Abstract
Arthritis is common, crippling, chronic and incurable. Many patients respond poorly to conventional treatments and thus the pursuit of novel therapies is encouraged. For reasons defended elsewhere (Evans and Robbins, 1994a, b) we suggest the development of gene treatments for arthritis.
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References
Arend, W.P. (1993) Interleukin-1 receptor antagonist. Adv. Immunol., 54, 167–227.
Bandara, G., Robbins, P.D., Georgescu, H.I. et al. (1992) Gene transfer to synoviocytes: prospects for gene treatment of arthritis. DNA Cell Biol., 11, 227–31.
Bandara, G., Mueller, G.M., Galea-Lauri, J. et al. (1993) Intraarticular expression of biologically active interleukin-1 receptor antagonist protein by ex vivo gene transfer. Proc. Natl Acad. Sci. USA, 90, 10764–8.
Coulton, L.A., Henderson, B., Biterski, L. et al. (1980) DNA synthesis in human rheumatoid synovial lining. Ann. Rheum. Dis., 39, 241–7.
DeLuca, N.A., McCarthy, A. and Schaffer, P.A. (1985) Isolation and characterization of deletion mutants of herpes simplex virus type I in the gene encoding immediate-early regulatory protein ICP4. J. Virol., 56, 558–70.
Evans, C.H. and Robbins, P.D. (1994a) Gene therapy for arthritis, in Gene Therapeutics: Methods and Applications of Direct Gene Transfer, (ed. J.A. Wolff), Birkhauser, Boston, pp. 320–43.
Evans, C.H. and Robbins, P.D. (1994b) Prospects for treating arthritis by gene therapy. J. Rheumatol., 21, 779–82.
Evans, C.H. and Robbins, P.D. (1994c) The interleukin-1 receptor antagonist and its delivery by gene transfer. Receptor, 4, 9–15.
Evans, C.H., Bandara, G., Mueller, G.M. et al. (1992) Synovial cell transplants for gene transfer to joints. Transplantation Proc., 24, 2966.
Evans, C.H., Bandara, G., Robbins, P.D. et al. (1993) Gene therapy for ligament healing, in The Anterior Cruciate Ligament: Current and Future Concepts, (eds S. Arnoczsky, S.L. Woo, C.B. Frank et al.), Raven Press, New York, pp. 419–22.
Gao, X. and Huang, L. (1991) A novel cationic liposome reagent for efficient transfection of mammalian cells. Biochem. Biophys. Res. Commun., 179, 280–5.
Georgescu, H.I., Mendelow, D. and Evans, C.H. (1988) HIG-82: an established line from rabbit periarticular soft tissue which retains the “activatable” phenotype. In Vitro, 24, 1015–22.
Hung, G.L., Galea-Lauri, J., Mueller, G.M. et al. (1994) Suppression of intraarticular responses to interleukin-1 by transfer of the interleukin-1 receptor antagnoist gene to synovium. Gene Therapy, 1, 64–9.
Lalor, P.A., Mapp, P.I., Hall, P.A. et al. (1987) Proliferative activity of cells in the synovium as demonstrated by monoclonal antibody, Ki-67. Rheumatol. Int., 7, 183–6.
Lewthwaite, J.C., Blake, S.M., Hardingham, T.E. et al. (1993) The effect of interleukin-1 receptor antagonist on the progression of antigen-induced arthritis in the rabbit. Trans. Orthop. Res. Soc., 18, 237.
Mohr, W., Beneke, G. and Mohing, W. (1975) Proliferation of synovial lining cells and fibroblasts. Ann. Rheum. Dis., 34, 219–24.
Palmer, T.D., Rosman, G.J., Osborne, W.B.A. et al. (1991) Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes. Proc. Natl Acad. Sci. USA, 88, 1330–4.
Qu, Z., Garcia, CH., O’Rourke, L.M. et al. (1994) Local proliferation of fibroblast-like synoviocytes contributes to synovial hyperplasia. Arthritis Rheum., 37, 212–20.
Raz, E., Watanabe, A., Baird, S.M. et al. (1993) Systemic immunological effects of cytokine genes injected into skeletal muscle. Proc. Natl Acad. Sci. USA, 90, 4523–7.
Roessler, B.J., Allen, E.D., Wilson, J.M. et al. (1993) Adenoviral-mediated gene transfer to rabbit synovium in vivo. J. Clin. Invest., 92, 1085–92.
Singhal, A. and Huang, L. (1994) Gene transfer in mammalian cells using liposomes as carriers in Gene Therapeutics: Methods and Applications of Direct Gene Transfer, (ed. J.A. Wolff), Birkhauser, Boston, pp. 118–42.
Wolff, J.A., Malone, R.W., Williams, P. et al. (1990) Direct gene transfer into mouse muscle in vivo. Science, 247, 1465–8.
Wooley, P.H., Whalen, J.D., Chapman, D.L. et al. (1993) The effect of an interleukin-1 receptor antagonist protein on type II collagen-induced arthritis and antigen-induced arthritis in mice. Arthritis Rheum., 36, 1305–14.
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Evans, C.H., Robbins, P.D. (1995). Arthritis. In: Dickson, G. (eds) Molecular and Cell Biology of Human Gene Therapeutics. Molecular and Cell Biology of Human Diseases Series, vol 20. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0547-7_13
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DOI: https://doi.org/10.1007/978-94-011-0547-7_13
Publisher Name: Springer, Dordrecht
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