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Human Obesities

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Genetic factors in coronary heart disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 156))

Abstract

A high body mass for stature and more importantly a high body fat content are associated with an augmented risk for various atherosclerotic diseases, such as coronary heart disease (CHD), and with an increased death rate attributable to CHD1–3. Several prospective studies have shown that the risk is more important when the excess fat mass of the obese person is stored primarily on the trunk and abdominal areas (upper body fat or android obesity) than when it resides in the gluteo-femoral depots (lower body fat or gynoid obesity)4–6. Several clinical investigations have recently suggested that the risks may be even higher when the abdominal visceral adipose tissue mass is excessively large7–10. However, there are no data yet on the role of abdominal visceral obesity in the aetiology of CHD or death rate from CHD.

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References

  1. Lew EA, Garfinkel L. Variations in mortality by weight among 750,000 men and women. J Chron Dis. 1979;32:563–76.

    Article  PubMed  CAS  Google Scholar 

  2. Bray GA, Gray DS. Obesity. Part I–Pathogenesis. West J Med. 1988;149:429–41.

    PubMed  CAS  Google Scholar 

  3. Lindsted K, Tonstad S, Kuzma JW. Body mass index and patterns of mortality among Seventh-day Adventist men. Int J Obes. 1991;15:397–406.

    PubMed  CAS  Google Scholar 

  4. Lapidus L, Bengtsson C, Larsson B, Pennert K, Rybo E, Sjöström L. Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow-up of participants in the population study of women in Gothenburg, Sweden. Br Med J. 1984;289:1261–3.

    Article  Google Scholar 

  5. Larsson B, Svardsudd K, Welin L, Wilhemsen L, Björntorp P, Tibblin G. Abdominal adipose tissue distribution, obesity and risk of cardiovascular disease and death: 13 year follow-up of participants in the study of men born in 1913. Br Med J. 1984;288:1401–4.

    Article  CAS  Google Scholar 

  6. Ducimetière P, Richard J, Cambien F. The pattern of subcutaneous fat distribution in middle-aged men and the risk of coronary heart disease: the Paris Prospective Study. Int J Obes. 1986;10:229–40.

    PubMed  Google Scholar 

  7. Björntorp P. Portal adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis. 1990;10:493–6.

    Article  PubMed  Google Scholar 

  8. Bouchard C, Bray GA, Hubbard V. Basic and clinical aspects of regional fat distribution. Am J Clin Nutr. 1990;52:946–50.

    PubMed  CAS  Google Scholar 

  9. Després JP, Moorjani S, Lupien PJ, Tremblay A, Nadeau A, Bouchard C. Regional distribution of body fat, plasma lipoproteins, and cardiovascular disease. Arteriosclerosis. 1990;10:497–511.

    Article  PubMed  Google Scholar 

  10. Kissebah AH, Freedman DS, Peiris AN. Health risks of obesity. Med Clin N Am. 1989;73:111–38.

    PubMed  CAS  Google Scholar 

  11. Bouchard C. Heredity and the path to overweight and obesity. Med Sci Sport Exerc. 1991;23:285–91.

    CAS  Google Scholar 

  12. Garn SM, Leonard WR, Hawthorne VM. Three limitations of the body mass index. Am J Clin Nutr. 1986;44:996–7.

    PubMed  CAS  Google Scholar 

  13. Bray GA. The inheritance of corpulence. In: Cioffi LA, James WPT, Van Itallie TB, eds. The body weight regulatory system: normal and disturbed mechanisms. New York: Raven Press; 1981:185–95.

    Google Scholar 

  14. Bouchard C. Genetic factors in obesity. Med Clin N Am. 1989;73:67–81.

    PubMed  CAS  Google Scholar 

  15. Bouchard C, Pérusse L. Heredity and body fat. Annu Rev Nutr. 1988;8:259–77.

    Article  PubMed  CAS  Google Scholar 

  16. Stunkard AJ, Harris JR, Pedersen NL, McClearn GE. The body-mass index of twins who have been reared apart. N Engl J Med. 1990;322:1483–7.

    Article  PubMed  CAS  Google Scholar 

  17. Stunkard AJ, Foch TT, Hrubec Z. A twin study of human obesity. J Am Med Assoc. 1986;256:51–4.

    Article  CAS  Google Scholar 

  18. Pérusse L, Leblanc C, Bouchard C. Intergeneration transmission of physical fitness in the Canadian population. Can J Sport Sci. 1988;13:8–14.

    PubMed  Google Scholar 

  19. Bouchard C, Pérusse L, Leblanc C, Tremblay A, Thériault G. Inheritance of the amount and distribution of human body fat. Int J Obes. 1988;12:205–15.

