Skip to main content
SpringerLink
Log in
Book cover

The Genetics of Cancer pp 1–19Cite as

Breast cancer genetics

  • Chapter

  • 98 Accesses

Part of the book series: Cancer Biology and Medicine ((CABM,volume 4))

Abstract

The observation that some families have an excess of breast cancers, not readily accounted for by chance, is not new. Breast cancer families have been recognized since Ancient Roman times1. One of the earliest and most striking published reports was by a French physician, Paul Broca, who in 1866 reported a four-generation family where breast cancer had affected ten out of twenty-four women2. It is only in the last 10 years, however, that significant advances have led to a better understanding of familial clustering of this disease.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Steel CM, Clayton J, Thompson A. Genetic aspects of breast cancer. Br Med Bull. 1991; 47(2): 504–518.

    PubMed  CAS  Google Scholar 

  2. Broca P (1866). Trait des tumeurs. Des tumeurs en general. Vol 1. Paris: Anselin, Becket et Labe.

    Google Scholar 

  3. Brinton LA, Hoover R, Frauneni JF Jr. Interaction of familial and hormonal risk factors for breast cancer. J Natl Cancer Inst. 1982; 69: 817–822.

    PubMed  CAS  Google Scholar 

  4. Adami HO, Hansen J, Jung B, Rimsten A. Familiality in breast cancer: a case control study in a Swedish population. Br J Cancer. 1980; 42: 71–77.

    PubMed  CAS  Google Scholar 

  5. Negri E, La Vecchia C, Bruzzi P et al. Risk factors for breast cancer: pooled results from three Italian case-control studies. Am J Epidemiol. 1988; 128: 1207–1215.

    PubMed  CAS  Google Scholar 

  6. Claus EB, Risch N, Thompson WD. Using age of onset to distinguish between symptoms of breast cancer. Ann Hum Genet. 1990; 54: 169–177.

    PubMed  CAS  Google Scholar 

  7. Claus EB, Risch N, Thompson W. Age as an indicator of familial risk of breast cancer. Am J Epidemiol. 1990; 131: 961–972.

    PubMed  CAS  Google Scholar 

  8. Anderson K, Easton DF, Mathews FE, Peto J. Cancer morbidity in the first degree relatives of young breast cancer patients. Br J Cancer. 1992; 66: 599–602.

    PubMed  CAS  Google Scholar 

  9. Tulinius H, Egilsson V, Olafsdottin GH, Sigvaldon H. Risk of prostate, ovarian and endometrial cancer among selectives of women with breast cancer. Br Med J. 1992; 305: 855–857.

    CAS  Google Scholar 

  10. Claus EB, Risch N, Thompson D. Genetic analysis of breast cancer in the cancer and steroid hormone study. Am J Hum Genet. 1991; 48: 232–241.

    PubMed  CAS  Google Scholar 

  11. Williams WR, Anderson DE. Genetic epidemiology of breast cancer: segregation analysis of 200 Danish pedigrees. Genet Epidemiol. 1984; 1: 7–20.

    PubMed  CAS  Google Scholar 

  12. Iselius L, Slack J, Littler M, Morton N. Genetic epidemiology of breast cancer in Britain. Ann Hum Genet. 1991; 55(2): 151–159.

    PubMed  CAS  Google Scholar 

  13. Newman B, Austin M, Lee M, King M-C. Inheritance of human breast cancer: evidence for autosomal dominant transmission in high risk families. Proc Natl Acad Sci USA. 1988; 85: 3044–3048.

    PubMed  CAS  Google Scholar 

  14. Narod SA, Lynch H, Conway T, Watson P, Fenteum J, Lenoir G. Increasing incidence of breast cancer in a family with BRCAI mutation. Lancet. 1993; 341: 1101–1102.

    PubMed  CAS  Google Scholar 

  15. Lynch HT, Harris RE, Guirgis HA et al. Familial association of breast/ovarian carcinoma. Cancer 1978; 41: 1543–1549.

    PubMed  CAS  Google Scholar 

  16. Schildkraut JM, Risch N, Thompson WD. Evaluating genetic association among ovarian, breast and endometrial cancer: evidence for a breast/ovarian cancer relationship. Am J Hum Genet. 1989; 45: 521–529.

