Abstract
Amikacin is a semisynthetic aminoglycoside antibiotic derived from kanamycin A and used like gentamicin in the treatment of Gram-negative infections. Excretion in urine by glomerular filtration is largely of unchanged compound with a plasma half-life of 2 to 3 hours. Ototoxicity and nephrotoxicity are minimized by avoiding peak plasma concentrations measured one hour after administration of > 30 μg/ml or trough concentrations measured before the next dose of > 10 μg/ ml. The therapeutic range in plasma is 15-25 μg/ml for peak concentrations and 4-6 μg/ml for the trough. Concentrations cannot be predicted accurately from dose, hence monitoring is used to avoid undertreatment and ensure safety.
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© 1995 Springer Science+Business Media New York
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Wilson, J.F. (1995). Amikacin. In: Wilson, J.F. (eds) Drugs Eicosanoids. Immunoassay Kit Directory, vol 1 / 3 / 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0679-5_3
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DOI: https://doi.org/10.1007/978-94-011-0679-5_3
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-7923-8863-0
Online ISBN: 978-94-011-0679-5
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