Abstract
In the western world the median age of the menopause is close to 51 years of age [1,2]. At this age nearly all follicles have reached atresia and the remaining number is insufficient to sustain the cyclic hormonal process, necessary for menstruation. In modern statistic terms it would be natural to define precocious menopause as the cessation of menstruation before the age of two times the standard deviation of the mean age of menopause. However, precocious menopause is typically defined as occurring before the age of 40 [3]. Originally it has been assumed that precocious menopause is similar to the natural menopause with permanent loss of follicles and fertility. We do now know, that if we widen the definition, several reports in the literature demonstrate recurrent ovarian activity in women with well-documented premature ovarian failure. Since an increasing number of women are delaying pregnancy until an older age, and since we better understand that hormonal replacement therapy (HRT) is necessary in premature hypergonadotropic hypogonadism, early cessation of menses becomes a diagnostic challenge. Before discussing the several different pathophysiologic mechanisms underlying premature hypergonadotropic hypogonadism a short review will be given of normal ovarian development and of menopause.
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References
Brand PC. Age at Menopause. (dissertation). Univ. of Utrecht (NI), 1978.
Richardson SJ, Senikas V, Nelson JF. Follicular depletion during the menopausal transition: evidence for accelerated loss and ultimate exhaustion. J Clin Endocrinol Metab 1987;65:1231–1237.
Coulam CB. Premature gonadal failure. Fertil Steril 1982;38:645–655.
Gillman J. The development of the gonads in man, with a consideration of the role of fetal endocrines and the histogenesis of ovarian tumors. Contrib Embryol Carnegie Inst. 1948;32:82.
Pelliniemi LI. Ultrastructure of the gonadal ridge in the male and female pig embryos. Mat Embryol 1975;147:19.
McDonough P. Genetic aspects of ovarian failure. In: Proceedings of the 8th Reinier de Graaf Symposium: “Ovarian Endocrinopathies” Amsterdam Sept 1993. Excerpta Medica: In preparation.
Baker TG. Oogenesis and ovulation. In: Austin CR, Short RV, editors. Reproduction in mammals. I: Germ cells and fertilization. Cambridge University Press, Cambridge, 1972:14–45.
Singh RP, Carr DH. Anatomic findings in human abortions of known chromosomal constitution. Obst Gynec 1967;29:806–818.
Jirasek JE. Principles of reproductive embryology. In: Simpson JL, editor. Disorders of sexual differentiation. Academic Press, New York 1976: 51.
Gougeon A. Dynamics of human follicular growth. A morphologic perspective. In: Adashi EY, Leung PCK, editors. The ovary. Raven Press, Ltd. New York, 1993: 21–39.
Gougeon A. Dynamics of follicular growth in the human: a model from preliminary results. Human Reprod 1986;I:81–87.
Faddy MJ, Gosden RG, Gougeon A, Richardson SJ, Nelson JF. Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause. Human Reprod 1992;7:1342–1346.
Carr DH. Chromosomes and abortion. In: Harris H, Hirschhorn K, editors. Advances in human genetics. Plenum Press, New York, 1971: 201–257.
Rolland R, Kirkels VGHJ. Gonadal disorders of genetic origin. In: Crosignani PC, Rubin BL, editors. Endocrinology of human infertility. Serono Clinical Colloquia on reproduction 2. Academic Press/Grune & Stratton 1981: 359–375.
Simpson JL. Gonadal dysgenesis and sex chromosome abnormalities: Phaenotypic - karyotypic correlations. In: Vallet HL, Porter IH, editors. Genetic mechanisms of sexual development. Academic Press, New York 1979: 365–406.
Krauss CM, Turksoy RN, Atkins L, McLaughlin C, Brown LG, et al. Familial premature ovarian failure due to an interstitial deletion of the long arm of the X-chromosome. N Engl J Med 1987;317:125–131.
Wyss D, Delozier CD, Daniell J, Engel E. Structural anomalies of the X-chromosome: personal observation and review of non-mosaic cases. Clin Gen 1992;21:145–159.
Behzadian MA, Tho SPT, McDonough PG. The presence of the testicular determining sequence, SRY, in 46,XY females with gonadal dysgenesis (Swyer syndrome). Am J Obstet Gynecol 1991;165:1887–1890.
Fisher EMC, Beer-Romero P, Brown LG, Rioley A, McNeil JA, et al. Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X-inactivation and possible implications for Turner syndrome. Cell 1990;63:1205–1218.
