistry, 263, 15578–15584.

    Google Scholar 

  • Ando, Y. and Hattori, H. (1977) Effects of noise on human placental lactogen (hPL) levels in maternal plasma. British Journal of Obstetrics and Gynaecology, 84, 115–118.

    Article  PubMed  CAS  Google Scholar 

  • Anon, (1985) Can adoptive mothers breast feed? (abstract). Lancet, 2, 426–427.

    Google Scholar 

  • Armstrong, E.G., Ehrlich, P.H., Birken, S., Schlatterer, J.P., Siris, E., Hembree, W.C. and Canfield, R.E. (1984) Use of a highly sensitive and specific immunoradiometric assay for detection of human chorionic gonadotropin in urine of normal, non-pregnant and pregnant individuals. Journal of Clinical Endocrinology and Metabolism, 59, 867–873.

    Article  PubMed  CAS  Google Scholar 

  • Asch, R.H.J., Fernandez, E.O. and Pauerstein, C.J. (1977) Immunodetection of human chorionic gonadotropin-like substance in human sperm. Fertility and Sterility, 28, 1258–1262.

    PubMed  CAS  Google Scholar 

  • Aschheim, S. (1930) Early diagnosis of pregnancy, chorionepithelioma and hydatidiform mole by the Aschheim-Zondek test. American Journal of Obstetrics and Gynecology, 19, 335–342.

    Google Scholar 

  • Aschheim, S. and Zondek, B. (1927a) Das Hormon des Hypophysenvordelappens: Testobjekt zum Nachweis des Hormons. Klinische Wochenschrift, 6, 248–252.

    Article  Google Scholar 

  • Aschheim, S. and Zondek, B. (1927b) Hypophys-envorderlappenhormon und ovarialhormone im harn von schwangeren. Klinische Wochenschrift, 6, 1322.

    Article  Google Scholar 

  • Aschheim, S. and Zondek, B. (1928) Die schwan-gerschaftsdiagnose aus dem harn durch nach weis des hypophysenvorderlappen-hormone. II. Praktische und theoretische ergebnisse aus den harnunter suchungen. Klinische Wochenschrift, 7, 1453–1457.

    Google Scholar 

  • Ashitaka, Y., Mochizuki, M. and Tojo, S. (1972) Purification and properties of chorionic gonadotropin from the trophoblastic tissue of hydatidiform mole. Endocrinology, 90, 609–617.

    Article  PubMed  CAS  Google Scholar 

  • Ayala, A.R., Bustos, H. and Aguilar, R.M.A. (1984) Daily rhythm of serum human chorionic gonadotropin and human chorionic somato-mammotropin in normal pregnancy (abstract). International Journal of Gynecology and Obstetrics, 22, 173–176.

    Article  PubMed  CAS  Google Scholar 

  • Bagga, R., Vasishta, K., Majumdar, S. and Garg, S.K. (1990) Correlation between human placental lactogen levels and glucose metabolism in pregnant women with intrauterine growth retardation. Australia and New Zealand Journal of Obstetrics and Gynaecology, 30, 310–313.

    Article  CAS  Google Scholar 

  • Bagshawe, K.D. (1980) Management of trophoblastic tumours. Excerpta Medica, International Congress Series, 512, 576–578.

    Google Scholar 

  • Bagshawe, K.D. (1984) Clinical applications of hCG. Advances in Experimental Biology and Medicine, 176, 313–324.

    Article  CAS  Google Scholar 

  • Bahl, O.P. (1969) Human chorionic gonadotrophin. II. Nature of the carbohydrate units. Journal of Biological Chemistry, 244, 575–583.

    PubMed  CAS  Google Scholar 

  • Bahl, O.P. and Wagh, P.V. (1986) Characterization of glycoproteins: carbohydrate structures of gly-coprotein hormones, in Advances in Experimental Medicine and Biology, (eds D.S. Dinsha and O.P. Bahl), Plenum Press, New York, pp. 1–51.

    Google Scholar 

  • Balfour, N.J., Franklyn, J.A., Gurr, J.A. and Sheppard, M.C. (1990) Multiple DNA elements determine basal and thyroid hormone regulated expression of the human glycoprotein α-subunit gene in pituitary cells. Journal of Molecular Endocrinology, 4, 187–190.

    Article  PubMed  CAS  Google Scholar 

  • Bangham, D.R. and Grab, B. (1964) The second international standard for chorionic gonado-trophin. Bulletin of the World Health Organization, 31, 111–125.

    PubMed  CAS  Google Scholar 

  • Bangham, D.R. and Stoning, P.L. (1982) Standardization of human chorionic gonadotro-pin, hCG subunits, and pregnancy tests. Lancet, 1, 390.

    Article  PubMed  CAS  Google Scholar 

  • Barbieri, R.L., Saltzman, D. and Phillipe, M. (1985) Elevated β-human chorionic gonadotro-pin and testosterone in cord serum of male infants of diabetic mothers. Journal of Clinical Endocrinology and Metabolism, 61, 976–979.

    Article  PubMed  CAS  Google Scholar 

  • Barbieri, R.L., Saltzman, D.H., Torday, J.S., Randal, R.W., Frigoletto, F.D. and Ryan, K.J. (1986) Elevated concentrations of the beta-subunit of human chorionic gonadotropin and testosterone in the amniotic fluid of diabetic mothers. American Journal of Obstetrics and Gynecology, 154, 1039–1043.

    PubMed  CAS  Google Scholar 

  • Barrera-Saldana, H.A., Seeburg, P.H. and Saunders, G.F. (1983) Two structurally different genes produce the same human placental lacto-gen hormone. Journal of Biological Chemistry, 258, 3787–3799.

    PubMed  CAS  Google Scholar 

  • Barsh, G.S., Seeburg, P.H. and Gelinas, R.E. (1983) The human growth hormone gene family: structure and evolution of the chromosomal locus. Nucleic Acids Research, 11, 3939.

    Article  PubMed  CAS  Google Scholar 

  • Basch, C.V. and Talmantes, F. (1986) In vitro kinetics of synthesis and release of mouse placental lactogen. Endocrinology, 119, 1939–1947.

    Article  PubMed  CAS  Google Scholar 

  • Bates, R.W., Garrison, M.M., Cooper, J.A and Condliffe, P.G. (1968) Further studies on the purification of human thyrotropm. Endocrinology, 83, 721–730.

    Article  PubMed  CAS  Google Scholar 

  • Batra, S., Sjoberg, N.O. and Aberg, A. (1978) Human placental lactogen, estradiol-17 beta, and progesterone levels in the third trimester and their respective values for detecting twin pregnancy. American Journal of Obstetrics and Gynecology, 131, 69–72.

    PubMed  CAS  Google Scholar 

  • Batzer, F.R. (1980) Hormonal evaluation of early pregnancy. Fertility and Sterility, 34, 1–13.

    PubMed  CAS  Google Scholar 

  • Baylin, S.B. and Mendelsohn, G. (1980) Ectopic (inappropriate) hormone production by tumors. Mechanisms involved and the biological and clinical implications. Endocrine Reviews, 1, 45–79.

    Article  PubMed  CAS  Google Scholar 

  • Beck, P. (1970) Reversal of progesterone-enhanced insulin production by human chorionic somato-mammotropin. Endocrinology, 87, 311–315.

    Article  PubMed  CAS  Google Scholar 

  • Beck, P. and Daughaday, W.H. (1967) Human placental lactogen levels: studies of its acute metabolic effects and disposition in normal man. Journal of Clinical Investigation, 1, 103–110.

    Article  Google Scholar 

  • Beck, P., Parker, M.L. and Daughaday, W.H. (1965) Radioimmunologic measurement of human placental lactogen in plasma by a double antibody method during normal and diabetic pregnancies. Journal of Clinical Endocrinology and Metabolism, 25, 1457–1462.

    Article  PubMed  CAS  Google Scholar 

  • Beebe, J.S., Krzesicki, R.F., Norton, S.E., Perini, F., Peters, B.P. and Ruddon, R.W. (1989) Identification and characterization of subpopulations of the free α-subunit that vary in their ability to combine with chorionic gonadotropin-β. Endocrinology, 124, 1613–1624.

    Article  PubMed  CAS  Google Scholar 

  • Beling, C.G., Cederqvist, L.L. and Fuchs, F. (1976) Demonstration of gonadotropin during the second half of the cycle in women using intra-uterine contraception. American Journal of Obstetrics and Gynecology, 125, 855–858.

    PubMed  CAS  Google Scholar 

  • Belisle, S., Bellabarba, D., Gallo-Payet, N., Lehoux, J.G. and Guevin, V.F. (1986) On the role of luteinizing hormone-releasing hormone in the in vitro synthesis of bioactive human chorionic gonadotrophin in human pregnancies. Canadian Journal of Physiology and Pharmacology, 54, 1229–1235.

    Article  Google Scholar 

  • Bell, J.J., Canfield, R.E. and Sciarra, J.J. (1969) Purification and characterization of human chorionic gonadotropin. Endocrinology, 84, 298–307.

    Article  PubMed  CAS  Google Scholar 

  • Bellet, D., Arang, J.M., Contesso, G., Gailland, J.M. and Bohuon, C. (1980) Localization of the beta-subunit of human chorionic gonadotrophin on various tumours. European Journal of Cancer, 16, 433–439.

    PubMed  CAS  Google Scholar 

  • Berczi, I. and Nagy, E. (1991) Placental lactogen is a haemopoietic hormone. British Journal of Haematology, 79, 355–358.

    Article  PubMed  CAS  Google Scholar 

  • Bewley, T.A. and Li, C.H. (1974) Structural similarities between human pituitary growth hormone, human chorionic somatomammotropin and ovine pituitary growth hormones, in Lactogenic Hormones, Fetal Nutrition and Lactation, (ed. B.J. Josimovich), John Wiley & Sons, New York, pp. 19–32.

    Google Scholar 

  • Bewley, T.A. and Li, C.H. (1984) Conformational comparison of human pituitary growth hormone and human chorionic somatomammotro-phin (human placental lactogen) by second-order absorption spectroscopy. Archives of Biochemistry and Biophysics, 233, 219–227.

    Article  PubMed  CAS  Google Scholar 

  • Bhaumick, B., Dawson, E.P. and Bala, R.M. (1987) The effects of insulin-like growth factor-I and insulin on placental lactogen production by human term placenta. Biochemical and Biophysical Research Communications, 144, 674–682.

    Article  PubMed  CAS  Google Scholar 

  • Bidart, J.M., Ozturk, M., Bellett, D.H., Jolivet, M., Grasse-Masse, H., Troalen, F., Bohon, C.J. and Wands, J.R. (1985) Identification of epitopes associated with hCG and beta hCG carboxy terminus by monoclonal antibodies produced against a synthetic peptide. Journal of Immunology, 134, 457–464.

    CAS  Google Scholar 

  • Bidart, J.M., Troalen, F., Salesse, F., Bousfield, G.R., Buhuon, C.J. and Bellet, D.H. (1987) Topographic antigenic determinants recognized by monoclonal antibodies of human choriogonadotropin-β-subunit. Journal of Biological Chemistry, 262, 8551–8556.

    PubMed  CAS  Google Scholar 

  • Bidart, J.M., Troalen, F., Puisieux, A., Bressac, B., Ozturk, M., Bohuon, C. and Bellet, D. (1988) Recent progress in the immunochemistry of human chorionic gonadotropin, in Placental Protein Hormones, (eds M. Mochizuki and R. Hussa), Elsevier, Amsterdam, pp. 63–72.

    Google Scholar 

  • Billingsley, S.A. and Wooding, F.B.P. (1990) An immunogold, cryoultrastructural study of sites of synthesis and storage of chorionic gonadotropin and placental lactogen in human syncytiotrophoblast. Cell and Tissue Research, 261, 375–382.

    Article  PubMed  CAS  Google Scholar 

  • Birken, S., Smith, D.L., Canfield, R.E. and Boime, I. (1977) Partial amino acid sequence of human placental lactogen precursor and its mature hormone form produced by membrane-associated activity. Biochemical and Biophysical Research Communications, 74, 106–116.

    Article  PubMed  CAS  Google Scholar 

  • Birken, S.E., Armstrong, E.G., Gawinowicz Kolks, M.A., Cole, L.A., Agosto, G.M., Krichevsky, A., Vaitukaitis, J.L. and Canfield, R.E. (1988) Structures of the human chorionic gonadotropin β-subunit fragment from pregnancy urine. Endocrinology, 123, 572–583.

    Article  PubMed  CAS  Google Scholar 

  • Bischof, P., Martin du Pan, R. and Lauber, K. (1983) Human seminal plasma contains a protein that shares physicochemical, immuno-chemical and immunosuppressive properties with pregnancy-associated plasma protein-A. Journal of Clinical Endocrinology, 56, 359–362.

    Article  CAS  Google Scholar 

  • Biswas, S., Murrey, M., Buffoe, G., Graves, L., Jelowitz, J. and Dewhurst, J. (1980) Placental lactogen as a reliable index of fetal outcome in threatened abortion during early pregnancy. Journal of Obstetrics and Gynaecology, 1, 75–77.

    Article  Google Scholar 

  • Blithe, D.L. and Nisula, B.C. (1985) Variations in the oligosaccharides of free and combined α-subunits of human choriogonadotropin in pregnancy. Endocrinology, 117, 2218–2228.

    Article  PubMed  CAS  Google Scholar 

  • Blithe, D.L., Akar, A.H., Wehmann, R.E. and Nisula, B.C. (1988) Purification of β-core fragment from pregnancy urine and demonstration that its carbohydrate moieties differ from those of native human chorionic gonadotropin-B. Endocrinology, 122, 173–180.

    Article  PubMed  CAS  Google Scholar 

  • Blobel, G. and Dobberstein, B. (1975) Transfer of proteins across membranes. Journal of Cell Biology, 67, 835–845.

    Article  PubMed  CAS  Google Scholar 

  • Bo, M. and Boime, I. (1992) Identification of the transcriptionally active genes of the chorionic gonadotropin β gene in vivo. Journal of Biological Chemistry, 267, 3179–3184.

    PubMed  CAS  Google Scholar 

  • Bogart, M.H., Pandian, M.R. and Jones, O.W. (1987) Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalities. Prenatal Diagnosis, 7, 623–630.

    Article  PubMed  CAS  Google Scholar 

  • Boime, I. and Boguslawski, S. (1974) The synthesis of human placental lactogen by ribosomes derived from human placenta. Proceedings of the National Academy of Sciences of the USA, 74, 1322–1325.

    Article  Google Scholar 

  • Boime, I., McWilliams, D., Szcesena, E. and Camel, M. (1976) Synthesis of hPL messenger RNA, a function of gestation. Journal of Biological Chemistry, 251, 820–825.

    PubMed  CAS  Google Scholar 

  • Bolander, F.F. and Fellows, R.E. (1976) Growth-promoting and lactogenic activities of bovine placental lactogen. Journal of Endocrinology, 71, 173–174.

    Article  PubMed  CAS  Google Scholar 

  • Bolander, F.F., Ulberg, L.C. and Fellows, R.E. (1976) Circulating placental lactogen levels in dairy and beef cattle. Endocrinology, 99, 1273–1278.

    Article  PubMed  CAS  Google Scholar 

  • Bolton, R.A., Coulam, C.B. and Ryan, R.J. (1980) Specific binding of human chorionic gonadotropin to human corpora lutea in the menstrual cycle. Obstetrics and Gynecology, 56, 336–338.

    PubMed  CAS  Google Scholar 

  • Boorstein, W.R., Vamvakopoulos, N.C. and Fiddes, J.C. (1982) Human chorionic gonadotropin β-subunit is encoded by at least eight genes arranged in tandem and inverted pairs. Nature, 300, 419–422.

    Article  PubMed  CAS  Google Scholar 

  • Boothby, M., Ruddon, R.W., Anderson, C., McWilliams, D. and Boime, I. (1981) A single gonadotropin α-subunit gene in normal tissue and tumour-derived cell lines. Journal of Biological Chemistry, 256, 5121–5127.

    PubMed  CAS  Google Scholar 

  • Boroditsky, R.S., Reye, F.I., Winter, J.S.D. and Faiman, C.F. (1975) Serum human chorionic gonadotropin and progesterone patterns in the last trimester of pregnancy: relationship to fetal sex. American Journal of Obstetrics and Gynecology, 121, 238–241.

    PubMed  CAS  Google Scholar 

  • Borody, I.B. and Carlton, M.A. (1981) Isolated defect in human placental lactogen synthesis in a normal pregnancy. British Journal of Obstetrics and Gynaecology, 88, 447–449.

    Article  PubMed  CAS  Google Scholar 

  • Bousfield, G.R., Sugino, H. and Ward, D.N. (1985) Demonstration of a COOH-terminal extension on equine lutropin by means of a common acid-labile bond to equine lutropin and equine chorionic gonadotropin. Journal of Biological Chemistry, 260, 9531–9533.

    PubMed  CAS  Google Scholar 

  • Bousfield, G.R., Liu, W.K., Sugino, H. and Ward, D.N. (1987) Structural studies on equine glyco-protein hormones. Amino acid sequence of equine lutropin β-subunit. Journal of Biological Chemistry, 262, 8610–8620.

    PubMed  CAS  Google Scholar 

  • Boyce, A., Schwartz, D., Hubert, C., Cedard, I. and Dreyfus, J. (1975) Smoking, human placental lactogen and birth weight. British Journal of Obstetrics and Gynaecology, 82, 864–867.

    Google Scholar 

  • Bradbury, J.T., Brown, W.E. and Gray, L.A. (1950) Maintenance of the corpus luteum and physiological action of progesterone. Recent Progress in Hormone Research, 5, 151–194.

    Google Scholar 

  • Braunstein, G.D. (1983) hCG expression in trophoblastic and nontrophoblastic tumors, in Oncodevelopmental Markers: Biologic, Diagnostic, and Monitoring Aspects, (ed. W.H. Fishman), Academic Press, New York, pp. 351.

    Google Scholar 

  • Braunstein, G.D. and Asch, R.H. (1983) Predictive value of analysis of measurements of human chorionic gonadotropin, pregnancy-specific beta-1 glycoprotein, placental lactogen and cys-tine aminopeptidase for the diagnosis of ectopic pregnancy. Fertility and Sterility, 39, 62–67.

    PubMed  CAS  Google Scholar 

  • Braunstein, G.D., Vaitukaitis, J.L., Carbone, P.P. and Ross, G.T. (1973) Ectopic production of human chorionic gonadotrophin by neoplasms. Annals of Internal Medicine, 78, 39–43.

    PubMed  CAS  Google Scholar 

  • Braunstein, G.D., Rasor, J., Adler, D., Danzer, H. and Wade, M.E. (1976) Serum human chorionic gonadotropin levels throughout normal pregnancy. American Journal of Obstetrics and Gynecology, 126, 678–681.

    PubMed  CAS  Google Scholar 

  • Braunstein, G.D., Karow, W.G., Gentry, W.C., Rasor, T. and Wade, M.M. (1978) First trimester chorionic gonadotropin measurements as an aid in the diagnosis of early pregnancy disorders. American Journal of Obstetrics and Gynecology, 143, 25–32.

    Google Scholar 

  • Braunstein, G.D., Kamdar, V., Rasor, J., Swaminathan, N. and Wade, M.E. (1979) Widespread distribution of a chorionic gonadotropin-like substance in normal human tissues. Journal of Clinical Endocrinology and Metabolism, 49, 917–922.

    Article  PubMed  CAS  Google Scholar 

  • Briet, J.W. and Hoorn, R.K.J. (1982) The use of human placental lactogen, oxytocinase and estriol in twin pregnancies with intrauterine growth retardation. European Journal of Obstetrics, Gynecology and Reproductive Biology, 13, 7–14.

    Article  CAS  Google Scholar 

  • Brinsmead, M.W., Waters, M.J., Thorburn, G.D., Owens, P.C., Bancroft, B.J. and Tennison, M. (1980) Increase in placental lactogen and so-matomedins after fetal nephrectomy. Journal of Developmental Physiology, 2, 205–218.

    PubMed  CAS  Google Scholar 

  • Brinsmead, M.W., Bancroft, B.J., Thorburn, G.D. and Waters, J. (1981) Fetal and maternal ovine placental lactogen during hyperglycaemia, hypoglycaemia and fasting. Journal of Endocrinology, 90, 337–343.

    Article  PubMed  CAS  Google Scholar 

  • Broder, L.E., Weintraub, B.D., Rosen, S.W., Cohen, M.H. and Tejada, F. (1977) Placental markers and their subunits as tumor markers in prostatic carcinoma. Cancer, 40, 211–216.

    Article  PubMed  CAS  Google Scholar 

  • Brody, S. and Carlstrom, G. (1965) Human chorionic gonadotropin pattern in serum and its relation to the sex of the fetus. Journal of Clinical Endocrinology and Metabolism, 25, 792–797.

    Article  PubMed  CAS  Google Scholar 

  • Burg-Kurland, C.L., Purnell, D.M., Combs, J.W., Valerio, M.G., Harris, C.C. and Trump, B.F. (1986) Immunocytochemical evaluation of primary human esophageal carcinomas and their xenografts for keratin beta-chorionic gonadotropin, placental lactogen, alphafetoprotein, carci-noembryonic antigen, and nonspecific cross-reacting antigen. Cancer Research, 46, 5730–5737.

    PubMed  CAS  Google Scholar 

  • Burgos, M.H. and Rodriguez, E.M. (1966) Specialized zones in the trophoblast of the human term placenta. American Journal of Obstetrics and Gynecology, 96, 342.

