Abstract
Hybridomas producing human monoclonal antibodies (h-MoAbs) were generated by using lymphocytes of the regional lymph node from cancer patients or peripheral blood lymphocytes (PBL) from healthy volunteers which were immunized in vitro. The h-MoAbs thus obtained were applied to a wide range of clinical purposes, including the immunocytological detection of cancer cells in sputum, the radioimmunoimaging of lung cancer and the therapies of tetanus and cancer. Cancer cells in sputum can be simply detected by the immunostaining method using h-MoAb AE-6. Clear images of lung cancer xenografts in nude mice were obtained with 125I-labeled h-MoAb HB4C5. Tetanus was successfully cured by the use of a combination of h-MoAbs G2 and G6 in animal tests. Cancer xenografts in nude mice were regressed by the administration of h-MoAb S-97 conjugated with Pseudomonas exotoxin A (PE). These data indicate that h-MoAbs are clinically of potent value.
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© 1994 Springer Science+Business Media Dordrecht
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Hashizume, S. et al. (1994). Clinical Applications of Human Monoclonal Antibodies. In: Kobayashi, T., Kitagawa, Y., Okumura, K. (eds) Animal Cell Technology: Basic & Applied Aspects. The Sixth International Meeting of Japanese Association for Animal Cell Technology JAACT’93, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0848-5_10
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DOI: https://doi.org/10.1007/978-94-011-0848-5_10
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