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The Role of Passenger Leukocytes in Rejection and “Tolerance” after Solid Organ Transplantation: A Potential Explanation of a Paradox

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Book cover Rejection and Tolerance

Part of the book series: Transplantation and Clinical Immunology ((TRAC,volume 25))

Abstract

The concept that passenger leukocytes are more “immunogenic” and thus initiate rejection, which is ultimately directed against the parenchyma and vessels of solid organ allografts, was first proposed by Snell (1) and later proved by Steinmuller (2) . Steinman and Cohn (3–6) subsequently showed that a distinct type of passenger leukocyte, the dendritic cell, provides the most potent of the allogeneic stimuli. Besides dendritic cells, which reside in the interstitium of all allografts, every organ also carries with it a variable number of T and B lymphocytes, macrophages and myeloid cells. Therefore, each type of allograft presents a heterogenous stimulatory profile as well as the potential for graft-versus-host (GVH) reactions.

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Authors and Affiliations

  1. Pittsburgh Transplant Institute, Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA

    Anthony J. Demetris M.D. & Abdul S. Rao M.D., D. Phil.

  2. Pittsburgh Transplant Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA

    Noriko Murase M.D., Abdul S. Rao M.D., D. Phil. & Thomas E. Starzl M.D., Ph.D.

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  1. Anthony J. Demetris M.D.
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  3. Abdul S. Rao M.D., D. Phil.
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  4. Thomas E. Starzl M.D., Ph.D.
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J. L. Touraine J. Traeger H. Bétuel J. M. Dubernard J. P. Revillard C. Dupuy

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Demetris, A.J., Murase, N., Rao, A.S., Starzl, T.E. (1994). The Role of Passenger Leukocytes in Rejection and “Tolerance” after Solid Organ Transplantation: A Potential Explanation of a Paradox. In: Touraine, J.L., Traeger, J., Bétuel, H., Dubernard, J.M., Revillard, J.P., Dupuy, C. (eds) Rejection and Tolerance. Transplantation and Clinical Immunology, vol 25. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0802-7_29

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