Abstract
Propionyl-L-carnitine (PLC) is a carnitine derivative which has been reported to exert relevant cardiovascular effects. Results from several animal studies seem to indicate that PLC may directly influence the myocardium, thus improving its performance [1, 2]. The aim of this article is to review the cellular electrophysiological effects provoked by PLC.
“It could be hypothesized that action potential duration prolongation, which we have demonstrated to occur in papillary muscles isolated from the heart of rabbits treated for ten days with propionyl-L-carnitine (and which might be due to a reduction in transient outward potassium current), is somehow related to the observed improvement in the contractile properties of the intact myocardium.”
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© 1995 Springer Science+Business Media Dordrecht
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Mugelli, A., Cerbai, E., Barbieri, M. (1995). Cardiac electrophysiology of propionyl-L-carnitine. In: De Jong, J.W., Ferrari, R. (eds) The Carnitine System. Developments in Cardiovascular Medicine, vol 162. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0275-9_18
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DOI: https://doi.org/10.1007/978-94-011-0275-9_18
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