Abstract
Catalytic RNA molecules are metalloenzymes which require only water and magnesium ions for their biological function. The specificity and precision of their catalytic activity stem from their intricate three-dimensional structures which are attained and maintained through RNA-RNA interactions. In several instances, adenine residues of single-strands, internal loops or hairpin loops, have been implicated in tertiary contacts either unspecifically to the sugar-phosphate backbone or specifically to the shallow groove side of G-C base pairs. Examples from each of the three families of catalytic RNAs are described.
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Westhof, E. (1995). On the Role of Single-Stranded Adenines in RNA-RNA Recognition. In: Pullman, A., Jortner, J., Pullman, B. (eds) Modelling of Biomolecular Structures and Mechanisms. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0497-5_23
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DOI: https://doi.org/10.1007/978-94-011-0497-5_23
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