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Induction of Donor-Specific Tolerance by Intrathymic Cellular Transplantation

  • Chapter
Rejection and Tolerance

Part of the book series: Transplantation and Clinical Immunology ((TRAC,volume 25))

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Abstract

The acquisition of immunologic tolerance is primarily achieved by selective deletion of self-reactive T cells within the thymus, whereby the interaction between self-antigen and the T cell receptor at an immature stage in T cell differentiation aborts further development of the cell (1,2). Within the thymus, developing thymocytes are subjected to both positive and negative selection. It is believed that positive selection permits development of thymocytes bearing receptors capable of binding self-MHC and foreign peptide. Negative selection (or tolerance induction), on the other hand, is thought to arrest the maturation of those thymocytes with high affinity for self-MHC (3). Both bone marrow derived antigen presenting cells and thymic epithelial cells have been demonstrated to be involved in tolerance induction within the thymus (4–7).

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Authors and Affiliations

  1. Department of Surgery, Hospital of the University of Pennsylvania, 3400 Spruce Street, 4 Silverstein, Philadelphia, PA, 19104, USA

    George L. Mayo, Andrew M. Posselt, Luis Campos, Barbara C. Deli, Sean P. Mayo, Clyde F. Barker & Ali Naji

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  1. George L. Mayo
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  2. Andrew M. Posselt
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  3. Luis Campos
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  4. Barbara C. Deli
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  5. Sean P. Mayo
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  6. Clyde F. Barker
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  7. Ali Naji
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Editor information

J. L. Touraine J. Traeger H. Bétuel J. M. Dubernard J. P. Revillard C. Dupuy

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© 1994 Springer Science+Business Media Dordrecht

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Mayo, G.L. et al. (1994). Induction of Donor-Specific Tolerance by Intrathymic Cellular Transplantation. In: Touraine, J.L., Traeger, J., Bétuel, H., Dubernard, J.M., Revillard, J.P., Dupuy, C. (eds) Rejection and Tolerance. Transplantation and Clinical Immunology, vol 25. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0802-7_23

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  • DOI: https://doi.org/10.1007/978-94-011-0802-7_23

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4345-8

  • Online ISBN: 978-94-011-0802-7

  • eBook Packages: Springer Book Archive

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