The Use of SPET in the Thorax

Part of the Developments in Nuclear Medicine book series (DNUM, volume 25)


Thallium-201 has been in use for many years for the evaluation of the myocardium, it’s great advantage being the fact that it is possible to examine a patient on one day due to the fact that Thallium-201 shows rapid redistribution after injection at peak stress. In addition Thallium-201 is readily available and relatively non-expensive. Traditionally it has been used in a standard 3 projection protocol, namely anterior-posterior, left-anterior-oblique and left-lateral. The usual dose is being 74 MBq, which is relatively small and this together with the physical characteristics of Thallium-201 do not make it an optimal pharmaceutical for SPET imaging; the main drawback being the long acquisition time. However SPET imaging with Thallium-201 is widely used because of the cost-effectiveness and it’s capability to evaluate viable myocardium. In addition there are relatively large databases available for use in the so called Polar Images which is not the case in for example Technetium-99m-Hexamibi.


Myocardial Perfusion Imaging Reverse Redistribution SPET Imaging Redistribution Image MIBI SPECT 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Friedman J, Van Train K, Maddahi J, et al. “Upward creep” of the heart: A frequent source of false-positive reversible defects during thallium-201 stress-redistribution SPECT. J Nucl Med 1989;30:1718–1722.PubMedGoogle Scholar
  2. 2.
    van Eck-Smit BLF, van der Wall EE, Kuijper AFM, Zwinderman AH, Pauwels EKJ. Immediate Thallium-201 reinjection following stress imaging: A time-saving approach for detection of myocardial viability. J Nucl Med 1993;34:737–743.PubMedGoogle Scholar
  3. 3.
    Wackers FJT. SestaMIBI: Will it replace Tl-201 in clinical cardiology? In: Reiber JHC,van der Wall EE, eds. Cardiovascular Nuclear Medicine and MRI. Dordrecht: Kluwer Academic Publishers, 1992:239–248.CrossRefGoogle Scholar
  4. 4.
    Oosterhuis WP, Niemeyer MG, Breeman A, et al. Exercise 201Tl scintigraphy: evaluation of the additional diagnostic value. Nucl Med Commun 1993;14:87–95.PubMedCrossRefGoogle Scholar
  5. 5.
    Pace L, Cuocolo A, Maurea S, et al. Reverse redistribution in resting thallium-201 myocardial scintigraphy in patients with coronary artery disease: Relation to coronary anatomy and ventricular function. J Nucl Med 1993;34:1688–1692.PubMedGoogle Scholar
  6. 6.
    Liu P, Burns RJ. Easy come, easy go: Time to pause and put thallium reverse redistribution in perspective. J Nucl Med 1993;34:1692–1694.PubMedGoogle Scholar
  7. 7.
    Marzullo P, Sambuceti G, Parodi O. The role of sestamibi scintigraphy in the radioisotopic assessment of myocardial viability. J Nucl Med 1992;33:1925–1930.8.PubMedGoogle Scholar
  8. 8.
    Kiat H,Maddahi J,Roy LT. Comparison of technetium 99m methoxyisobutyl isonitrile and thallium201 for evaluation of coronary artery disease by planar and tomographic methods. Am Heart J 19891171–11.PubMedCrossRefGoogle Scholar
  9. 9.
    Maublant JC, Peycelon P, Kwiatkowski F, Lusson J-R, Standke RH, Veyre A. Comparison between 180° and 360° data collection in technetium-99m MIBI SPECT of the myocardium. J Nucl Med 1989;30:295–300.PubMedGoogle Scholar
  10. 10.
    Taillefer R, Laflamme L, Dupras G, Picard M, Phaneuf D-C, Léveillé J. Myocardial perfusion imaging with 99mTc-methoxy-isobutyl-isonitrile (MIBI): Comparison of short and long time intervals between rest and stress injections. Eur J Nucl Med 1988;13:515–522.PubMedCrossRefGoogle Scholar
  11. 11.
    Taillefer R, Gagnon A, Laflamme L, Léveillé J, Phaneuf D-C. Same day injections of Tc-99m methoxy isobutyl isonitrile (hexamibi) for myocardial tomographic imaging: Comparison between rest-stress and stress-rest injection sequences. Eur J Nucl Med 1989;15:113–117.PubMedGoogle Scholar
  12. 12.
