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Genetic factors in coronary heart disease pp 331–336Cite as

Intimal Thickening, Morphology and Epidemiology

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 156))

Abstract

The idea that early structural changes in coronary arteries are precursors of adult atherosclerosis and eventual coronary heart disease (CHD) morbidity and mortality rests on a solid body of evidence. The function of the intimai smooth muscle cell (SMC) in atherogenesis is highly significant1. Intimai SMCs originate in the media. Proliferation of SMC and migration to the intima is the hallmark of the early stages of lesion formation. Nilsson and Nilsson outline in this book (Chapter 24) the embryonic development of the artery, the role of SMC in lesion formation, the modulation of SMC phenotype between the synthetic and contractile phenotypes and the factors that stimulate SMC growth. They discuss the response-to-injury theory as well as the alternative theory of monoclonal origin of SMC.

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Authors and Affiliations

  1. Section of Epidemiology and Biostatistics Henry N. Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer, 52621, Israel

    Uri Goldbourt

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  1. Uri Goldbourt
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Editors and Affiliations

  1. Sackler Medical Faculty, Epidemiology and Biostatistics, the Neufeld Cardiac Research Institute, Sheba Medical Center and Tel Aviv University, Israel

    Uri Goldbourt (Professor of Epidemiology and Preventive Medicine, Head) (Professor of Epidemiology and Preventive Medicine, Head)

  2. Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden

    Ulf de Faire (Professor) (Professor)

  3. Institute of Medical Genetics, Department of Medical Genetics, Ullevål University Hospital, Oslo, Norway

    Kåre Berg (Professor of Medicine, Chairman, Director and Physician-in-Chief) (Professor of Medicine, Chairman, Director and Physician-in-Chief)

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© 1994 Springer Science+Business Media Dordrecht

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Goldbourt, U. (1994). Intimal Thickening, Morphology and Epidemiology. In: Goldbourt, U., de Faire, U., Berg, K. (eds) Genetic factors in coronary heart disease. Developments in Cardiovascular Medicine, vol 156. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1130-0_23

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  • DOI: https://doi.org/10.1007/978-94-011-1130-0_23

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4494-3

  • Online ISBN: 978-94-011-1130-0

  • eBook Packages: Springer Book Archive

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