    PubMed  CAS  Google Scholar 

  • Burnside, J., Buckland, P.R. and Chin, W.W. (1988) Isolation and characterization of the gene encoding the α-subunit of the rat pituitary glycoprotein hormones. Gene, 70, 67–74.

    Article  PubMed  CAS  Google Scholar 

  • Burt, R.L., Leake, N.H. and Pruitt, A.B. (1966) Observations on the metabolic activity of human placental fraction. American Journal of Obstetrics and Gynecology, 95, 579–585.

    PubMed  CAS  Google Scholar 

  • Burt, R.L., Leake, N.H. and Rhyne, A.L. (1970) Human placental lactogen and insulin-blood glucose homeostasis. Obstetrics and Gynecology, 36, 233–237.

    PubMed  CAS  Google Scholar 

  • Butcher, D.N., Gregory, W.N., Gunter, P.A., Masters, J.R. and Parkinson, M.C. (1985) The biological and clinical significance of hCG-containing cells in seminoma. British Journal of Cancer, 51, 473–478.

    Article  PubMed  CAS  Google Scholar 

  • Buttle, H.L. and Forsyth, I.A. (1976) Placental lac-togen in the cow. Endocrinology, 68, 141–146.

    Article  CAS  Google Scholar 

  • Buttle, H.L., Forsyth, I.A. and Knaggs, G.S. (1972) Plasma prolactin measured by radioimmuno-assay and bioassay in pregnant and lactating goats and the occurrence of a placental lactogen. Journal of Endocrinology, 53, 483–491.

    Article  PubMed  CAS  Google Scholar 

  • Byatt, J.C., Shimomura, K., Duello, T.M. and Bremel, R.D. (1986) Isolation and characterization of multiple forms of bovine placental lactogen from secretory granules of the fetal cotyledon. Endocrinology, 119, 1343–1350.

    Article  PubMed  CAS  Google Scholar 

  • Byatt, J.C., Warren, W.C., Eppard, P.J., Staten, N.R., Krivi, G.G. and Collier, R.J. (1992) Ruminant placental lactogens: structure and biology. Journal of Animal Science, 70, 2911–2923.

    PubMed  CAS  Google Scholar 

  • Campbell, K.L., Bagavandoss, P., Byrne, M.D., Jonassen, J.A., Landefeld, T.D., Quasney, M.W., Sanders, M.M. and Midgley, A.R. (1981) Differential processing of the two subunits of human choriogonadotropin by granulosa cells. II. In vivo studies. Endocrinology, 109, 1858–1871.

    Article  PubMed  CAS  Google Scholar 

  • Campbell, R.K., Matzuk, M.M., Canfield, R.E., Boime, I. and Moyle, W.R. (1988) Use of monoclonal antibodies and mutagenesis to study the structure of human chorionic gonadotropin (hCG), in Placental Protein Hormones, (eds M. Mochizuki and R. Hussa), Elsevier, Amsterdam, pp. 123–132.

    Google Scholar 

  • Canfield, R.E., Morgan, R.J., Kammerman, S., Bell, J.J. and Agosto, G.M. (1971) Studies of human chorionic gonadotropin. Recent Progress in Hormone Research, 27, 121–164.

    PubMed  CAS  Google Scholar 

  • Canfield, R.E., O’Connor, J.F., Birken, S., Krichevsky, A., Wilcox, A.J., Lustbader, J. and Moyle, W. (1988) hCG immunochemistry as related to clinical applications, in Placental Protein Hormones, (eds M. Mochizuki and R. Hussa), Elsevier, Amsterdam, pp. 55–61.

    Google Scholar 

  • Canick, J.A., Stevens, L.D., Abell, K.B., Panizza, D.S., Osathanondh, R., Knight, G.J., Palomaki, G.E. and Haddow, J.K.E. (1989) Second trimester maternal serum unconjugated estriol and human chorionic gonadotropin in pregnancies affected with fetal trisomy 18, anencephaly, and open spina bifida. American Journal of Human Genetics, 45, A255.

    Google Scholar 

  • Carenza, L., Gregorio, R., Mocci, C., Moro, M. and Pala, A. (1980) Ectopic human chorionic gonadotropin: gynaecological tumors and non-malignant conditions. Gynecological Oncology, 10, 32–38.

    Article  CAS  Google Scholar 

  • Catt, K.J., Dufau, M.L. and Tsuruhara, T. (1971) Studies on a radioligand-receptor assay system for luteinizing hormone and chorionic gonadotropin. Journal of Clinical Endocrinology and Metabolism, 32, 860–863.

    Article  PubMed  CAS  Google Scholar 

  • Caulfield, M.J., Dilkes, M.G., Iles, R.K., Handel, B.T. and Oliver, R.T.D. (1990) Rapid diagnosis of testicular choriocarcinoma by urinary pregnancy tests. Lancet, 335, 1230.

    Article  PubMed  CAS  Google Scholar 

  • Cerni, C., Tatra, G. and Bohn, H. (1977) Immunosuppression by human placental lactogen (HPL) and the pregnancy-specific beta-1 glycoprotein (SP-1). Archiv fur Gynakologie, 223, 1–7.

    Article  PubMed  CAS  Google Scholar 

  • Chakravarti, A., Phillips, J.A., Mellits, K.H., Buetow, K.H. and Seeburg, P.H. (1984) Patterns of polymorphism and linkage disequilibrium suggest independent origins of the human growth hormone gene cluster. Proceedings of the National Academy of Sciences of the USA, 81, 6085–6089.

    Article  PubMed  CAS  Google Scholar 

  • Chambers, W.L. (1949) Adrenal cortical carcinoma in males with excess gonadotropin in urine. Journal of Clinical Endocrinology, 9, 451–456.

    Article  CAS  Google Scholar 

  • Chan, S.Y.W., Chan, P.H., Tang, L.C.H., Ho, P.C. and Tang, G.W.K. (1986) Seminal plasma β-human chorionic gonadotropin (β-hCG): relationships with seminal characteristics and spermatozoal fertilizing capacity. Andrologia, 18, 50–55.

    Article  PubMed  CAS  Google Scholar 

  • Chang, C.C, Tsong, Y.Y. and Nash, H.A. (1985) Formulation of a potent anti pregnancy vaccine based on the β-subunit of human chorionic gonadotropin (β-hCG). III. Evaluation of various vehicles and adjuvants. Journal of Reproductive Immunology, 7, 163–169.

    Article  PubMed  CAS  Google Scholar 

  • Chang, D., Sairam, M.R. and Li, C.H. (1973) The primary structure of ovine interstitial cell-stimulating hormone. III. Disulfide bridges of the α-subunit. Archives of Biochemistry and Biophysics, 159, 678–682.

    Article  Google Scholar 

  • Chang, D., Sairam, M.R and Li, C.H. (1975) The primary structure of ovine interstitial cell-stimulating hormone. IV. Disulfide bridges of the β-subunit. International Journal of Peptide and Protein Research, 7, 487.

    Article  Google Scholar 

  • Chard, T. (1979) Human placental lactogen, in Hormones in Blood, (eds C.H. Gray and V.H.T. James), Academic Press, London, pp. 333–409.

    Google Scholar 

  • Chard, T. (1981) Synthesis of placental lactogen by human placentae, in Hormones in Normal and Abnormal Human Tissues, (eds K. Fotherby and S.B. Pal), Walter de Gruyter, Berlin, p. 4098.

    Google Scholar 

  • Chard, T. (1982) An Introduction to Radioimmuno-assay and Related Techniques, Elsevier Biomedical Press, Amsterdam.

    Google Scholar 

  • Chard, T. (1983) Human placental lactogen, in Hormones in Blood, (eds C.H. Gray and V.H.T. James), Academic Press, London, pp. 137–145.

    Google Scholar 

  • Chard, T. (1984) Placental function tests, in Antenatal and Neonatal Screening, (ed. N.J. Wald), Oxford University Press, Oxford, pp. 510–522.

    Google Scholar 

  • Chard, T. (1987) What is happening to placental function tests? Annals of Clinical Biochemistry, 24, 43–439.

    Google Scholar 

  • Chard, T. (1991) Frequency of implantation and early pregnancy loss in natural cycles. Bailliere’s Clinical obstetrics and Gynaecology, 5, 179–189.

    Article  PubMed  CAS  Google Scholar 

  • Chard, T. (1992) Placental hormones and metabolism, in Medicine of the Fetus and Mother, (eds L.A. Reece, J.C. Hobbins, MJ. Mahoney and R.H. Petrie), J.B. Lippincott Philadelphia, pp. 88–96.

    Google Scholar 

  • Chard, T. and Grudzinskas, J.G. (1992) Placental proteins and steroids and the immune relationship between mother and fetus, in Immunological Obstetrics, (eds C.B. Coulam, W. Page Faulk and J.A. McIntyre), W.W. Norton, New York, pp. 282–289.

    Google Scholar 

  • Chard, T. and Klopper, A. (1982) Placental Function Tests, Springer-Verlag, Berlin.

    Google Scholar 

  • Chard, T. and Sykes, A. (1979) Fluoroimmuno-assay for human choriomammotropin. Clinical Chemistry, 25, 973–975.

    PubMed  CAS  Google Scholar 

  • Chard, T., Sturdee, J., Cockrill, B. and Obiekwe, B.C. (1985) Which is the best placental function test? A comparison of placental lactogen and unconjugated oestriol in the prediction of intra-uterine growth retardation. European Journal of Obstetrics, Gynaecology and Reproductive Biology, 19, 13–17.

    Article  CAS  Google Scholar 

  • Chard, T., Craig, P.H., Menabawey, M. and Lee, C. (1986) Alpha interferon in human pregnancy. British Journal of Obstetrics and Gynaecology, 93, 1145–1149.

    Article  PubMed  CAS  Google Scholar 

  • Chartier, M.M., Roger, M., Barratt, J. and Michelson, B. (1979) Measurement of plasma hCG and beta-hCG in the late luteal phase: evidence of the occurrence of spontaneous menstrual abortions in infertile women. Fertility and Sterility, 31, 134–137.

    PubMed  CAS  Google Scholar 

  • Chen, F. and Puett, D. (1992) A single amino acid residue replacement in the β-subunit of human chorionic gonadotrophin results in the loss of biological activity. Journal of Molecular Endocrinology, 8, 87–89.

    Article  PubMed  CAS  Google Scholar 

  • Chen, H.C., Hodgen, G.D., Matsuwra, S., Lin, L.J., Gross, L., Reichet, L.E., Birken, S., Canfield, R.E. and Ross, G.T. (1976) Evidence for a gonadotropin from non-pregnant subjects that has physical, immunological and biological similarities to human chorionic gonadotropin. Proceedings of the National Academy of Sciences of the USA, 73, 2885–2889.

    Article  PubMed  CAS  Google Scholar 

  • Chen, H.C., Matsuura, S., Hodgen, G.D. and Ross, G.T. (1978) A human chorionic gonadotropin-like substance from human lutei-nizing hormone, in Novel Aspects of Reproductive Physiology, (eds G.H. Spitman and J.W. Wilks), Spectrum Publishers, New York, pp. 289–308.

    Google Scholar 

  • Chen, H.C., Shimohigashi, Y., Dufau, M.C. and Catt, K.J. (1982) Characterization and biological properties of chemically deglycosylated human chorionic gonadotropins. Journal of Biological Chemistry, 257, 14446–14452.

    PubMed  CAS  Google Scholar 

  • Chiang, M.H. and Nicoll, C.S. (1992) Human placental lactogen inhibits growth without changing serum levels of IGF-1 in rats: an apparent specific action of the hormone. Acta Endocrino-logica, 127, 146–151.

    CAS  Google Scholar 

  • Chin, W.W. (1988) Hormonal regulation of thyro-tropin and gonadotropin gene expression. Clinical Research, 36, 484–493.

    PubMed  CAS  Google Scholar 

  • Chin, W.W. and Gharib, S.D. (1986) Organization and expression of gonadotropin genes. Advances in Medicine and Biology, 205, 345–365.

    Google Scholar 

  • Chou, J.Y., Hugumin, P.E. and Mano, T. (1983) Control of placental protein production by reti-noic acid in cultured placental cells. In vitro, 19, 571–575.

    Article  PubMed  CAS  Google Scholar 

  • Christakos, S. and Bahl, O.P. (1979) Pregnant mare serum gonadotropin: purification and physico-chemical, biological and immunological characteristics. Journal of Biological Chemistry, 254, 4253–4261.

    PubMed  CAS  Google Scholar 

  • Christensen, A., Frayshov, O. and Fylling, P. (1974) Hormone and enzyme assays in pregnancies. Acta Endocrinologica, 77, 344–355.

    PubMed  CAS  Google Scholar 

  • Cohen, H., Grumbach, M.M. and Kaplan, S.L. (1964) Preparation of human chorionic ‘growth hormone-prolactin’. Proceedings of the Society for Experimental Biology and Medicine, 117, 438–441.

    PubMed  CAS  Google Scholar 

  • Cohen, M., Haour, F., Dumont, M. and Bertrand, J. (1973) Prognostic value of human chorionic somatomammotropin plasma levels in diabetic patients. American Journal of Obstetrics and Gynecology, 115, 202–210.

    PubMed  CAS  Google Scholar 

  • Cole, H.H. and Hart, G.H. (1930) The potency of blood serum of mares in progressive stages of pregnancy in effecting the sexual maturation of the immature rat. American Journal of Physiology, 93, 57–68.

    CAS  Google Scholar 

  • Cole, L.A. (1987) Distribution of O-linked sugar units on hCG and its free α-subunit. Molecular and Cellular Biology, 50, 45–57.

    CAS  Google Scholar 

  • Cole, L.A. and Birken, S. (1988) Origin and occurrence of human chorionic gonadotropin β-subunit core fragment. Molecular Endocrinology, 2, 825–830.

    Article  PubMed  CAS  Google Scholar 

  • Cole, L.A. and Nam, J.H. (1989) Urinary gonadotropin fragments (UGF) measurements in the diagnosis and management of ovarian cancer. Yale Journal of Biology and Medicine, 62, 367–378.

    PubMed  CAS  Google Scholar 

  • Cole, L.A., Kroll, T.G., Ruddon, R.W. and Hussa, R.O. (1984a) Differential occurrence of free beta and free alpha subunits of human chorionic gonadotrophin (hCG) in pregnancy sera. Journal of Clinical Endocrinology and Metabolism, 58, 1200–1202.

    Article  PubMed  CAS  Google Scholar 

  • Cole, L.A., Perini, F., Birken, S. and Ruddon, R.W. (1984b) An oligosaccharide of the O-linked type distinguishes the free from the combined form of hCG alpha subunit. Biochemical and Biophysical Research Communications, 122, 1260–1267.

    Article  PubMed  CAS  Google Scholar 

  • Cole, L.A., Wang, Y., Elliot, M., Latiff, M., Chambers, J.T., Chambers, S.K. and Schwartz, P.E. (1988) Urinary human chorionic gonadotrophin free β-subunit and β-core fragment a new marker of gynaecological cancers. Cancer Research, 48, 1356–1360.

    PubMed  CAS  Google Scholar 

  • Cole, L.A., Kardana, A. and Birken, S. (1990) The isomers, subunits and fragments of hCG. Serono Symposium, 65, 59–79.

    Google Scholar 

  • Cole, L.A., Kardana, A., Park, S.Y. and Braunstein, G.D. (1993) The deactivation of hCG by nicking and dissociation. Journal of Clinical Endocrinology and Metabolism, 76, 704–710.

    Article  PubMed  CAS  Google Scholar 

  • Collet-Cassart, D., Limet, J.N., Van Krieken, L. and De Hertogh, R. (1989) Turbidimetric latex immunoassay of placental lactogen on microtiter plates. Clinical Chemistry, 35, 141–143.

    PubMed  CAS  Google Scholar 

  • Colosi, P., Thordarson, G., Hellmiss, R., Singh, K., Forsyth, I.A., Gluckman, P. and Wood, W.I. (1989) Cloning and expression of ovine placental lactogen. Molecular Endocrinology, 3, 1462–1469.

    Article  PubMed  CAS  Google Scholar 

  • Combarnous, Y. (1981) Physico-chemical properties of pregnancy mare serum gonadotropin. Biochimica et Biophysica Acta, 667, 267–276.

    Article  PubMed  CAS  Google Scholar 

  • Contractor, S.F. and Davies, H. (1973) Effect of human chorionic somatomammotropin and human chorionic gonadotrophin on phyto-haemagglutinin-induced lymphocyte transformation. Nature New Biology, 243, 284–285.

    Article  PubMed  CAS  Google Scholar 

  • Corless, C.L., Matzuk, M.M., Ramabhadran, T.V., Krichevsky, A. and Boime, I. (1987) Gonadotropin beta subunits determine the rate of assembly and the oligosaccharide processing of hormone dimer in transfected cells. Journal of Cell Biology, 104, 1173–1181.

    Article  PubMed  CAS  Google Scholar 

  • Cornell, J.S. and Pierce, J.G. (1974) Studies on the disulphide bonds of glycoprotein hormones, locations in the alpha chain based on partial reductions and formation of the 14-C-labelled S-carboxymethyl derivatives. Journal of Biological Chemistry, 249, 4166–4174.

    PubMed  CAS  Google Scholar 

  • Cox, G.S., Weintraub, B.D., Rosen, S.W. and Maxwell, E.S. (1976) Properties of biologically active messenger RNA from human placenta. Journal of Biological Chemistry, 251, 1723–1728.

    PubMed  CAS  Google Scholar 

  • Cramer, D.W., Beck, B. and Makowski, E.L. (1971) Correlation of gestational age with maternal human chorionic somatomammotropin and maternal and fetal growth hormone plasma concentrations during labor. American Journal of Obstetrics and Gynecology, 109, 649–655.

    PubMed  CAS  Google Scholar 

  • Crosignani, P.G., Nencioni, T. and Brambati, B. (1972) Concentration of chorionic gonadotrophin and chorionic somatomammotrophin in maternal serum, amniotic fluid and cord blood serum at term. Journal of Obstetrics and Gynaecology of the British Commonwealth, 79, 122–126.

    Article  PubMed  CAS  Google Scholar 

  • Csapo, A.I. and Pulkkinen, M. (1978) Indispensability of the human corpus luteum in the maintenance of early pregnancy: luteectomy evidence. Obstetrical and Gynaecological Survey, 33, 69–81.

    Article  CAS  Google Scholar 

  • Currie, W.B., Kelly, P.A., Friesen, H.G. and Thorburn, G.D. (1977) Caprine placental lactogen: levels of prolactin-like growth hormone-like activities in the circulation of pregnant goats determined by radioreceptor assays. Journal of Endocrinology, 73, 215–226.

    Article  PubMed  CAS  Google Scholar 

  • Currie, W.B., Card, C.E., Michel, F.J. and Ignotz, G. (1990) Purification and partial characterization, and development of a specific radioimmunoassay for goat placental lactogen. Journal of Reproduction and Fertility, 90, 25–36.

    Article  PubMed  CAS  Google Scholar 

  • D’Souza, S.W., Lieberman, B., Cadman, J. and Richards, B. (1988) Maternal serum placental lactogen and α-fetoprotein in smokers: relationship to placental weight and birth weight. Journal of Obstetrics and Gynaecology, 9, 94–99.

    Article  Google Scholar 

  • Daikoku, N.H., Tyson, J.E., Graf, C., Scott, R., Smith, B., Johnson, J.W.C. and King, T.M. (1979) The relative significance of human placental lactogen in the diagnosis of retarded fetal growth. American Journal of Obstetrics and Gynecology, 135, 516–520.

    PubMed  CAS  Google Scholar 

  • Damm, J.B.L., Boshol, H., Hard, K., Kamerling, J.P., Van Dedem, G.W.K. and Vliegenthart, J.F.G. (1988) The β-subunit of human chorionic gonadotropin contains N-glycosidic trisialo tri and tri-antennary carbohydrate chains. Glyconjugate Journal, 5, 221–233.

    Article  CAS  Google Scholar 

  • Das, S., Mukherjee, K., Battacharya, S. and Chowdhury, J.R. (1983) Ectopic production of placental hormones (human chorionic gonadotropin and human placental lactogen) in carcinoma of the uterine cervix. Cancer, 51, 1854–1857.

    Article  PubMed  CAS  Google Scholar 

  • Day, J.R., Ogren, L. and Talamantes, F. (1986) The effect of hypophysectomy on serum placental lactogen and progesterone in the mouse. Endocrinology, 119, 259–269.

    Article  Google Scholar 

  • Deb, S., Faria, T.N., Roby, K.F., Larsen, D., Kwok, S.C., Talamantes, F. and Soares, M.J. (1991) Identification and characterization of a new member of the prolactin family, placental lactogen-I variant. Journal of Biological Chemistry, 266, 1605–1610.

    PubMed  CAS  Google Scholar 

  • Desoye, G., Schweditsch, M.O., Pfeiffer, K.P., Sechner, R. and Kostner, G.M. (1987) Correlation of hormones with lipid and lipopro-tein levels during normal pregnancy and post-partum. Journal of Clinical Endocrinology and Metabolism, 64, 704–712.

    Article  PubMed  CAS  Google Scholar 

  • Dias, J.A. (1992) Recent progress in structure-function and molecular analyses of the pituitary/ placental glycoprotein hormone receptors (abstract). Biochimica et Biophysica Acta, 1135, 278–294.

    Article  Google Scholar 

  • Diczfalusy, E., Hogberg, B. and Westman, A. (1950) Use of the ventral prostate in the assay of human chorionic gonadotropin. Acta Endocrino-logica, 5, 226–234.

