Abstract
In a double-blind placebo controlled crossover trial of 24 weeks 31 patients with Raynaud’s syndrome were treated with the alpha-blocker phenoxybenzamine (10–20 mg daily) and with the combination of the alpha-blocker phenoxybenzamine (10–20 mg daily) and the beta-blocker Sotalol (40–80 mg daily). A favorable effect on recovery of finger temperature after finger cooling was demonstrated after alpha-blockade as compared to the before treatment situation. This favorable effect was not different when the group received the combined alpha- and beta-blockade. The blood pressure was not influenced by either of the 2 medications. Fluid retention appeared with alpha-blockade and was absent with combined alpha- and beta-blockade. Decrease of heart rate occurred with alpha-plus beta-blockade and was absent with alpha-blockade alone. Clinical symptoms of Raynaud’s syndrome were equally alleviated by the two medications. Common, and equally frequent side effects of the two medications were nasal congestion, disturbed ejaculation and potence, dry mouth, exercise-induced, and orthostatic dizziness.
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© 1995 Springer Science+Business Media Dordrecht
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Cleophas, T.J.M. (1995). Alpha-Blocker Induced Hypotension and Fluid Retention Prevented by Nonselective Beta-Blockers. In: Beta-Blockers in Hypertension and Angina Pectoris. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0129-5_3
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DOI: https://doi.org/10.1007/978-94-011-0129-5_3
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