Abstract
Recognition between the base pairs in complementary oligonucleotide strands is a model for efforts to understand intermolecular complexation and to design intermolecular recognition systems generally. We have asked whether synthetic organic chemistry, enzymology, and molecular biology can be applied together to obtain an expanded molecular recognition system, modeled on nucleic acids, that:
-
(a)
is one-dimensional, and therefore is easy to synthesize.
-
(b)
is capable of duplication via principles of complementarity analogous to those used by DNA and RNA.
-
(c)
can encode information concerning the structure of other biopolymers.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Benner, S. A., Allemann, R. K., Ellington, A. D., Ge, L., Glasfeld, A., Leanz, G. F., Krauch, T., MacPherson, L. J., Moroney, S. A., Piccirilli, J. A., and Weinhold, E. (1987) Cold Spring Harbor Sym. Quant. Biol. 52, 53–63.
Krosigk, U. v. (1993) Entwurf und Synthese eines neuen Basenpaars für das genetischen Alphabet, ETH Diss. Nr. 10164.
Vögel, J. J., Krosigk, U. v. and Benner, S. A. (1993) J. Org. Chem. 58, 7542–7547.
Vögel, J. J., Altorfer, M. M., and Benner, S. A. (1993) Helv. Chim Acta 76, 2061–2069.
Piccirilli, J. A., Krauch, T., MacPherson, L. J. and Benner, S. A. (1991) Helv. Chim. Acta 74, 397–406.
Vögel, J. J., and Benner, S. A. (1994) J. Am. Chem. Soc. 116, 6929–6930.
Piccirilli, J. A., Krauch, T., Moroney, S. E. and Benner, S. A. (1990) Nature 343, 33–37.
Bain, J. D., Chamberlin, A. R., Switzer, C. Y. and Benner, S. A. (1992) Nature 356, 537–539.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Benner, S.A., Horlacher, J., Vögel, J., von Krosigk, U. (1995). A New Molecular Encoding System. In: Siegel, J.S. (eds) Supramolecular Stereochemistry. NATO ASI Series, vol 473. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0353-4_8
Download citation
DOI: https://doi.org/10.1007/978-94-011-0353-4_8
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-010-4157-7
Online ISBN: 978-94-011-0353-4
eBook Packages: Springer Book Archive