    CAS  Google Scholar 

  • Dittmar, D., Monji, N., Cid, A., Malkus, H. and Castro, A. (1979) Enzyme-linked immunosorbent choriomammotropin assay. Clinical Chemistry, 25, 227–229.

    PubMed  CAS  Google Scholar 

  • Duckworth, M.L., Kirk, K.L. and Friesen, H.G. (1986) Isolation and identification of a cDNA clone of rat placental lactogen. II. Journal of Biological Chemistry, 261, 10871–10878.

    PubMed  CAS  Google Scholar 

  • Duello, T.M., Byatt, J.C. and Bremel, R.D. (1986) Immunohistochemical localization of placental lactogen in binucleate cells of bovine placen-tomes. Endocrinology, 119, 1351–1355.

    Article  PubMed  CAS  Google Scholar 

  • Dufau, M.L., Mendelson, C. and Catt, K.J. (1974) A highly sensitive bioassay for luteinizing hormone and chorionic gonadotropin: testosterone production by dispersed Leydig cells. Journal of Clinical Endocrinology and Metabolism, 39, 610–613.

    Article  PubMed  CAS  Google Scholar 

  • Eakle, K.A., Arima, Y., Swanson, P., Grimek, H. and Bremel, R.D. (1982) A 32, 000 molecular weight protein from bovine placenta with placental lactogen-like activity in radioreceptor assays. Endocrinology, 110, 1758–1765.

    Article  PubMed  CAS  Google Scholar 

  • Edmonds, D.K., Miller, K.S., Miller, J.R., Williamson, E. and Wood, P.J. (1982) Early embryonic mortality in women. Fertility and Sterility, 39, 447–453.

    Google Scholar 

  • Edwards, R.G. and Steptoe, P.C. (1983) Current status of in vitro fertilisation and implantation of human embryos. Lancet, 2, 112651269.

    Google Scholar 

  • Edwards, R.P., Diver, M.J., Davis, J.C. and Hipkin, L. (1976) Plasma oestriol and human placental lactogen measurements in patients with high risk pregnancies. British Journal of Obstetrics and Gynaecology, 83, 1229237.

    Google Scholar 

  • Ehrlich, P.H., Moyle, W.R., Moustafa, Z.A. and Canfield, R.E. (1982) Mixing two monoclonal antibodies yields enhanced affinity for antigen. Journal of Immunology, 128, 1709–2713.

    Google Scholar 

  • El-Deiry, S., Kaetzel, D., Kennedy, G., Nilson, J. and Puett, D. (1989) Site-directed mutagenesis of the human chorionic gonadotropin β-subunit: bioactivity of a heterologous hormone, bovine α-subunit 1(122145)B. Molecular Endocrinology, 3, 115231528.

    Article  Google Scholar 

  • El-Tomi, A.E.F., Crystle, C.D. and Stevens, V.C. (1971) Effects of immunization with human placental lactogen on reproduction in female rabbits. American Journal of Obstetrics and Gynecology, 109, 17480.

    Google Scholar 

  • Elkind-Hirsch, K.E., Reynolds, M.V. and Goldzieher, J.W. (1989) Comparison of immuno-reactive gonadotrophin releasing hormone on human chorionic gonadotrophin in term placentas from normal women and those with insulin-dependent and gestational diabetes. American Journal of Obstetrics and Gynecology, 160, 17–78.

    Google Scholar 

  • Endo, Y., Yamashita, K., Tachibana, Y., Tojo, S. and Kobata, A. (1979) Structures of the asparagine-linked sugar chains of human chorionic gonadotropin. Journal of Biochemistry (Tokyo), 85, 669–679.

    CAS  Google Scholar 

  • England, P., Lorrimer, D., Fergusson, J.C., Moffatt, A.M. and Kelly, A.M. (1974) Human placental lactogen: the watchdog of fetal distress. Lancet, 1, 5–6.

    Article  PubMed  CAS  Google Scholar 

  • Falconer, J., Owens, J.A., Allotta, E. and Robinson, J.S. (1985) Effect of restriction of placental growth on the concentrations of insulin, glucose and placental lactogen in the plasma of sheep. Journal of Endocrinology, 106, 7–11.

    Article  PubMed  CAS  Google Scholar 

  • Fenstermaker, R.A., Milstead, A., Virgin, J.B., Miller, W.L. and Nilson, J.H. (1989) The tran-scriptional response of the human chorionic gonadotropin β-subunit gene to cAMP is cyclo-heximide sensitive and is mediated by cis-acting sequences different from that found in the α-subunit gene. Molecular Endocrinology, 3, 11070–1076.

    Article  Google Scholar 

  • Fiddes, J.C. and Goodman, H.M. (1979) Isolation, cloning and sequence analysis of the cDNA for the α-subunit of human chorionic gonado-trophin. Nature, 281, 351–356.

    Article  PubMed  CAS  Google Scholar 

  • Fiddes, J.C. and Goodman, H.M. (1980) The cDNA for the β-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3′-untranslated region. Nature, 386, 648–687.

    Google Scholar 

  • Fiddes, J.C. and Talmadge, K. (1984) Structure, expression and evolution of the genes for the human glycoprotein hormones. Recent Progress in Hormone Research, 40, 43–53.

    PubMed  CAS  Google Scholar 

  • Fielder, P.J. and Talamantes, F. (1987) The lipoly-tic effects of mouse placental lactogen II, mouse prolactin, and mouse growth hormone on adipose tissue from virgin and pregnant mice. Endocrinology, 121, 493–497.

    Article  PubMed  CAS  Google Scholar 

  • Fielder, P.J., Robleto, D.O., Ogren, L. and Talamantes, F. (1989) Ethanol consumption during pregnancy in mice: effects on hormone concentrations. American Journal of Physiology, 257, E561–E566.

    PubMed  CAS  Google Scholar 

  • Filstein, M.R., Culliman, J.A. and Strauss, J.F. (1983) Aberrant results in serum β-human chorionic gonadotropin assays. An infrequent but vexing problem. Fertility and Sterility, 39, 714–716.

    PubMed  CAS  Google Scholar 

  • Fishel, S.B., Edwards, R.G. and Evans, C.J. (1984) Human chorionic gonadotropin secreted by pre-implantation embryos cultured in vitro. Science, 233, 816–818.

    Article  Google Scholar 

  • Flint, A.P.F., Lamming, E.G. and Stewart, H.J. (1988) A role for interferons in the maternal recognition of pregnancy. Molecular and Cellular Endocrinology, 58, 109–111.

    Article  PubMed  CAS  Google Scholar 

  • Florini, J.R., Tonelli, G., Breuer, C.B., Coppola, J., Ringler, I. and Bell, P.H. (1966) Characterization and biological effects of purified placental protein (human). Endocrinology, 79, 692–708.

    Article  PubMed  CAS  Google Scholar 

  • Forsyth, I.A. and Bloomfield, G. (1986) Variation among species in the endocrine control of mammary growth and function: the roles of prolactin and growth hormone, and placental lactogen. Journal of Dairy Science, 69, 886–903.

    Article  PubMed  CAS  Google Scholar 

  • Fowlkes, J. and Freemark, M. (1992) Binding of placental lactogen and growth hormone to fetal sheep fibroblasts. Pediatrie Research, 32, 200–203.

    Article  CAS  Google Scholar 

  • Frankenne, F., Rentier-Delrue, F., Scippo, M.L., Martial, J. and Hennen, G. (1987) Expression of the growth hormone variant gene in human placenta. Journal of Clinical Endocrinology and Metabolism, 64, 635–637.

    Article  PubMed  CAS  Google Scholar 

  • Freemark, M. and Handwerger, S. (1986) The gly-cogenic effects of placental lactogen and growth hormone in ovine fetal liver are mediated through binding to specific fetal oPL receptors. Endocrinology, 118, 613–618.

    Article  PubMed  CAS  Google Scholar 

  • Freemark, M., Comer, M., Mularoni, T., D’Ercole, A.J., Grandis, A. and Kodak, L. (1989) Nutritional regulation of the placental lactogen receptor in fetal liver: implications for fetal metabolism and growth. Endocrinology, 125, 1504–1512.

    Article  PubMed  CAS  Google Scholar 

  • Freemark, M., Keen, A., Fowlkes, J., Mularoni, T., Comer, M., Grandis, A. and Kodak, L. (1992) The placental lactogen receptor in maternal and fetal sheep liver: regulation by glucose and role in the pathogenesis of fasting during pregnancy. Endocrinology, 130, 1063–1070.

    Article  PubMed  CAS  Google Scholar 

  • Friedman, M.H. and Lapham, M.E. (1931) A simple rapid procedure for the laboratory diagnosis of early pregnancies. American Journal of Obstetrics and Gynecology, 21, 405–410.

    Google Scholar 

  • Friesen, H. (1965) Purification of placental factor with immunological and chemical similarity to human growth hormone. Endocrinology, 76, 369–381.

    Article  PubMed  CAS  Google Scholar 

  • Fujiki, Y., Rathnam, P. and Saxena, B.B. (1980) Studies on the disulfide bonds in human pituitary follicle-stimulating hormone. Biochimica et Biophysica Acta, 624, 428–485.

    Article  PubMed  CAS  Google Scholar 

  • Gaede, P., Trolle, D. and Pedersen, H. (1978) Extremely low placental lactogen hormone values in an otherwise uneventful pregnancy. Acta Obstetrica et Gynecologica Scandinavica, 57, 203.

    Article  CAS  Google Scholar 

  • Garoff, L. and Seppala, M. (1973) Alpha feto-protein and human placental lactogen levels in maternal serum in multiple pregnancies. Journal of Obstetrics and Gynaecology of the British Commonwealth, 80, 695–700.

    Article  PubMed  CAS  Google Scholar 

  • Gartside, M.W. and Tindall, V.R. (1975) The prognostic value of human placental lactogen (HPL) levels in threatened abortion. British Journal of Obstetrics and Gynaecology, 82, 303–309.

    Article  PubMed  CAS  Google Scholar 

  • Gaspard, V.J., Reuter, A.M., Deville, J.L., Vrindts-Gevaert, Y., Bagshawe, K.D. and Franchimont, P. (1980) Serum concentrations of human chorionic gonadotrophin and its α and β subunits. 2. Trophoblastic tumours. Clinical Endocrinology, 13, 319–329.

    Article  PubMed  CAS  Google Scholar 

  • Gau, G. and Cadle, G. (1977) Placental lactogen levels associated with gross fetal abnormality. Obstetrics and Gynecology, 49, 243–244.

    PubMed  CAS  Google Scholar 

  • Gau, G. and Chard, T. (1975) The distribution of placental lactogen in the human term placenta. British Journal of Obstetrics and Gynaecology, 82, 790–793.

    Article  PubMed  CAS  Google Scholar 

  • Genazzani, A.R., Aubert, M.L., Casoli, M., Fioretti, P. and Felber, J.P. (1969) Use of human-placental-lactogen radioimmunoassay to predict outcome in cases of threatened abortion. Lancet, 2, 1385–1387.

    Article  PubMed  CAS  Google Scholar 

  • George, D.L., Phillips, J.A., Francke, U. and Seeburg, P.H. (1981) The genes for growth hormone and chorionic somatomammotropin are on the long arm of chromosome 17 in region q21-qter. Human Genetics, 57, 138–141.

    Article  PubMed  CAS  Google Scholar 

  • Gerhard, I. and Runnebaum, B. (1984) Predictive value of hormone determinations in the first half of pregnancy. European Journal of Gynecology and Reproductive Biology, 17, 1–7.

    Article  CAS  Google Scholar 

  • Gibbons, J.M., Mitnick, M. and Chieffo, V. (1975) in vitro biosynthesis of TSH-and LH-releasing factors by the human placenta. American Journal of Obstetrics and Gynecology, 121, 127–133.

    PubMed  CAS  Google Scholar 

  • Gillard, M., Letchworth, A.T. and Chard, T. (1973) Human placental lactogen levels in relation to the initiation and maintenance of labour. Obstetrics and Gynecology, 41, 774–776.

    PubMed  CAS  Google Scholar 

  • Goldstein, D.P. (1971) Serum placental lactogen activity in patients with molar pregnancy and trophoblastic tumors — a reliable index of malignancy. American Journal of Obstetrics and Gynecology, 110, 583–587.

    PubMed  CAS  Google Scholar 

  • Gordon, D.F., Wood, W.M. and Ridgeway, E.C. (1988) Organization and nucleotide sequence of the mouse α-subunit of the pituitary hormones. DNA, 7, 679–690.

    Article  PubMed  CAS  Google Scholar 

  • Gordon, Y.B and Chard, T. (1979) The specific proteins of the human placenta: some new hypotheses, in Placental Proteins, (eds A. Klopper and T. Chard), Springer-Verlag, Berlin, pp. 1–21.

    Chapter  Google Scholar 

  • Got, R. and Bourrillon, R. (1960) Nouvelles donnée physiques sur 1e gonadotrophine choriale humaine. Biochimica et Biophysica Acta, 39, 241–247.

    Article  PubMed  CAS  Google Scholar 

  • Goverde, B.C., Veenkamp, F.J.N. and Homan, J.D.H. (1968) Studies on human chorionic gonadotrophin. II. Chemical composition and its relation to biological activity. Acta Endocrinologica, 59, 110–119.

    Google Scholar 

  • Graham, M.Y., Otani, T., Boime, I., Olson, M.V., Carle, G.F. and Chaplin, D.D. (1987) Cosmid mapping of the human chorionic gonadotropin β-subunit genes by field-inversion gel electro-phoresis. Nucleic Acids Research, 15, 4437–4448.

    Article  PubMed  CAS  Google Scholar 

  • Granat, M., Sharf, M., Diengott, D., Spindel, A., Kahana, L. and Elrad, H. (1977) Further investigation of the predictive value of human placental lactogen in high-risk pregnancies. American Journal of Obstetrics and Gynecology, 129, 647–654.

    PubMed  CAS  Google Scholar 

  • Grandis, A., Jorgensen, V., Kodak, L., Quarfordt, S. and Handwerger, S. (1989) High-density lipo-proteins (HDL) stimulate placental lactogen secretion in pregnant ewes: further evidence for a role of HDL in placental lactogen secretion during pregnancy. Journal of Endocrinology, 120, 423–427.

    Article  PubMed  CAS  Google Scholar 

  • Gray, C.J. (1988) Glycoprotein gonadotropins. Structure and synthesis. Acta Endocrinologica (Copenhagen), 288, 20–27.

    CAS  Google Scholar 

  • Green, E.D., Boime, I. and Baenziger, J.U. (1986) Differential processing of Asn-linked oligosac-charides on pituitary glycoprotein hormones: implications for biologic function. Molecular and Cellular Biology, 72, 81–100.

    CAS  Google Scholar 

  • Griffin, J. and Odell, W.D. (1987) Two monoclonal Ab-sandwich-type assays of human lutropin with no cross reaction with choriogonadotropin. Clinical Chemistry, 33, 1603–1607.

    PubMed  Google Scholar 

  • Grudzinskas, J.G., Menabawey, M., Wiley, B.A., Teisner, B. and Chard, T. (1979) The relation between the concentration of placental specific proteins in retroplacental and peripheral blood. British Journal of Obstetrics and Gynaecology, 86, 891–893.

    Article  PubMed  CAS  Google Scholar 

  • Grudzinskas, J.G., Gordon, Y.B., Wadsworth, J., Menabawey, M. and Chard, T. (1982) Is placental function testing worthwhile? Australia and New Zealand Journal of Obstetrics and Gynaecology, 21, 103–105.

    Article  Google Scholar 

  • Grumbach, M. and Kaplan, S.L. (1964) On the placental origin and purification of chorionic ‘growth hormone-prolactin’ and its immunoas-say in pregnancy. Annals of the New York Academy of Science, 27, 167–188.

    Article  CAS  Google Scholar 

  • Gusdon, J.P. (1972) An immunologic method of pregnancy destruction and contraception. American Journal of Obstetrics and Gynecology, 112, 472.

    PubMed  Google Scholar 

  • Gusdon, J.P. and Sain, L.E. (1981) Uterine and peripheral blood concentrations of human chorionic gonadotropin and human placental lacto-gen. American Journal of Obstetrics and Gynecology, 139, 705–707.

    PubMed  CAS  Google Scholar 

  • Gusdon, J.P., Leake, N.H. and Burt, R.L. (1970) Naturally occurring antibody to placental protein in human pregnancy. American Journal of Obstetrics and Gynecology, 108, 1056–1062.

    PubMed  Google Scholar 

  • Hammond, C.B., Clarke-Pearson, D.L. and Soper, J.T. (1984) Management of patients with ges-tational trophoblastic neoplasia: experience of the Southeastern Regional Center. Advances in Medicine and Biology, 176, 369–381.

    Article  CAS  Google Scholar 

  • Handwerger, S. and Sherwood, I.M. (1974) Methods of Hormone Radioimmunoassay, in (eds B.M. Jaffe and H.F. Behrman), Academic Press, New York, pp. 427–436.

    Google Scholar 

  • Handwerger, S., Crenshaw, C., Maurer, W.F., Barrett, J., Hurley, T.W., Golander, A. and Fellows, R.E. (1977) Studies on ovine placental lactogen secretion by homologous radioimmunoassay. Journal of Endocrinology, 72, 27–34.

    Article  PubMed  CAS  Google Scholar 

  • Handwerger, S., Grandis, A., Barry, S. and Crenshaw, M.C. (1981) Stimulation by ornithine of ovine placental lactogen secretion. Journal of Endocrinology, 88, 283–288.

    Article  PubMed  CAS  Google Scholar 

  • Handwerger, S., Wilson, S.P., Tyrey, L. and Conn, P.M. (1987) Biochemical evidence that human placental lactogen and human chorionic gonadotropin are not stored in cytoplasmic secretion granules. Biology of Reproduction, 37, 28–32.

    Article  PubMed  CAS  Google Scholar 

  • Hanson, F.W., Powell, J.E. and Stevens, V.C. (1971) Effects of hCG and human pituitary LH on steroid secretion and functional life of the human corpus luteum. Journal of Clinical Endocrinology, 32, 211–215.

    Article  CAS  Google Scholar 

  • Harper, M.E., Barrera-Saldana, H.A. and Saunders, G.F. (1982) Chromosomal localization of the human placental growth hormone gene cluster to 17Q22-24. American Journal of Obstetrics and Gynecology, 34, 227–234.

    CAS  Google Scholar 

  • Harris, D.C., Machin, K.J., Evin, G.M., Morgan, F.J. and Isaacs, N.W. (1989) Preliminary X-ray diffraction analysis of human chorionic gonadotropin. Journal of Biological Chemistry, 264, 6705–6706.

    PubMed  CAS  Google Scholar 

  • Hartree, A.S., Shownkeen, R.C., Stevens, V.C, Matsuura, S., Ohashi, M. and Chen, H.C. (1983) Studies of the human chorionic gonadotrophin-like substance of human pituitary glands and its significance. Journal of Endocrinology, 96, 115–126.

    Article  PubMed  CAS  Google Scholar 

  • Hayden, T.J., Buttle, H.L., Rees, P.L., Smith, S.V. and Forsyth, I.A. (1983) Simultaneous determinations of uterine blood flow and plasma concentrations of placental lactogen in late-pregnant goats. Journal of Reproduction and Fertility, 69, 503–510.

    Article  PubMed  CAS  Google Scholar 

  • Heal, A.V. and Gluck, J. (1980) Qualitative detection of human placental lactogen-binding substance by radioassay. American Journal of Obstetrics and Gynecology, 137, 975–977.

    PubMed  CAS  Google Scholar 

  • Healy, D., Herington, A.C. and O’Herlihy, C. (1985) Chronic polyhydramnios is a syndrome with a lactogen receptor defect in the chorion laeve. British Journal of Obstetrics and Gynaecology, 92, 461–467.

    Article  PubMed  CAS  Google Scholar 

  • Hearn, J.P. (1976) Immunization against pregnancy. Proceedings of the Royal Society of London, 195, 149–160.

    Article  PubMed  CAS  Google Scholar 

  • Hearn, J.P., Short, R.V. and Lunan, S.F. (1976) The effect of immunizing marmoset monkeys against the β-subunit of hCG, in Physiological Effects of Immunity against Reproductive Hormones, (eds R.G. Edwards and M.H. Johnson), Cambridge University Press, Cambridge, pp. 2298–242.

    Google Scholar 

  • van Hell, H., Matthijsen, R. and Homan, J.D.H. (1968) Studies on human chorionic gonado-trophin. I. Purification and some physicochemi-cal properties. Acta Endocrinologica, 59, 89–104.

    PubMed  CAS  Google Scholar 

  • Hennen, G., Frankenne, F., Closset, F.G., Pirens, G. and El Kyayat, N. (1985) A human placental GH: increasing levels during second half of pregnancy with pituitary GH suppression as revealed by monoclonal antibody radioimmuno-assays. International Journal of Fertility, 30, 27–33.

    PubMed  CAS  Google Scholar 

  • Hensleigh, P.A., Cheatum, S.G. and Spellacy, W.M. (1977) Oxytocinase and human placental lactogen for prediction of intrauterine growth retardation. American Journal of Obstetrics and Gynecology, 129, 675–678.

    PubMed  CAS  Google Scholar 

  • Hercz, P., Siklos, P., Ungar, L., Farquharson, R.G., Mohari, K. and Kocsar, L. (1987) Change of serum hPL level in maternal vein, umbilical cord vein and artery in mature and premature labour. European Journal of Obstetrics, Gynecology and Reproductive Biology, 24, 189–193.

