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Molecular biology of schizophrenia

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Book cover Molecular and Cell Biology of Neuropsychiatric Diseases

Part of the book series: Molecular and Cell Biology of Human Diseases Series ((Mol. Cell Biol. Hu. Dis.))

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Abstract

Schizophrenia is the term used to describe one of the principal forms of major mental illness or madness that affects mankind. It is found in all countries, societies and cultures and is estimated to affect approaching 1% of the world’s population. It usually becomes apparent in early adult life, both sexes are equally affected, and in the acute stages the illness is characterized by delusions, hallucinations and thought disorder. These often progress to a picture of chronic social withdrawal and deterioration of the personality. Although schizophrenia is known to be a familial disease, its mode of inheritance has not been established, it is defined symptomatically, and its natural boundaries, aetiology and pathogenesis remain obscure.

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References

  • Andrew, B., Watt, D.C., Gillespie, C. and Chapel, H. (1987) A study of genetic linkage in schizophrenia. Psychol. Med., 17, 363–370.

    Article  PubMed  CAS  Google Scholar 

  • Angst, J., Felder, W. and Lohmeyer, B. (1979) Schizoaffective disorders: results of a genetic investigation. I. J. Affective Disorders, 1, 139–153.

    Article  CAS  Google Scholar 

  • Aschauer, H., Ashauer-Trieber, G., Isenberg, K.E. et al. (1990) No evidence for linkage between chromosome 5 markers and schizophrenia. Hum. Hered., 40, 109–115.

    Article  PubMed  CAS  Google Scholar 

  • Barker, D., Wright, E., Nguyen, K. et al. (1987) Gene for von Recklinghausen neurofibromatosis is in the pericentric region of chromosome 17. Science, 236, 100–102.

    Article  Google Scholar 

  • Baron, M., Gruen, R., Rainer, J.D. et al. (1985) A family study of schizophrenic and normal control probands: Implications for the spectrum concept of schizophrenia. Am. J. Psychiatry, 142, 447–455.

    PubMed  CAS  Google Scholar 

  • Bassett, A.S., McGillivray, B.C., Jones, B. and Pantzar, J.T. (1988) Partial trisomy chromosome 5 cosegregating with schizophrenia. Lancet, 1, 799–801.

    Article  PubMed  CAS  Google Scholar 

  • Blackwood, D.H.R., St Clair, D.M., Muir, W.J. and Duffy, J.C. (1991) Auditory P300 and eye tracking dysfunction in schizophrenic pedigrees. Arch. Gen. Psychiatry, 48, 899–909.

    Article  PubMed  CAS  Google Scholar 

  • Bleuler, E. (1950) Dementia Praecox or the Group of Schizophrenias, (tr. J. Zinkin), International Universities Press, New York.

    Google Scholar 

  • Bodmer, W.F., Bailey, C.J., Bodmer, J. et al. (1987) Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature, 328, 614–616.

    Article  PubMed  CAS  Google Scholar 

  • Cavanee, W.K., Dryja, T.P., Phillips, R.A. et al. (1983) Expression of recessive alleles by chromosomal mechanisms in retinoblastoma. Nature, 305, 779–784.

    Article  Google Scholar 

  • Chada, R., Kulhara, P., Singh, T. and Sehgal, S. (1986) HLA antigens in schizophrenia: A family study. Br. J. Psychiatry, 149, 612–615.

    Article  Google Scholar 

  • Chamberlain, S., Shaw, J., Rowland, A. et al. (1988) Mapping of the mutation causing Friedreich’s ataxia to human chromosome 9. Nature, 334, 248–249.

    Article  PubMed  CAS  Google Scholar 

  • Crow, T.J. (1986) The continuum of psychosis and its implication for the structure of the gene. Br. J. Psychiatry, 149, 419–429.

    Article  PubMed  CAS  Google Scholar 

  • Davies, K.E., Pearson, P.L., Harper, P.S. et al. (1983) Linkage analysis of two cloned DNA sequences flanking the Duchenne muscular dystrophy locus on the short arm of the human X chromosome. Nucleic Acids Res., 11, 2303–2313.

    Article  PubMed  CAS  Google Scholar 

  • Detera-Wadleigh, S.D., Goldin, L.R., Sherrington, R. et al. (1989) Exclusion of linkage to 5q11-13 in families with schizophrenia and other psychiatric disorders. Nature, 340, 391–393.

    Article  PubMed  CAS  Google Scholar 

  • Egeland, J.A., Gerhard, D.S., Pauls, D.L. et al. (1987) Bipolar affective disorder linked to DNA markers on chromosome 11. Nature, 325, 783–787.

    Article  PubMed  CAS  Google Scholar 

  • Farmer, A.E., McGuffin, P. and Gottesman, I.I. (1987) Twin concordance for DSM-III schizophrenia: scrutinizing the validity of the definition. Arch. Gen. Psychiatry, 44, 634–641.

