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Rhodium, iridium and palladium compounds as experimental anticancer drugs

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Metal Compounds in Cancer Therapy

Abstract

In recent decades a large amount of effort has been devoted to the study of the antitumour properties of metal complexes. Whereas much of this effort has concentrated on identifying platinum complexes having improved characteristics compared to cisplatin, there have also been numerous investigations involving other complexes of the transition metals. It is to be hoped that any new metal drug would have reduced toxic side-effects compared to platinum agents in current use but another objective is to develop a drug that is active against those tumours that are resistant to the platinum compounds. Analogues of cisplatin might well display a similar spectrum of clinical activity to that of cisplatin, as was observed for the second generation agent carboplatin (Canetta et al., 1990; Reed, 1991). However, a complex having a different metal coordination centre would have an increased chance of showing a different range of activity.

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Authors
  1. Robert G. Buckley
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Editors and Affiliations

  1. Johnson Matthey Technology Centre, Reading, UK

    Simon P. Fricker

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© 1994 Springer Science+Business Media Dordrecht

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Buckley, R.G. (1994). Rhodium, iridium and palladium compounds as experimental anticancer drugs. In: Fricker, S.P. (eds) Metal Compounds in Cancer Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1252-9_5

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  • DOI: https://doi.org/10.1007/978-94-011-1252-9_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4545-2

  • Online ISBN: 978-94-011-1252-9

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