    PubMed  CAS  Google Scholar 

  17. Cannon L, Bishop DT, Skolnick M, Hunt S, Lyon JL, Smart CR. Genetic epidemiology of prostate cancer in the Utah Mormon genealogy. Cancer Surveys. 1982; 1: 47–69.

    Google Scholar 

  18. Houlston RS, McCarter E, Parbhoo S, Scurr J, Slack J. Family history and risk of breast cancer. J Med Genet. 1992; 29: 154–157.

    PubMed  CAS  Google Scholar 

  19. Ron E, Kleinerman RA, Li Volsi VA, Fraumeni JF Jr. Familial non-medullary thyroid cancer. Oncology. 1991; 48: 309–311.

    PubMed  CAS  Google Scholar 

  20. Goldgar DE, Easton DF, Cannon-Albright L, Skolnick MH. A systematic population-based assessment of cancer risk in first degree relatives of cancer probands. JNCI. 1994; 86: 1600–1608.

    PubMed  CAS  Google Scholar 

  21. De Mars R. In: 23rd annual symposium on fundamental cancer research 1969. Baltimore: Williams and Wilkins; 1970: 105–106.

    Google Scholar 

  22. Knudson A. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA. 1971; 68(4): 820–823.

    PubMed  Google Scholar 

  23. Lee WH, Bookstein R, Hong F, Young LJ, Shaw JY, Lee EYHP. Human retinoblastoma susceptibility gene — cloning, identification and sequence. Science. 1987; 235: 1394–1399.

    PubMed  CAS  Google Scholar 

  24. Huang HS, Yee J, Shew J et al. Suppression of the neoplastic phenotype by replacement of the RB gene in human cancer cells. Science. 1988; 242: 1563–1566.

    PubMed  CAS  Google Scholar 

  25. Srivastava S, Wang S, Tong Y, Pirollo K, Chang E. Several p53 proteins detected in cancer prone families with Li-Fraumeni syndrome exhibit transdominant effects on the biochemical properties of the wild-type p53. Oncogene. 1993; 8(9): 2449–2456.

    PubMed  CAS  Google Scholar 

  26. Tripathy D, Benz CC. Activated oncogenes and putative tumour suppressor genes involved in human breast cancers. Cancer Treatment Res. 1992; 63: 15–60.

    CAS  Google Scholar 

  27. Devilee P, Van den Broek M, Kuipers-Dijkshoorn et al. At least four different chromosomal regions are involved in loss of heterozygosity in human breast carcinoma. Genomics. 1989; 5: 554–560.

    PubMed  CAS  Google Scholar 

  28. Sato T, Tanigami A, Yamakawa K et al. Allelotype of breast cancer: cumulative allele losses promote tumour progression in primary breast cancer. Cancer Res. 1990; 50: 7184–7189.

    PubMed  CAS  Google Scholar 

  29. Cropp CS, Lidereau R, Campbell G, Champene M. Loss of heterozygosity on chromosome 17 and 18 in breast carcinoma: two additional regions identified. Proc Natl Acad Sci USA. 1990; 87: 7737–7741.

    PubMed  CAS  Google Scholar 

  30. Callahan R, Cropp C, Merlo GR et al. Somatic mutations and human breast cancer. A status report. Cancer. 1992; 69(6 Suppl): 1582–1588.

    PubMed  CAS  Google Scholar 

  31. Hall JM, Lee MK, Newman B et al. Linkage of early-onset familial breast cancer to chromosome 17q21. Science. 1990; 250: 1684–1689.

    PubMed  CAS  Google Scholar 

  32. Narod SA, Lynch H, Feunteun J et al. Familial breast-ovarian cancer locus on chromosome 17q 12-23. Lancet. 1991; 338: 82–83.

    PubMed  CAS  Google Scholar 

  33. Solomon E, Ledbetter DH. Report of the committee on the genetic constitution of chromosome 17. Cytogenet Cell Genet. 1991; 58: 686–738.

    Google Scholar 

  34. Easton DF, Bishop DT, Ford D, Crockford GP and the Breast Cancer Linkage Consortium. Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. Am J Hum Genet. 1993; 52(4): 678–701.

    PubMed  CAS  Google Scholar 

  35. Miki Y, Swensen J, Shattuck-Eidens D et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCAI. Science. 1994; 266: 66–71.