    Baillet GY, Mena IG, Kuperus JH, Robertson JM, French WJ. Simultaneous technetium-99m MIBI angiography and myocardial perfusion imaging. J Nucl Med 1989;30:38–44.PubMedGoogle Scholar
  13. 13.
    Berman DS, Kiat H, Maddahi J. The new 99mTc myocardial perfusion imaging agents: 99mTc-sestamibi and 99mTc-teboroxime. Circulation 1991;84[suppll]:I-7-I–21Google Scholar
  14. 14.
    Leppo JA, Meerdink DJ. Comparative myocardial extraction of two technetium-labeled BATO derivatives (SQ30217, SQ32014) and thallium. J Nucl Med 1990;31:67–74.PubMedGoogle Scholar
  15. 15.
    Verzijlbergen JF, Suttorp MJ, Ascoop CAPL. Combined assessment of technetium-99m sestamibi planar myocardial perfusion images at rest and during exercise with rest/exercise left ventricular wall motion studies evaluated from gated myocardial perfusion studies. Am Heart J 1992;123:59–68.PubMedCrossRefGoogle Scholar
  16. 16.
    Taillefer R, Lambert R, Essiambre R, Phaneuf D-C, L’veillé J. Comparison between thallium-201, technetium-99m-sestamibi and technetium-99m-teboroxime planar myocardial perfusion imaging in detection of coronary artery disease. J Nucl Med 1992;33:1091–1098.PubMedGoogle Scholar
  17. 17.
    Mannting F, Morgan-Mannting MG. Gated SPECT with technetium-99m-sestamibi for assessment of myocardial perfusion abnormalities. J Nucl Med 1993;34:601–608.PubMedGoogle Scholar
  18. 18.
    Kouris K, Abdel-Dayem HM, Taha B, Ballani N, Hassan IM, Constantinides C. Left ventricular ejection fraction and volumes calculated from dual gated SPECT myocardial imaging with 99Tcm-MIBI. Nucl Med Commun 1992;13:648– Roberti RR, Van Tosh A, Baruchin MA, et al. Left ventricular cavity-to-myocardial count ratio: a new parameter for detecting resting left ventricular dysfunction directly from tomographic thallium perfusion scintigraphy. J Nucl Med 1993;34:193–198.Google Scholar
  19. 20.
    Tonami N, Shuke N, Yokoyama K, et al. Thallium-201 single photon emission computed tomography in the evaluation of suspected lung cancer. J Nucl Med 1989; 30:997–1004.PubMedGoogle Scholar
  20. 21.
    Harris EW, Rakow JI, Weiner M, Agress H. Thallium-201 scintigraphy for assessment of a gallium-67-avid mediastinal mass following therapy for Hodgkin’s disease. J Nucl Med 1993;34:1326–1330.PubMedGoogle Scholar
  21. 22.
    Cox PH, Belfer AJ, van der Pompe WB. Thallium 201 chloride uptake in tumors, a possible complication in heart scintigraphy. Br J Radiol 1976;49:767–768.PubMedCrossRefGoogle Scholar
  22. 23.
    Togawa T, Suzuki A, Higuchi Y. 201Tl to 67Ga crude uptake ratio in primary lung cancer with reference to histological type. Lung Cancer 1985;25:187–195.CrossRefGoogle Scholar
  23. 24.
    Itoh K, Takekawa H, Tsukamoto E, et al. Single photon emission computed tomography using 201Tl chloride in pulmonary nodules: comparison with 67Ga citrate and 99mTc-labeled hexamethylpropyleneamine-oxime. Ann Nucl Med 1992;6:253–260.PubMedCrossRefGoogle Scholar
  24. 25.
    Kao CH, Wang SJ, Lin WY, Hsu CY, Liao SQ, Yeh SH. Differentiation of single solid lesions in the lungs by means of single-photon emission tomography with technetium-99m methoxyisobutylisonitrile. Eur J Nucl Med 1993;20:249–254.PubMedGoogle Scholar
  25. 26.
    Tonami N, Yokoyama K, Shuke N, et al. Evaluation of suspected malignant pulmonary lesions with 201Tl single photon emission computed tomography. Nucl Med Commun 1993;14:602–610.PubMedCrossRefGoogle Scholar
  26. 27.
    Hirose Y, Imaeda T, Doi H, Kokubo M, Sakai S, Hirose H. Lung perfusion SPECT in predicting postoperative pulmonary function in lung cancer. Ann Nucl Med 1993;7:12 3–126.PubMedCrossRefGoogle Scholar
  27. 28.
    Eustace S, Phelan N, Dowsett DJ, Ennis JT. A comparison of SPECT and planar ventilation perfusion lung scanning. Ir J Med Sci 1993;162:82–85.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1995

Authors and Affiliations

There are no affiliations available

Personalised recommendations