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Viruses in Human Gene Therapy pp 77–107Cite as

Retroviral Vectors in Human Gene Therapy

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Abstract

The discipline of human gene therapy is emerging as an accepted clinical practice quicker than many in the field expected. While the emphasis in many laboratories centers on the application of gene therapy to treat genetic diseases, this technology can be applied to such diverse diseases as cancer, cardiovascular disease, and AIDS. The most widely used gene transfer system in these clinical trials is that of retroviral mediated gene transfer. The aim of this chapter is to describe to the reader the technology of retroviral-mediated gene transfer and then to discuss the current clinical applications for which this technology is being applied. Other recent reviews on retro viral-mediated gene transfer and gene therapy can be found elsewhere (Anderson 1992; Kriegler 1990; Miller 1992a; Miller 1992b; Miller et al. 1993; Mulligan 1992; Mulligan 1993; Morgan and Anderson 1993).

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  1. Richard A. Morgan Ph.D.
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  1. Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC, USA

    Jean-Michel H. Vos D.Sc.

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© 1995 Jean-Michel H. Vos

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Morgan, R.A. (1995). Retroviral Vectors in Human Gene Therapy. In: Vos, JM.H. (eds) Viruses in Human Gene Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0555-2_4

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  • DOI: https://doi.org/10.1007/978-94-011-0555-2_4

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