    PubMed  CAS  Google Scholar 

  36. Peltomaki P, Aaltonen LA, Sistonen P et al. Genetic mapping of a locus predisposing to human colorectal cancer. Science. 1993; 260: 810–812.

    PubMed  CAS  Google Scholar 

  37. Fishel R, Lescoe M, Rao M et al. The human imitator gene homolog HMSH2 and its association with hereditary nonpolyposis colon cancer. Cell. 1993; 75: 1027–1038.

    PubMed  CAS  Google Scholar 

  38. Leach FS, Nicolaides NC, Papadopoulos N, et al. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell. 1993; 75: 1215–1225.

    PubMed  CAS  Google Scholar 

  39. Bronner C, Baker S, Morrison P, et al. Mutations in the DNA mismatch homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature (London). 1994; 368: 258–261.

    CAS  Google Scholar 

  40. Wooster R, Cleton-Jansen A-M, Collins N et al. Instability of short tandem repeats (microsatellites) in human cancers. Nature Genetics. 1994; 6: 152–156.

    PubMed  CAS  Google Scholar 

  41. Easton DF, Ford D, Peto J. Inherited susceptibility to breast cancer. Cancer Surv. 1993; 18: 95–113.

    PubMed  CAS  Google Scholar 

  42. Lane D, Crawford L. T-antigen is bound to a host protein in SV40 transformed cells. Nature. 1979; 278: 261–263.

    PubMed  CAS  Google Scholar 

  43. Isobe M, Emanuel B, Givol D, Oren M, Croce C. Localisation of the gene for human p53 tumour antigen to band 17p13. Nature. 1986; 320: 84–85.

    PubMed  CAS  Google Scholar 

  44. Eliyahu D, Michalovitz D, Oren M. (1985). Overproduction of p53 antigen makes established cells highly tumorigenic. Nature (London). 1985; 316: 158–160.

    CAS  Google Scholar 

  45. Hinds P, Finlay C, Levine A. Mutation is required to activate the p53 gene for co-operation with the ras oncogene and transformation. J Virol. 1989; 63(2): 739–746.

    PubMed  CAS  Google Scholar 

  46. Lavigueur A, Maltby V, Mock D, Rossant J, Pawson T, Bernstein A. High incidence of lung, bone, and lymphoid tumours in mice overexpressing mutant alleles of the p53 oncogene. Mol Cell Biol. 1989; 9(9): 3982–3991.

    PubMed  CAS  Google Scholar 

  47. Malkin D, Li F, Strong L, et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas and other neoplasms. Science. 1990; 250: 1233–1238.

    PubMed  CAS  Google Scholar 

  48. Srivistava S, Zou Z, Pirollo K, Blattner W, Chang E. Germ-line transmission of a mutated p53 gene in a cancer prone family with Li-Fraumeni syndrome. Nature (London). 1990; 348: 747–749.

    Google Scholar 

  49. Li FP, Fraumeni JF. Soft tissue sarcomas, breast cancer and other neoplasms. A familial syndrome? Ann Intern Med. 1969; 71: 747–752.

    PubMed  CAS  Google Scholar 

  50. Birch JM, Hartley AL, Tricker KJ et al. Prevelance and diversity of constitutional mutations in the p53 gene among 21 Li-Fraumeni families. Cancer Res. 1994; 54(5): 1298–1304.

    PubMed  CAS  Google Scholar 

  51. Warren W, Eeles R, Ponder BA et al. No evidence for germline mutations in the p53 gene in 25 breast cancer families. Oncogene. 1992; 7(5): 1043–1046.

    PubMed  CAS  Google Scholar 

  52. Prosser J, Elder P, Condie A, MacFadyen I, Steel CM, Evans HJ. Mutations in p53 do not account for heritable breast cancer: a study in five affected families. Br J Cancer. 1991; 63: 181–184.

    PubMed  CAS  Google Scholar 

  53. Borresen A-L, Andersen TI, Garber J et al. Screening for germ-line TP53 mutations in breast cancer patients. Cancer Res. 1992; 52: 3234–3236.

    PubMed  CAS  Google Scholar 

  54. Sidransky D, Tokino T, Helzlsouer K et al. Inherited p53 gene mutations in breast cancer. Cancer Res. 1992; 5(10): 2984–2986.