    Article  CAS  Google Scholar 

  • Herington, A.C., Graham, J.Y. and Healy, D.L. (1980) The presence of lactogen receptors in human chorion laeve. Journal of Clinical Endocrinology and Metabolism, 51, 1466–1468.

    Article  PubMed  CAS  Google Scholar 

  • Hershman, J.M., Kojima, A. and Friesen, H.G. (1973) Effect of thyrotropin-releasing hormone on human pituitary thyrotropin, prolactin, placental lactogen and chorionic thyrotropin. Journal of Clinical Endocrinology and Metabolism, 36, 497–501.

    Article  PubMed  CAS  Google Scholar 

  • Hertogh, R.D., Thomas, K., Hoet, JJ. and Vanderheyder, I. (1976) Plasma concentrations of unconjugated estrone, estradiol-17 beta and estriol, and HCG throughout pregnancy in diabetics and gestational diabetes. Diabetologica, 12, 455–461.

    Article  Google Scholar 

  • Hertz, J.B. and Schultz-Larsen, P. (1983) Human placental lactogen, pregnancy specific beta-1-glycoprotein and alpha-fetoprotein in serum in threatened abortion. International Journal of Gynecology and Obstetrics, 21, 111–117.

    Article  PubMed  CAS  Google Scholar 

  • Heyderman, E., Chapman, D.V., Richardson, T.C., Calvert, I. and Rosen, S.W. (1985) Human chorionic gonadotropin and human placental lactogen in extragonadal tumors. Cancer, 56, 2674–2682.

    Article  PubMed  CAS  Google Scholar 

  • Higashi, K. (1962) Studies on the prolactin-like substance in human placenta. IV. Endocrinologica Japonica, 9, 1–11.

    Article  CAS  Google Scholar 

  • Hill, D.J., Crace, C.J. and Milner, R.D.G. (1985) Incorporation of 3-H thymidine by isolated fetal myoblasts and fibroblasts in response to human placental lactogen (hPL): possible mediation of hPL action by release of immunoreactive SM-C. Journal of Cell Physiology, 125, 337–344.

    Article  CAS  Google Scholar 

  • Hill, D.J., Freemark, M., Strain, A.J., Hand-werger, S. and Milner, R.D.G. (1988) Placental lactogen and growth hormone receptors in human fetal tissues: relationship to fetal plasma hPL concentrations and fetal growth. Journal of Clinical Endocrinology and Metabolism, 66, 1283–1290.

    Article  PubMed  CAS  Google Scholar 

  • Hirt, H., Kimelman, J., Birnbaum, M.J., Chen, E.Y., Seeburg, P.H., Eberhardt, N.L. and Barta, A. (1987) The human growth hormone locus: structure, evolution and allelic variations. DNA, 6, 59–70.

    Article  PubMed  CAS  Google Scholar 

  • Hobson, B. and Wide, L. (1972) A comparison between chorionic gonadotropins extracted from human, rhesus monkey and marmoset placentae. Journal of Endocrinology, 55, 363–368.

    Article  PubMed  CAS  Google Scholar 

  • Hodgen, G.D., Chen, H.C., Dufau, M.L., Klein, T.A. and Mishell, D.R. (1978) Transitory hCG-like activity in the urine of some IUD users. Journal of Clinical Endocrinology, 46, 698–702.

    Article  CAS  Google Scholar 

  • Hogarth, PJ. (1982) Immunological Aspects of Mammalian Reproduction, Blackie, Glasgow.

    Book  Google Scholar 

  • Hoshina, M., Boothby, M. and Boime, I. (1982) Cytological localization of chorionic gonadotropin alpha and placental lactogen mRNAs during development of the human placenta. Journal of Cell Biology, 93, 190.

    Article  PubMed  CAS  Google Scholar 

  • Houghton, D.J., Newnham, J.P., Lo, K., Rice, A. and Chard, T. (1982) Circadian variation of circulating levels of four placental proteins. British Journal of Obstetrics and Gynaecology, 89, 831–635.

    Article  PubMed  CAS  Google Scholar 

  • Houghton, D.J., Shackleton, P., Obiekwe, B.C. and Chard, T. (1984) Relationship of maternal and fetal levels of human placental lactogen to weight and sex of the fetus. Placenta, 5, 455–458.

    Article  PubMed  CAS  Google Scholar 

  • Huang, S.C., Chen, R.J., Hsieh, C.Y., Wei, P.Y. and Ouyang, P.C. (1984) The secretion of human chorionic gonadotrophin-like substance in women employing contraceptive measures. Journal of Clinical Endocrinology and Metabolism, 58, 646–653.

    Article  PubMed  CAS  Google Scholar 

  • Hubert, C., Moudon, F. and Cedard, L. (1981) Distribution, quantification and biological activity of messenger RNA coding for human chorionic somatomammotropin during normal pregnancy. Molecular and Cellular Endocrinology, 24, 339–355.

    Article  PubMed  CAS  Google Scholar 

  • Hubert, C., Descombey, D., Mondon, F. and Daffos, F. (1983) Plasma human chorionic somatomammotropin deficiency in a normal pregnancy is the consequence of low concentration of messenger RNA, coding for human chorionic somatomammotropin. American Journal of Obstetrics and Gynecology, 147, 676–678.

    PubMed  CAS  Google Scholar 

  • Hunt, R.E., Moffatt, K. and Goldes, D.W. (1981) Purification and crystallization of the polypep-tide hormone human chorionic somatomammotropin. Journal of Biological Chemistry, 256, 7042–7045.

    PubMed  CAS  Google Scholar 

  • Huot, R.I., Foidart, J.M., Nardone, R.M. and Stromberg, K. (1981) Differential modulation of human chorionic gonadotropin secretion by epidermal growth factor in normal and malignant placental cultures. Journal of Clinical Endocrinology, 53, 1059–1063.

    Article  CAS  Google Scholar 

  • Hussa, R.O. (1987) The Clinical Marker HCG, Praeger Publishers, Westport, USA.

    Google Scholar 

  • Hussa, R.O., Rinke, M. and Schweitzer, P.G. (1985) Discordant human chorionic gonadotropin results: causes and solutions. Obstetrics and Gynecology, 65, 211–219.

    PubMed  CAS  Google Scholar 

  • Huyler, S.E., Butler, W.R., Grandis, A., Mann, C., Figueroa, J.P., Nathanielsz, P.W., Mitchell, M. and Handwerger, S. (1985) Stimulation of ovine placental lactogen secretion by arachi-donic acid. Endocrinology, 106, 43–47.

    Article  CAS  Google Scholar 

  • Ikonicoff de, L.K. and Cedard, L. (1973) Localization of human chorionic gonadotropin and somatomammotropic hormones by the per-oxidase immunohistoenzymologic method in villi and amniotic epithelium of human placentas (from six weeks to term). American Journal of Obstetrics and Gynecology, 116, 1124–1132.

    Google Scholar 

  • Iles, R.K. and Chard, T. (1989a) Enhancement of ectopic beta-human chorionic gonadotrophin expression by interferon. Journal of Endocrinology, 123, 501–507.

    Article  PubMed  CAS  Google Scholar 

  • Iles, R.K. and Chard, T. (1989b) Immunochemical analysis of the human chorionic gonadotrophin-like material secreted by ‘normal’ and neoplastic urothelial cells. Journal of Molecular Endocrinology, 2, 107–112.

    Article  PubMed  CAS  Google Scholar 

  • Iles, R.K. and Chard, T. (1991) Human chorionic gonadotrophin expression by bladder cancers: biology and clinical potential. Journal of Urology, 145, 453–458.

    PubMed  CAS  Google Scholar 

  • Iles, R.K., Czepulkowski, B.H., Young, B.D. and Chard, T. (1989) Amplification or rearrangement of the beta-human chorionic gonadotrophin (beta-hCG)-human LH-gene cluster is not responsible for the ectopic production of beta-hCG by bladder tumour cells. Journal of Molecular Endocrinology, 2, 113–117.

    Article  PubMed  CAS  Google Scholar 

  • Iles, R.K., Lee, C.L., Howes, I., Davies, S., Edwards, R. and Chard, T. (1992) Immunoreactive beta-core-like material in normal postmenopausal urine: human chorionic gonadotrophin or LH origin? Evidence for the existence of LH core. Journal of Endocrinology, 133, 459–466.

    Article  PubMed  CAS  Google Scholar 

  • Iles, R.K., Purkis, P.E., Whitehead, P.C., Oliver, R.T.D., Leigh, I. and Chard, T. (1990) Expression of beta human chorionic gonadotrophin by non-trophoblastic non-endocrine ‘normal’ and malignant epithelial cells. British Journal of Cancer, 61, 663–666.

    Article  PubMed  CAS  Google Scholar 

  • Imakawa, K., Anthony, R.V., Kazemi, M., Marotti, K.R., Polites, H.G. and Roberts, R.M. (1987) Interferon-like sequence of ovine tropho-blast protein secreted by embryonic trophecto-derm. Nature, 330, 377–379.

    Article  PubMed  CAS  Google Scholar 

  • Ito, Y. and Higashi, K. (1961) Studies on the prolactin-like substance in human placenta. II. Endocrinologica Japonica, 8, 279–287.

    Article  CAS  Google Scholar 

  • Ito, Y. and Higashi, K. (1974) The discovery of human placental lactogen. American Journal of Obstetrics and Gynecology, 120, 427–430.

    PubMed  CAS  Google Scholar 

  • Jackson, L.L., Colosi, P., Talamantes, F. and Linzer, D.I. (1986) Molecular cloning of mouse placental lactogen cDNA. Proceedings of the National Academy of Sciences of the USA, 83, 8496–8500.

    Article  PubMed  CAS  Google Scholar 

  • Jameson, J.L. and Lindell, C.M. (1988) Isolation and characterization of the human chorionic gonadotropin β-subunit gene cluster: regulation of a transcriptionally active CGB gene by cyclic AMP. Molecular and Cellular Biology, 8, 5100–5107.

    PubMed  CAS  Google Scholar 

  • Jameson, J.L., Lindell, C.M. and Habener, J.F. (1987) Gonadotropin and thyrotropin and subunit gene expression in normal and neoplastic tissues characterized by using specific messenger ribonucleic acid hybridization probes. Journal of Clinical Endocrinology and Metabolism, 64, 319–326.

    Article  PubMed  CAS  Google Scholar 

  • Jepson, J.J. and Friesen, H.G. (1968) The mechanism of action of human placental lactogen on erythropoiesis. British Journal of Haematology, 15, 465–471.

    Article  PubMed  CAS  Google Scholar 

  • Jones, H.W., Acosta, A.A., Andrews, M.C, Gardia, J.E., Jones, G.S. and Sandow, B.A. (1983) What is pregnancy? A question for in vitro fertilisation. Fertility and Sterility, 40, 728–733.

    PubMed  Google Scholar 

  • Josimovich, J.B. (1966) Potentiation of somato-trophic and diabetogenic effects of growth hormone by placental lactogen (HPL). Endocrinology, 78, 707–714.

    Article  PubMed  CAS  Google Scholar 

  • Josimovich, J.B. and Archer, D.F. (1977) The role of lactogenic hormones in the pregnant woman and the fetus. American Journal of Obstetrics and Gynecology, 129, 777–780.

    PubMed  CAS  Google Scholar 

  • Josimovich, J.B. and Brande, B.L. (1964) Chemical properties and biologic effects of human placental lactogen (HPL). Annals of the New York Academy of Science, 27, 161–166.

    Article  CAS  Google Scholar 

  • Josimovich, J.B. and MacLaren, J.A. (1962) Presence in the human placenta and term serum of a highly lactogenic substance immunologi-cally related to pituitary growth hormone. Endocrinology, 71, 209–220.

    Article  PubMed  CAS  Google Scholar 

  • Josimovich, J.B., Stock, R.J. and Tobon, H. (1974) Effects of primate placental lactogen upon lactation, in Lactogenic Hormones, Fetal Nutrition and Lactation, (ed. J.B. Josimovich), John Wiley & Sons, New York, pp.335–350.

    Google Scholar 

  • Jouppila, P., Tapanainen, J. and Huhtaniemi, I. (1979) Plasma hCG levels in patients with bleeding in the first and second trimesters of pregnancy. British Journal of Obstetrics and Gynaecology, 86, 343–349.

    Article  PubMed  CAS  Google Scholar 

  • Jovanovic, L., Dawood, M.Y., Landesman, R. and Saxena, B.B. (1978) Hormonal profile as a prognostic index of early threatened abortion. American journal of Obstetrics and Gynecology, 130, 274–278.

    PubMed  CAS  Google Scholar 

  • Julier, C., Weil, D., Couillin, P., Cote, J.C., Nguyen, V.C., Foubert, C., Boue, A., Thirion, J.P., Kaplan, J.C. and Junien, C. (1984) The β-chorionic gonadotropin-β-luteinizing gene cluster maps to human chromosomes. Human Genetics, 67, 174–177.

    Article  PubMed  CAS  Google Scholar 

  • Kaetzel, D.M. and Nilson, J.H. (1988) Methotrexate-induced amplification of the bovine lutropin genes in Chinese hamster ovary cells: relative concentration of the α and β-subunits determines the extent of heterodimer assembly. Journal of Biological Chemistry, 263, 6344–6351.

    PubMed  CAS  Google Scholar 

  • Kahn, R.C., Rosen, S.W., Weintraub, S.D., Fajan, S.S. and Gordon, P. (1977) Ectopic production of chorionic gonadotrophin and its subunits by islet cell tumors. New England Journal of Medicine, 297, 565–569.

    Article  PubMed  CAS  Google Scholar 

  • Kalkhoff, R.K., Richardson, B.L. and Beck, P. (1969) Relative effects of pregnancy, human placental lactogen and prednisolone on carbohydrate tolerance in normal and subclinical diabetic subjects. Diabetes, 18, 153–175.

    PubMed  CAS  Google Scholar 

  • Kaplan, S. and Grumbach, M.M. (1965) Serum chorionic ‘growth hormone-prolactin’ and serum pituitary growth hormone in mother and fetus at term. Journal of Clinical Endocrinology, 25, 1370–1374.

    Article  CAS  Google Scholar 

  • Kaplan, S.L., Gurpide, E., Sciarra, J.J. and Grumbach, M.M. (1968) Metabolic clearance rate and production rate of chorionic growth hormone-prolactin in late pregnancy. Journal of Clinical Endocrinology, 28, 1450–1460.

    Article  CAS  Google Scholar 

  • Kardana, A., Taylor, M.E., Southall, J.P., Boxer, G.M., Rowan, A.J. and Bagshawe, K.D. (1988) Urinary gonadotropin peptide — isolation and purification, and its immunohistochemical distribution in normal and neoplastic tissues. British Journal of Cancer, 58, 281–286.

    Article  PubMed  CAS  Google Scholar 

  • Kato, Y. and Braunstein, G.D. (1988) Beta-core fragment is a major form of immunoreactive urinary chorionic gonadotropin in human pregnancy. Journal of Clinical Endocrinology and Metabolism, 66, 1197–1201.

    Article  PubMed  CAS  Google Scholar 

  • Katzman, P.A. and Doisy, E.A. (1934) The quantitative determination of small amounts of gonadotropin material. Journal of Biological Chemistry, 106, 125–139.

    CAS  Google Scholar 

  • Katzman, P.A., Gotfrid, M., Cain, C.K. and Doisy, E.A. (1943) The preparation of chorionic gonadotropins by Chromatographic adsorption. Journal of Biological Chemistry, 148, 501–507.

    CAS  Google Scholar 

  • Kazer, R.R., Cheng, E.R., Unterman, T.C. and Glick, R.P. (1991) Maternal plasma concentrations of insulin-like growth factor-I (IGF-I) and human placental lactogen (hPL) in twin pregnancies. Acta Geneticae Medicae et Gemellologiae, 40, 383–387.

    PubMed  CAS  Google Scholar 

  • Keene, J.L., Matzuk, M.M. and Boime, I. (1989) Expression of recombinant human choriogona-dotropin in Chinese hamster ovary glycosyl-ation mutants. Molecular Endocrinology, 3, 2011–2017.

    Article  PubMed  CAS  Google Scholar 

  • Keller, P.J., Baertschi, U., Bader, P., Gerber, C., Schmid, J., Solterman, R. and Kopper, E. (1971) Biochemical detection of fetoplacental distress in risk pregnancies. Lancet, 2, 729–731.

    Article  Google Scholar 

  • Kelly, A.M., England, P., Lorrimer, J.D., Fergusson, J.C. and Govan, A.D.T. (1975) An evaluation of human placental lactogen levels in hypertension of pregnancy. British Journal of Obstetrics and Gynaecology, 82, 272–277.

    Article  PubMed  CAS  Google Scholar 

  • Kelly, P.A., Shiu, R.P.C. and Friesen, H.G. (1976) Characterization of rat chorionic mammotropin. Endocrinology, 96, 1187–1197.

    Article  Google Scholar 

  • Kennedy, J.F. and Chaplin, M.F. (1976) The structures of the carbohydrate moieties of the α-subunit of human chorionic gonadotrophin. Biochemical Journal, 155, 303–315.

    PubMed  CAS  Google Scholar 

  • Kessler, M.J., Reddy, M.S., Shah, R.H. and Bahl, O.P. (1979a) Structures of N-glycosidic carbohydrate subunits of human chorionic gonadotropin. Journal of Biological Chemistry, 254, 7901–7908.

    PubMed  CAS  Google Scholar 

  • Kessler, M.J., Mise, J., Ghai, R.D. and Bahl, O.P. (1979b) Structure and location of the O-glycosidic carbohydrate units of human chori-onic gonadotropin. Journal of Biological Chemistry, 254, 7909–7914.

    PubMed  CAS  Google Scholar 

  • Keutman, H.T., Dawson, B., Bishop, W.H. and Ryan, R.J. (1978) Structure of human luteinizing hormone alpha subunit. Endocrine Research Communications, 5, 57–70.

    Google Scholar 

  • Keutman, H.T., Charlesworth, M.C., Mason, K.A., Ostrea, T., Johnson, L. and Ryan, R.J. (1987) A receptor-binding region in human choriogonadotropin/lutropin β-subunit. Proceedings of the National Academy of Sciences of the USA, 84, 2038–2042.

    Article  Google Scholar 

  • Khazaeli, M.B., Hedayat, M.M., Hatch, K.D., To, A.C.W., Soong, S.j., Shingleton, H.M., Boots, L.R. and LoBuglio, A.F. (1989) Radioimmuno-assay of free β-subunit of human chorionic gonadotropin as a prognostic test for persistent trophoblastic disease in molar pregnancy. American Journal of Obstetrics and Gynecology, 155, 320–324.

    Google Scholar 

  • Khodr, G. and Siler-Khodr, T.M. (1978) The effect of luteinizing hormone-releasing factor on human chorionic gonadotrophin secretion. Fertility and Sterility, 30, 301–304.

    PubMed  CAS  Google Scholar 

  • Kim, Y.J. and Felig, P. (1971) Plasma chorionic somatomammotropin levels during starvation in mid-pregnancy. Journal of Clinical Endocrinology and Metabolism, 32, 864–867.

    Article  PubMed  CAS  Google Scholar 

  • Kim, S.J., Namkoong, S.E., Lee, O.W., Jung, U.K., Kang, B.C. and Oarj, J.S. (1987) Response of human chorionic gonadotrophin to luteinizing hormone-releasing hormone stimulation in the culture media of normal human placenta choriocarcinoma cell lines, and in the serum of patients with gestational trophoblastic disease. Placenta, 8, 257–264.

    Article  PubMed  CAS  Google Scholar 

  • Kishi, K., Hirashiba, M. and Hasegawa, Y. (1992) Multiple forms of rat placental lactogen-II (rPL-II): purification and partial characterization of rPL-II. Placenta, 13, 63–79.

    Article  PubMed  CAS  Google Scholar 

  • Klassen, M.E., Nachtigal, M.W. and Cattini, P.A. (1989) Human chorionic somatomammotropin gene expression in primary placental cell cultures. Placenta, 10, 321–329.

    Article  PubMed  CAS  Google Scholar 

  • Klebe, J.G., Marushak, A. and Bock, J. (1990) Human placental lactogen lactogenic hormone as a parameter for placental function in renal transplanted women. Acta Obstetrica et Gynecologica Scandinavica, 69, 41–43.

    Article  CAS  Google Scholar 

  • Kliman, H.J., Nestler, J.E., Sermasi, E., Sanger, J.M. and Strauss, J.F. (1986) Purification, characterization and in vitro differentiation of cytotro-phoblasts from human term placentae. Endocrinology, 118, 1567–1582.

    Article  PubMed  CAS  Google Scholar 

  • Klopper, A. and Hughes, G. (1978) Placental secretion of oestrogens and protein hormones. Archives of Gynecology, 225, 171–177.

    CAS  Google Scholar 

  • Knoll, B.J. (1992) Gene expression in the human placental trophoblast: a model for developmental gene regulation. Placenta, 13, 311–327.

    Article  PubMed  CAS  Google Scholar 

  • Kobata, A. (1988) Altered glycosylation of human chorionic gonadotropin in malignant trophoblastic diseases, in Placental Protein Hormones, (eds M. Mochizuki and R. Hussa), Elsevier, Amsterdam, pp. 133–142.

    Google Scholar 

  • Kofler, E. and Spona, J. (1971) Hormone studies of an ovarian dysgerminoma. American Journal of Obstetrics and Gynecology, 111, 1028–1033.

