Abstract
αs1-casein has been found to be one of the major allergens in bovine milk. We isolated 28 αs1-casein-specific T cell lines (TCLs) from 4 milk-allergic patients and characterized their epitope specificites and functions. Stimulation of these αs1-casein-specific TCLs with sequential peptides of αs1-casein revealed the determinants recognized by 5 TCLs. They each reacted to different peptides. In response to αs1-casein, some of them secreted both interleukin 4 (IL-4) and interferon (IFN) -γ, some either IL-4 or IFN-γ only, and the others neither of the two cytokines.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Taylor, S. (1986), J. Food Protection 49, 239–250.
Zittle, C.A., Cerbulis, J., et al. (1959), J.Dairy Sci. 42, 1897–1902.
Pette, M., et al. (1990), Proc. Natl. Acad. Sci. USA., 87, 7968–7972.
Ebner, C., Szepfalusi, Z., et al. (1993), J. Immunol. 150, 1047–1054.
Parronchi, P., et al. (1991), Proc. Natl. Acad. Sci. USA 88, 4538–4542.
Wierenga, E.A., Snoek, M., et al. (1990), J. Immunol. 144, 4651–4656.
Hans, Y., Johnson, K.E., et al. (1992), J. Immunol. 148, 738–745.
Kay, A.B., Ying, S., et al. (1991), J. Exp. Med. 173, 775–778.
Dhillon, M., et al. (1992), J. Allergy Clin. Immunol. 90, 42–51.
Pene, J., Rousset, F., et al. (1988), Proc. Natl. Acad. Sci. USA 85, 6880–6884.
Kondo, N., Fukutomi, O., et al. (1993), J. Allergy Clin. Immunol. 91, 658–668.
Salgame, P., Abrams, J.S., et al. (1991), Science 254, 279–282.
Mosmann, T.R., et al. (1988), Annu. Rev. Immunology 7, 145–173.
Rentz, H., Lack, G., Saloga, J., et al. (1994), J. Immunol. 152, 351–360.
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Nakajima, H. et al. (1994). Establishment and Characterization of αs1-Casein-Specific T Cell Lines from Milk-Allergic Patients. In: Kobayashi, T., Kitagawa, Y., Okumura, K. (eds) Animal Cell Technology: Basic & Applied Aspects. The Sixth International Meeting of Japanese Association for Animal Cell Technology JAACT’93, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0848-5_41
Download citation
DOI: https://doi.org/10.1007/978-94-011-0848-5_41
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-4366-3
Online ISBN: 978-94-011-0848-5
eBook Packages: Springer Book Archive