    Google Scholar 

  55. Lidereau R, Soussi T. Absence of p53 germline mutations in bilateral breast cancer patients. Hum Genet. 1992; 89: 250–252.

    PubMed  CAS  Google Scholar 

  56. Toguchida J, Yamaguchi T, Dayton S et al. Prevalence and spectrum of germline mutations of the p53 gene among patients with sarcomas. N Engl J Med. 1992; 326: 1301–1308.

    PubMed  CAS  Google Scholar 

  57. Malkin D, Jolly K, Barbier N et al. Germline mutations of the p53 tumour-suppressor in children and young adults with second malignant neoplasms. N Engl J Med. 1992; 326: 1309–1315.

    PubMed  CAS  Google Scholar 

  58. Lane DP. p53, guardian of the genome. Nature (London). 1992; 358: 15–16.

    CAS  Google Scholar 

  59. Birch JM, Easton D, Ponder B, Spurr N, Lane D, Craft A, Hopwood P, on behalf of the UK Cancer Families Study Group. Guidelines for testing for germline p53 mutations and the management of families with such mutations. [Prepared December 1993] Available from Eh* JM Birch, The Christie Hospital, Manchester, UK.

    Google Scholar 

  60. Boder E. Ataxia-telangiectasia: an overview. In: Giatii RA, Swift M, eds. Ataxia-telangiectasia: genetics, neuropathology, and immunology of a degenerative disease of childhood. New York: Alan Liss; 1985: 1–63.

    Google Scholar 

  61. Spector BD, Filipovich AH, Perry GS III, Kersey JH. Epidemiology of cancer in ataxia-telangiectasia. In: Bridges BA, Harnden G, eds. Ataxia-telangiectasia: a cellular and molecular link between cancer, neuropathology and immune deficiency. Chichester, England: John Wiley; 1982: 103–138.

    Google Scholar 

  62. Morrell D, Cramatie E, Swift M. Mortality and cancer incidence in 263 patients with ataxia-telangiectasia. J Natl Cancer Inst. 1986; 77: 89–92.

    PubMed  CAS  Google Scholar 

  63. Pippard EC, Hall AJ, Barker DJP, Bridges BA. Cancer in homozygotes and heterozygotes of ataxia-telangiectasia and xeroderma pigmentosum in Britain. Cancer Res. 1988; 48: 2929–2932.

    PubMed  CAS  Google Scholar 

  64. Swift M, Morrell D, Cromatie E, Chamberlain AR, Skolnick MH, Bishop DT. The incidence and gene frequency of ataxia-telangiectasia in the United States. Am J Hum Genet. 1986; 39: 573–583.

    PubMed  CAS  Google Scholar 

  65. Swift M, Morrell D, Massey RB, Chase C. Incidence of cancer in 161 families affected by ataxia-telangiectasia. N Engl J Med. 1991; 325: 1831–1836.

    PubMed  CAS  Google Scholar 

  66. Swift M, Sholman L, Perry M, Chase C. Malignant neoplasms in families of patients with ataxia-telangiectasia. Cancer Res. 1976; 36: 209–215.

    PubMed  CAS  Google Scholar 

  67. Swift M, Reitnauer PJ, Morrell D, Chase CL. Breast and other cancers in families with ataxia-telangiectasia. N Engl J Med. 1987; 316: 1289–1294.

    PubMed  CAS  Google Scholar 

  68. Borresen A-L, Andersen Ti, Treti S, Heiberg A, Moller P. Breast cancer and other cancers in Norwegian families with ataxia-talangiectasia. Genes Chromosomes Cancer. 1990; 2: 339–340.

    PubMed  CAS  Google Scholar 

  69. Easton DE. Some problems of the genetic epidemiology of cancer [PhD thesis]. University of London; 1992.

    Google Scholar 

  70. Gatti RA, Berkel I, Boder E et al. Localisation of an ataxia-telangiectasia gene to chromosome llq22-23. Nature (London). 1988; 336: 577–580.

    CAS  Google Scholar 

  71. Foroud T, Wei S, Zvi Y et al. Localisation of an ataxia-telangiectasia locus to a 3cM interval on chromosome 11q22-q23: linkage analysis of 11 families by an international consortium. Am J Hum Genet. 1991;49: 1263–1279.

