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Potassium Channels in The Regulation of Vascular Smooth Muscle Tone

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Pharmacological Control of Calcium and Potassium Homeostasis

Part of the book series: Medical Science Symposia Series ((MSSS,volume 9))

Abstract

Blood vessel tone is the complex resultant of the effects exerted by blood pressure and flow, the presence of endogenous constrictors and relaxants and the inherent properties of the constituent vascular smooth muscle cells [1]. Potassium (K) channels affect tone by modifying the prevailing level of membrane potential with consequent effects on the gating of voltage-sensitive calcium (Ca) channels. With the K equilibrium potential (EK) at -85mV, K channel opening produces hyperpolarization and relaxation. Conversely, the closure of open K channels depolarizes the membrane and primes the cell for contraction [2].

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Author information

Authors and Affiliations

  1. School of Biological Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK

    Gillian Edwards & Arthur H. Weston

Authors
  1. Gillian Edwards
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  2. Arthur H. Weston
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Editor information

Editors and Affiliations

  1. Laboratory of Pharmacology, Catholic University of Louvain, Brussels, Belgium

    T. Godfraind

  2. Center of Physiology, Hypertension Clinic, University of Milan, Milan, Italy

    G. Mancia

  3. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    M. P. Abbracchio

  4. Baylor College of Medicine, Houston, Texas, USA

    L. Aguilar-Bryan

  5. Institute of Pharmacology, University of Pavia, Pavia, Italy

    S. Govoni

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© 1995 Springer Science+Business Media Dordrecht

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Edwards, G., Weston, A.H. (1995). Potassium Channels in The Regulation of Vascular Smooth Muscle Tone. In: Godfraind, T., Mancia, G., Abbracchio, M.P., Aguilar-Bryan, L., Govoni, S. (eds) Pharmacological Control of Calcium and Potassium Homeostasis. Medical Science Symposia Series, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0117-2_9

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  • DOI: https://doi.org/10.1007/978-94-011-0117-2_9

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4056-3

  • Online ISBN: 978-94-011-0117-2

  • eBook Packages: Springer Book Archive

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