Abstract
Among the various K+channels existing in vascular smooth muscle (VSM), the ATP-sensitive K+channel (KATP) deserves particular interest both from pathophysiological and therapeutic points of view. FirstlyKATPconstitute an important link between cellular energy metabolism and the contractile tone of VSM cells and may hence play a role in the regulation of tissueO Z supply. Secondly, potent vasodilator drugs are available for medical use which act via modulation of the open-probability ofKATPin VSM. Some of this material has been published elsewhere [1 2].
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References
Kreye VAW, Lenz T, PfründerD.Mode of action of potassium channel openers in vascular smooth muscle. J Contemp Pharmacol 1993;4:185–198.
Pfründer D, Anghelescu I, Kreye VAW. Intracellular ADP activates ATP-sensitive K+channels in vascular smooth muscle of the guinea pig portal vein. Pflügers Arch 1993;423:149–151.
Ltibbers DW. Grundlagen und Bedeutung der lokalen Sauerstoffdruckmessung und des p02-Histogramms für die Beurteilung der Sauerstoffversorgung der Organe und des Organismus. In: Ehrly AM, editor. Messung des Gewebesauerstoffdrucks bei Patienten. Baden-Baden: Verlag Gerhard Witzstrock 1981:15–21.
Daut J, Maier-Rudolph W, von Beckerath N, Mehrke G, Günther K, Goedel-Meinen L. Hypoxic dilation of coronary arteries is mediated by ATP-sensitive potassium channels. Science 1990;247:1341–1344.
Clayton FC, Hess TA, Smith MA, Grover GJ. Coronary reactive hyperemia and adenosine-induced vasodilatation are mediated partially by a glyburide-sensitive mechanism. Pharmacology 1992;44:92–100.
Davies NW, Standen NB, Stanfield PR. ATP-dependent potassium channels of muscle cells: Their properties, regulation, and possible functions. J Bioenerg Biomemb 1991:23;509–535.
Cook DL, Satin LS, Ashford MU, Hales N. ATP-sensitive K+; channels in pancreatic ß-cells. Spare-channel hypothesis. Diabetes 1988;37:495–498.
Schwanstecher C, Dickel C, Panten U. Cytosolic nucleotides enhance the tolbutamide sensitivity of the ATP-dependent K` channel in mouse pancreatic B cells by their combined actions at inhibitory and stimulatory receptors. Mol Pharmacol 1992;41:480–486.
Allard B, Lazdunski M. Nucleotide diphosphates activate the ATP-sensitive potassium channel in mouse skeletal muscle. Pflügers Arch 1992;422:185–192.
Findlay I. Effects of ADP upon the ATP-sensitive K+channel in rat ventricular myocytes. J Membr Biol 1988;101:83–92.
Kajioka S, Kitamura K, Kuriyama H. Guanosine diphosphate activates an adenosine 5’-triphosphate-sensitive K+channel in the rabbit portal vein. J Physiol 1991;444:397–418.
Beech DJ, Zhang H, Nakao K, Bolton TB. K channel activation by nucleotide diphosphates and its inhibition by glibenclamide in vascular smooth muscle cells. Br J Pharmacol 1993;110:573–582.
Pfründer D, Anghelescu I, Kreye VAW. Evidence that intracellular ADP activates ATP-dependent potassium channels and enhances their reactivity to cromakalim in vascular smooth muscle cells - a whole-cell clamp study. Pflügers Arch 1993;422 (Supp1.1):R78.
Beech DJ, Bolton TB. Properties of the cromakalim-induced potassium conductance in smooth muscle cells isolated from the rabbit portal vein. Br J Pharmacol 1989;98:851–864.
Edwards G, Ibbotson T, Weston AH. Levcromakalim may induce a voltage-independent K-current in rat portal veins by modifying the gating properties of the delayed rectifier. Br J Pharmacol 1993;110:1037–1048.
Ashford MU, Bond CT, Blair TA, Adelman W. Cloning and functional expression of a rat heartKornchannel. Nature 1994;370:456–459.
Kajioka S, Pfründer D, Karle C, Kreye VAW. Inhibitory action of okadaic acid and 8-bromo-cyclic-AMP on ATP-sensitive K+currents (KA.) in vascular smooth muscle cells. Pflügers Arch 1994;426(Suppl.):R91.
Ferrier CP, Kurtz A, Lehner P, et al. Stimulation of renin secretion by potassium channel activation with cromakalim. Eur J Clin Pharmacol 1989;36:443–447.
Cook NS, Fozard JR, Hof RP. The potential of potassium channel openers in peripheral vascular disease. In: Escande D, Standen N, editors. K+channels in cardiovascular medicine. Paris: Springer-Verlag, 1993:305–319.
Richer C, Pratz J, Mulder P, Mondot S, Giudicelli JF, Cavero I. Cardiovascular and biological effects of K+channel openers, a class of drugs with vasorelaxant and cardioprotective properties. Life Sci 1990;47:1693–1705.
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Kreye, V.A., Anghelescu, I., Kajioka, S., Karle, C., Pfründer, D. (1995). Atp-Dependent K+Channels in Vascular Smooth Muscle. In: Godfraind, T., Mancia, G., Abbracchio, M.P., Aguilar-Bryan, L., Govoni, S. (eds) Pharmacological Control of Calcium and Potassium Homeostasis. Medical Science Symposia Series, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0117-2_28
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DOI: https://doi.org/10.1007/978-94-011-0117-2_28
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