    PubMed  CAS  Google Scholar 

  72. Wooster R, Ford D, Mangion J et al. Absence of linkage to ataxia-telangiectasia locus in familial breast cancer. Hum Genet. 1993; 92: 91–94.

    PubMed  CAS  Google Scholar 

  73. Jehgers H, McKusick V, Katz KH. Generalised intestinal polyposis and melanin spots of the oral mucosa, lips and digits. N Engl J Med. 1979; 241: 993–1005.

    Google Scholar 

  74. Konishi F, Wyse NE, Muto T et al. Peutz-Jehgers polyposis associated with carcinoma of the digestive organs. Dis Colon Rectum. 1987; 30: 790–799.

    PubMed  CAS  Google Scholar 

  75. Spiegelman AD, Murday V, Phillips RKS. (1989). Cancer and the Peutz-Jehgers syndrome. Gut. 1989; 30: 1588–1590.

    Google Scholar 

  76. Utsunomiya J, Gocho T, Miyanaga E et al. Peutz-Jehgers syndrome; its natural course and management. Johns Hopkins Med J. 1974; 136: 71–82.

    Google Scholar 

  77. Giardello FM, Welsh SB, Hamilton SR et al. Increased risk of cancer in the Peutz-Jehgers syndrome. N Engl J Med. 1987; 316: 1511–1514.

    Google Scholar 

  78. Bagan JV, Penarrocha M, Vera-Sempere F. Cowden syndrome: clinical and pathological considerations in two new cases. Oral Maxillofacial Surg. 1989; 47: 289–294.

    Google Scholar 

  79. Carlson GJ, Nivatvongs S, Snover DC. Colorectal polyps in Cowden’s disease (multiple hamartomatous syndrome). Am J Pathol. 1984; 8: 763–769.

    CAS  Google Scholar 

  80. Guerin V, Bene MC, Judlin P, Beurey J, Landes P, Faure G. Cowden disease in a young girl; gynaecologic and immunologic overview in a case and in the literature. Obstet Gynecol. 1989; 73: 890–892.

    PubMed  CAS  Google Scholar 

  81. Lloyd KM, Dennis M. Cowden’s disease; a possible new symptom complex with multiple system involvement. Ann Intern Med. 1963;58: 136–142.

    PubMed  Google Scholar 

  82. Mallory SB. Genodermatoses with malignant potential. In: Alper JC, ed. Genetic disorders of the skin. St Louis: Mosby Year Books; 1990: 224–266.

    Google Scholar 

  83. Russell Jones R, O’Brien M, Wells RS. Cowden’s syndrome. Br J Dermatol. 1981; 105(suppl 19): 57–58.

    Google Scholar 

  84. Brownstein MH, Mehregan AH, Bikowski JB et al. The dermatopathology of Cowden’s disease. Br J Dermatol. 1979; 100: 667–673.

    PubMed  CAS  Google Scholar 

  85. Starink TM, Vander Veen JPW, Arwert F et al. The Cowden syndrome; a clinical and genetic study in 21 patients. Clin Genet. 1986; 29: 223–233.

    Google Scholar 

  86. Gardner DJ. Case of the season. Semin Roentgenol. 1990; 25: 223–224.

    PubMed  CAS  Google Scholar 

  87. Chilovi F, Zancaella L, Perino F et al. Cowden’s disease with gastrointestinal polyposis. Gastrointest Endosc. 1990; 36: 323–324.

    PubMed  CAS  Google Scholar 

  88. Starink TM, James WD, Rodman OC et al. (1986). Multiple hamartoma syndrome (Cowden’s disease) associated with non-Hodgkins lymphoma. Arch Dermatol. 1986; 122: 572–575.

    Google Scholar 

  89. Willard W, Borgen P, Bol R, Tiwari R, Osbourne M. Cowden’s disease; a case report with analysis at the molecular level. Cancer. 1992; 69: 2969–2974.

    Google Scholar 

  90. Eeles RA, Warren W, Knee G et al. Constitutional mutation in exon 8 of the p53 gene in a patient with multiple primary tumours; molecular and immunohistochemical findings. Oncogene. 1993;8: 1269–1276.

