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Twists and Turns in DNA: Predicting Base Sequence Effects on the Conformation of the Double Helix

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Book cover Modelling of Biomolecular Structures and Mechanisms

Part of the book series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry ((JSQC,volume 27))

Abstract

The present study presents the results of molecular modelling of base sequence effects on the structure of the DNA double helix. An appropriate choice of the modelling algorithm and the use of helical symmetry has enabled a very thorough investigation of the conformational space of all unique tetranucleotide repeating sequences. The results indicate that each sequence is associated with a considerable number of stable sub-states characterised by their sugar puckers. Using this data it is possible to envisage predicting the conformation of much longer pieces of DNA using the superposition of tetranucleotide fragments.

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Author information

Authors and Affiliations

  1. Laboratoire de Biochimie Théorique, CNRS URA 77, Institut de Biologie Physico-Chimique, 13, rue Pierre et Marie Curie, Paris, 75005, France

    Richard Lavery

Authors
  1. Richard Lavery
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Editor information

Editors and Affiliations

  1. Fondation Edmond de Rothschild, Institut de Biologie Physico-Chimique, Paris, France

    A. Pullman  & B. Pullman  & 

  2. The Israel Academy of Sciences and Humanities, Jerusalem, Israel

    J. Jortner

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© 1995 Springer Science+Business Media Dordrecht

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Lavery, R. (1995). Twists and Turns in DNA: Predicting Base Sequence Effects on the Conformation of the Double Helix. In: Pullman, A., Jortner, J., Pullman, B. (eds) Modelling of Biomolecular Structures and Mechanisms. The Jerusalem Symposia on Quantum Chemistry and Biochemistry, vol 27. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0497-5_18

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  • DOI: https://doi.org/10.1007/978-94-011-0497-5_18

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4222-2

  • Online ISBN: 978-94-011-0497-5

  • eBook Packages: Springer Book Archive

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