Abstract
This overview will address the current state-of-the-art in characterising metal ionoligonucleotide interaction by NMR spectroscopy. First the methodology of structure determination of oligonucleotides — metal ion complexes in solution will be discussed. In the second part recent results on sequence-selective metal ion binding to DNA oligonucleotides by NMR methods will be presented. Metal ion titrations of several dodecamer duplexes have been carried out using Mn(II), Zn(II), Hg(II) and Pd(II) salts. The selectivity is shown to be determined by the sequential variation in molecular electrostatic potential along the chain and also to a certain degree by the preferred coordination geometry of the metal ion.
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Sletten, E., Frøystein, N.Ă. (1995). NMR Spectroscopic Structure Determination of Metal Ion — Oligonucleotide Complexes — The Results of Sequence-Selective Binding Studies. In: Kessissoglou, D.P. (eds) Bioinorganic Chemistry. NATO ASI Series, vol 459. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0255-1_13
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DOI: https://doi.org/10.1007/978-94-011-0255-1_13
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