    PubMed  CAS  Google Scholar 

  91. Eng C, Murday V, Mohammed S et al. Cowden syndrome and Lhermitte-Duclos disease in a family; a single genetic syndrome with pleiotropy? J Med Genet. 1994; 31: 458–461.

    PubMed  CAS  Google Scholar 

  92. Rosenblatt KA, Thomas DB, McTieman A et al. Breast cancer in men: aspects of familial aggregation. J Natl Cancer Inst. 1991; 83: 849–853.

    PubMed  CAS  Google Scholar 

  93. Stratton MR, Ford D, Neuhasen S et al. Familial male breast cancer is not linked to the BRCAI locus on chromosome 17q. Nature Genet. 1994; 7: 103–107.

    PubMed  CAS  Google Scholar 

  94. Wooster R, Mangion J, Eeles R et al. A germline mutation in the androgen receptor gene in two brothers with breast cancer and Reifstein syndrome. Nature Genet. 1992; 2: 132–134.

    PubMed  CAS  Google Scholar 

  95. Lobaccaro J-M, Lumbroso S, Belon C et al. Male breast cancer and the androgen receptor gene. Nature Genet. 1993; 5: 109–110.

    PubMed  CAS  Google Scholar 

  96. Adami H-O, Adams G, Boyle P et al. Report of a working party for the Nordic Cancer Union. Breast cancer etiology. Int J Cancer. 1990;Suppl 5: 22–39.

    Google Scholar 

  97. Sellers TA, Kushi LH, Potter JD et al. Effect of family history, body fat distribution, and reproductive factors on the risk of post-menopausal breast cancer. N Engl J Med. 1992; 326: 1323–1329.

    PubMed  CAS  Google Scholar 

  98. Feinleib M. Breast cancer and artificial menopause: a cohort study. JNCI. 1968; 41: 315–329.

    PubMed  CAS  Google Scholar 

  99. Biggs PJ, Warren W, Venitt S, Stratton M. (1993). Does a genotoxic carcinogen contribute to human breast cancer? The value of mutational spectra in unravelling the aetiology of cancer. Mutagenesis. 1993; 8: 275–283.

    PubMed  CAS  Google Scholar 

  100. UK National Case-Control Study Group. Oral contraceptive use and breast cancer risk in young women: subgroup analysis. Lancet. 1990; 335: 1507–1509.

    Google Scholar 

  101. Steinberg K, Thacker SB, Smith L et al. A meta-analysis of the effect of oestrogen replacement therapy on the risk of breast cancer. JAMA. 1991; 265: 1985–1990.

    PubMed  CAS  Google Scholar 

  102. Kaufman DW, Palmer JR, de Mouzon J, et al. Estrogen replacement therapy and the risk of breast cancer: results from the case control surveillance study. Am J Epidemiol. 1991; 134: 1375–1385.

    PubMed  CAS  Google Scholar 

  103. Higginson J, Muir CS, Munoz N. Human cancer: epidemiology and environmental causes. Cambridge monographs on cancer research. Cambridge: Cambridge University Press; 1992: 39–44.

    Google Scholar 

  104. Lincoln DW. Contraception for the year 2020 [review]. Br Med Bull. 1993; 49: 222–236.

    PubMed  CAS  Google Scholar 

  105. Lange K, Weeks D, Boelinke M. Programs for pedigree analysis: MENDEL, FISHER and dGene. Genetic Epidemiol. 1988; 5: 471–472.

    CAS  Google Scholar 

  106. Bishop DT. Familial predisposition to cancer. Cancer Topics. 1992: 66–68.

    Google Scholar 

  107. Wooster R, Neuhausen SL, Mangion J, et al. Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13ql2-13. Science. 1994; 265: 2088–2090.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. D. Eccles
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Houlston
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Cambridge, UK

    B. A. J. Ponder (Professor of Human Cancer Genetics) & M. J. Waring (Reader in Chemotherapy) (Professor of Human Cancer Genetics) &  (Reader in Chemotherapy)

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Eccles, D., Houlston, R. (1995). Breast cancer genetics. In: Ponder, B.A.J., Waring, M.J. (eds) The Genetics of Cancer. Cancer Biology and Medicine, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0677-1_1

Download citation

  • DOI: https://doi.org/10.1007/978-94-011-0677-1_1

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4294-9

  • Online ISBN: 978-94-011-0677-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation