Abstract
T-cell tolerance can be defined as specific unresponsiveness of T cells to a nominal antigen or to an alloantigen. In the case of the nominal antigen, the unresponsiveness is expected to be directed towards peptides derived from the protein and associated with self major histocompatibility complex (MHC) molecules. In the case of the alloantigen, the unresponsiveness is expected to be directed to epitopes on the foreign MHC molecule itself as well as to undefined self-peptides associated with foreign MHC molecules. It is also possible that some peptides derived from foreign MHC molecules could be presented by self MHC molecules (1). Physical elimination of self-reactive T cells during their maturation in the thymus is the best-known mechanism for the establishment of self-tolerance, along with a variety of non-deletional mechanisms of tolerance in the thymus and the periphery (2, 3, 4). A detailed knowledge of tolerance induction in mature peripheral T cells is essential for therapeutic intervention, merely to understand and ensure tolerance in organ transplantation. It must be stressed that 3 different situations might bring about some clue on transplantation tolerance, namely in “in vitro” models, in experimental models and finally in the organ transplant human situation. But this last situation is hardly complex, occuring in an immunological status barely “naïve” and associated with other events which might interfere with the establishment and the maintenance of tolerance such as immunosuppressive drugs, as viral infections, blood transfusions.
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References
Benichou G., Takizawa P.A., Olson CA., McMillan M., Sercarz E.E. Donor major histocompatibility complex (MHC) peptides are presented by recipients Mhc molecules during graft rejection J. Exp. Med., 1992, 175, 305–308
Strobers T-cell tolerance Transplant. Proa, 1991, 23, 34–35
Miller J.F.A.P., Morahan G. Peripheral T cell tolerance Annu. Rev. Immunol., 1992, 10, 51–69
Sachs D.H. Antigen-specific transplantation tolerance Clin. Transplantation, 1990, 4, 78–81
Thomas J., Thomas F., Mendez-Picon G., Lee H. Immunological monitoring of long-surviving renal transplant recipients Surgery, 1977, 81, 125–136
Charpentier B., Lang PH., Martin B., Fries D. Specific recipient donor unresponsiveness mediated by a suppressor cell system in human kidney allograft tolerance Transplantation, 1982, 33, 470–476
Charpentier B., Bach M.A., Lang Ph., Fries D. Expression of OKT8 antigen and Fc γ receptors by suppressor cells mediating specific unresponsiveness between recipient and donor in renal allograft tolerant recipient Transplantation, 1983, 36, 495–501
Hutchinson I.V. Suppressor T cells in allogenic models Transplantation, 1986, 41, 547
Lantz O., Alard P., Ben Aribia M.H. et al. Persistance of donor-specific IL2 secreting cells and Ctl precursors in human kidney transplant recipients evidenced by limiting dilution analysis J. Immunol., 1990, 144, 3748–3755
Alard P., Lantz O., Perrot J.Y., Chavanel G., Senik A., Charpentier B. A possible role for specific anergy in immunologic hyporeactivity to donor stimulation in human kidney allograft recipients Transplantation, 1993, 55, 277–283
Starzl T.E., Demetris A.J., Murase N., Ildstad S., Ricordi C, Trucco M. Cell migration, chimerism and graft acceptance Lancet, 1992, 339, 1579–1582
Arnold B., Schonrich G., Hammerling G. Multiple levels of peripheral tolerance Immunol. Today, 1993, 14, 12–14
Blackman M., Kappler J., Marrack P. The role of the T cell receptor in positive and negative selection of developing T cells Science, 1990, 248, 1355–1341
Mueller D.L., Jenkins M.K., Schwartz R.H. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy Ann. Rev. Imunol., 1989, 7, 445–480
Dallmann M.J., Shiho O., Page T.H., Wood K.J., Morris P.J. Peripheral tolerance to alloantigen results from altered regulation of the IL2 pathway J. Exp. Med., 1991, 173, 79–87.
Alters S., Shizuru J.A., Ackerman J., Grossmann D., Seydel K.B., Fataman C.G. Anti-CD4 mediates clonal anergy during transplantation tolerance induction J. Exp. Med., 1991, 173, 491–494
Goss J.A., Pyo R., Flye M.W., Connolly J.M., Hansen T.H. Major histocompatibility complex-specific prolongation of murine skin and cardiac allograft survival after in vivo depletion of Vβ+ T cells J. Exp. Med., 1993, 177, 35–44
Anasetti C, Tan P., Hansen J.A., Martin P.J. Induction of specific nonresponsiveness in unprimed human T cells by anti-CD3 antibody and alloantigen J. Exp. Med., 1990, 172, 1691–1700
Tan P., Anasetti C, Hansen J.A. et al. Induction of alloantigen-specific hyporesponsivenes in human T lymphocytes by blocking interactions of CD28 with its natural ligand B7/BB1 J. Exp. Med., 1993, 177, 165–173
Thomas J.M., Carver F.M., Cunningham P.R.G., Olson L.C., Thomas FT. Kidney allograft tolerance in primates without chronic immunosuppression. The role of veto cells Transplantation, 1991, 51, 198–207
Shixin Q., Cobbold S.P., Pope H., Elliott J., Kioussis D., Davies J., Walddmann H. “Infectious” transplantation tolerance Science, 1993, 259, 974–976
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© 1994 Springer Science+Business Media Dordrecht
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Charpentier, B., Alard, P., Hiesse, C., Lantz, O. (1994). Peripheral T Cell Tolerance. In: Touraine, J.L., Traeger, J., Bétuel, H., Dubernard, J.M., Revillard, J.P., Dupuy, C. (eds) Rejection and Tolerance. Transplantation and Clinical Immunology, vol 25. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0802-7_22
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DOI: https://doi.org/10.1007/978-94-011-0802-7_22
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