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Left ventricular function by stress MR imaging

Animal studies using dobutamine

  • Chapter
Advances in Imaging Techniques in Ischemic Heart Disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 171))

  • 41 Accesses

Summary

The study describes the application of end-systolic pressure-volume relations (ESPVR) to assess cardiac contractility and pump function and how these quantities change with stress. Pressure-volume loops were constructed in ten anesthetized pigs, using both MRI and the conductance catheter to obtain left ventricular volume, combined with a special micromanometer-tip catheter for pressure measurement. The loops were obtained both during normal and reduced hemodynamic loading conditions, the latter acquired bij nitroprusside. Stress conditions were induced by dobutamine at an infusion rate of 10 μg/kg/min.

The ESPVR showed a parallel leftward shift (decreasing volume intercept) with dobutamine, indicating increased contractile state. The leftward shift was similar for the two methods: 6.9 ml for MRI and 7.4 ml for the conductance catheter method on the average. The slope of the ESPVR did not change significantly for either method. This finding is in agreement with results obtained by other investigators. It is concluded that, just as had been shown previously for the conductance method, pressure-volume loops and -relations may be obtained reliably using MRI for left ventricular volume measurement. This is promising for future applications of MRI to assess pump function during dobutamine-induced stress in patients diagnosed for left ventricular dysfunction.

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References

  1. Grossman W, Lorell BH, editors. Diastolic relaxation of the heart. Boston: Martinus Nijhoff, 1988.

    Google Scholar 

  2. Suga H, Sagawa K. Instantaneous pressure-volume relationships and their ratio in the excised, supported canine left ventricle. Circ Res1974;35:117–126.

    Article  PubMed  CAS  Google Scholar 

  3. Baan J, van der Velde ET, Steendijk P. Ventricular pressure-volume relations in vivo. Eur Heart J 1992; 13Suppl E:2–6.

    Article  PubMed  Google Scholar 

  4. Little WC. The left ventricular dP dtmax-end-diastolic volume relation in closed-chest dogs. Circ Res 1985;56:808–815.

    Article  PubMed  CAS  Google Scholar 

  5. Glower DD, Spratt JA, Snow ND, et al. Linearity of the Frank-Starling relationship in the intact heart: the concept of preload recruitable stroke work. Circulation 1985;71:994–1009.

    Article  PubMed  CAS  Google Scholar 

  6. Baan J, van der Velde ET, de Bruin HG, et al. Continuous measurement of left ventricular volume in animals and humans by conductance catheter. Circulation 1984;70:812–823.

    Article  PubMed  CAS  Google Scholar 

  7. Van Bel F, Steendijk P, Teitel DF, de Winter PJ, van der Velde ET, Baan J. Cerebral blood flow velocity: the influence of myocardial contractility on the velocity waveform of brain supplying arteries. Ultrasound Med Biol 1992; 18:441–449.

    Article  PubMed  Google Scholar 

  8. Teitel DF, Klautz RJM, Steendijk P, van der Velde ET, van Bel F, Baan J. The end-systolic pressure-volume relationship in the newborn lamb: effects of loading and inotropic interventions. Pediatr Res 1991;29:473–482.

    Article  PubMed  CAS  Google Scholar 

  9. Leatherman GF, Shook TL, Leatherman SM, Colucci WS. Use of a conductance catheter to detect increased left ventricular inotropic state by end-systolic pressure-volume analysis. Basic Res Cardiol 1989;84: Suppl 1:247–256.

    Article  PubMed  Google Scholar 

  10. Kass DA, Maughan WL. From ‘Emax’ to pressure-volume relations: a broader view. Circulation1988;77:1203–1212.

    Article  PubMed  CAS  Google Scholar 

  11. Baur LHB, Schipperheyn JJ, Baan J, et al. Influence of angiotensin converting enzyme inhibition on pump function and cardiac contractility in patients with chronic congestive heart failure. Br Heart J 1991;65:137–142.

    Article  PubMed  CAS  Google Scholar 

  12. Baan J. Evaluation of left ventricular dysfunction by pressure-volume loops. In Baur LHB, et al., editors. Opsporing en behandeling van een gestoorde linker-kamerfunctie na het myocardinfarct. Leiden: Boerhaave Commissie voor Postacademisch Onderwijs in de Geneeskunde,1993:103–115.

    Google Scholar 

  13. DellTtalia LJ, Carter B, Millar H, Pohost GM. Development of a micromanometer-tip catheter to record high-fidelity pressures during cine-gated NMR without significant image distortion. Magn Reson Med 1991;17:119–125.

    Article  Google Scholar 

  14. Pirolo JS, Branham BH, Cresswell LL, Perman WH, Vannier MW, Pasque MK. Pressure-gated acquisition of cardiac MR images. Radiology 1992;183:487–492.

    PubMed  CAS  Google Scholar 

  15. Pattynama PMT, van der Velde ET, Steendijk P, Lamb HJ, Baan J, de Roos A. Cardiovascular MR imaging: pressure-gating using the arterial pressure signal from a conventional ferromagnetic micromanometer-tip catheter. Magn Res Imaging 1994;12:531–534.

