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Pharmacological Control of Calcium and Potassium Homeostasis pp 73–83Cite as

Endothelium-Dependent Hyperpolarization and Potassium Channels

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Part of the book series: Medical Science Symposia Series ((MSSS,volume 9))

Abstract

In response to various neurohumoral mediators and physical stimuli, the endothelium elicits relaxations or contractions of the underlying vascular smooth muscle. Endothelium-dependent relaxations can be mediated by the release of the endothelium-derived nitric oxide and prostacyclin [1-2]. In addition, endothelial cells release a yet unidentified endothelium-derived hyperpolarizing factor (EDHF), which causes membrane hyperpolarization by opening potassium channels in vascular smooth muscle [3-4]. However, the possibility that EDHF may contribute to endothelium-dependent hyperpolarization and the mechanism underlying this response is the subject of some controversy. Since both NO and some synthesized prostanoids [5] can cause membrane hyperpolarization under certain conditions, depending on the tissues and/or the species studied, the electrophysiological changes attributed to EDHF have to be distinguished from those of either NO or prostanoids by demonstrating its occurrence during combined inhibition of NO synthase and cyclooxygenase [6]. This brief review focuses on endothelium-dependent hyperpolarizations which cannot be attributed to the release of nitric oxide or prostanoids.

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  1. Institut de Recherches Servier, 11 rue des Moulineaux, 92150, Suresnes, France

    Mikio Nakashima, Michel Félétou & Paul M. Vanhoutte

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  1. Mikio Nakashima
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  2. Michel Félétou
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Editors and Affiliations

  1. Laboratory of Pharmacology, Catholic University of Louvain, Brussels, Belgium

    T. Godfraind

  2. Center of Physiology, Hypertension Clinic, University of Milan, Milan, Italy

    G. Mancia

  3. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    M. P. Abbracchio

  4. Baylor College of Medicine, Houston, Texas, USA

    L. Aguilar-Bryan

  5. Institute of Pharmacology, University of Pavia, Pavia, Italy

    S. Govoni

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Nakashima, M., Félétou, M., Vanhoutte, P.M. (1995). Endothelium-Dependent Hyperpolarization and Potassium Channels. In: Godfraind, T., Mancia, G., Abbracchio, M.P., Aguilar-Bryan, L., Govoni, S. (eds) Pharmacological Control of Calcium and Potassium Homeostasis. Medical Science Symposia Series, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0117-2_8

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