    Article  PubMed  CAS  Google Scholar 

  • Francke, U., Ochs, H.D, Demartinville, B. et al. (1985) Minor Xp21 chromosome deletion in a male associated with expression of Duchenne muscular dystrophy, chronic granulomatous disease, retinitis pigmentosa, and McLeod syndrome. Am. J. Hum. Genet., 27, 250–267.

    Google Scholar 

  • Friend, S.H., Bernhards, R., Rogeli, S. et al. (1986) A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature, 323, 643–646.

    Article  PubMed  CAS  Google Scholar 

  • Goate, A.M., Haynes, A.R., Owen, M.J. et al. (1989) Predisposing locus for Alzheimer’s disease on chromosome 21. Lancet, 2, 352–355.

    Article  Google Scholar 

  • Goate, A., Chartier-Harlin, M-C., Mullan, M. et al. (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease. Nature, 349, 704–706.

    Article  PubMed  CAS  Google Scholar 

  • Goldin, L.R., Delisi, L.E. and Gershon, E.S. (1987) Relationship of HLA to schizophrenia in 10 nuclear families. Psychiatry Res., 20, 69–77.

    Article  PubMed  CAS  Google Scholar 

  • Gottesman, I.I. and Shields, J. (1982) Schizophrenia, The Epigenetic Puzzle. Cambridge University Press, Cambridge.

    Google Scholar 

  • Griesinger, W. (1867) Mental Pathology and Therapeutics, 2nd edn, (tr. C. Lockhart Robertson and J. Rutherford), New Syndenham Society, London.

    Book  Google Scholar 

  • Gunderson, J.G., Siever, L.J. and Spaulding, E. (1983) The search for a schizotype: Crossing the border again. Arch. Gen. Psychiatry, 40, 15–22.

    Article  PubMed  CAS  Google Scholar 

  • Gusella, J.F., Wexler, N.S., Conneally, P.M. et al. (1983) A polymorphic DNA marker genetically linked to Huntington’s chorea. Nature, 306, 234–238.

    Article  PubMed  CAS  Google Scholar 

  • Herrerra, L., Kakati, S., Gibas, L. et al. (1986) Gardner syndrome in a man with an interstitial deletion of 5q. Am. J., Med. Genet., 25, 473–476.

    Article  Google Scholar 

  • Kaneko, Y., Egues, M.C. and Rowley, J.D. (1981) Interstitial deletion of short arm chromosome 11 limited to Wilms tumor cells in a patient without aniridia. Cancer Res., 41, 4577–4578.

    PubMed  CAS  Google Scholar 

  • Kendell, R.E. (1987) Diagnosis and classification of functional psychoses. Br. Med. Bull., 43, 499–513.

    PubMed  CAS  Google Scholar 

  • Kendell, R.E. and Brockington, I.F. (1981) The identification of disease entities and the relationship between schizophrenic and affective psychoses. Br. J. Psychiatry, 137, 324–331.

    Article  Google Scholar 

  • Kendell, R.E. and Gourlay, J. (1970) The clinical distinction between the affective psychoses and schizophrenia. Br. J. Psychiatry, 117, 257–260.

    PubMed  CAS  Google Scholar 

  • Kendler, K.S. and Gruenberg, A.M. (1984) An independent analysis of the Copenhagen sample of the Danish adoption study. VI. The pattern of psychiatric illness, as defined by DSMIII in adoptees and relatives. Arch. Gen. Psychiatry, 41, 555–564.

    Article  PubMed  CAS  Google Scholar 

  • Kendler, K.S., Gruenberg, A.M. and Tsuang, M.T. (1985) Psychiatric illness in first degree relatives of schizophrenic and surgical control patients. Arch. Gen. Psychiatry, 42, 770–779.

    Article  PubMed  CAS  Google Scholar 

  • Kennedy, J.E., Guiffra, L.A., Moises, H.W. et al. (1988) Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree. Nature, 336, 167–170.

    Article  PubMed  CAS  Google Scholar 

  • Kety, S.S. (1983) Mental illness in the biological and adoptive relatives of schizophrenic adoptee; findings relevant to genetic and environmental factors in etiology. Am. J. Psychiatry, 140, 720–727.

    PubMed  CAS  Google Scholar 

  • Kety, S., Rosenthal, D., Wender, P. and Schulsinger, F. (1968) The type and prevalence of mental illness in the biological and adoptive families of adopted schizophrenics, in The Translation of Schizophrenia, (eds S. Kety and D. Rosenthal), Pergamon Press, Oxford.

    Google Scholar 

  • Koenig, M., Hoffman, E.P., Bertelson, C.J. et al. (1987) Complete cloning of the Duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals. Cell, 50, 509–517.

    Article  PubMed  CAS  Google Scholar 

  • Kraepelin, E. (1919) Dementia Praecox and Paraphrenia, (ed. G.M. Robertson), E. & S. Livingstone, Edinburgh.