    Article  CAS  Google Scholar 

  16. Pattynama PMT, Lamb HJ, van der Velde EA, van der Wall EE, de Roos A. Left ventricular measurements with cine and spin-echo MR imaging: a study of reproducibility with variance component analysis. Radiology 1993; 187:261–268.

    PubMed  CAS  Google Scholar 

  17. Press WH, Teukolsky SA, Vetterling WT, Flannery BP. Numerical recipes in C: the art of scientific computing: second edition. Cambridge: Cambridge University Press, 1992.

    Google Scholar 

  18. Steendijk P, van der Velde ET, Baan J. Single and dual excitation of the conductance-volume catheter analyzed in a spheroidal mathematical model of the canine left ventricle. Eur Heart J 1992; 13 Suppl E:28–34.

    Article  PubMed  Google Scholar 

  19. Steendijk P, van Der Velde ET, Baan J. Left ventricular stroke volume by single and dual excitation of the conductance catheter in dogs. Am J Physiol 1993;264:H2189–2207.

    Google Scholar 

  20. Baan J, van der Velde ET, Steendijk P, Koops J. Calibration and application of the conductance catheter for ventricular volume measurement. Automedica 1989; 11:357–365.

    Google Scholar 

  21. Boltwood CM Iv, Appleyard RF, Glantz SA. Left ventricular volume measurement by conductance catheter in intact dogs. Parallel conductance volume depends on left ventricular size. Circulation 1989;80:1360–1377.

    Article  PubMed  Google Scholar 

  22. Baan J, van der Velde ET. Sensitivity of left ventricular end-systolic pressure-volume relation to type of loading intervention in dogs. Circ Res 1988;62:1247–1258.

    Article  PubMed  CAS  Google Scholar 

  23. Van der Velde ET, Burkhoff D, Steendijk P, Karsdon J, Sagawa K, Baan J. Nonlinearity and afterload sensitivity of end-systolic pressure-volume relation of canine left ventricle in vivo. Circulation 1991;83:315–327.

    Article  PubMed  Google Scholar 

  24. Pattynama PMT. Functional magnetic resonance imaging of the heart [Dissertation]. Leiden: Leiden University, 1994

    Google Scholar 

  25. Pattynama PMT, de Roos A, van der Velde ET, Lamb HJ, Steendijk P, Baan J. Magnetic resonance analysis of left ventricular pressure-volume relations: validation with the conductance method at rest and during dobutamine stress. Magn Reson Med. In press.

    Google Scholar 

  26. Van Bel F, Klautz RJM, Schipper IB, Teitel DF, Baan J. Autoregulatory ability of cerebral circulation before and after indomethacin in the newborn lamb [abstract]. Pediatr Res 1991;29:364A.

    Google Scholar 

  27. Little WC, Cheng CP, Peterson T, Vinten-Johansen J. Response of the left ventricular end-systolic pressure-volume relation in conscious dogs to a wide range of contractile states. Circulation 1988;78:736–745.

    Article  PubMed  CAS  Google Scholar 

  28. Longmore DB, Klipstein RH, Underwood SR, et al. Dimensional accuracy of magnetic resonance in studies of the heart. Lancet 1985; 1:1360–1362.

    Article  PubMed  CAS  Google Scholar 

  29. Borow KM, Neumann A, Wynne J. Sensitivity of end-systolic pressure-dimension and pressure-volume relations to the inotropic state in humans. Circulation 1982;65:988–997.

    Article  PubMed  CAS  Google Scholar 

  30. Carabello BA, Nolan SP, McGuire LB. Assessment of preoperative left ventricular function in patients with mitral regurgitation: value of the end-systolic wall stress-end-systolic volume ratio. Circulation 1981;64:1212–1217.

    Article  PubMed  CAS  Google Scholar 

  31. Van Rugge FP, van der Wall EE, Spanjersberg SJ, et al. Magnetic resonance imaging during dobutamine stress for detection and localization of coronary artery disease. Quantitative wall motion analysis using a modification of the centerline method. Circulation1994;90:127–138.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Cardiology, Leiden University Hospital, the Netherlands

    J. Baan

  2. Department of Diagnostic Radiology and Nucleair Medicine, Leiden University Hospital, the Netherlands

    P. M. T. Pattynama

Authors
  1. J. Baan
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  2. P. M. T. Pattynama
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Editor information

Editors and Affiliations

  1. Department of Cardiology, University Hospital Leiden, Leiden, The Netherlands

    Ernst E. Van Der Wall

  2. Department of Cardiology, Cleveland Clinic Foundation, Cleveland, USA

    Thomas H. Marwick

  3. Department of Diagnostic Radiology, University Hospital Leiden, Leiden, The Netherlands

    Johan H. C. Reiber

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© 1995 Springer Science+Business Media Dordrecht

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Baan, J., Pattynama, P.M.T. (1995). Left ventricular function by stress MR imaging. In: Van Der Wall, E.E., Marwick, T.H., Reiber, J.H.C. (eds) Advances in Imaging Techniques in Ischemic Heart Disease. Developments in Cardiovascular Medicine, vol 171. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0365-7_5

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  • DOI: https://doi.org/10.1007/978-94-011-0365-7_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4163-8

  • Online ISBN: 978-94-011-0365-7

  • eBook Packages: Springer Book Archive

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