Abstract
Atherosclerosis is the major cause for cardiovascular diseases, including myocardial infarction and stroke, responsible for about 50% of total mortality in Europe, the United States, and Japan. The formation of the atherosclerotic lesion is a multifactorial process that involves several mechanisms: endothelial damage; lipid accumulation in the intimai tissue of the arterial vessel; smooth muscle cell proliferation and migration from the medial layer to the intimal layer of the artery; and synthesis and accumulation of proteoglycans and other components of the extracellular matrix [1]. Several growth factors including cytokines and vasoactive molecules are also involved in the atherosclerotic lesion formation [1]. These factors can be synthesized by the different cell types involved in the atherosclerotic process: endothelial cells, smooth muscle cells, macrophages, and platelets [1].
Keywords
- Angiotensin Converting Enzyme
- Calcium Antagonist
- Atherosclerotic Lesion
- Smooth Muscle Cell Migration
- Atherosclerotic Lesion Formation
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Paoletti, R. (1995). Rationale for Combined Therapy with Calcium Antagonists and Ace Inhibitors. In: Godfraind, T., Mancia, G., Abbracchio, M.P., Aguilar-Bryan, L., Govoni, S. (eds) Pharmacological Control of Calcium and Potassium Homeostasis. Medical Science Symposia Series, vol 9. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0117-2_18
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DOI: https://doi.org/10.1007/978-94-011-0117-2_18
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