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Modulation of K+ Channels: Pharmacological and Therapeutic Aspects

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Pharmacological Control of Calcium and Potassium Homeostasis

Part of the book series: Medical Science Symposia Series ((MSSS,volume 9))

Abstract

In most cells, the plasma membrane at rest is more permeable to K+than to Na+CI-or Ca2+; hence, K+channels are the major factor contributing to resting membrane potential and cell excitability. Furthermore, these channels intervene in the regulation of several cellular functions, such as cytosolic volume and hormone secretion [1] The opening of K+channels drives the membrane potential towards the K+equilibrium potential, which is around -90 mV. In excitable cells endowed with depolarization (voltage)-gated Ca2+channels, hyperpolarization prevents such channels from opening and, hence, negates Ca2+entry. In cells lacking voltage-gated Ca2+channels, such as the endothelial cells and leukocytes, hyperpolarization, by increasing the driving force for the entry of Ca2+into the cell, promotes Ca2+influx via pathways yet poorly characterized [2]. In view of the physiological importance of K+channels, it is no surprise that this class of ion channels is particularly heterogeneous.

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Authors and Affiliations

  1. Department of Pharmacology, University of Tübingen, Wilhelmstr. 56, Tübingen, D-72074, Germany

    Ulrich Quast

  2. Rhône-Poulenc Rorer Recherche-Développement, CRVA, 13, Quai Jules Guesde, 94403, Vitry-sur-Seine, France

    Jean-Michel Guillon & Icilio Cavero

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  1. Ulrich Quast
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  2. Jean-Michel Guillon
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  3. Icilio Cavero
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Editor information

Editors and Affiliations

  1. Laboratory of Pharmacology, Catholic University of Louvain, Brussels, Belgium

    T. Godfraind

  2. Center of Physiology, Hypertension Clinic, University of Milan, Milan, Italy

    G. Mancia

  3. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    M. P. Abbracchio

  4. Baylor College of Medicine, Houston, Texas, USA

    L. Aguilar-Bryan

  5. Institute of Pharmacology, University of Pavia, Pavia, Italy

    S. Govoni

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Quast, U., Guillon, JM., Cavero, I. (1995). Modulation of K+ Channels: Pharmacological and Therapeutic Aspects. In: Godfraind, T., Mancia, G., Abbracchio, M.P., Aguilar-Bryan, L., Govoni, S. (eds) Pharmacological Control of Calcium and Potassium Homeostasis. Medical Science Symposia Series, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0117-2_4

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  • DOI: https://doi.org/10.1007/978-94-011-0117-2_4

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