Abstract
Amino acids precursors are reduced in a two-phase system ethyl acetate-water with e.e. up to 90 % in the presence of a rhodium complex associated with chiral sulfonated diphosphines. Performing the reaction in deuterium oxide allows the regiospecific introduction of a deuterium atom at the carbon a to the acetamido and the ester group.
Palladium(0)-catalyzed allylic substitution of acetates or carbonates occur in a two-phases system nitrile-water using tppts as the ligand; recycling of the catalyst is possible whatever the nucleophile used (carbo or heteronucleophile). The application of this methodology to uracil and 2-thiouracil derivatives afford the regiospecific allylated product at N-1 for the uracil and at sulfur for the thiouracil series.
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Sinou, D. (1995). Organometallic Catalysis in Water and in a Two-Phase System. In: Horváth, I.T., Joó, F. (eds) Aqueous Organometallic Chemistry and Catalysis. NATO ASI Series, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0355-8_22
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DOI: https://doi.org/10.1007/978-94-011-0355-8_22
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