    PubMed  CAS  Google Scholar 

  20. Moll PP, Burns TL, Lauer RM. The genetic and environmental sources of body mass index variability: the Muscatine Ponderosity Family Study. Am J Hum Genet. 1991;49:1243–55.

    PubMed  CAS  Google Scholar 

  21. Price RA, Ness R, Laskarzewski P. Common major gene inheritance of extreme overweight. Hum Biol. 1990;62:747–65.

    PubMed  CAS  Google Scholar 

  22. Province MA, Arnqvist P, Keller J, Higgins M, Rao DC. Strong evidence for a major gene for obesity in the large, unselected, total Community Health Study of Tecumseh. Am J Hum Genet. 1990;47(suppl):A143.

    Google Scholar 

  23. Borecki IB, Rice T, Bouchard C, Rao DC. Commingling analysis of generalized body mass and composition measures: the Quebec Family Study. Int J Obes. 1991;15:763–73.

    PubMed  CAS  Google Scholar 

  24. Rice T, Borecki IB, Bouchard C, Rao DC. Segregation analysis of fat mass and other body composition measures derived from underwater weighing. Am J Hum Genet. 1993;52:967–73.

    PubMed  CAS  Google Scholar 

  25. Bouchard C, Tremblay A, Després JP, et al. The response to long-term overfeeding in identical twins. N Engl J Med. 1990;322:1477–82.

    Article  PubMed  CAS  Google Scholar 

  26. Bouchard C, Tremblay A, Després JP, et al. Sensitivity to overfeeding: the Quebec experiment with identical twins. Prog Food Nutr Sci. 1988;12:45–72.

    PubMed  CAS  Google Scholar 

  27. Poehlman ET, Tremblay A, Després JP, et al. Genotype-controlled changes in body composition and fat morphology following overfeeding in twins. Am J Clin Nutr. 1986;43:723–31.

    PubMed  CAS  Google Scholar 

  28. Pérusse L, Tremblay A, Leblanc C, et al. Familial resemblance in energy intake: contribution of genetic and environmental factors. Am J Clin Nutr. 1988;47:629–35.

    PubMed  Google Scholar 

  29. Tarasuk V, Beaton GH. The nature and individuality of within-subject variation in energy intake. Am J Clin Nutr. 1991;54:464–70.

    PubMed  CAS  Google Scholar 

  30. Ravussin E, Bogardus C. Relationship of genetics, age, and fitness to daily energy expenditure and fuel utilisation. Am J Clin Nutr. 1989;49:968–75.

    PubMed  CAS  Google Scholar 

  31. Bouchard C, Tremblay A, Nadeau A, et al. Genetic effect in resting and exercise metabolic rates. Metabolism. 1989;38:364–70.

    Article  PubMed  CAS  Google Scholar 

  32. Bouchard C. Reproducibility of body composition and adipose tissue measurements in humans. In: Roche AF, ed. Body composition assessment in youth and adult. Report of the Sixth Ross Conference on Medical Research. Columbus, Ohio: Ross Laboratories, 1985:9–13.

    Google Scholar 

  33. Fontaine E, Savard R, Tremblay A, Després JP, Poehlman ET, Bouchard C. Resting metabolic rate in monozygotic and dizygotic twins. Acta Genet Med Gemellol. 1985;34:41–7.

    PubMed  CAS  Google Scholar 

  34. Bogardus C, Lillioja S, Ravussin E, et al. Familial dependence of the resting metabolic rate. N Engl J Med. 1986;315:96–100.

    Article  PubMed  CAS  Google Scholar 

  35. Bouchard C, Pérusse L, Dériaz O, Després JP, Tremblay A. Genetic influences on energy expenditure in humans. Crit Rev Food Sci Nutr. 1993;33:345–50.

    Article  PubMed  CAS  Google Scholar 

  36. Pérusse L, Leblanc C, Bouchard C. Familial resemblance in lifestyle components: results from the Canada Fitness Survey. Can J Public Health. 1988;79:201–5.

    PubMed  Google Scholar 

  37. Pérusse L, Tremblay A, Leblanc C, Bouchard C. Genetic and environmental influences on level of habitual physical activity and exercise participation. Am J Epidemiol. 1989;129:1012–22.

    PubMed  Google Scholar 

  38. Moore LL, Lombardi DA, White MJ, Campbell JL, Oliveria SA, Ellison SA. Influence of parents’ physical activity levels on young children. J Pediatr. 1991;118:215–19.

    Article  PubMed  CAS  Google Scholar 

  39. Bouchard C. The genetics of body energy content and energy balance: an overview. In: Bray GA, Ryan DH, eds. The science of food regulation. Baton Rouge, LA: Louisiana State University Press; 1992:3–21.

    Google Scholar 

  40. Bouchard C, Després JP, Mauriège P, et al. The genes in the constellation of determinants of regional fat distribution. Int J Obes. 1991;15:9–18.

