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Use of Anti-CD4 Monoclonal Antibodies for Tolerance Induction

  • Chapter
Rejection and Tolerance

Part of the book series: Transplantation and Clinical Immunology ((TRAC,volume 25))

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Abstract

Polyclonal antibody preparations, anti-lymphocyte globulin (ALG or ALS) and anti-thymocyte globulin (ATG) have been used successfully as anti-rejection agents for many years (1). Monoclonal antibodies (mabs) targeting a number cell surface molecules on either T cells, most notably, CD4 (e.g⋯(2–6)), CD25 (IL-2R) and CD11a/CD18 (LFA-1) (7-10), or the cells of the organ graft, CD54 (ICAM-1) (8) have also been shown to be capable of prolonging graft survival. The ability of antibodies, either polyclonal or monoclonal to create an environment for the induction of tolerance to alloantigen is currently under investigation.

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Authors and Affiliations

  1. Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, England

    Kathryn J. Wood

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  1. Kathryn J. Wood
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J. L. Touraine J. Traeger H. Bétuel J. M. Dubernard J. P. Revillard C. Dupuy

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© 1994 Springer Science+Business Media Dordrecht

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Wood, K.J. (1994). Use of Anti-CD4 Monoclonal Antibodies for Tolerance Induction. In: Touraine, J.L., Traeger, J., Bétuel, H., Dubernard, J.M., Revillard, J.P., Dupuy, C. (eds) Rejection and Tolerance. Transplantation and Clinical Immunology, vol 25. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0802-7_24

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  • DOI: https://doi.org/10.1007/978-94-011-0802-7_24

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4345-8

  • Online ISBN: 978-94-011-0802-7

  • eBook Packages: Springer Book Archive

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