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The aetiology of Alzheimer’s disease

  • Chapter
Molecular and Cell Biology of Neuropsychiatric Diseases

Part of the book series: Molecular and Cell Biology of Human Diseases Series ((Mol. Cell Biol. Hu. Dis.))

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Abstract

A genetic basis for Alzheimer’s disease (AD) has been demonstrated in only a very few patients with early onset disease. Most patients have no family history, and the pathogenesis is probably multifactorial, with affected individuals having possibly an inherited higher-than-normal susceptibility to a specific factor or agent. However, at present, the only certain risk factors for AD are age (although, fortunately, AD is not an invariable consequence of growing old) and Down’s syndrome (DS). Other possible factors include toxins, transmissible agents, DNA repair defects, and head trauma. Each of these will be discussed in detail below.

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Authors
  1. Ruth F. Itzhaki
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Editors and Affiliations

  1. Department of Physiology, University of Manchester, UK

    Frank Owen

  2. Department of Optometry and Vision Sciences, UMIST, UK

    Ruth Itzhaki

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Itzhaki, R.F. (1994). The aetiology of Alzheimer’s disease. In: Owen, F., Itzhaki, R. (eds) Molecular and Cell Biology of Neuropsychiatric Diseases. Molecular and Cell Biology of Human Diseases Series. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0709-9_3

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  • DOI: https://doi.org/10.1007/978-94-011-0709-9_3

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