    Google Scholar 

  • McGuffin, P., Festenstein, H. and Murray, R. (1983) A family study of HLA antigens and other genetic markers in schizophrenia. Psychol. Med., 13, 31–43.

    Article  PubMed  CAS  Google Scholar 

  • McGuffin, P., Sargeant, M., Hetti, G. et al. (1990) Exclusion of schizophrenia susceptibility gene from the chromosome 5q11-q13 region; new data and reanalysis of previous reports. Am. J. Hum. Genet., 47, 524–535.

    PubMed  CAS  Google Scholar 

  • Merry, D.E., Lesko, J.G., Siu, V. et al. (1990) DX165 detects a translocation breakpoint in a woman with choroideremia and a de novo X;13 translocation. Genomics, 6, 609–615.

    Article  PubMed  CAS  Google Scholar 

  • Monaco, A.P., Neve, R.L., Coletti-Feener, C. et al. (1986) Isolation of candidate CDNA for portions of the Duchenne muscular dystrophy gene. Nature, 323, 646–650.

    Article  PubMed  CAS  Google Scholar 

  • Nakamura, Y., Leppert, M., O’Connel, P. et al. (1987) Variable number of tandem repeats (VNTR) marker for human gene mapping. Science, 235, 1616–1622.

    Article  PubMed  CAS  Google Scholar 

  • Reeders, S.T., Breuning, M.H., Davies, K.E. et al. (1985) A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16. Nature, 317, 542–544.

    Article  PubMed  CAS  Google Scholar 

  • Riordan, J.R., Rommens, J.M., Kerem, B-S. et al. (1989) Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science, 245, 1066–1073.

    Article  PubMed  CAS  Google Scholar 

  • Roberts, G.W. and Crow, T.J. (1987) The neuropathology of schizophrenia — a progress report. Br. Med. Bull., 43, 599–615.

    PubMed  CAS  Google Scholar 

  • Roberts, L. (1990) Down the wire for the NF gene. Science, 249, 236–268.

    Article  PubMed  CAS  Google Scholar 

  • Royer-Pokora, B., Kunkel, L.M., Monaco, A.P. et al. (1986) Cloning the gene for the inherited disorder chronic granulomatous disease on the basis of its chromosomal location. Nature, 322, 23–28.

    Article  Google Scholar 

  • Sherrington, R., Brynjolfsson, J., Petursson, H. et al. (1988) Localization of a susceptibility locus for schizophrenia on chromosome 5. Nature, 336, 164–167.

    Article  PubMed  CAS  Google Scholar 

  • St Clair, D., Blackwood, D., Muir, W. et al. (1989) No linkage to chromosome 5q11-q13 markers to schizophrenia in Scottish families. Nature, 339, 305–309.

    Article  PubMed  CAS  Google Scholar 

  • Tsuang, M.T., Winokur, G. and Crowe, R.R. (1980) Morbidity risks of schizophrenia and affective disorders among first degree relatives of patients with schizophrenia, mania, depression and surgical conditions. Br. J. Psychiatry, 137, 497–504.

    Article  PubMed  CAS  Google Scholar 

  • Tsui, L-C., Buchwald, M., Barker, D. et al. (1985) Cystic fibrosis locus defined by a genetically linked polymorphic marker. Science, 230, 1054–1057.

    Article  PubMed  CAS  Google Scholar 

  • Turner, W.J. (1979) Genetic markers for schizophrenia. Biol. Psychiatry, 14, 177–206.

    PubMed  CAS  Google Scholar 

  • Wallace, M.R., Marchuk, D.A., Andersen, L.B. et al. (1990) Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients. Science, 249, 181–186.

    Article  PubMed  CAS  Google Scholar 

  • Weatherall, D.J. (1991) The New Genetics and Clinical Practice, 3rd edn., Oxford University Press, Oxford.

    Google Scholar 

  • Weber, J.L. and May, P.E. (1989) Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am. J. Hum. Genet., 44, 388–396.

    PubMed  CAS  Google Scholar 

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Authors
  1. David St Clair
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  2. Walter Muir
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  3. Douglas Blackwood
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Editor information

Editors and Affiliations

  1. Department of Physiology, University of Manchester, UK

    Frank Owen

  2. Department of Optometry and Vision Sciences, UMIST, UK

    Ruth Itzhaki

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© 1994 Springer Science+Business Media Dordrecht

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St Clair, D., Muir, W., Blackwood, D. (1994). Molecular biology of schizophrenia. In: Owen, F., Itzhaki, R. (eds) Molecular and Cell Biology of Neuropsychiatric Diseases. Molecular and Cell Biology of Human Diseases Series. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0709-9_7

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  • DOI: https://doi.org/10.1007/978-94-011-0709-9_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4305-2

  • Online ISBN: 978-94-011-0709-9

  • eBook Packages: Springer Book Archive

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