    PubMed  CAS  Google Scholar 

  • Kulski, J.K., Ethel, P., Hartmann, P.E. and Smith, M. (1982) Placental lactogen in human serum and colostrum. Hormone and Metabolic Research, 14, 441–442.

    Article  PubMed  CAS  Google Scholar 

  • Lagrew, D.C., Wilson, E.A. and Fried, A.M. (1984) Accuracy of serum human chorionic gonadotropin concentrations and ultrasonic fetal measurements in determining gestational age. American Journal of Obstetrics and Gynecology, 149, 165–168.

    PubMed  CAS  Google Scholar 

  • Landesman, R., Continho, E.M. and Saxena, B.B. (1976) Detection of hCG in blood of regularly bleeding women using copper intrauterine contraceptive devices. Fertility and Sterility, 27, 1062–1064.

    PubMed  CAS  Google Scholar 

  • Larinkari, J., Laatikainen, L., Ranta, T., Moronen, P. and Pesonen, K. (1982) Metabolic control and serum hormone levels in relation to retinopathy in diabetic pregnancy. Diabetologica, 22, 327–332.

    Article  CAS  Google Scholar 

  • Laurin, J., Persson, P.H. and Fernlund, P. (1987) The efficacy of biochemical assays in assessing an IUGR risk-group, preselected with ultrasound fetometry. European Journal of Obstetrics, Gynecology and Reproductive Biology, 24, 177–187.

    Article  CAS  Google Scholar 

  • Lee, C.L., Shepherd, J.H., Hudson, C.N. and Chard, T. (1991) The purification and development of a radioimmunoassay for beta-core fragment of human chorionic gonadotrophin in urine: application as a marker of gynaecological cancer in premenopausal and postmenopausal women. Journal of Endocrinology, 130, 481–489.

    Article  PubMed  CAS  Google Scholar 

  • Lee, J.N., Grudzinskas, J.G. and Chard, T. (1980) Circulating human placental lactogen (HPL) levels in relation to smoking during pregnancy. Journal of Obstetrics and Gynaecology, 1, 87–89.

    Article  CAS  Google Scholar 

  • Lee, J.N., Seppala, M. and Chard, T. (1981) The characterization of placental luteinizing hormone releasing factor-like material. Acta Endo-crinologica, 96, 394–397.

    CAS  Google Scholar 

  • Lee, J.N., Wu, P. and Chard, T. (1982) Identification of somatostatin in the human placenta. Acta Endocrinologica, 99, 601–604.

    PubMed  CAS  Google Scholar 

  • Lee, J.N., Lian, D.A., Lee, J.H. and Chard, T. (1983) Placental proteins (human chorionic gonadotrophin, human placental lactogen, pregnancy-specific beta-1 glycoprotein, and placental protein 5) in seminal plasma of normal men and patients with infertility. Fertility and Sterility, 39, 704–706.

    PubMed  CAS  Google Scholar 

  • Leigh, S.E.A. and Stewart, F. (1990) Partial cDNA sequence for the donkey chorionic gonadotropin-β-subunit suggests evolution from an ancestral LH-βgene. Journal of Endocrinology, 4, 143–150.

    CAS  Google Scholar 

  • Letch worth, A.T. (1976) Human placental lactogen assay as a guide to fetal wellbeing, in Plasma Hormone Assays in Evaluation of Fetal Wellbeing, (ed. A. Klopper), Churchill Livingstone, Edinburgh, pp. 143–173.

    Google Scholar 

  • Letchworth, A.T. and Chard, T. (1972a) Human placental lactogen in pre-eclampsia. Journal of Obstetrics and Gynaecology of the British Commonwealth, 79, 680.

    Article  PubMed  CAS  Google Scholar 

  • Letchworth, A.T. and Chard, T. (1972b) Placental lactogen levels as a screening test for fetal distress and neonatal asphyxia. Lancet, 1, 704.

    Article  PubMed  CAS  Google Scholar 

  • Letchworth, A.T., Boardman, R., Bristow, C., Landon, J. and Chard, T. (1971) A rapid radio-immunoassay for human chorionic somato-mammotrophin. Journal of Obstetrics and Gynaecology of the British Commonwealth, 78, 535.

    Article  PubMed  CAS  Google Scholar 

  • Letchworth, A.T., Howard, L. and Chard, T. (1974) Placental lactogen levels during bed rest. Obstetrics and Gynecology, 43, 702–703.

    PubMed  CAS  Google Scholar 

  • Li, C.H., Grumbach, M., Kaplan, S.L., Josimovich, J.B., Friesen, H. and Catt, K.J. (1968) Human chorionic somatotropin (HCS), proposed terminology for designation of a placental hormone. Experientia, 24, 1288.

    Article  PubMed  CAS  Google Scholar 

  • Light, P.A., Foster, J.P., Feltou, T., Eckert, H. and Tovey, K.C. (1983) Molecular heterogeneity of chorionic gonadotropin in some testicular cancer patients. Lancet, ii, 1284.

    Article  Google Scholar 

  • Lilford, R.J., Obiekwe, B.C. and Chard, T. (1983) Maternal blood levels of human placental lactogen in the prediction of fetal growth retardation: choosing a cut-off point between normal and abnormal. British Journal of Obstetrics and Gynaecology, 90, 511–515.

    Article  PubMed  CAS  Google Scholar 

  • Lin, T.M. and Halbert, S.P. (1978) Immunological relationships of human and subhuman primate pregnancy-associated plasma proteins. International Archives of Allergy and Applied Immunology, 56, 207–223.

    Article  PubMed  CAS  Google Scholar 

  • Lindberg, B.S., Martinsson, K., Lindberg, P., Nilsson, B.A. and Johansson, E.D.B. (1973) Variations in maternal plasma levels of HPL in normal pregnancy and labour. Journal of Obstetrics and Gynaecology of the British Commonwealth, 80, 619–626.

    Article  PubMed  CAS  Google Scholar 

  • Lindberg, B.S. and Nilsson, B.A. (1973) hPL levels in abnormal pregnancies. Journal of Obstetrics and Gynaecology of the British Commonwealth, 80, 1046–1053.

    Article  PubMed  CAS  Google Scholar 

  • Lolis, D., Kostantinidis, K., Papevangelou, G. and Kaskarelis, D. (1977) Comparative study of amniotic fluid and maternal blood serum human placental lactogen in normal and prolonged pregnancies. American Journal of Obstetrics and Gynecology, 128, 724–726.

    PubMed  CAS  Google Scholar 

  • Loosfelt, H., Misrahi, M., Atger, M., Salesse, R., Thi, M.T.V.H.L., Jolivet, A., Guiochon-Mantel, A., Sar, S., Jallal, B., Gamier, J. and Milgrom, E. (1989) Cloning and sequencing of porcine LH-hCG receptor cDNA: variants lacking trans-membrane domain. Science, 245, 525–528.

    Article  PubMed  CAS  Google Scholar 

  • Lopata, A. and Hay, D.L. (1988) Chorionic gonadotropin secretion by human embryos in vitro. Journal of Clinical Endocrinology and Metabolism, 67, 1322–1324.

    Article  PubMed  Google Scholar 

  • Lopez, M.F., Carrion, F.A. and Talamantes, F. (1991) Pituitary-placental interaction: hypophy-sectomy modulates the secretion of mouse placental lactogen-I. Endocrinology, 129, 2325–2328.

    Article  PubMed  CAS  Google Scholar 

  • Louvet, J.P., Ross, G.T., Birken, S. and Canfield, R.E. (1974) Absence of neutralizing effect of antisera to the unique structural region of human chorionic gonadotropin. Journal of Clinical Endocrinology and Metabolism, 39, 1155–1158.

    Article  PubMed  CAS  Google Scholar 

  • Lowman, H.B., Cunningham, B.C. and Wells, J. A. (1991) Mutational analysis and protein engineering of receptor-binding determinants in human placental lactogen. Journal of Biological Chemistry, 266, 10982–10988.

    PubMed  CAS  Google Scholar 

  • Lustbader, J.W., Birken, S., Pileggi, N.F., Gawinowicz Kolks, M.A., Pollak, S., Cuff, M.E., Yang, W., Hendrickson, W.A. and Canfield, R.E. (1989) Crystallization and characterization of human chorionic gonadotropin in chemically deglycosylated and enzymatically desialylated states. Biochemistry, 28, 9239–9243.

    Article  PubMed  CAS  Google Scholar 

  • Macaron, C., Famuyiwa, O. and Sing, P. (1978) In vitro effect of dopamine and pimozide on human chorionic somatomammotropin (hCG) secretion. Journal of Clinical Endocrinology and Metabolism, 47, 168–170.

    Article  PubMed  CAS  Google Scholar 

  • MacDonald, D.J., Nicol, K.M., Belfield, A., Shah, M.M. and Mack, D.S. (1980) Enzyme-linked immunoassay for placental lactogen in human serum. Clinical Chemistry, 26, 745–747.

    PubMed  CAS  Google Scholar 

  • MacDonald, D.J., Scott, J.M., Gemmell, R.S. and Mack, D.S. (1983) A prospective study of three biochemical fetoplacental tests: serum human placental lactogen, pregnancy-specific beta-1 glycoprotein and urinary estrogens, and their relationship to placental insufficiency. American Journal of Obstetrics and Gynecology, 147, 430–436.

    PubMed  CAS  Google Scholar 

  • McFarland, K.C., Sprengel, R., Phillips, H.S., Kohler, M., Rosemblit, N., Nikolics, K., Segaloff, D.L. and Seeburg, A. (1989) Lutropin-choriogonadotropin receptor: an unusual member of the G protein-coupled receptor family. Science, 245, 494–499.

    Article  PubMed  CAS  Google Scholar 

  • McFadzean, A.J.S. (1946) Feminisation associated with carcinoma of the adrenal cortex. Lancet, 2, 940–943.

    Article  PubMed  CAS  Google Scholar 

  • McManus, L.M., Naughton, M.A. and Martinez-Hernandez, A.M. (1976) Human chorionic gonadotropin in human neoplastic cells. Cancer Research, 36, 3476–3481.

    PubMed  CAS  Google Scholar 

  • McWilliams, D. and Boime, I. (1980) Cytological localization of placental lactogen messenger ribonucleic acid in syncytiotrophoblast layers of human placenta. Endocrinology, 10, 761–765.

    Article  Google Scholar 

  • Mann, K., Schneider, N. and Hoerman, R. (1986) Thyrotropic activity of acidic isoelectric variants of human chorionic gonadotropin from trophob-lastic tumours. Endocrinology, 118, 1558–1566.

    Article  PubMed  CAS  Google Scholar 

  • Marcillac, I., Troalen, F., Bidart, J.M., Ghillani, P., Ribrag, V., Escudier, B., Malassagne, B., Droz, J.P., L’homme, C., Rougier, P., Duvillard, P., Pade, M., Lugagne, P.M., Richard, F., Bohuon, C., Wands, J. and Bellet, D. (1992) Free human chorionic gonadotropin β subunit in gonadal and nongonadal neoplasms. Cancer Research, 52, 3901–3907.

    PubMed  CAS  Google Scholar 

  • Markkanen, S.O., Tollikko, K., Vanha-Perttula, T. and Rajaniemi, H. (1979) Disappearance of human 125-I-iodochorionic gonadotropin from the circulation of the rat: tissue uptake and degradation. Endocrinology, 104, 1540–1547.

    Article  PubMed  CAS  Google Scholar 

  • Markoff, E. and Talamantes, F. (1981) Serum placental lactogen in mice in relation to day of gestation and number of conceptuses. Biology of Reproduction, 24, 846–849.

    Article  PubMed  CAS  Google Scholar 

  • Marsh, J.M. and LeMaire, WJ. (1974) Cyclic AMP accumulation and steroidogenesis in the human corpus luteum: effect of gonadotropins and prostaglandins. Journal of Clinical Endocrinology and Metabolism, 38, 99–106.

    Article  PubMed  CAS  Google Scholar 

  • Martin, J.E., Jenkins, B.J., Zuk, R.J., Oliver, R.T.D. and Baithun, S.I. (1989) Human chorionic gonadotrophin expression and histological findings as predictors of response to radiotherapy in carcinoma of the bladder. Virchows Archives A (Pathological Anatomy and Histopathology), 414, 273–277.

    Article  CAS  Google Scholar 

  • Martin, J.M. and Friesen, H. (1969) Effect of human placental lactogen on the isolated islets of Langerhans in vitro. Endocrinology, 84, 619–621.

    Article  PubMed  CAS  Google Scholar 

  • Maruo, T., Matsuo, H., Ohtani, T., Hoshina, M. and Mochizuki, M. (1986) Differential modulation of chorionic gonadotropin (CG) sub-unit messenger ribonucleic acid levels and CG secretion by progesterone in normal placenta and choriocarcinoma cultured in vitro. Endocrinology, 119, 855–864.

    Article  PubMed  CAS  Google Scholar 

  • Maruo, T., Matsuo, H., Murata, K. and Mochizuki, M. (1992) Gestational age-dependent dual action of epidermal growth factor on human placenta early in gestation. Journal of Clinical Endocrinology and Metabolism, 75, 1362–1367.

    Article  PubMed  CAS  Google Scholar 

  • Masson, G. M., Klopper, A. and Wilson, G.R. (1977) Plasma estrogens and pregnancy-associated plasma proteins. A study of their variability in late pregnancy. Obstetrics and Gynecology, 50, 435–438.

    PubMed  CAS  Google Scholar 

  • Masson, G.M., Anthony, F., Wilson, M.S. and Lindsay, K. (1983) Comparison of serum and urine hCG levels with SP1 and PAPP-A levels in patients with first trimester vaginal bleeding. Obstetrics and Gynecology, 61, 223–226.

    PubMed  CAS  Google Scholar 

  • Matsuura, S., Ohashi, M., Chen, H.C., Shownkeen, R.C., Stockell Hartree, A., Reichert, L.E., Stevens, V.C. and Powell, J.E. (1980) Physicochemical and immunological characterization of an hCG-like substance from human pituitary glands. Nature, 286, 740–741.

    Article  PubMed  CAS  Google Scholar 

  • Matzuk, M.M., Husueh, A.J.W., Lappolt, P., Tsafriri, A., Keen, J.L. and Boime, I. (1990) The biological role of the carboxyl-terminal extension of human chorionic gonadotropin β-subunit. Endocrinology, 126, 376–383.

    Article  PubMed  CAS  Google Scholar 

  • Medvei, V.C. (1982) History of Endocrinology, MTP Press, Lancaster.

    Book  Google Scholar 

  • Merkatz, J.R., Nitowsky, H.M., Macri, J.N. and Johnson, W.E. (1984) An association between low maternal serum alpha-fetoprotein and fetal chromosomal abnormalities. American Journal of Obstetrics and Gynecology, 14, 886–894.

    Google Scholar 

  • Metzger, B.E., Rodeck, C., Freinkel, N., Price, J. and Young, M. (1985) Transplacental arteriovenous gradients for glucose, insulin, glucagon and placental lactogen during normoglycaemia in human pregnancy at term. Placenta, 6, 347–354.

    Article  PubMed  CAS  Google Scholar 

  • Miller, J.R., Williamson, E., Glue, J., Gordon, Y.B., Grudzinskas, J.G. and Sykes, A. (1980) Fetal loss after implantation. Lancet, 2, 554–556.

    Article  PubMed  CAS  Google Scholar 

  • Milman, N., Agger, A.O. and Nielsen, O.J. (1991) Iron supplementation during pregnancy. Effect on iron status markers, serum erythropoietin and human placental lactogen. A placebo controlled study in 107 Danish women. Danish Medical Bulletin, 38, 471–476.

    PubMed  CAS  Google Scholar 

  • Milstead, A., Cox, R.P. and Nilson, H.J. (1987) Cyclic AMP regulates transcription of the genes encoding chorionic gonadotrophin with different kinetics. DNA, 6, 213–219.

    Article  Google Scholar 

  • Mise, T. and Bahl, O.P. (1980) Assignment of disulphide bonds in the α-subunit of human chorionic gonadotropin. Journal of Biological Chemistry, 255, 8516–8522.

    PubMed  CAS  Google Scholar 

  • Mise, T. and Bahl, O.P. (1981) Assignment of disulphide bonds in the β-subunit of human chorionic gonadotropin. Journal of Biological Chemistry, 256, 6587–6592.

    PubMed  CAS  Google Scholar 

  • Mizuochi, T. and Kobata, A. (1980) Different asparagine-linked sugar chains on the two polypeptide chains of human chorionic gonadotropin. Biochemical and Biophysical Research Communications, 97, 772–778.

    Article  PubMed  CAS  Google Scholar 

  • Mizuochi, T., Nishimura, R., Derappe, C., Taniguchi, T., Hamamoto, T., Mochizuki, M. and Kobata, A. (1983) Structures of asparagine-linked sugar chains of human chorionic gonadotropin produced in choriocarcinoma. Appearance of triantennary sugar chains and unique biantennary sugar chains. Journal of Biological Chemistry, 258, 14126–14129.

    PubMed  CAS  Google Scholar 

  • Monteiro, J.C.M.P., Barker, G., Ferguson, K.M., Wiltshaw, E. and Munro Neville, A. (1983) Ectopic production of human chorionic gonadotrophin (hCG) and human placental lactogen (hPL) by ovarian carcinoma. European Journal of Cancer and Clinical Oncology, 19, 173–178.

    Article  CAS  Google Scholar 

  • Monteiro, J.C.M.P., Biswas, S., Al-Awqati, M.A., Greening, W.P., McKinna, J.A. and Neville, A.M. (1982) Serum levels of human placental lactogen, and pregnancy-specific beta-1 glycoprotein in breast cancer. British Journal of Cancer, 46, 279–282.

    Article  PubMed  CAS  Google Scholar 

  • Moore, W.T. and Ward, D.N. (1980) Pregnant mare serum gonadotropin: rapid Chromatographic procedures for the purification of intact hormone and isolation of subunits. Journal of Biological Chemistry, 255, 6923–6929.

    PubMed  CAS  Google Scholar 

  • Morgan, D.A., Caillaud, J.M., Bellet, D. and Eschwege, F. (1982) Gonadotropin-producing seminoma: a distinct category of germ cell neoplasm. Clinical Radiology, 33, 149–153.

    Article  PubMed  CAS  Google Scholar 

  • Morgan, F.J., Birken, S. and Canfield, R.E. (1975) The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit. Journal of Biological Chemistry, 250, 5247–5258.

    PubMed  CAS  Google Scholar 

  • Mori, K.F. (1970) Antigenic structure of human chorionic gonadotropins: importance of protein moiety to the antigenic structure of human chorionic gonadotropin. Endocrinology, 86, 97–106.

    Article  PubMed  CAS  Google Scholar 

  • Morris, H.H.B, Vinik, A.I. and Mulvihal, M. (1974) Effects of acute alterations in free fatty acid concentration in human chorionic somato-mammotropin secretion. American Journal of Obstetrics and Gynecology, 119, 224–229.

    PubMed  CAS  Google Scholar 

  • Morrish, D.W., Bhardwaj, D. and Paras, M.T. (1991) Transforming growth factor beta 1 inhibits placental differentiation and human chorionic gonadotropin and human placental lactogen secretion. Endocrinology, 129, 22–26.

    Article  PubMed  CAS  Google Scholar 

  • Morrison, I., Green, P. and Oomen, B. (1980) The role of human placental lactogen assays in antepartum fetal assessment. American Journal of Obstetrics and Gynecology, 136, 1055–1060.

    PubMed  CAS  Google Scholar 

  • Morse, J.H., Stearns, G., Arden, J., Agosts, G.M. and Canfield, R.E. (1976) The effects of crude and purified human gonadotropin in vitro stimulated human lymphocyte cultures. Cellular Immunology, 25, 178–188.

    Article  PubMed  CAS  Google Scholar 

  • Moser, R.J., Hollingsworth, D.R., Carlson, J.W. and Lamotte, L. (1974) Human chorionic soma-tomammotropin in normal adolescent primiparous pregnancy. American Journal of Obstetrics and Gynecology, 120, 1080–1806.

    PubMed  CAS  Google Scholar 

  • Moyle, W.R., Lustbader, J.W. and Canfield, R.E. (1987) Discussion Section of: Ryan RJ, Keutmann HT, Charlesworth MC, McCormick DJ, Milius RP, Calvo FO and Vutyavanich T (1987) Structure-function relationships of gona-dotropins. Recent Progress in Hormone Research, 43, 383–429.

    Google Scholar 

  • MRC Working Party on Testicular Tumours (1985) Prognostic factors in advanced non-seminomatous germ-cell testicular tumours: results of a multicentre study. Lancet, 1, 8–11.

    Google Scholar 

  • Muchmore, A.V. and Blaese, R.M. (1977) Immunoregulatory properties of fractions from human pregnancy urine: evidence that human chorionic gonadotropin is not responsible. Journal of Immunology, 118, 881–886.

    CAS  Google Scholar 

  • Murakawa, S. and Raben, M.S. (1968) Effect of growth hormone and placental lactogen on DNA synthesis in rat costal cartilage and adipose tissue. Endocrinology, 83, 645–650.

    Article  PubMed  CAS  Google Scholar 

  • Nagasawa, H., Yanai, R. and Yamanouchi, K. (1976) Inhibition of pituitary prolactin secretion by human placental lactogen in rats. Journal of Endocrinology, 71, 115–120.

    Article  PubMed  CAS  Google Scholar 

  • Nam, J.H., Chang, K.C., Chambers, J.T., Schwartz, P.E. and Cole, L.A. (1989) Urinary gonadotropin fragment, a new tumor marker. III. Use in cervical and vulvar cancers. Gynecological Oncology, 38, 66–70.

