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Accumulation of fatty acids and their carnitine derivatives during myocardial ischemia

  • Chapter
The Carnitine System

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 162))

Abstract

Fatty acids are important substrates for the heart. Under normal conditions fatty acids are continuously extracted from the extracellular space, transported through the cytoplasm to the mitochondria by fatty acid-binding proteins (FABP), and converted to fatty acyl CoA. Part of acyl CoA is used for the formation of complex lipids (triacylglycerols and phospholipids), the majority of the acyl residues is channeled across the mitochondrial inner membrane into the mitochondrial matrix with the use of a carnitine-mediated transport system [1].

“The intracellular enzymatic machinery avidly converts fatty acids, keeping the cellular level as low as possible. The latter condition promotes diffusion of fatty acids from the extracellular compartment to the cytoplasm of the cardiomyocyte by creating a concentration gradient across the sarcolemma and protects cellular structures against deleterious high levels of fatty acyl moieties.”

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Author information

Authors and Affiliations

  1. Department of Physiology, Faculty of Medicine, University of Limburg, P.O. Box 616, 6200 MD, Maastricht, The Netherlands

    Professor Ger J. van der Vusse

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  1. Professor Ger J. van der Vusse
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Editors and Affiliations

  1. Thoraxcenter, Erasmus University, Rotterdam, The Netherlands

    J. W. De Jong

  2. Cattedra di Cardiologia, Università degli Studi di Brescia, Fondazione Clinica del Lavoro di Pavia, Gussago/Brescia, Italy

    R. Ferrari

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van der Vusse, G.J. (1995). Accumulation of fatty acids and their carnitine derivatives during myocardial ischemia. In: De Jong, J.W., Ferrari, R. (eds) The Carnitine System. Developments in Cardiovascular Medicine, vol 162. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0275-9_5

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  • DOI: https://doi.org/10.1007/978-94-011-0275-9_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4122-5

  • Online ISBN: 978-94-011-0275-9

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