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The Role of Oxidized Lipids in Cardiovascular Disease

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Active Oxygen in Biochemistry

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Abstract

Lipid oxidation products play an important role in normal biology and in a number of disease processes (Sevanian and Hochstein, 1985; Marx, 1987). Oxidation products have been shown to be abnormal in many of the major chronic diseases, including rheumatoid arthritis, cancer, Alzheimer’s disease, and diabetes. In the last 5 years, the role of oxidized lipids in cardiovascular disease has been the subject of extensive studies (Steinberg et al., 1989; Witztum and Steinberg, 1991). Alterations in the synthetic rates of naturally occurring oxidized lipids and effects of lipid oxidation products that form as the result of non-physiological free-radical-generating processes have been shown to play a key role in blood vessel diseases such as atherosclerosis and thrombosis. Atherosclerosis leads to thickening of the wall of the blood vessel, reducing blood flow. Thrombosis is the formation of a blood clot which can completely stop blood flow in an already narrowed vessel. Ischemia (interruption of blood flow) following the development of atherosclerosis and thrombosis is the predominant cause of heart attacks, strokes (blood clots shutting off brain vessels), and ischemic syndromes (chest pains and irregular heartbeat) which are responsible for significant human morbidity and mortality. In this chapter, we will focus on the role of oxidized lipids in atherosclerosis and thrombosis.

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Authors
  1. Judith A. Berliner
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  2. Andrew D. Watson
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Editors and Affiliations

  1. University of California, Los Angeles, USA

    Joan Selverstone Valentine  & Christopher S. Foote  & 

  2. University of North Carolina at Charlotte, USA

    Arthur Greenberg

  3. University of Maryland Baltimore County, USA

    Joel F. Liebman

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Berliner, J.A., Watson, A.D. (1995). The Role of Oxidized Lipids in Cardiovascular Disease. In: Valentine, J.S., Foote, C.S., Greenberg, A., Liebman, J.F. (eds) Active Oxygen in Biochemistry. Structure Energetics and Reactivity in Chemistry Series (SEARCH series), vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0609-2_10

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  • DOI: https://doi.org/10.1007/978-94-011-0609-2_10

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