Abstract
Glycopyrronium bromide or glycopyrrolate is a quaternary ammonium compound used as a peripheral antimuscarinic agent similar in action to atropine. It is used as a premedication, in the treatment of peptic ulcer and to relieve visceral spasm. Less than 25% is absorbed by the oral route. It is rapidly cleared from plasma following intravenous administration with < 10% remaining after 5 minutes. The antisecretory action lasts up to 3 hours. Eighty-five percent of excretion is in urine as mainly free drug and the remainder in bile. About 20% of the dose is metabolized by hydroxylation and oxidation.
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© 1995 Springer Science+Business Media New York
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Wilson, J.F. (1995). Glycopyrronium Bromide. In: Wilson, J.F. (eds) Drugs Eicosanoids. Immunoassay Kit Directory, vol 1 / 3 / 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0679-5_24
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DOI: https://doi.org/10.1007/978-94-011-0679-5_24
Publisher Name: Springer, Dordrecht
Print ISBN: 978-0-7923-8863-0
Online ISBN: 978-94-011-0679-5
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