    Article  Google Scholar 

  • Nash, H.A., Chang, C.C. and Tsong, Y.Y. (1985) Formulation of a potent anti pregnancy vaccine based on the β-subunit of human chorionic gonadotropin (β-hCG). II. Use of compounds of the muramyl dipeptide (MDP) family as adjuvants. Journal of Reproductive Immunology, 7, 151–162.

    Article  PubMed  CAS  Google Scholar 

  • Naylor, S.L., Chin, W.W., Goodman, H.M., Lalley, P.A., Grzeschik, K.H. and Sakaguchi, A.Y. (1983) Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse. Somatic Cell Genetics, 9, 757–770.

    Article  PubMed  CAS  Google Scholar 

  • Newnham, J.P., Lam, R.W., Hobel, C.J., Padbury, J.F., Polk, D.H. and Fisher, D.A. (1986a) Differential response of ovine placental lactogen levels in maternal and fetal circulations following single umbilical artery ligation in fetal sheep. Placenta, 7, 51–64.

    Article  PubMed  CAS  Google Scholar 

  • Newnham, J.P., Lam, R.W., Hobel, C.J., Polk, D.H. and Fisher, D.A. (1986b) Blunted response of maternal ovine placental lactogen levels to arginine stimulation after single umbilical artery ligation in pregnancy sheep. American Journal of Obstetrics and Gynecology, 154, 663–666.

    PubMed  CAS  Google Scholar 

  • Niall, H.D., Hogan, M.L., Sauer, R., Rosenblum, I.Y. and Greenwood, F.C. (1971) Sequences of pituitary and placental lactogenic and GH evolution from a primordial peptide by gene reduplication. Proceedings of the National Academy of Sciences of the USA, 68, 866–869.

    Article  PubMed  CAS  Google Scholar 

  • Niall, H.D., Hogan, M.L., Tregear, G.W., Seagre, G.V., Hwang, P. and Friesen, H.G. (1973) The chemistry of growth hormone and the lactogenic hormones. Recent Progress in Hormone Research, 29, 387–398.

    PubMed  CAS  Google Scholar 

  • Nicolaides, K.H., Faratian, B. and Symonds, E.M. (1982) Effect of low implantation of the placenta on maternal blood pressure and placental function. British Journal of Obstetrics and Gynaecology, 89, 806–810.

    Article  PubMed  CAS  Google Scholar 

  • Nielsen, P.V., Pedersen, H. and Kampmann, E.M. (1979) Absence of human placental lactogen in an otherwise uneventful pregnancy. American Journal of Obstetrics and Gynecology, 135, 322–326.

    PubMed  CAS  Google Scholar 

  • Nilsson, B., Rosen, S.W., Weintraub, B.D. and Zopf, D.A. (1986) Differences in the carbohydrate moieties of the common α-subunits of human chorionic gonadotropin, luteinizing hormone, follicle-stimulating hormone and thyrotropin: preliminary structural inferences for direct methylation analysis. Endocrinology, 119, 2737–2743.

    Article  PubMed  CAS  Google Scholar 

  • Nishimura, R., Endo, Y., Tanabe, K., Ashitaka, Y. and Tojo, S. (1981) The biochemical properties of urinary human chorionic gonadotropin from the patients with trophoblastic disease. Journal of Endocrinological Investigations, 4, 349–358.

    CAS  Google Scholar 

  • Nisula, B. and Bartocci, A. (1984) Choriogonado-tropin and immunity: a reevaluation. Annales d’Endocrinologie (Paris), 45, 315–319.

    CAS  Google Scholar 

  • Nisula, B.C., Blithe, D.L., Akar, A., Lefort, G. and Wehmann, R.E. (1989) Metabolic fate of human choriogonadotropin. Journal of Steroid Biochemistry, 33, 733–737.

    Article  PubMed  CAS  Google Scholar 

  • Niven, P.A.R., Chard, T. and Landon, J. (1972) Placental lactogen levels as a guide to the outcome of threatened abortion. British Medical Journal, 3, 799.

    Article  PubMed  CAS  Google Scholar 

  • Niven, P.A.R., Ward, R.H.T. and Chard, T. (1974) Human placental lactogen levels in amniotic fluid in Rhesus isoimmunization. Journal of Obstetrics and Gynaecology of the British Commonwealth, 81, 988.

    Article  PubMed  CAS  Google Scholar 

  • Norman, R.J., Poulton, T., Gard, T. and Chard, T. (1985a) Monoclonal antibodies to human chorionic gonadotrophin: implications for antigenic mapping, immunoradiometric assays and clinical applications. Journal of Clinical Endocrinology and Metabolism, 61, 1031–1038.

    Article  PubMed  CAS  Google Scholar 

  • Norman, R.J., Lowings, C. and Chard, T. (1985b) Dipstick method for human chorionic gonado-tropin suitable for emergency use on whole blood and other fluids. Lancet, 1, 19–20.

    Article  PubMed  CAS  Google Scholar 

  • Norman, R.J., Lowings, C., Oliver, T. and Chard, T. (1985c) Human chorionic gonadotrophin and subunits-heterogeneity in serum of male patients with tumours of the genital tract. Clinical Endocrinology, 27, 25–34.

    Article  Google Scholar 

  • Novy, M.J., Aubert, M.L., Kaplan, S.L. and Grumbach, M.M. (1981) Regulation of placental growth and chorionic somatomammotropin in the rhesus monkey: effects of protein deprivation, fetal anencephaly and placental vessel ligation. American Journal of Obstetrics and Gynecology, 140, 552–562.

    PubMed  CAS  Google Scholar 

  • Nygren, K.G., Johansson, E.D.B. and Wide, L. (1973) Evaluation of the prognosis of threatened abortion from the peripheral levels of plasma progesterone, estradiol and human chorionic gonadotropin. American Journal of Obstetrics and Gynecology, 116, 916–922.

    PubMed  CAS  Google Scholar 

  • Obiekwe, B.C. and Chard, T. (1982a) Human chorionic gonadotrophin levels in maternal blood in late pregnancy: relation to birthweight, sex and condition of the infant at birth. British Journal of Obstetrics and Gynaecology, 89, 543–546.

    Article  PubMed  CAS  Google Scholar 

  • Obiekwe, B.C. and Chard, T. (1982b) What do placental function tests predict? Observations on placental lactogen levels in growth retardation and fetal distress. European Journal of Obstetrics, Gynecology and Reproductive Biology, 14, 69–73.

    Article  CAS  Google Scholar 

  • Obiekwe, B.C. and Chard, T. (1983a) Placental proteins in late pregnancy: relation to fetal sex. Journal of Obstetrics and Gynaecology, 3, 163–164.

    Article  Google Scholar 

  • Obiekwe, B.C. and Chard, T. (1983b) A comparative study of the clinical use of four placental proteins in the third trimester. Journal of Perinatal Medicine, 11, 121–126.

    Article  PubMed  CAS  Google Scholar 

  • Obiekwe, B.C. and Chard, T. (1984) The value of serial estimations of placental lactogen for fetop-lacental function testing in the diagnosis of intra-uterine growth retardation. Journal of Obstetrics and Gynaecology, 4, 157–160.

    Article  CAS  Google Scholar 

  • Obiekwe, B.C., Sturdee, D., Cockrill, B.L. and Chard, T. (1984) Human placental lactogen in pre-eclampsia. British Journal of Obstetrics and Gynaecology, 91, 1077–1080.

    Article  PubMed  CAS  Google Scholar 

  • Odell, W.D. and Griffin, J. (1987) Pulsatile secretion of human chorionic gonadotropin in normal adults. New England Journal of Medicine, 317, 1688–1691.

    Article  PubMed  CAS  Google Scholar 

  • Odell, W.D. and Griffin, J. (1989) Pulsatile secretion of chorionic gonadotropin during the normal menstrual cycle. Journal of Clinical Endocrinology and Metabolism, 69, 528–532.

    Article  PubMed  CAS  Google Scholar 

  • Ogren, L., Southard, J.N., Colosi, P., Linzer, D.I.H. and Talamantes, F. (1989) Mouse placental lactogen-I: RIA and gestational profile in maternal serum. Endocrinology, 125, 2253–2257.

    Article  PubMed  CAS  Google Scholar 

  • Oliver, M.H., Harding, J.E., Breier, B.H., Evans, P.C. and Gluckman, P.D. (1992) The nutritional regulation of circulating placental lactogen in fetal sheep. Pediatric Research, 31, 520–523.

    Article  PubMed  CAS  Google Scholar 

  • Otani, T., Otani, F., Bo, M., Chaplin, D. and Boime, I. (1988) Promoter sequences in the chorionic gonadotropin β-subunit gene, in Placental Protein Hormones, (eds M. Mochizuki and R. Hussa), Elsevier, Amsterdam, pp. 87–100.

    Google Scholar 

  • Pala, A., Meirinho, M. and Benajiano, G. (1973) Purification and properties of chorionic gonadotrophin from trophoblastic tissue, urine and plasma of a patient with hydatidiform mole. Journal of Endocrinology, 56, 441–450.

    Article  PubMed  CAS  Google Scholar 

  • Papapetrou, P.D. and Nicopoulou, S.C. (1986) The origin of a human chorionic gonadotropin β-subunit-core fragment excreted in the urine of patients with cancer. Acta Endocrinologica, 112, 415–122.

    PubMed  CAS  Google Scholar 

  • Parks, J.S., Nielsen, P.V., Sexton, L.A. and Jorgensen, E.H. (1985) An effect of gene dosage on production of human chorionic somatomammotropin. Journal of Clinical Endocrinology and Metabolism, 60, 994–997.

    Article  PubMed  CAS  Google Scholar 

  • Parsons, T.F., Bloomfield, G.A. and Pierce, J.G. (1983) Purification of an alternate form of the α-subunit of the glycoprotein hormones from bovine pituitaries and identification of its O-linked oligosaccharide. Journal of Biological Chemistry, 258, 240–244.

    PubMed  CAS  Google Scholar 

  • Parsons, T.F. and Pierce, J.G. (1980) Oligosaccharide moieties of glycoprotein hormones: bovine lutropin resists enzymatic deglycosylation because of terminal O-sulfated N-acetyl hexosa-mines. Proceedings of the National Academy of Sciences of the USA, 77, 7089–7093.

    Article  PubMed  CAS  Google Scholar 

  • Parsons, T.F. and Pierce, J.G. (1984) Free α-like material from bovine pituitaries. Removal of its O-linked oligosaccharide permits combination with lutropin-B. Journal of Biological Chemistry, 259, 2662–2666.

    PubMed  CAS  Google Scholar 

  • Patillo, R.A., Shalby, M.R., Hussa, R.O., Bahl, O.P. and Mattingly, R.F. (1976) Effect of crude and purified hCG on lymphocyte blastogenesis. Obstetrics and Gynecology, 47, 557–561.

    Google Scholar 

  • Pavlou, C., Chard, T. and Letchworth, A.T. (1972) Circulating levels of human chorionic somnato-mammotrophin in late pregnancy: disappearance from the circulation after delivery, variation during labour, and circadian rhythm. Journal of Obstetrics and Gynaecology of the British Commonwealth, 79, 629.

    Article  PubMed  CAS  Google Scholar 

  • Pavlou, C., Chard, T., Landon, J. and Letchworth, A.T. (1973) Circulating levels of human placental lactogen in late pregnancy: the effects of glucose loading, smoking and exercise. European Journal of Obstetrics, Gynecology and Reproductive Biology, 3, 45.

    Article  CAS  Google Scholar 

  • Peters, B.P., Krzesicki, R.F., Perini, F. and Ruddon, R.W. (1989) O-glycosylation of the alpha-subunit does not limit the assembly of chorionic gonadotropin alpha beta dimer in human malignant and nonmalignant trophob-lastic cells. Endocrinology, 124, 1602–1612.

    Article  PubMed  CAS  Google Scholar 

  • Petit, A., Guillon, G., Tence, M., Jard, S., Gallo-Payet, N., Bellabarba, D., Lehoux, J.G. and Belisle, S. (1989) Antiotensin II stimulates both inositol phosphate production and human placental lactogen release from human trophoblastic cells. Journal of Clinical Endocrinology and Metabolism, 69, 280–286.

    Article  PubMed  CAS  Google Scholar 

  • Pierce, J.G. and Parsons, T.F. (1981) Glycoprotein hormones: structure and function. Annual Reviews of Biochemistry, 50, 465–495.

    Article  CAS  Google Scholar 

  • Pilistine, S.J., Moses, A.C. and Munro, H.N. (1984) Placental lactogen administration reverses the effect of low-protein diet on maternal and fetal serum somatomedin levels in the pregnant rat. Proceedings of the National Academy of Sciences of the USA, 81, 5853–5857.

    Article  PubMed  CAS  Google Scholar 

  • Pittaway, D.E., Reish, M.S. and Wentz, A.C. (1985a) Doubling times of human chorionic gonadotropin increase in early viable intra-uterine pregnancies. American Journal of Obstetrics and Gynecology, 152, 299–302.

    PubMed  CAS  Google Scholar 

  • Pittaway, D.E., Wentz, A.C., Maxon, W.S., Herbert, C., Daniell, J. and Fleischer, A.C. (1985b) The efficacy of early pregnancy monitoring with serial chorionic gonadotropin determinations and real-time ultrasonography in an infertile population. Fertility and Sterility, 44, 190–194.

    PubMed  CAS  Google Scholar 

  • Pledger, D.R., Lunan, C.B. and Belfield, A. (1982) Human placental lactogen and pregnancy specific-beta-1 glycoprotein in pregnant diabetic women. British Journal of Obstetrics and Gynaecology, 89, 827–830.

    Article  PubMed  CAS  Google Scholar 

  • Pledger, D.R., Belfield, A., Calder, A.A. and Wallace, A.M. (1984) The predictive value of three pregnancy-associated proteins in the detection of the light-for-dates baby. British Journal of Obstetrics and Gynaecology, 91, 870–874.

    Article  PubMed  CAS  Google Scholar 

  • Policastro, P., Ovitt, C.E., Hoshina, M., Fukuoka, H., Noothby, M.R. and Boime, I. (1983) The β-subunit of human chorionic gonadotropin is encoded by multiple genes. Journal of Biological Chemistry, 258, 11492–11499.

    PubMed  CAS  Google Scholar 

  • Policastro, P.F., Daniels-McQueen, S., Carle, G. and Boime, I. (1986) A map of the hCGβ-LHβ cluster. Journal of Biological Chemistry, 261, 5907–5916.

    PubMed  CAS  Google Scholar 

  • Porter, D.G. (1980) Review Article: Feto-maternal relationships: The actions and control of certain placental hormones. Placenta, 1, 259–274.

    Article  PubMed  CAS  Google Scholar 

  • Prieto, J.C., Cifuentes, I. and Serrano-Rios, M. (1976) hCS regulation during pregnancy. Obstetrics and Gynecology, 48, 287–301.

    Google Scholar 

  • Quigley, M.M., Tyrey, L. and Hammond, C.B. (1980a) α-subunit in sera of choriocarcinoma patients in remission. Journal of Clinical Endocrinology and Metabolism, 50, 98–102.

    Article  PubMed  CAS  Google Scholar 

  • Quigley, M.M., Tyrey, L. and Hammond, C.B. (1980b) Utility of assay of alpha subunit of human chorionic gonadotropin in management of gestational, trophoblastic malignancies. American Journal of Obstetrics and Gynecology, 138, 545–549.

    PubMed  CAS  Google Scholar 

  • Ranta, T., Sitteri, J.E. and Koistinen, R. (1981) Human seminal plasma contains a protein that shares physicochemical and immunochemical properties with placental protein 5 from the human placenta. Journal of Clinical Endocrinology and Metabolism, 53, 1087–1089.

    Article  PubMed  CAS  Google Scholar 

  • Ranta, T., Chen, H.C., Jalkanen, J., Nikula, H., Shimohigashi, Y. and Huhtaniemi, I. (1987) Receptor binding properties and biologic action of deglycosylated human chorionic gonadotropin in human ovary and testis. Obstetrics and Gynecology, 70, 171–174.

    PubMed  CAS  Google Scholar 

  • Redman, C.W.G. (1986) Immunology of the placenta, in The Human Placenta. Clinical Obstetrics and Gynecology, (ed. T. Chard), W.B. Saunders, London, pp. 469–499.

    Google Scholar 

  • Reeve, J.R., Cheng, K.W. and Pierce, J.G. (1975) Partial reduction of disulphide bonds in the hormone specific subunits of TSH and LH. Biochemical and Biophysical Research Communications, 67, 149–155.

    Article  PubMed  CAS  Google Scholar 

  • Rice, G.E. and Thorburn, G.D. (1986) Characterization of particle associated chorio-mammotrophin and progesterone in ovine placentomes. Journal of Endocrinology, 111, 217–223.

    Article  PubMed  CAS  Google Scholar 

  • Richardson, M.C. and Masson, G.M. (1981) Stimulation by human chorionic gonadotropin of oestradiol production by dispersed cells from human corpus luteum: comparison with progesterone production; utilization of exogenous testosterone. Journal of Endocrinology, 91, 197–203.

    Article  PubMed  CAS  Google Scholar 

  • Riggi, S.J., Boshart, C.R., Bell, P.H. and Ringler, I. (1966) Some effects of purified placental protein (human) on lipid and carbohydrate metabolism. Endocrinology, 79, 709–715.

    Article  PubMed  CAS  Google Scholar 

  • Robertson, D.M., Suginami, H., Montes, H.H., Puri, C.P. and Choi, S.K. (1978) Studies on a human chorionic gonadotrophin-like material present in non-pregnant subjects. Acta Endocrinologica, 89, 492–505.

    PubMed  CAS  Google Scholar 

  • Robertson, M.C., Gillespie, B. and Friesen, H.G. (1982) Characterization of the two forms of rat placental lactogen (rPL): rPL-I and rPL-II. Endocrinology, 111, 1862–1866.

    Article  PubMed  CAS  Google Scholar 

  • Robertson, M.C., Owens, R.E. and Friesen, H.G. (1984) Ovariectomy leads to a rapid increase in rat placental lactogen secretion. Endocrinology, 114, 1805–1811.

    Article  PubMed  CAS  Google Scholar 

  • Romero, R., Kadar, N., Copel, J.A., Jeanty, P., DeCherney, A.H. and Hobbins, J.C (1985a) The effect of different human chorionic gonadotropin assay sensitivity on screening for ectopic pregnancy. American Journal of Obstetrics and Gynecology, 153, 72–74.

    PubMed  CAS  Google Scholar 

  • Romero, R., Kadar, N., Jeanty, P., Copel, J.A., Chervenak, F.A., DeCherney, A. and Hobbins, J.C (1985b) Diagnosis of ectopic pregnancy: value of the discriminatory human chorionic gonadotropin zone. Obstetrics and Gynecology, 66, 357–360.

    PubMed  CAS  Google Scholar 

  • Rosa, C., Amr, S., Birken, S., Wehmann, R. and Nisula, B. (1984) Effect of desialylation of human chorionic gonadotropin on its metabolic clearance rate in humans. Journal of Clinical Endocrinology and Metabolism, 59, 1215–1219.

    Article  PubMed  CAS  Google Scholar 

  • Rosen, S.W., Weintraub, B.D. and Aaronson, S.A. (1980a) Nonrandom ectopic protein production by malignant cells: direct evidence in vitro. Journal of Clinical Endocrinology and Metabolism, 50, 834–841.

    Article  PubMed  CAS  Google Scholar 

  • Rosen, S., Kaminska, J., Calvert, I., Ellmore, N. and Aaronson, S. (1980b) Ectopic production of ‘pregnancy-specific’ beta-1 glycoprotein in vitro: discordance with three other placental proteins. American Journal of Obstetrics and Gynecology, 137, 525–529.

    PubMed  CAS  Google Scholar 

  • Ruddon, R.W., Anderson, C., Meade-Cobun, K.S., Aldenderfer, P.H. and Neuwald, P.D. (1979a) Content of gonadotropins in cultured human malignant cells and effects of sodium butyrate treatment on gonadotropin secretion by HeLa cells. Cancer Research, 39, 3885–3892.

    PubMed  CAS  Google Scholar 

  • Ruddon, R.W., Hanson, C.A. and Addison, N.J. (1979b) Synthesis and processing of human chorionic gonadotropin subunits in cultured choriocarcinoma cells. Proceedings of the National Academy of Sciences of the USA, 76, 5143–5147.

    Article  PubMed  CAS  Google Scholar 

  • Ruddon, R.W., Krzesicki, R.F., Norton, S.E., Saccuzzo-Beebe, J., Peters, B.P. and Perini, F. (1987) Detection of glycosylated incompletely folded form of chorionic gonadotropin beta subunit that is a precursor of hormone assembly in trophoblastic cells. Journal of Biological Chemistry, 262, 12533–12540.

    PubMed  CAS  Google Scholar 

  • Ruddon, R.W., Krzesicki, R.F., Loesel, L., Saccuzzo-Beebe, J., Peters, B.P. and Perini, F. (1988) Biosynthesis and combination of chorionic gonadotropin subunits in human cells, in Proceedings of the Satellite Symposium on Placental Protein Hormones (Japan), (eds M. Mochilzuki and R. Hussa), Excerpta Medica, Amsterdam, pp. 75–85.

    Google Scholar 

  • Russell, J., Sherwood, L.M., Kowalski, K. and Schneider, A.R. (1981a) Recombinant hormones from fragments of human growth hormone and human placental lactogen. Journal of Biological Chemistry, 256, 296–300.