    PubMed  Google Scholar 

  41. Bouchard C. Genetic factors in the regulation of adipose tissue distribution. Acta Med Scand. 1988;(suppl 723):135–41.

    Google Scholar 

  42. Bouchard C. Inheritance of human fat distribution. In: Bouchard C, Johnston FE, eds. Fat distribution during growth and later health outcomes. New York: Alan Liss; 1988:103–25.

    Google Scholar 

  43. Bouchard C. Genetic and environmental influences on regional fat distribution. In: Oomura Y, Tarui S, Inoue S, Shimazu T, eds. Progress in obesity research 1990. London: Libbey; 1991:303–8.

    Google Scholar 

  44. Bouchard C. Inheritance of human fat distribution and adipose tissue metabolism. In: Vague J, Björntörp P, Guy-Grand B, Rebuffé-Scrive M, Vague P, eds. Metabolie complications of human obesities. Amsterdam: Elsevier; 1985:87–96.

    Google Scholar 

  45. Després JP, Bouchard C, Savard R, Prud’homme D, Bukowiecki L, Thériault G. Adaptive changes to training in adipose tissue lipolysis are genotype dependent. Int J Obes. 1984;8:87–95.

    PubMed  Google Scholar 

  46. Mauriège P, Després JP, Marcotte M, et al. Adipose tissue lipolysis after long-term overfeeding in identical twins. Int J Obes. 1992;16:219–25.

    Google Scholar 

  47. Poehlman ET, Després JP, Marcotte M, Tremblay A, Thériault G, Bouchard C. Genotype dependency of adaptation in adipose tissue metabolism after short-term overfeeding. Am J Physiol. 1986;250:E480–5.

    Google Scholar 

  48. Savard R, Bouchard C. Genetic effects in the response of adipose tissue lipoprotein lipase activity to prolonged exercise: a twin study. Int J Obes. 1990;14:771–7.

    PubMed  CAS  Google Scholar 

  49. Bouchard C. L’obésité est-elle héréditaire? Rev Praticien. 1990;19:1773–6.

    Google Scholar 

  50. Hasstedt SJ, Ramirez ME, Kuida H, Williams RR. Recessive inheritance of a relative fat pattern. Am J Hum Genet. 1989;45:917–25.

    PubMed  CAS  Google Scholar 

  51. Enzi G, Gasparo M, Biondetti PR, Flor D, Semisa M, Zurlo F. Subcutaneous and visceral fat distribution according to sex, age, and overweight, evaluated by computed tomography. Am J Clin Nutr. 1986;44:739–46.

    PubMed  CAS  Google Scholar 

  52. Johnson PR, Greenwood MRC, Horwitz BA, Stern JS. Animal models of obesity: genetic aspects. Ann Rev Nutr. 1991;11:325–53.

    Article  CAS  Google Scholar 

  53. Friedman JM, Leibel RL, Bahary N. Molecular mapping of obesity genes. Mammalian Genome. 1991;1:130–44.

    Article  PubMed  CAS  Google Scholar 

  54. Lander ES, Botstein D. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics. 1989;121:185–99.

    PubMed  CAS  Google Scholar 

  55. Bouchard C. Current understanding of the etiology of obesity: genetic and nongenetic factors. Am J Clin Nutr. 1991;53:1561S–65S.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Physical Activity Sciences Laboratory, PEPS Laval University, Ste-Foy, Quebec, Canada, G1K7P4

    Claude Bouchard

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  1. Claude Bouchard
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Editors and Affiliations

  1. Sackler Medical Faculty, Epidemiology and Biostatistics, the Neufeld Cardiac Research Institute, Sheba Medical Center and Tel Aviv University, Israel

    Uri Goldbourt (Professor of Epidemiology and Preventive Medicine, Head) (Professor of Epidemiology and Preventive Medicine, Head)

  2. Division of Epidemiology, Institute of Environmental Medicine, Karolinska Institute and Division of Cardiovascular Medicine, Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden

    Ulf de Faire (Professor) (Professor)

  3. Institute of Medical Genetics, Department of Medical Genetics, Ullevål University Hospital, Oslo, Norway

    Kåre Berg (Professor of Medicine, Chairman, Director and Physician-in-Chief) (Professor of Medicine, Chairman, Director and Physician-in-Chief)

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© 1994 Springer Science+Business Media Dordrecht

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Bouchard, C. (1994). Human Obesities. In: Goldbourt, U., de Faire, U., Berg, K. (eds) Genetic factors in coronary heart disease. Developments in Cardiovascular Medicine, vol 156. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1130-0_13

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  • DOI: https://doi.org/10.1007/978-94-011-1130-0_13

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4494-3

  • Online ISBN: 978-94-011-1130-0

  • eBook Packages: Springer Book Archive

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