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AIDS and HIV infection

  • Chapter
Molecular and Cell Biology of Human Gene Therapeutics

Part of the book series: Molecular and Cell Biology of Human Diseases Series ((Mol. Cell Biol. Hu. Dis.,volume 20))

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Abstract

Infection with the human immunodeficiency virus (HIV) is a paradigm for serious viral diseases which may be treatable with gene therapy. The biology of the virus and the pathophysiology of infection with HIV are rapidly being clarified and a number of potential targets for gene therapy interventions have been identified. HIV infects primarily the hematopoietic system which is relatively easy to obtain, manipulate, assess and transplant. Current pharmacologic, immunologic, and biotherapeutic approaches to treating HIV infection have been disappointing, propelling the development of alternative treatment approaches. This chapter will review the features of HIV biology relevant to gene therapy, HIV gene therapy inhibition strategies and gene delivery systems, preclinical models for evaluating the safety and efficacy of gene therapy approaches to HIV infection, and the initial potential clinical applications of this technology.

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Authors
  1. Clay Smith
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  2. Bruce A. Sullenger
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Editors and Affiliations

  1. Department of Biochemistry, Royal Holloway, University of London, Egham, Surrey, TW20 0EX, UK

    George Dickson

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Smith, C., Sullenger, B.A. (1995). AIDS and HIV infection. In: Dickson, G. (eds) Molecular and Cell Biology of Human Gene Therapeutics. Molecular and Cell Biology of Human Diseases Series, vol 20. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0547-7_11

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  • DOI: https://doi.org/10.1007/978-94-011-0547-7_11

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