    PubMed  CAS  Google Scholar 

  • Russell, J., Katzhendler, J., Kowalski, K., Schneider, A.B. and Sherwood, L.M. (1981b) The single tryptophan residue of human placental lactogen. Journal of Biological Chemistry, 256, 304–307.

    PubMed  CAS  Google Scholar 

  • Rutanen, E.M. (1978) The circulating alpha subunit of human chorionic gonadotropin in gynae-cologic tumours. International Journal of Cancer, 22, 413–421.

    Article  CAS  Google Scholar 

  • Rutanen, E.M. and Seppala, M. (1978) The hCG-beta subunit radioimmunoassay in nontrophob-lastic gynecologic tumors. Cancer, 41, 692–696.

    Article  PubMed  CAS  Google Scholar 

  • Ryan, R.J., Keutmann, H.T., Charlesworth, M.C., McCormick, D.J., Milius, R.P., Calvo, F.O. and Vutyavanich, T. (1987) Structure-function relationships of gonadotropins. Recent Progress in Hormone Research, 43, 383–429.

    PubMed  CAS  Google Scholar 

  • Ryan, R.J., Charlesworth, M.C., McCormick, D.J., Morris, J.C., Milius, R., Begert, E. and Keutmann, H.T. (1988) Some structural and functional features of the glycoprotein hormones, in Placental Protein Hormones, (eds M. Mochizuki and R. Hussa), Elsevier, Amsterdam, pp. 111–122.

    Google Scholar 

  • Rzasa, P.J., Caride, V.J. and Prokop, E.K. (1984) Discordant inter-kit results in the radioimmunoassay for choriogonadotropin in serum. Clinical Chemistry, 30, 1240–1243.

    PubMed  CAS  Google Scholar 

  • Sagen, N., Nilse, S.T., Kimm, H.C., Koller, O. and Bergsjo, P. (1984) The predictive value of total estriol, HPL and HB on perinatal outcome in severe pre-eclampsia. Acta Obstetrica et Gynecologica Scandinavica, 63, 603–608.

    Article  CAS  Google Scholar 

  • Said, M.E., Campbell, D.M., Azzam, M.E. and MacGillivray, I. (1984) Beta-human chorionic gonadotrophin levels before and after development of pre-eclampsia. British Journal of Obstetrics and Gynaecology, 91, 772–775.

    Article  PubMed  CAS  Google Scholar 

  • Sairam, M.R. and Bhargavi, G.N. (1985) A role for glycosylation of the α-subunit in transduction of biological signal in glycoprotein hormones. Science, 229, 65–67.

    Article  PubMed  CAS  Google Scholar 

  • Sakbun, V., Ali, S., Greenwood, F.C. and Bryant-Greenwood, G.D. (1990) Human relaxin in the amnion, chorion, decidua parietalis, basal plate and placental trophoblast by immunohisto-chemistry and Northern analysis. Journal of Clinical Endocrinology and Metabolism, 70, 508–514.

    Article  PubMed  CAS  Google Scholar 

  • Salem, H.T., Lee, J.N., Seppala, M., Vaara, L., Aula, P., Al-Ani, A.T.M. and Chard, T. (1981) Measurement of placental protein 5, placental lactogen and pregnancy-specific glycoprotein in mid-trimester as a predictor of outcome of pregnancy. British Journal of Obstetrics and Gynaecology, 88, 371–374.

    Article  PubMed  CAS  Google Scholar 

  • Salem, H.T., Shaaban, M.M., Ghaneimah, S.A., Seppala, M. and Chard, T. (1983) Circulating levels of placental proteins, placental protein 5 (PP5), placental lactogen and Schwangerschaftsprotein 1 (SP1), in antepartum eclampsia. British Journal of Obstetrics and Gynaecology, 90, 618–622.

    Article  PubMed  CAS  Google Scholar 

  • Salem, H.T., Menabawey, M., Seppala, M., Shaaban, M.M. and Chard, T. (1984a) Human seminal plasma contains a wide range of trophoblast specific proteins. Placenta, 5, 413–418.

    Article  PubMed  CAS  Google Scholar 

  • Salem, H.T., Ghaneimah, S.A., Shaaban, M.M. and Chard, T. (1984b) Prognostic value of biochemical tests in the assessment of fetal outcome in threatened abortion. British Journal of Obstetrics and Gynaecology, 91, 382–385.

    Article  PubMed  CAS  Google Scholar 

  • Sailer, B., Clara, R., Spottl, G., Siddle, K. and Mann, K. (1990) Testicular cancer secretes intact choriogonadotropin (hCG) and its free β-subunit: evidence that hCG(+hCG-B) assays are the most reliable in diagnosis and follow-up. Clinical Chemistry, 36, 234–239.

    Google Scholar 

  • Samaan, N., Yen, S.C.C. and Friesen, H.G. (1966) Serum placental lactogen levels during pregnancy and in trophoblastic disease (abstract). Journal of Clinical Endocrinology, 26, 1303–1308.

    Article  CAS  Google Scholar 

  • Saxena, B.B., Goldstein, D.P., Emerson, K. and Selenkow, H.A. (1968) Serum placental lactogen levels in patients with molar pregnancy and trophoblastic tumors (abstract). American Journal of Obstetrics and Gynecology, 102, 115–121.

    PubMed  CAS  Google Scholar 

  • Saxena, B.B., Emerson, K. and Selenkow, H.A. (1969) Serum placental lactogen (HPL) levels as an index of placental function (abstract). New England Journal of Medicine, 281, 225–231.

    Article  PubMed  CAS  Google Scholar 

  • Schneider, A.B., Kowalski, K., Buckman, G. and Sherwood, L.M. (1977) Dimeric human placental lactogen, immunological and biological activity (abstract). Biochimica et Biophysica Acta, 493, 69–77.

    Article  PubMed  CAS  Google Scholar 

  • Schoknecht, P.A., Nobrega, S.N., Petterson, J.A., Ehrhardt, R.A., Slepetis, R. and Bell, A.W. (1991) Relations between maternal and fetal plasma concentrations of placental lactogen and placental and fetal weights in well-fed ewes. Journal of Animal Science, 69, 1059–1063.

    PubMed  CAS  Google Scholar 

  • Schreyer, P., Zer, Y., Ariely, S., Herman, A. and Caspi, E. (1989) Influence of ritodrine on plasma steroids and human placental lactogen levels in third trimester pregnancies. Gynecologic and Obstetric Investigation, 27, 10–13.

    Article  PubMed  CAS  Google Scholar 

  • Schuette, J., Niederle, N., Scheulen, M.E., Seeber, S. and Schmidt, C.G. (1985) Chemotherapy of metastatic seminoma. British Journal of Cancer, 51, 467–472.

    Article  PubMed  CAS  Google Scholar 

  • Schwarz, S., Berger, P. and Wick, G. (1985) Epitope-selective, monoclonal-antibody-based immunoradiometric assays of predictable specificity for differential measurement of choriogonadotropin and its subunits. Clinical Chemistry, 31, 1322–1328.

    PubMed  CAS  Google Scholar 

  • Sciarra, J.J., Sherwood, L.M., Varma, A.A. and Lundberg, W.B. (1968) Human placental lactogen (HPL) and placental weight (abstract). American Journal of Obstetrics and Gynecology, 101, 413–416.

    PubMed  CAS  Google Scholar 

  • Selby, M.J., Barta, A., Baxter, J.D., Bell, G.I. and Eberhardt, N.L. (1984) Analysis of a major human chorionic somatomammotropin gene: evidence for two functional promoter elements (abstract). Journal of Biological Chemistry, 259, 13131–13138.

    PubMed  CAS  Google Scholar 

  • Selenkow, H.A., Varma, K., Younger, D., White, P. and Emerson, K. (1969) Patterns of serum immunoreactive human placental lactogen (IR-HPL) and chorionic gonadotropin (IR-HCG) in diabetic pregnancy (abstract). Diabetes, 20, 696–706.

    Google Scholar 

  • Selvanayagam, C.S., Tsait, S.Y., Tsait, M.J., Selvanayagam, P. and Saunders, G.F. (1984) Multiple origins of transcription of the human placental lactogen genes. Journal of Biological Chemistry, 259, 4642–4646.

    Google Scholar 

  • Seppala, M., Lehtovirta, P. and Rutanen, E.M. (1978) Detection of chorionic gonadotrophin like activity in infertile cycles. Acta Endocrinologica, 88, 164–168.

    PubMed  CAS  Google Scholar 

  • Seppala, M., Ranta, T., Tontti, K., Stenman, U.H. and Chard, T. (1980) Use of a rapid hCG-beta subunit radioimmunoassay in acute gynaecological emergencies. Lancet, 1, 165–166.

    Article  PubMed  CAS  Google Scholar 

  • Seppala, M., lino, K. and Rutanen, E.V. (1986) Placental proteins in oncology. Clinics in Obstetrics and Gynaecology, 14, 593–610.

    Google Scholar 

  • Shapiro, H.A. and Swarenstein, H.A. (1934) A rapid test for pregnancy on Xenopus 1aevis. Nature, 133, 762.

    Article  Google Scholar 

  • Sharp, N.C, Anthony, F., Miller, J.F. and Masson, G.M. (1986) Early conceptual loss in subfertile patients. British Journal of Obstetrics and Gynaecology, 93, 1072–1077.

    Article  PubMed  CAS  Google Scholar 

  • Sherman, G.B., Wolfe, M.W., Farmerie, T.A., Clay, C.M., Threadgill, D.S., Sharp, D.C. and Nilson, J.H. (1992) A single gene encoded the β-subunits of equine luteinizing hormone and chorionic gonadotropin. Molecular Endocrinology, 6, 951–959.

    Article  PubMed  CAS  Google Scholar 

  • Sherwood, L.M., Burstein, Y. and Schecter, T. (1979) Primary structure of the NH2 terminal extra piece of the precursor to human placental lactogen (abstract). Proceedings of the National Academy of Sciences of the USA, 76, 3819–3823.

    Article  PubMed  CAS  Google Scholar 

  • Shida, M.M., Jackson-Grusby, L.L., Ross, S.R. and Linzer, D.I. (1992) Placental-specific expression from the mouse placental lactogen II gene promoter. Proceedings of the National Academy of Sciences of the USA, 89, 3864–3868.

    Article  PubMed  CAS  Google Scholar 

  • Shinde, S.R., Adil, M.A., Sheth, A.R., Kjoppikar, M.G. and Sheth, N.A. (1981) Ectopic human placental lactogen and beta-human chorionic gonadotropin in gastric fluid of patients with malignant and non-malignant conditions of the stomach (abstract). Oncology, 38, 277–280.

    Article  PubMed  CAS  Google Scholar 

  • Shome, B. and Parlow, A.F. (1973) The primary structure of the hormone specific beta subunit of human pituitary luteinizing hormone (hLH). Journal of Clinical Endocrinology and Metabolism, 36, 618–621.

    Article  PubMed  CAS  Google Scholar 

  • Shome, B. and Parlow, A.F. (1977) The entire linear amino acid sequence (abstract). Journal of Clinical Endocrinology, 45, 1112–1115.

    Article  CAS  Google Scholar 

  • Shu-Rong, Z., Bremme, K., Eneroth, P. and Nordberg, A. (1982) The regulation of in vitro placental release of human chorionic gonadotropin, placental lactogen and prolactin: effects of an adrenergic beta-receptor agonist and antagonist. American Journal of Obstetrics and Gynecology, 143, 444–450.

    PubMed  CAS  Google Scholar 

  • Sideri, M., De Virgiliis, G., Guidobono, F., Borgese, N., Sereni, L.P., Nicolini, U. and Remotti, G. (1983) Immunologically undetectable human placental lactogen in normal pregnancy. Case report. British Journal of Obstetrics and Gynaecology, 90, 771–773.

    Article  PubMed  CAS  Google Scholar 

  • Siler-Khodr, T.M., Khodr, G.S., Vickery, B.H. and Nestor, J.J. (1983) Inhibition of hCG, alpha hCG and progesterone release from human placental tissue in vitro by a GnRH antagonist. Life Sciences, 32, 2741–2745.

    Article  PubMed  CAS  Google Scholar 

  • Siler-Khodr, T.M., Khodr, G.S., Valenzuela, G. and Rhode, J. (1986) Gonadotrophin-releasing hormone effects on placental hormones during gestation. I. Alpha-human chorionic gonadotropin, human chorionic gonadotropin and human chorionic somatomammotropin. Biology of Reproduction, 34, 245–254.

    Article  PubMed  CAS  Google Scholar 

  • Simon, P., Decoster, C., Brocas, H., Schwers, J. and Vassart, G. (1986) Absence of human chorionic somatomammotropin during pregnancy associated with two types of gene deletion. Human Genetics, 74, 235–238.

    Article  PubMed  CAS  Google Scholar 

  • Soares, M.J. and Talamantes, F. (1983) Genetic and litter size effects on serum placental lactogen in the mouse. Biology of Reproduction, 28, 165–171.

    Article  Google Scholar 

  • Soares, M.J. and Talamantes, F. (1985) Placental lactogen secretion in the mouse: in vitro responses and ovarian and hormonal influences. Journal of Experimental Zoology, 234, 97–102.

    Article  PubMed  CAS  Google Scholar 

  • Soares, M.J., Colosi, P. and Talamantes, F. (1982) The development and characterisation of a homologous radioimmunoassay for mouse placental lactogen. Endocrinology, 11, 668–676.

    Article  Google Scholar 

  • Soler, N.G., Nicholson, H.O. and Malins, J.M. (1975) Serial determinations of human placental lactogen in the management of diabetic pregnancy. Lancet, 2, 54–57.

    Article  PubMed  CAS  Google Scholar 

  • Soma, H., Kikuchi, K., Takayama, M., Saegusa, H., Saito, T., Kashiwagi, H. and Sayama, S. (1981) Concentrations of SP1 and beta-hCG in serum and cerebrospinal fluid and concentrations of hCG in urine in patients with trophoblastic tumour. Archives of Gynecology, 230, 321–327.

    Article  PubMed  CAS  Google Scholar 

  • Southard, J.N. and Talamantes, F. (1989) High molecular weight forms of placental lactogen: evidence for lactogen-macroglobulin complexes in rodents and humans. Endocrinology, 125, 791–800.

    Article  PubMed  CAS  Google Scholar 

  • Southard, J.N., Thordarson, G. and Talamantes, F. (1986) Purification and partial characterization of hamster placental lactogen. Endocrinology, 119, 508–514.

    Article  PubMed  CAS  Google Scholar 

  • Southard, J.N., Campbell, G.T. and Talamantes, F. (1987) Hamster placental lactogens: gestational profiles and high molecular weight forms. Endocrinology, 121, 900–906.

    Article  PubMed  CAS  Google Scholar 

  • Sowers, J.R., Pekary, A.E., Hershman, J.M., Kanter, M. and Distefano, J.J. (1979) Metabolism of exogenous human chorionic gonadotropin in men. Journal of Endocrinology, 80, 83–89.

    Article  PubMed  CAS  Google Scholar 

  • Spellacy, W.N., Carlson, K.L. and Birk, S.A. (1966) Dynamics of human placental lactogen. American Journal of Obstetrics and Gynecology, 96, 1164–1173.

    PubMed  CAS  Google Scholar 

  • Spellacy, W.N., Buhi, W.C., Schram, J.D. and Birk, S.A. (1971) Control of human chorionic somatomammotrophin levels during pregnancy. Obstetrics and Gynecology, 37, 567–572.

    PubMed  CAS  Google Scholar 

  • Spellacy, W.N., Buhi, W.C. and Birk, S.A. (1975) The effectiveness of human placental lactogen measurements as an adjunct in decreasing perinatal deaths. American Journal of Obstetrics and Gynecology, 121, 835–844.

    PubMed  CAS  Google Scholar 

  • Spellacy, W.N., Buhi, W.C. and Birk, S.A. (1977) The effect of smoking on serum human placental lactogen levels. American Journal of Obstetrics and Gynecology, 127, 232–234.

    PubMed  CAS  Google Scholar 

  • Spellacy, W.N., Cruz, A., Kalra, P.S., Kellner, K.R., Quinlan, R.W. and Buhi, W.C. (1979) Oxytocin challenge test results compared with simultaneously studied serum human placental lactogen and free estriol levels in high-risk pregnant women. American Journal of Obstetrics and Gynecology, 135, 917–923.

    PubMed  CAS  Google Scholar 

  • Spencer, K., Coombes, E.J., Mallard, A.S. and Milford-Ward, A. (1992) Free beta human choriogonadotropin in Down’s syndrome screening: a multicentre study of its role compared with other biochemical markers. Annals of Clinical Biochemistry, 29, 506–518.

    PubMed  Google Scholar 

  • Spies, H.G. and Chappel, S.C. (1984) Mammals: non-human primates, in Marshall’s Physiology of Reproduction, Vol. 4, 4th edn (ed. G.E. Lamming), Churchill Livingstone, Edinburgh, pp. 659–712.

    Google Scholar 

  • Sprague, A.D., Duhring, J.L., Moser, R.J. and Hollingsworth, D. (1973) Maternal and fetal levels of HCS in preeclampsia. Obstetrics and Gynecology, 41, 770–773.

    PubMed  CAS  Google Scholar 

  • Stanhope, C.R., Smith, J.P., Brittan, J.C. and Crosley, P.K. (1979) Serial determination of marker substances in ovarian cancer. Gynecological Oncology, 8, 284–287.

    Article  CAS  Google Scholar 

  • Stenman, U.H., Bidart, J.M., Birken, S., Mann, K., Nisula, B. and O’Connor, J. (1993) Standardization of protein immunoprocedures. Choriogonadotropin (CG). Scandinavian Journal of Clinical Laboratory Investigation, 53, Suppl. 216, 42–79.

    Article  CAS  Google Scholar 

  • Stevens, V.C. (1975) Female contraception by immunization with hCG — prospects and status, in Immunization with Hormones in Reproductive Research, (ed. E. Nieschlag), North-Holland Publishing, Amsterdam, pp. 217–222.

    Google Scholar 

  • Stevens, V.C. (1976) Antifertility effects of immunizations with intact, subunits and fragments of hCG, in Physiological Effects of Immunity against Reproductive Hormones, (eds R.G. Edwards and M.H. Johnson), Cambridge University Press, Cambridge, pp. 249–264.

    Google Scholar 

  • Stevens, V.C. (1986) Use of synthetic peptides as immunogens for developing a vaccine against human chorionic gonadotropin, in Synthetic Peptides as Antigens, Wiley, Chichester, pp. 200–225.

    Google Scholar 

  • Stevens, V.C. and Crystle, G.D. (1973) Effects of immunization with hapten-coupled hCG on the human menstrual cycle. Obstetrics and Gynecology, 42, 484–495.

    Google Scholar 

  • Stevens, V.C., Powell, T.E., Lee, A.C. and Griffin, D. (1981) Antifertility effects of immunization on female baboons with C-terminal peptides of the β-subunit of human chorionic gonadotropin. Fertility and Sterility, 36, 98–105.

    PubMed  CAS  Google Scholar 

  • Stewart, F. and Maher, J.K. (1991) Analysis of horse and donkey gonadotrophin genes using southern blotting and DNA hybridization techniques. Journal of Reproduction and Fertility, 44, 19–25.

    PubMed  CAS  Google Scholar 

  • Stewart, M.O., Whittaker, P.G., Persson, B., Hanson, U. and Lind, T. (1989) A longitudinal study of circulating progesterone, oestradiol, hCG and hPL during pregnancy in type 1 diabetic mothers. British Journal of Obstetrics and Gynaecology, 96, 415–423.

    Article  PubMed  CAS  Google Scholar 

  • Stockell Hartree, A. (1989) Multiple forms of pituitary and placental gonadotropins, in Oxford Reviews of Reproductive Biology, (ed. S.R. Milligan), Oxford University Press, Oxford, pp. 147–165.

    Google Scholar 

  • Stoning, P.O., Gaines-Das, R.E. and Bangham, D.R. (1980) International reference preparation of human chorionic gonadotropin for immunoassay: potency estimates in various bioassay and protein binding assay systems; and international reference preparations of the a and β subunits of human chorionic gonadotropin for immunoassay. Journal of Endocrinology, 84, 295–310.

    Article  Google Scholar 

  • Suganuma, N., Matzuk, M.M. and Boime, I. (1989) Elimination of disulphide bonds affects assembly and secretion of the human chorionic gonadotropin β-subunit. Journal of Biological Chemistry, 264, 19302–19307.

    PubMed  CAS  Google Scholar 

  • Suwa, S. and Friesen, H. (1969a) Biosynthesis of human placental proteins and human placental lactogen (hPL) in vitro. I. Identification of 3H-labelled hPL. Endocrinology, 85, 1028–1036.

    Article  PubMed  CAS  Google Scholar 

  • Suwa, S. and Friesen, H. (1969b) Biosynthesis of human placental proteins and human placental lactogen (hPL) in vitro. II. Dynamic studies of normal term placentas. Endocrinology, 85, 1037–1045.

    Article  PubMed  CAS  Google Scholar 

  • Swenne, I., Hill, DJ., Strain, A.J. and Milner, R.D.G. (1987) Effects of human placental lactogen and growth hormone on the production of insulin and somatomedin C/insulin-like growth factor I by human fetal pancreas in tissue culture. Journal of Endocrinology, 113, 297–303.

