Abstract
Quinidine is the dextro-rotatory isomer of quinine obtained from the bark of the Cinchona tree. It is used as a class la antiarrhythmic agent and has antimuscarinic and α-adrenoceptor blocking activity. It is readily absorbed orally and metabolized mainly by hydroxylation in liver to active metabolites. Excretion of parent compound (20%) and metabolites is by the kidney. The half-life in plasma is 4-12 hours. Therapeutic concentrations in plasma are 2-6 μg/ml but there is considerable intersubject variability. Concentrations > 15 μg/ml produce gastrointestinal or cardiovascular toxicity in 50% of patients.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Wilson, J.F. (1995). Quinidine. In: Wilson, J.F. (eds) Drugs Eicosanoids. Immunoassay Kit Directory, vol 1 / 3 / 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0679-5_46
Download citation
DOI: https://doi.org/10.1007/978-94-011-0679-5_46
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-7923-8863-0
Online ISBN: 978-94-011-0679-5
eBook Packages: Springer Book Archive