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Computational Aspects in Supramolecular Chemistry: Chiral Discrimination in Chromatography

  • K. B. Lipkowitz
  • A. G. Anderson
Chapter
Part of the NATO ASI Series book series (ASIC, volume 426)

Abstract

The supramolecular assemblies that form during chiral chromatographic resolution of enantiomers are diastereomeric. A variety of computational approaches are used to discern where and how chiral discrimination takes place on increasingly more complex chiral stationary phases (CSPs) beginning with simple brush-like CSPs, and continuing to macrocyclic cyclodextrins and chiral polymers like cellulose triacetate. In all cases computational chemistry provides detailed atomic level information not amenable to experimentation.

Keywords

Atomic Force Microscope Intermolecular Hydrogen Bond Chiral Stationary Phase Chiral Separation Supramolecular Assembly 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 1994

Authors and Affiliations

  • K. B. Lipkowitz
    • 1
  • A. G. Anderson
    • 2
  1. 1.Departments of ChemistryIUPUIIndianapolisUSA
  2. 2.Wittenberg UniversitySpringfieldUSA

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