Meadows AT, Krejmans NL, Belasco JB. The medical cost of cure: sequelae in survivors of childhood cancer. In: Van Eys J, Sullivan MP, editors. Status of curability of childhood cancers. Raven Press, New York, 1980: 263–276.
Baker TG. Radiosensitivity of mammalian oocytes with particular reference to the human female. Am J Obstet Gynecol 1971;110:746–761.
Ash P. The influence of radiation on fertility in man. Br J Radiol 1980; 53:271–278.
Gans B, Bahary C, Levie B. Ovarian regeneration and pregnancy following massive radiotherapy for dysgerminoma. Obstet Gynecol 1963;5:596–600.
Bakri YN, Pedersen P, Nassar M. Normal pregnancy after curative multiagent chemotherapy for choriocarcinoma with brain metastases. Acta Obstet Gynaecol Scand 1991;70:611–613.
Koyama H, Wada T, Nishizawa Y et al. Cyclophosphoramide-induced ovarian failure and its therapeutic significance in patients with breast cancer. Cancer 1977;39:1403–1409.
Gradishar WJ, Schilsky RL. Ovarian function following radiation and chemotherapy for cancer. Sem Oncol 1989;16:425–436.
McKinlay SM, Bifano NL, McKinlay JB. Smoking and age at menopause. Ann Intern Med 1985;103:350–356.
Kaufman FR, Donnell GN, Roet F, Kogut MD. Gonadal function in patients with galactosaemia. J Inher Metab Dis 1986;9:140–146.
Kaufman FR, Yan Kang XU, Wong NG, Donnell GN. Correlation of ovarian function with galactose-1-phosphate uridyl transferase levels in galactosemia. J Ped 1988;112:754–756.
Eisenbarth GS, Jackson RA. The immunoendocrinopathy syndrome. In: Wilson JC, Foster DW, editors. Williams textbook of endocrinology. W.B. Saunders, Philadelphia 1992: 1555.
Escobar ME, Cigorraga SB, Chiazzi VA, Chapreau EH, Rivarola MA. Development of the gonadotropic resistant ovary syndrome in myasthenia gravis: suggestion of similar autoimmune mechanisms. Acta Endocrinol (Copenh) 1982;99:431–436.
Pekonen F, Siegberg R, Makinen T, Miettinen T, Yli-Korkala O. Immunological disturbances in patients with premature ovarian failure. Clin Endocrinol 1986;25:1–6.
Siddle N, Sarrell P, Whitehead MI. The effect of hysterectomy on the age at ovarian failure: identification of a subgroup of women with premature loss of ovarian function and literature review. Fertil Steril 1987;47:94–100.
Rebar RW, Connolly HV Clinical features of young women with hypergonadotropic amenorrhea. Fertil Steril 1990;53:804–810.
Polansky S, de Papp EW. Pregnancy associated with hypergonadotropic hypogonadism. Obstet Gynecol 1976;47:478–518.
Gosden RG. Follicular growth and endocrinology during the transition from fertile life to postmenopausal era. In: Proceedings of the 8th Reinier de Graaf Symposium: “Ovarian Endocrinopathies” Amsterdam Sept 1993. Excerpta Medica: In preparation.
Check JH. Can in vitro fertilization be successful in women with elevated serum levels. In: Proceedings of the 8th Reinier de Graaf Symposium: “Ovarian Endocrinopathies” Amsterdam Sept 1993. Excerpta Medica: In preparation.
Paulson RI, Saver MV, Lobo RA. Factors affecting implantation after in vitro fertilization: a hypothesis. Am J Obstet Gynecol 1990;163:2020–2023.
Wade JC, Gosden RG. Assessment of oocyte survival in cortical grafts of ovine and human ovaries after frozen storage and xenografting. In: Proceedings of the 8th Reinier de Graaf Symposium: “Ovarian Endocrinopathies” Amsterdam Sept 1993. Excerpta Medica: In preparation.
Taylor AE, Schneyer AL, Sluss PM, Crowley Jr WF. Ovarian failure, resistance and activation. In: Adashi EY, Leung PCK, editors. The Ovary. Raven Press Ltd New York. 1993:629–661.
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© 1994 Springer Science+Business Media Dordrecht
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Rolland, R. (1994). Precocious Menopause: A Diagnostic Challenge. In: Crosignani, P.G., Paoletti, R., Sarrel, P.M., Wenger, N.K., Meschia, M., Soma, M. (eds) Women’s Health in Menopause. Medical Science Symposia Series, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1024-2_4
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DOI: https://doi.org/10.1007/978-94-011-1024-2_4
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