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Genetic factors in coronary heart disease pp 373–383Cite as

Gene-environment Interaction: Variability Gene Concept

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 156))

Abstract

Studies on genetic markers in relation to risk factors for atherosclerotic disease, particularly coronary heart disease (CHD), have traditionally focused on the search for correlations between genetic markers and absolute risk factor levels under certain ‘basic’ conditions (usually the fasting state). Since Western man is postprandial for more than half of every 24-hour period, measurement of lipid levels in the fasting state provides little information about fluctuations in risk factor levels through a 24-hour period. Data on day-to-day fluctuations in lipid levels are scarce. It is known, however, that fasting cholesterol levels may exhibit significant fluctuations when blood samples drawn at intervals of many weeks or several months are examined.

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Author information

Authors and Affiliations

  1. Institute of Medical Genetics, University of Oslo and Ullevål University Hospital, P.O. Box 1036, Blindem, N-0135, Oslo 3, Norway

    Kåre Berg

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  1. Kåre Berg
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Editor information

Editors and Affiliations

  1. Sackler Medical Faculty, Epidemiology and Biostatistics, the Neufeld Cardiac Research Institute, Sheba Medical Center and Tel Aviv University, Israel

    Uri Goldbourt (Professor of Epidemiology and Preventive Medicine, Head) (Professor of Epidemiology and Preventive Medicine, Head)

  2. Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden

    Ulf de Faire (Professor) (Professor)

  3. Institute of Medical Genetics, Department of Medical Genetics, Ullevål University Hospital, Oslo, Norway

    Kåre Berg (Professor of Medicine, Chairman, Director and Physician-in-Chief) (Professor of Medicine, Chairman, Director and Physician-in-Chief)

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© 1994 Springer Science+Business Media Dordrecht

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Berg, K. (1994). Gene-environment Interaction: Variability Gene Concept. In: Goldbourt, U., de Faire, U., Berg, K. (eds) Genetic factors in coronary heart disease. Developments in Cardiovascular Medicine, vol 156. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1130-0_26

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  • DOI: https://doi.org/10.1007/978-94-011-1130-0_26

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4494-3

  • Online ISBN: 978-94-011-1130-0

  • eBook Packages: Springer Book Archive

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