    Article  PubMed  CAS  Google Scholar 

  • Taketani, Y., Taga, M., Minaguchi, H., Mizuno, M. and Sakamoto, S. (1984) Elevated concentrations of prolactin, human growth hormone and human placental lactogen in cord sera obtained for light-for-date babies near term. Asia-Oceania Journal of Obstetrics and Gynaecology, 10, 235–240.

    Article  PubMed  CAS  Google Scholar 

  • Talmadge, K., Vamvakopoulos, N.C. and Fiddes, J.C. (1984a) Evolution of the genes for the beta subunit of human chorionic gonadotropin and luteinizing hormone. Nature, 307, 37–40.

    Article  PubMed  CAS  Google Scholar 

  • Talmadge, K., Boorstein, W.R., Vamvakopoulos, N.C., Gething, M.J. and Fiddes, J.C. (1984b) Only three of the seven human chorionic gonadotrophin β-subunit genes can be expressed in the placenta. Nucleic Acids Research, 12, 8145–8436.

    Article  Google Scholar 

  • Tatra, G., Tempfer, H. and Placheta, P. (1977) Influence of amino acid administration on serum concentrations of pregnancy-specific proteins SP1 and hPL during last trimester of pregnancy. European Journal of Gynecology and Reproductive Biology, 7, 29–32.

    Article  CAS  Google Scholar 

  • Tatra, G., Tempfer, H. and Gruber, W. (1984) Influence of 16-beta-methylprednisone on serum concentrations of pregnancy specific protein SP1 and hPL during the last trimester of pregnancy. European Journal of Gynecology and Reproductive Biology, 6, 49–52.

    Google Scholar 

  • Taylor, M.J., Jenkin, G., Robinson, J.S., Thorburn, G.D., Friesen, H. and Chan, J.S.D. (1980) Concentrations of placental lactogen in chronically catheterized ewes and fetuses in late pregnancy. Journal of Endocrinology, 85, 27–34.

    Article  PubMed  CAS  Google Scholar 

  • Taylor, M.J., Jenkin, G., Robinson, J.S. and Thorburn, G.D. (1982) Regulation of ovine placental lactogen: lack of correlation with progesterone secretion. Journal of Endocrinology, 95, 275–279.

    Article  PubMed  CAS  Google Scholar 

  • Taylor, M.J., Robinson, J.S., Jenkin, G. and Thorburn, G.D. (1983a) Ovine placental lactogen concentrations during premature delivery induced by infusion of dexamethasone or adre-nocorticotrophin to the fetus. Journal of Endocrinology, 98, 197–200.

    Article  PubMed  CAS  Google Scholar 

  • Taylor, M.J., McMillen, C., Jenkin, G., Robinson, S. and Thorburn, G.D. (1983b) The regulation of ovine placental lactogen the role of the fetal hypothalamic-pituitary axis. Journal of Developmental Physiology, 5, 251–258.

    PubMed  CAS  Google Scholar 

  • Tepper, M. A. and Roberts, J.L. (1984) Evidence for only one β-luteinizing hormone and no β-chorionic gonadotropin gene in the rat. Endocrinology, 115, 385–391.

    Article  PubMed  CAS  Google Scholar 

  • Thanavale, Y.Y., Hay, F.C. and Stevens, V.C. (1978) Immunological control of fertility: measurement of the affinity of antibodies to human chorionic gonadotropin. Clinical and Experimental Immunology, 33, 403–409.

    Google Scholar 

  • Thomas, G.M. (1985) Controversies in the management of testicular seminoma. Cancer, 55, 2296–2302.

    Article  PubMed  CAS  Google Scholar 

  • Thomson, M.A.R., Duncan, R.O. and Cunningham, P. (1988) The value of serum human placental lactogen and Schwangerschaftsprotein 1 to determine gestation in an ante-natal population. Human Reproduction, 3, 463–465.

    PubMed  CAS  Google Scholar 

  • Thordarson, G., Villalobos, R., Colosi, P., Southard, J., Ogren, L. and Talamantes, F. (1986) Lactogenic response of cultured mouse mammary epithelial cells to mouse placental lactogen. Journal of Endocrinology, 109, 263–274.

    Article  PubMed  CAS  Google Scholar 

  • Thordarson, G., McDowell, G.H., Smith, S.V., Iley, S. and Forsyth, I.A. (1987) Effects of continuous intravenous infusion of an ovine placental extract enriched in placental lactogen on plasma hormones, metabolites, and metabolite biokinetics in non-pregnant sheep. Journal of Endocrinology, 113, 277–283.

    Article  PubMed  CAS  Google Scholar 

  • Tominaga, N., Sakakibaro, R. and Yokoo, Y. (1989) Existence of associated, non-associated and oligomeric forms of human chorionic gona-dotropin subunits in placental extracts. Journal of Biochemistry (Tokyo), 105, 992–997

    CAS  Google Scholar 

  • Tonkowicz, P.A. and Voogt, J.L. (1984) Ovarian and fetal control of rat placental lactogen and prolactin secretion at midpregnancy. Endocrinology, 114, 254–259.

    Article  PubMed  CAS  Google Scholar 

  • Tormey, D.C., Waalkes, T.P., Ahmann, D., Gehrke, C.W., Zumwatt, R.W., Snyder, J. and Hansen, H. (1975) Biological markers in breast carcinoma. I. Incidence of abnormalities of CEA, hCG, 3 polyamines and 3 minor nucleotides. Cancer, 35, 1095–1100.

    Article  PubMed  CAS  Google Scholar 

  • Trapp, M., Kato, K., Bohnet, H.G., Gerhard, I., Weise, H.C. and Leidenberger, F. (1986) Human placental lactogen and unconjugated estriol concentrations in twin pregnancy: monitoring of fetal development in intrauterine growth retardation and single intrauterine death. American Journal of Obstetrics and Gynecology, 155, 1027–1031.

    PubMed  CAS  Google Scholar 

  • Tsong, Y.Y., Chang, C.C. and Nash, H.A. (1985) Formulation of a potent anti pregnancy vaccine based on the β-subunit of human chorionic gonadotropin (β-hCG). I. Alternative macromol-ecular carriers. Journal of Reproductive Immunology, 7, 139–149.

    Article  PubMed  CAS  Google Scholar 

  • Tsunasawara, S., Liu, W.K., Burleigh, B.D. and Ward, D.N. (1977) Studies of disulphide bond location in ovine lutropin β-subunit. Biochimica et Biophysica Acta, 492, 340–356.

    Article  Google Scholar 

  • Tullner, W. and Hertz, R. (1966) Chorionic gonadotropin levels in the rhesus monkey during early pregnancy. Endocrinology, 78, 204–207.

    Article  PubMed  CAS  Google Scholar 

  • Tulsky, A.S. and Koff, A.K. (1957) Some observations on the role of the corpus luteum in early pregnancy. Fertility and Sterility, 8, 181–186.

    Google Scholar 

  • Tyson, J.E., Rabinowitz, D., Merimee, T.J. and Friesen, H. (1969) Response of plasma insulin and human growth hormone to arginine in pregnant and post partum females. American Journal of Obstetrics and Gynecology, 103, 313–319.

    PubMed  CAS  Google Scholar 

  • Ursell, W., Brudenell, M. and Chard, T. (1973) Placental lactogen levels in diabetic pregnancy. British Medical Journal, 1, 80–82.

    Article  Google Scholar 

  • Vaitukaitis, J.L. (1973) Immunological and physical characterization of human chorionic gonadotropin (hCG) secreted by tumors. Journal of Clinical Endocrinology and Metabolism, 37, 505–514.

    Article  PubMed  CAS  Google Scholar 

  • Vaitukaitis, J.L. (1985) Radioimmunoassay of human choriogonadotropin. Clinical Chemistry, 31, 1749–1754.

    PubMed  CAS  Google Scholar 

  • Vaitukaitis, J. and Ebersole, E.R. (1976) Evidence for altered synthesis of human chorionic gonadotropin in gestational trophoblastic tumours. Journal of Clinical Endocrinology and Metabolism, 42, 1048–1055.

    Article  PubMed  CAS  Google Scholar 

  • Vaitukaitis, J.L., Braunstein, G.D. and Ross, G.T. (1972) A RIA which specifically measures hCG in the presence of LH. American Journal of Obstetrics and Gynecology, 113, 751–757.

    PubMed  CAS  Google Scholar 

  • Valkirs, G.E. and Barton, R. (1985) Immunocon-centration — a new format for solid-phase immu-noassays. Clinical Chemistry, 31, 1427–1431.

    PubMed  CAS  Google Scholar 

  • Van Hall, E.V., Vaitukaitis, J.L. and Ross, G.T. (1971) Immunological and biological activity of hCG following progressive desialation. Endocrinology, 88, 456–464.

    Article  PubMed  Google Scholar 

  • Virgin, J.B., Silver, B.J., Thomason, A.R. and Nilson, J.H. (1985) The gene for the β-subunit of bovine luteinizing hormone encodes a gonadotropin mRNA with an unusually short 5′-untranslated region. Journal of Biological Chemistry, 260, 7072–7077.

    PubMed  CAS  Google Scholar 

  • Voogt, J., Robertson, M. and Friesen, H. (1982) Inverse relationship of prolactin and rat placental lactogen during pregnancy. Biology of Reproduction, 26, 800–805.

    Article  PubMed  CAS  Google Scholar 

  • Voogt, J.L., Pakrasi, P.L., Johnson, D.C. and Dey, S.K. (1985) Evidence for pituitary regulation of placental lactogen in the rat. Journal of Endocrinology, 107, 121–126.

    Article  PubMed  CAS  Google Scholar 

  • Wald, N.J., Cuckle, H.S., Densem, J.W., Nanchahal, K., Royston, P., Chard, T., Haddow, J.E., Knight, G.J., Palomaki, G.E. and Canick, J.A. (1988) Maternal serum screening for Down’s syndrome in early pregnancy. British Medical Journal, 297, 883–887.

    Article  PubMed  CAS  Google Scholar 

  • Walker, W.H., Fitzpatrick, S.L. and Saunders, G.F. (1990) Human placental lactogen transcriptional enhancer. Journal of Biological Chemistry, 265, 12940–12948.

    PubMed  CAS  Google Scholar 

  • Walsh, S.W., Wolf, R.C., Meyer, R.K., Aubert, M.L. and Friesen, H.G. (1977) Chorionic gona-dotropin, chorionic somatomammotropin, and prolactin in the uterine vein and peripheral plasma of pregnant rhesus monkeys. Endocrinology, 100, 851–855.

    Article  PubMed  CAS  Google Scholar 

  • Wang, H., Segal, S.J. and Koide, S.S. (1988) Purification and characterization of an incompletely glycosylated form of human chorionic gonadotropin from human placenta. Endocrinology, 123, 795–803.

    Article  PubMed  CAS  Google Scholar 

  • Wang, Y., Schwartz, P.E., Chambers, J.T. and Cole, L.A. (1988) Urinary gonadotrophin fragment (UGF) in cancers of the reproductive tract. II. Initial series studies. Gynecological Oncology, 31, 91–100.

    Article  CAS  Google Scholar 

  • Ward, R.H.T., Letchworth, A.T., Niven, P.A.R. and Chard, T. (1974) Placental lactogen levels in rhesus isoimmunization. British Medical Journal, 1, 347–349.

    Article  PubMed  CAS  Google Scholar 

  • Ward, R.H.T., Whyley, G.A., Fairweather, D.V.I., Allen, E.I. and Chard, T. (1977) A comparative study of plasma 17β-oestradiol, progesterone, placental lactogen and chorionic gonadotrophin in abortion induced with intra-amniotic prosta-glandin F. British Journal of Obstetrics and Gynaecology, 84, 363–369.

    Article  PubMed  CAS  Google Scholar 

  • Warren, W.C., Liang, R., Krivi, G.G., Siegel, N.R. and Anthony, R.V. (1990) Purification and structural characterization of ovine placental lactogen. Journal of Endocrinology, 126, 141–149.

    Article  PubMed  CAS  Google Scholar 

  • Waters, M.J., Oddy, V.H., McCloghry, C.E., Gluckman, P.D., Diplock, R., Owens, P.C. and Brinsmead, M.W. (1985) An examination of the proposed roles of placental lactogen in the ewe by means of antibody neutralization. Journal of Endocrinology, 106, 377–386.

    Article  PubMed  CAS  Google Scholar 

  • Wehmann, R.E. and Nisula, B.C. (1980a) Renal clearance rates of the subunits of human chorionic gonadotropin in man. Journal of Clinical Endocrinology and Metabolism, 50, 101–105.

    Article  Google Scholar 

  • Wehmann, R.E. and Nisula, B.C. (1980b) Characterization of a discrete degradation product of the human chorionic gonadotropin β-subunit in humans. Journal of Clinical Endocrinology and Metabolism, 51, 101–105.

    Article  PubMed  CAS  Google Scholar 

  • Wehmann, R.E. and Nisula, B.C. (1981) The metabolic and renal clearance rates of purified human chorionic gonadotropin. Journal of Clinical Investigation, 68, 186–194.

    Article  Google Scholar 

  • Wehmann, R.E., Blithe, D.L., Akar, A.H. and Nisula, B.C. (1987) β-core fragments are contaminants of the World Health Organization Reference Preparations of human choriogona-dotropin and its α-subunit. Journal of Endocrinology, 117, 147–152.

    Article  Google Scholar 

  • Wehmann, R.E., Blithe, D.L., Flack, M.R. and Nisula, B.C. (1989) Metabolic clearance rate and urinary clearance of purified beta-core. Journal of Clinical Endocrinology and Metabolism, 69, 510–517.

    Article  PubMed  CAS  Google Scholar 

  • Wehmann, R.E., Blithe, D.L., Akar, A.H. and Nisula, B.C. (1990) Disparity between β-core levels in pregnancy urine and serum: implications for the origin of urinary β-core. Journal of Clinical Endocrinology and Metabolism, 70, 371–378.

    Article  PubMed  CAS  Google Scholar 

  • Westergaard, J.C., Teisner, B., Grudzinskas, J.G. and Chard, T. (1985a) Placental function studies in low birth weight infants with and without dysmaturity. Obstetrics and Gynaecology, 65, 316–318.

    CAS  Google Scholar 

  • Westergaard, J.G., Teisner, B., Grudzinskas, J.G. and Chard, T. (1985b) Single measurements of chorionic gonadotropin and Schwangerschafts protein for assessing gestational age and predicting day of delivery. Journal of Reproductive Medicine, 30, 57–60.

    PubMed  CAS  Google Scholar 

  • Westergaard, J.G., Teisner, B., Grudzinskas, J.G. and Chard, T. (1985c) Pregnancy associated plasma protein A (PAPP-A) in preovulatory, nonovulatory healthy and atretic human ovarian follicles during the natural cycle. Annals of the New York Academy of Science, 442, 205–211.

    Article  CAS  Google Scholar 

  • White, J.W., Sobnosky, M., Rogers, B.L., Walker, W.H. and Saunders, G.F. (1993) Nucleotide sequence of a transcriptional enhancer located 2.2 kb 3′ of a human placental lactogen-encoding gene. Gene, 84, 521–522.

    Article  Google Scholar 

  • Whitfield, G.K. and Kourides, I.A. (1985) Expression of chorionic gonadotropin alpha-and beta-genes in normal and neoplastic human tissues: relationship to deoxyribonucleic acid structure. Endocrinology, 117, 231–236.

    Article  PubMed  CAS  Google Scholar 

  • Whittaker, P.G., Taylor, A. and Lind, T. (1983) Unsuspected pregnancy loss in healthy women. Lancet, 1, 1126–1127.

    Article  PubMed  CAS  Google Scholar 

  • WHO (1985) Special programme of research, development and research training in human reproduction. Fourteenth Annual Report, 53-61.

    Google Scholar 

  • Wide, L. and Gemzell, C.A. (1960) An immunological pregnancy test. Acta Endocrinology, 35, 261–267.

    CAS  Google Scholar 

  • Wide, L. and Hobson, B. (1974) Relationship between the sex of the fetus and the amount of human chorionic gonadotropin in placentae from the 10th — 20th week of pregnancy. Journal of Endocrinology, 61, 75–81.

    Article  PubMed  CAS  Google Scholar 

  • Wilcox, A.J., Weinburg, C.R., Wehmann, R.E., Armstrong, E.G., Canfield, R.E. and Nisula, B.C. (1985) Measuring early pregnancy loss: laboratory and field methods. Fertility and Sterility, 44, 366–374.

    PubMed  CAS  Google Scholar 

  • Willey, K.P. and Leidenberger, F. (1989) Functionally distinct agonist and receptor-binding regions in human chorionic gonadotropin. Journal of Biological Chemistry, 264, 19716–19729.

    PubMed  CAS  Google Scholar 

  • Wilson, C.A., Leigh, A.J. and Chapman, A.J. (1990) Gonadotropin glycosylation and function. Journal of Endocrinology, 125, 3–14.

    Article  PubMed  CAS  Google Scholar 

  • Wilson, E.A. and Jawad, M.J. (1982) Stimulation of human chorionic gonadotropin secretion by glucocorticoids. American Journal of Obstetrics and Gynecology, 142, 344–348.

    PubMed  CAS  Google Scholar 

  • Wilson, E.A., Jawad, M.J. and Dickson, L.H. (1980) Suppression of human chorionic gonadotropin by progestational steroids. American Journal of Obstetrics and Gynecology, 138, 708–713.

    PubMed  CAS  Google Scholar 

  • Wilson, E.A., Jawad, M.J. and Powell, D.E. (1984a) Effect of estradiol and progesterone on human chorionic gonadotropin secretion in vitro. American Journal of Obstetrics and Gynecology, 149, 143–148.

    PubMed  CAS  Google Scholar 

  • Wilson, E.A., Jawad, M.J. and Vernon, M.W. (1984b) Effect of epidermal growth factor on hormone secretion by term placenta in organ culture. American Journal of Obstetrics and Gynecology, 149, 579–580.

    PubMed  CAS  Google Scholar 

  • Wiltberger, P.B. and Miller, D.F. (1948) The male frog, Rana pipiens, as a new test animal for early pregnancy. Science, 107, 198.

    Article  PubMed  CAS  Google Scholar 

  • Wooding, F.B., Morgan, G., Forsyth, I.A., Butcher, G., Hutchings, A., Billingsley, S.A. and Gluckman, P.D. (1992) Light and electron microscopic studies of cellular localization of oPL with monoclonal and polyclonal antibodies. Journal of Histochemistry and Cytochemistry, 40, 1001–1009.

    Article  PubMed  CAS  Google Scholar 

  • Yamaguchi, M., Endo, H., Thordarson, G., Ogren, L. and Talamantes, F. (1992) Modulation of mouse placental lactogen-I secretion in vitro: effects of progesterone and mouse placental lactogen-II. Endocrinology, 130, 2897–2905.

    Article  PubMed  CAS  Google Scholar 

  • Yamini, G., Chard, T. and Blake, M.E. (1972) Some biological effects of antisera to human placental lactogen in rodents. Journal of Endocrinology, 55, 29.

    Google Scholar 

  • Yazaki, K., Yazaki, C., Wakabayashi, K. and Igarashi, M. (1980) Isoelectric heterogeneity of human chorionic gonadotropin: presence of choriocarcinoma-specific components. American Journal of Obstetrics and Gynecology, 138, 189–194.

    PubMed  CAS  Google Scholar 

  • Ylikorkala, O. and Pennanen, S. (1973) Human placental lactogen (hPL) levels in maternal serum during abortion induced by intra-and extra amniotic injection of prostaglandin F2-alpha. Journal of Obstetrics and Gynaecology of the British Commonwealth, 80, 927–931.

    Article  PubMed  CAS  Google Scholar 

  • Yogev, L., Gibber, J.R. and Terkel, J. (1983) Failure of rat placenta to inhibit rat prolactin secretion by ectopic pituitary gland. Journal of Endocrinology, 97, 91–95.

    Article  PubMed  CAS  Google Scholar 

  • Yoshimi, T., Strott, C., Marshall, J. and Lipsett, M. (1969) Corpus luteum function in early pregnancy. Journal of Clinical Endocrinology and Metabolism, 29, 225–230.

    Article  PubMed  CAS  Google Scholar 

  • Yoshimoto, Y., Wolfsen, A.R., Hirose, F. and Odell, W.D. (1979) Human chorionic gonadotropin-like material: presence in normal human tissues. American Journal of Obstetrics and Gynecology, 134, 729–733.

    PubMed  CAS  Google Scholar 

  • Yovich, J.L., Wilcox, D.L., Grudzinskas, H.G. and Bolton, A.E. (1986) The prognostic value of hCG, PAPP-A, oestradiol-17 beta and progesterone in early human pregnancy. Australia and New Zealand Journal of Obstetrics and Gynaecology, 26, 59–64.

    Article  CAS  Google Scholar 

  • Zeitler, P., Markoff, E. and Handwerger, S. (1983) Characterization of the synthesis and release of human placental lactogen and human chorionic gonadotropin by an enriched population of dispersed placental cells. Journal of Clinical Endocrinology and Metabolism, 57, 812–818.

    Article  PubMed  CAS  Google Scholar 

  • Zondek, B. (1930) Schwangerschafts reaktion aus dem harn bei Mensch und Tier. Klinische Wochenschrift, 9, 2285–2289.

    Article  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 G. E. Lamming

About this chapter

Cite this chapter

Butt, W.R., Chard, T., Iles, R.K. (1994). Hormones of the Placenta: hCG and hPL. In: Lamming, G.E. (eds) Marshall’s Physiology of Reproduction. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1286-4_5

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-1286-4_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4561-2

  • Online ISBN: 978-94-011-1286-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics