Abstract
This chapter explores the premise that assessment of a drug’s effect in the CNS requires consideration of not only the receptors targeted by the drug but also the cerebral regions and neuronal circuits that are functionally modulated by the drug in vivo. A series of combined drug and behavioural PET rCBF activation paradigms are described to illustrate this conjecture.
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Grasby, P.M., Friston, K.J. (1995). Brain Activation Under Drug Treatment. In: Comar, D. (eds) PET for Drug Development and Evaluation. Developments in Nuclear Medicine, vol 26. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0429-6_15
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DOI: https://doi.org/10.1007/978-94-011-0429-6_15
Publisher Name: Springer, Dordrecht
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